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Protein

Cementoblastoma-derived protein 1

Gene

CEMP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in development of the periodontium which surrounds and supports the teeth by promoting the differentiation of multi-potent cells from the periodontal ligament into cementoblasts to form the cementum (PubMed:21929512, PubMed:17509525, PubMed:21465469). Binds hydroxyapatite and may promote the biomineralization of the cementum (PubMed:19393626). Also promotes cell proliferation (PubMed:17509525, PubMed:21929512, PubMed:26011628).5 Publications

GO - Molecular functioni

  • hydroxyapatite binding Source: UniProtKB

GO - Biological processi

  • biomineral tissue development Source: UniProtKB
  • cell differentiation Source: UniProtKB
  • cell proliferation Source: UniProtKB
  • odontogenesis Source: UniProtKB

Keywordsi

Biological processDifferentiation

Names & Taxonomyi

Protein namesi
Recommended name:
Cementoblastoma-derived protein 1Curated
Alternative name(s):
Cementum protein 11 Publication
Cementum protein 231 Publication
Short name:
CP-231 Publication
Gene namesi
Name:CEMP1Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000205923.3
HGNCiHGNC:32553 CEMP1
MIMi611113 gene
neXtProtiNX_Q6PRD7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi752014
OpenTargetsiENSG00000205923
PharmGKBiPA162382169

Polymorphism and mutation databases

BioMutaiCEMP1
DMDMi74709987

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002644751 – 247Cementoblastoma-derived protein 1Add BLAST247

Post-translational modificationi

Phosphorylated.1 Publication
N-glycosylated.1 Publication

Proteomic databases

EPDiQ6PRD7
PaxDbiQ6PRD7
PeptideAtlasiQ6PRD7
PRIDEiQ6PRD7
ProteomicsDBi67259

PTM databases

iPTMnetiQ6PRD7
PhosphoSitePlusiQ6PRD7

Expressioni

Tissue specificityi

Expressed by cementoblasts, a subpopulation of periodontal ligament cells and cells located around vessels in periodontium (at protein level).2 Publications

Inductioni

Up-regulated by hypoxia (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000205923 Expressed in 142 organ(s), highest expression level in right adrenal gland
CleanExiHS_CEMP1
ExpressionAtlasiQ6PRD7 baseline and differential
GenevisibleiQ6PRD7 HS

Organism-specific databases

HPAiHPA057658

Interactioni

Protein-protein interaction databases

IntActiQ6PRD7, 2 interactors
STRINGi9606.ENSP00000371787

Structurei

3D structure databases

ProteinModelPortaliQ6PRD7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410JIJY Eukaryota
ENOG41115YI LUCA
GeneTreeiENSGT00410000029488
HOGENOMiHOG000111536
InParanoidiQ6PRD7
OrthoDBiEOG091G0G9A
PhylomeDBiQ6PRD7
TreeFamiTF343729

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q6PRD7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGTSSTDSQQ AGHRRCSTSN TSAENLTCLS LPGSPGKTAP LPGPAQAGAG
60 70 80 90 100
QPLPKGCAAV KAEVGIPAPH TSQEVRIHIR RLLSWAAPGA CGLRSTPCAL
110 120 130 140 150
PQALPQARPC PGRWFFPGCS LPTGGAQTIL SLWTWRHFLN WALQQREENS
160 170 180 190 200
GRARRVPPVP RTAPVSKGEG SHPPQNSNGE KVKTITPDVG LHQSLTSDPT
210 220 230 240
VAVLRAKRAP EAHPPRSCSG SLTARVCHMG VCQGQGDTED GRMTLMG
Length:247
Mass (Da):25,959
Last modified:July 5, 2004 - v1
Checksum:i81FEEA1D26E47022
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BPU9H3BPU9_HUMAN
Cementoblastoma-derived protein 1
CEMP1
48Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05079255K → E. Corresponds to variant dbSNP:rs13331643Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY584596 mRNA Translation: AAT01221.1
BC146925 mRNA Translation: AAI46926.1
BC146926 mRNA Translation: AAI46927.1
CCDSiCCDS42108.1
RefSeqiNP_001041677.1, NM_001048212.3
UniGeneiHs.433499
Hs.737156

Genome annotation databases

EnsembliENST00000567119; ENSP00000457380; ENSG00000205923
GeneIDi752014
KEGGihsa:752014
UCSCiuc002cqr.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY584596 mRNA Translation: AAT01221.1
BC146925 mRNA Translation: AAI46926.1
BC146926 mRNA Translation: AAI46927.1
CCDSiCCDS42108.1
RefSeqiNP_001041677.1, NM_001048212.3
UniGeneiHs.433499
Hs.737156

3D structure databases

ProteinModelPortaliQ6PRD7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ6PRD7, 2 interactors
STRINGi9606.ENSP00000371787

PTM databases

iPTMnetiQ6PRD7
PhosphoSitePlusiQ6PRD7

Polymorphism and mutation databases

BioMutaiCEMP1
DMDMi74709987

Proteomic databases

EPDiQ6PRD7
PaxDbiQ6PRD7
PeptideAtlasiQ6PRD7
PRIDEiQ6PRD7
ProteomicsDBi67259

Protocols and materials databases

DNASUi752014
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000567119; ENSP00000457380; ENSG00000205923
GeneIDi752014
KEGGihsa:752014
UCSCiuc002cqr.3 human

Organism-specific databases

CTDi752014
DisGeNETi752014
EuPathDBiHostDB:ENSG00000205923.3
GeneCardsiCEMP1
H-InvDBiHIX0202290
HGNCiHGNC:32553 CEMP1
HPAiHPA057658
MIMi611113 gene
neXtProtiNX_Q6PRD7
OpenTargetsiENSG00000205923
PharmGKBiPA162382169
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JIJY Eukaryota
ENOG41115YI LUCA
GeneTreeiENSGT00410000029488
HOGENOMiHOG000111536
InParanoidiQ6PRD7
OrthoDBiEOG091G0G9A
PhylomeDBiQ6PRD7
TreeFamiTF343729

Miscellaneous databases

GenomeRNAii752014
PROiPR:Q6PRD7
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000205923 Expressed in 142 organ(s), highest expression level in right adrenal gland
CleanExiHS_CEMP1
ExpressionAtlasiQ6PRD7 baseline and differential
GenevisibleiQ6PRD7 HS

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiCEMP1_HUMAN
AccessioniPrimary (citable) accession number: Q6PRD7
Secondary accession number(s): B2RUY1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: July 5, 2004
Last modified: November 7, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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