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Protein
Submitted name:

Transducin-like enhancer of split 3 splice variant 1

Gene

TLE3

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Enzyme and pathway databases

SignaLinkiQ6PRX3

Names & Taxonomyi

Protein namesi
Submitted name:
Transducin-like enhancer of split 3 splice variant 1Imported
Gene namesi
Name:TLE3Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PeptideAtlasiQ6PRX3
PRIDEiQ6PRX3

Structurei

3D structure databases

ProteinModelPortaliQ6PRX3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini474 – 647WD_REPEATS_REGIONInterPro annotationAdd BLAST174
Repeati564 – 605WDPROSITE-ProRule annotationAdd BLAST42
Repeati606 – 647WDPROSITE-ProRule annotationAdd BLAST42
Domaini688 – 764WD_REPEATS_REGIONInterPro annotationAdd BLAST77

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili26 – 60Sequence analysisAdd BLAST35

Keywords - Domaini

Coiled coilSequence analysis, WD repeatPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0639 Eukaryota
ENOG410XPX3 LUCA
HOGENOMiHOG000293211
HOVERGENiHBG004689

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR005617 Groucho/TLE_N
IPR009146 Groucho_enhance
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR10814 PTHR10814, 1 hit
PfamiView protein in Pfam
PF03920 TLE_N, 1 hit
PF00400 WD40, 2 hits
PRINTSiPR01850 GROUCHOFAMLY
SMARTiView protein in SMART
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 2 hits
PS50082 WD_REPEATS_2, 2 hits
PS50294 WD_REPEATS_REGION, 2 hits

Sequencei

Sequence statusi: Complete.

Q6PRX3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MYPQGRHPAP HQPGQPGFKF TVAESCDRIK DEFQFLQAQY HSLKVEYDKL
60 70 80 90 100
ANEKTEMQRH YVMYYEMSYG LNIEMHKQTE IAKRLNTILA QIMPFLSQEH
110 120 130 140 150
QQQVAQAVER AKQVTMTELN AIIGQQQLQA QHLSHATHGP PVQLPPHPSG
160 170 180 190 200
LQPPGIPPVT GSSSGLLALG ALGSQAHLTV KDEKNHHELD HRERESSANN
210 220 230 240 250
SVSPSESLRA SEKHRGSADY SMEAKKRKAE EKDSLSRYDS DGDKSDDLVV
260 270 280 290 300
DVSNEDPATP RVSPAHSPPE NGLVKARSLK KDAPTSPASV ASSSSAPSSK
310 320 330 340 350
TKDLGHNDKS STPGLKSNTP TPRNDAPTPG TSTTPGLRSM PGKPPGMDPI
360 370 380 390 400
ASALRTPISI TSSYAAPFAM MSHHEMNGSL TSPGAYAGLH NIPPQMSAAA
410 420 430 440 450
AAAAAAYGRS PMVGFDPHPP MRATGLPSSL ASIPGGKPAY SFHVSADGQM
460 470 480 490 500
QPVPFPHDAL AGPGIPRHAR QINTLSHGEV VCAVTISNPT RHVYTGGKGC
510 520 530 540 550
VKIWDISQPG SKSPISQLDC LNRDNYIRSC KLLPDGRTLI VGGEASTLTI
560 570 580 590 600
WDLASPTPRI KAELTSSAPA CYALAISPDA KVCFSCRSDG NIAVWDLHNQ
610 620 630 640 650
TLVRQFQGHT DGASCIDISH DGTKLWTGGL DNTVRSWDLR EGRQLQQHDF
660 670 680 690 700
TSQIFSLGYC PTGEWLAVGM ESSNVEVLHH TKPDKYQLHL HESCVLSLKF
710 720 730 740 750
AYCGKWFVST GKDNLLNAWR TPYGASIFQS KESSSVLSCD ISADDKYIVT
760
GSGDKKATVY EVIY
Length:764
Mass (Da):82,661
Last modified:July 5, 2004 - v1
Checksum:iD8D48782C7EB80C2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY583459 mRNA Translation: AAS90945.1
RefSeqiNP_001269908.1, NM_001282979.1
UniGeneiHs.287362

Genome annotation databases

GeneIDi7090

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY583459 mRNA Translation: AAS90945.1
RefSeqiNP_001269908.1, NM_001282979.1
UniGeneiHs.287362

3D structure databases

ProteinModelPortaliQ6PRX3
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiQ6PRX3
PRIDEiQ6PRX3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi7090

Organism-specific databases

CTDi7090

Phylogenomic databases

eggNOGiKOG0639 Eukaryota
ENOG410XPX3 LUCA
HOGENOMiHOG000293211
HOVERGENiHBG004689

Enzyme and pathway databases

SignaLinkiQ6PRX3

Miscellaneous databases

ChiTaRSiTLE3 human
GenomeRNAii7090

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR005617 Groucho/TLE_N
IPR009146 Groucho_enhance
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR10814 PTHR10814, 1 hit
PfamiView protein in Pfam
PF03920 TLE_N, 1 hit
PF00400 WD40, 2 hits
PRINTSiPR01850 GROUCHOFAMLY
SMARTiView protein in SMART
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 2 hits
PS50082 WD_REPEATS_2, 2 hits
PS50294 WD_REPEATS_REGION, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiQ6PRX3_HUMAN
AccessioniPrimary (citable) accession number: Q6PRX3
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: October 10, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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