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Protein

Conglutin-7

Gene
N/A
Organism
Arachis hypogaea (Peanut)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Weak inhibitor of trypsin.1 Publication

Miscellaneous

Resistant to proteolysis.1 Publication

Temperature dependencei

Thermostable.1 Publication

GO - Molecular functioni

Keywordsi

Molecular functionIgE-binding protein, Protease inhibitor, Seed storage protein, Serine protease inhibitor, Storage protein

Names & Taxonomyi

Protein namesi
Recommended name:
Conglutin-71 PublicationImported
Alternative name(s):
2S protein 11 PublicationImported
Seed storage protein SSP11 PublicationImported
Seed storage protein SSP21 PublicationImported
Allergen: Ara h 2
OrganismiArachis hypogaea (Peanut)
Taxonomic identifieri3818 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideae50 kb inversion cladedalbergioids sensu latoDalbergieaePterocarpus cladeArachis

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human. Binds to IgE.1 Publication

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei1081 Ara h 2.0101
1082 Ara h 2.0201
51 Ara h 2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 212 PublicationsAdd BLAST21
ChainiPRO_000037068722 – 172Conglutin-72 PublicationsAdd BLAST151

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi33 ↔ 1161 Publication
Disulfide bondi45 ↔ 103Or C-45 with C-1041 Publication
Modified residuei674-hydroxyproline1 Publication1
Modified residuei744-hydroxyproline1 Publication1
Modified residuei864-hydroxyproline1 Publication1
Disulfide bondi104 ↔ 152Or C-103 with C-1521 Publication
Disulfide bondi118 ↔ 1601 Publication

Post-translational modificationi

The hydroxyproline modifications determined by mass spectrometry are probably 4-hydroxyproline as determined for other extracellular plant proteins.1 Publication

Keywords - PTMi

Disulfide bond, Hydroxylation

Expressioni

Tissue specificityi

Expressed in seeds, not expressed in leaves, roots and pegs.1 Publication

Developmental stagei

Expressed at very low levels in immature seeds and at high levels from 40-75 days after pollination. Expression decreases after 75 days after pollination.1 Publication

Inductioni

Repressed by water stress.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ6PSU2
SMRiQ6PSU2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the 2S seed storage albumins family.Sequence analysis

Keywords - Domaini

Signal

Family and domain databases

InterProiView protein in InterPro
IPR036312 Bifun_inhib/LTP/seed_sf
IPR016140 Bifunc_inhib/LTP/seed_store
PfamiView protein in Pfam
PF00234 Tryp_alpha_amyl, 1 hit
SMARTiView protein in SMART
SM00499 AAI, 1 hit
SUPFAMiSSF47699 SSF47699, 1 hit

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q6PSU2-1) [UniParc]FASTAAdd to basket
Also known as: P1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAKLTILVAL ALFLLAAHAS ARQQWELQGD RRCQSQLERA NLRPCEQHLM
60 70 80 90 100
QKIQRDEDSY GRDPYSPSQD PYSPSQDPDR RDPYSPSPYD RRGAGSSQHQ
110 120 130 140 150
ERCCNELNEF ENNQRCMCEA LQQIMENQSD RLQGRQQEQQ FKRELRNLPQ
160 170
QCGLRAPQRC DLEVESGGRD RY
Length:172
Mass (Da):20,114
Last modified:May 15, 2007 - v2
Checksum:iB8BB91C8D8C143AB
GO
Isoform 2 (identifier: Q6PSU2-2) [UniParc]FASTAAdd to basket
Also known as: P2

The sequence of this isoform differs from the canonical sequence as follows:
     76-87: Missing.

Show »
Length:160
Mass (Da):18,700
Checksum:iB6C7DDB9E32E3E07
GO
Isoform 3 (identifier: Q6PSU2-3) [UniParc]FASTAAdd to basket
Also known as: P3

The sequence of this isoform differs from the canonical sequence as follows:
     170-172: DRY → D

Show »
Length:170
Mass (Da):19,795
Checksum:i01C8D8C143AB90BD
GO
Isoform 4 (identifier: Q6PSU2-4) [UniParc]FASTAAdd to basket
Also known as: P4

The sequence of this isoform differs from the canonical sequence as follows:
     76-87: Missing.
     170-172: DRY → D

Show »
Length:158
Mass (Da):18,380
Checksum:iEDB9E32E3E079A4B
GO

Sequence cautioni

The sequence AAT00598 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAT00599 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAU21494 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2 – 3Missing in ACN62248 (Ref. 7) Curated2
Sequence conflicti10L → P in AAM78596 (Ref. 10) Curated1
Sequence conflicti27L → F in AAT00599 (Ref. 4) Curated1
Sequence conflicti61G → E in AAU21494 (Ref. 2) Curated1
Sequence conflicti61G → E in AAT00599 (Ref. 4) Curated1
Sequence conflicti61G → E in ACN62248 (Ref. 7) Curated1
Sequence conflicti61G → E in AAK96887 (PubMed:11295663).Curated1
Sequence conflicti65 – 78Missing in ABL14268 (Ref. 5) CuratedAdd BLAST14
Sequence conflicti163E → D in AAU21494 (Ref. 2) Curated1
Sequence conflicti163E → D in AAT00599 (Ref. 4) Curated1
Sequence conflicti163E → D in ACN62248 (Ref. 7) Curated1
Sequence conflicti163E → D in AAK96887 (PubMed:11295663).Curated1

Mass spectrometryi

Molecular mass is 18050 Da from positions 22 - 172. Determined by MALDI. Isoform 1.1 Publication
Molecular mass is 16670 Da from positions 22 - 172. Determined by MALDI. Isoform 3.1 Publication

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03891676 – 87Missing in isoform 2 and isoform 4. 3 PublicationsAdd BLAST12
Alternative sequenceiVSP_038917170 – 172DRY → D in isoform 3 and isoform 4. 1 Publication3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY158467 mRNA Translation: AAN77576.1
AY581853 mRNA Translation: AAT00598.1 Different initiation.
AY722689 mRNA Translation: AAU21494.1 Different initiation.
EF609644 Genomic DNA Translation: ABQ96215.1
AY581854 mRNA Translation: AAT00599.1 Different initiation.
EF080817 mRNA Translation: ABL14268.1
EF695402 Genomic DNA Translation: ABS28872.1
FJ713110 Genomic DNA Translation: ACN62248.1
AY007229 Genomic DNA Translation: AAK96887.1
AF366560 mRNA Translation: AAO61750.1
AY117434 mRNA Translation: AAM78596.1

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY158467 mRNA Translation: AAN77576.1
AY581853 mRNA Translation: AAT00598.1 Different initiation.
AY722689 mRNA Translation: AAU21494.1 Different initiation.
EF609644 Genomic DNA Translation: ABQ96215.1
AY581854 mRNA Translation: AAT00599.1 Different initiation.
EF080817 mRNA Translation: ABL14268.1
EF695402 Genomic DNA Translation: ABS28872.1
FJ713110 Genomic DNA Translation: ACN62248.1
AY007229 Genomic DNA Translation: AAK96887.1
AF366560 mRNA Translation: AAO61750.1
AY117434 mRNA Translation: AAM78596.1

3D structure databases

ProteinModelPortaliQ6PSU2
SMRiQ6PSU2
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei1081 Ara h 2.0101
1082 Ara h 2.0201
51 Ara h 2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiView protein in InterPro
IPR036312 Bifun_inhib/LTP/seed_sf
IPR016140 Bifunc_inhib/LTP/seed_store
PfamiView protein in Pfam
PF00234 Tryp_alpha_amyl, 1 hit
SMARTiView protein in SMART
SM00499 AAI, 1 hit
SUPFAMiSSF47699 SSF47699, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCONG7_ARAHY
AccessioniPrimary (citable) accession number: Q6PSU2
Secondary accession number(s): A1DZE8
, A5Z1R1, C0LJJ1, Q647H0, Q6PSU1, Q7Y1C0, Q84TU1, Q8GV20, Q941R0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 15, 2007
Last modified: September 12, 2018
This is version 55 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Allergens
    Nomenclature of allergens and list of entries
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