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Entry version 118 (16 Oct 2019)
Sequence version 2 (10 Jan 2006)
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Protein

Probable G-protein coupled receptor 179

Gene

GPR179

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Orphan receptor, involved in vision. Required for signal transduction through retinal depolarizing bipolar cells.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processSensory transduction, Vision

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable G-protein coupled receptor 179
Alternative name(s):
Probable G-protein coupled receptor 158-like 1
Short name:
GPR158-like
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GPR179
Synonyms:GPR158L, GPR158L1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:31371 GPR179

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
614515 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6PRD1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini26 – 381ExtracellularSequence analysisAdd BLAST356
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei382 – 402Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini403 – 415CytoplasmicSequence analysisAdd BLAST13
Transmembranei416 – 436Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini437 – 444ExtracellularSequence analysis8
Transmembranei445 – 465Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini466 – 493CytoplasmicSequence analysisAdd BLAST28
Transmembranei494 – 514Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini515 – 543ExtracellularSequence analysisAdd BLAST29
Transmembranei544 – 564Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini565 – 575CytoplasmicSequence analysisAdd BLAST11
Transmembranei576 – 594Helical; Name=6Sequence analysisAdd BLAST19
Topological domaini595 – 607ExtracellularSequence analysisAdd BLAST13
Transmembranei608 – 628Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini629 – 2367CytoplasmicSequence analysisAdd BLAST1739

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Night blindness, congenital stationary, 1E (CSNB1E)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive, non-progressive retinal disorder characterized by impaired night vision, absence of the electroretinogram (ERG) b-wave, and variable degrees of involvement of other visual functions. Affected individuals have an ERG waveform that lacks the b-wave because of failure to transmit the photoreceptor signal through the retinal depolarizing bipolar cells.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_067925126D → H in CSNB1E. 1 PublicationCorresponds to variant dbSNP:rs281875233EnsemblClinVar.1
Natural variantiVAR_067926220Y → C in CSNB1E. 1 PublicationCorresponds to variant dbSNP:rs281875236EnsemblClinVar.1
Natural variantiVAR_067927455G → D in CSNB1E. 1 PublicationCorresponds to variant dbSNP:rs281875235EnsemblClinVar.1
Natural variantiVAR_067928603H → Y in CSNB1E. 1 PublicationCorresponds to variant dbSNP:rs281875234EnsemblClinVar.1

Keywords - Diseasei

Congenital stationary night blindness, Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
440435

MalaCards human disease database

More...
MalaCardsi
GPR179
MIMi614565 phenotype

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
215 Congenital stationary night blindness

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134900696

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q6PRD1

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
GPR179

Domain mapping of disease mutations (DMDM)

More...
DMDMi
85540945

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 25Sequence analysisAdd BLAST25
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000004539726 – 2367Probable G-protein coupled receptor 179Add BLAST2342

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi75N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi298N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q6PRD1

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6PRD1

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q6PRD1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6PRD1

PeptideAtlas

More...
PeptideAtlasi
Q6PRD1

PRoteomics IDEntifications database

More...
PRIDEi
Q6PRD1

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
67258

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6PRD1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6PRD1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA017885

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
136572, 1 interactor

Protein interaction database and analysis system

More...
IntActi
Q6PRD1, 3 interactors

Molecular INTeraction database

More...
MINTi
Q6PRD1

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000483469

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi494 – 499Poly-Leu6
Compositional biasi551 – 554Poly-Leu4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4418 Eukaryota
ENOG410XXEC LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000015342

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6PRD1

KEGG Orthology (KO)

More...
KOi
K22961

Database of Orthologous Groups

More...
OrthoDBi
63351at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6PRD1

TreeFam database of animal gene trees

More...
TreeFami
TF319114

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR017978 GPCR_3_C
IPR032964 GPR179

The PANTHER Classification System

More...
PANTHERi
PTHR32546:SF7 PTHR32546:SF7, 5 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00003 7tm_3, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50259 G_PROTEIN_RECEP_F3_4, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q6PRD1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGTRGAVMPP PMWGLLGCCF VCAWALGGPR PIRSLPPLSS QVKPGSVPMQ
60 70 80 90 100
VPLEGAEAAL AYLYSGDAQQ LSQVNCSERY EARGAGAMPG LPPSLQGAAG
110 120 130 140 150
TLAQAANFLN MLLQANDIRE SSVEEDVEWY QALVRSVAEG DPRVYRALLT
160 170 180 190 200
FNPPPGASHL QLALQATRTG EETILQDLSG NWVQEENPPG DLDTPALKKR
210 220 230 240 250
VLTNDLGSLG SPKWPQADGY VGDTQQVRLS PPFLECQEGR LRPGWLITLS
260 270 280 290 300
ATFYGLKPDL SPEVRGQVQM DVDLQSVDIN QCASGPGWYS NTHLCDLNST
310 320 330 340 350
QCVPLESQGF VLGRYLCRCR PGFYGASPSG GLEESDFQTT GQFGFPEGRS
360 370 380 390 400
GRLLQCLPCP EGCTSCMDAT PCLVEEAAVL RAAVLACQAC CMLAIFLSML
410 420 430 440 450
VSYRCRRNKR IWASGVVLLE TVLFGFLLLY FPVFILYFKP SVFRCIALRW
460 470 480 490 500
VRLLGFAIVY GTIILKLYRV LQLFLSRTAQ RSALLSSGRL LRRLGLLLLP
510 520 530 540 550
VLGFLAVWTV GALERGIQHA PLVIRGHTPS GRHFYLCHHD RWDYIMVVAE
560 570 580 590 600
LLLLCWGSFL CYATRAVLSA FHEPRYMGIA LHNELLLSAA FHTARFVLVP
610 620 630 640 650
SLHPDWTLLL FFFHTHSTVT TTLALIFIPK FWKLGAPPRE EMVDEVCEDE
660 670 680 690 700
LDLQHSGSYL GSSIASAWSE HSLDPGDIRD ELKKLYAQLE VHKTKEMAAN
710 720 730 740 750
NPHLPKKRGS SCQGLGRSFM RYLAEFPEAL ARQHSRDSGS PGHGSLPGSS
760 770 780 790 800
RRRLLSSSLQ EPEGTPALHK SRSTYDQRRE QDPPLLDSLL RRKLAKKASR
810 820 830 840 850
TESRESVEGP PALGFRSASA HNLTVGERLP RARPASLQKS LSVASSREKA
860 870 880 890 900
LLMASQAYLE ETYRQAKERE ERKKAKAAMA SLVRRPSARR LERPRGAPLS
910 920 930 940 950
APPSPAKSSS VDSSHTSGRL HEEARRRLPH PPIRHQVSTP ILALSGGLGE
960 970 980 990 1000
PRMLSPTSTL APALLPALAP TPAPALAPVP VSPQSPNLLT YICPWENAEL
1010 1020 1030 1040 1050
PAKQENVPQE GPSGPERGHH SPAPARARLW RALSVAVEKS RAGENEMDAE
1060 1070 1080 1090 1100
DAHHQREAND VDEDRPKIFP KSHSLKAPVQ QGSMRSLGLA IKALTRSRST
1110 1120 1130 1140 1150
YREKESVEES PEGQNSGTAG ESMGAPSRSP RLGRPKAVSK QAALIPSDDK
1160 1170 1180 1190 1200
ESLQNQQNAH TSRMLQVCQR EGSREQEDRG RRMTQGLGER KAERAGKTGL
1210 1220 1230 1240 1250
AMLRQVSRDK NIKQSKETPV GWQELPKAGL QSLGSADHRV AEVCPWEVTE
1260 1270 1280 1290 1300
SETRQPDSGN KAEICPWETS EGAPESRALR QDPGDSQKKR GEARGKSEPI
1310 1320 1330 1340 1350
DVVPMMRKKP ERLVREQEAV CPWESADRGG LSPGSAPQDP GRIRDKSEAG
1360 1370 1380 1390 1400
DSVEARKVEK PGWEAAGPEA HTPDITKAEP CPWEASEGGE DGKPAQEAVK
1410 1420 1430 1440 1450
DLPQEKQKTR KATFWKEQKP GGDLESLCPW ESTDFRGPSA VSIQAPGSSE
1460 1470 1480 1490 1500
CSGSLGSGIA EVCLWEAGDA PAIQKAEICP WELDDNVMGQ EMLSLGTGRE
1510 1520 1530 1540 1550
SLQEKEKASR KGSFGEMGEQ TVKAVQKLSQ QQESVCPRES TVPGHSSPCL
1560 1570 1580 1590 1600
DNSSSKAGSQ FLCNGGSRAT QVCPQEDLRP EAQEATPAKT EICPWEVNER
1610 1620 1630 1640 1650
TREEWTSAQV PRGGESQKDK EKMPGKSEIE DVTAWEKPEG QIQKQEAVGP
1660 1670 1680 1690 1700
WESVDPGSFS PQPRPQDTER PQTLLQMSGS VGSKAADICP LDVEENLTAG
1710 1720 1730 1740 1750
KAEICPWEVG AGAGEERALG AEAIRKSPND TGKVSADLGP RERAVTAPEK
1760 1770 1780 1790 1800
PQKPTPEWEV ACPWGSVGPG ACSQHPGTLD ADGPKAGFQE LDHMGCRPGE
1810 1820 1830 1840 1850
VCPWEAQEAA TSEKAKICPW EVSEGTTGKG LDQKAGSESA EQREKALEKG
1860 1870 1880 1890 1900
RLTSLGEDVS KGMAKLCQQQ ETICIWENKD LRESPAQAPK ISDLPSSMSS
1910 1920 1930 1940 1950
EVAEGHSLEA TEKGDLRQDP KTGSFPEHIT QEKAPAADTE EFTTEDGEKT
1960 1970 1980 1990 2000
SHELQSVCPW ETTAPADSVS HLDRQRPDQP KASSQRLVST GGRAADVCPW
2010 2020 2030 2040 2050
DVPDAGVYKS DSSAKAETCP WEVTERIPVK GVSRQDGKGD SQEEKGRAPE
2060 2070 2080 2090 2100
KSEPKGVPVQ KKPEMADFRQ QEAVCPWESQ DGKGLSPQPA PDASDRSRGS
2110 2120 2130 2140 2150
SEAAGSVETR VAEVCLWEVV EAPSAKKAEI CPWEAGGGAA EEGEQERESQ
2160 2170 2180 2190 2200
GQGEMFLQKA GPGGTEEHFS KAAAKPREQE AVCPGEGTGS GGLLPQSGAL
2210 2220 2230 2240 2250
DPELKVSPKE AGSMGSRMAE LCQWEITDPE GNKIKGTMAD ICPGEETGVP
2260 2270 2280 2290 2300
SEESGLLALT ATRREFFPTA PEKPLCLLVH GPLDHFFPES KIPCPKVSRP
2310 2320 2330 2340 2350
ASTFTLEGVR ELQGPSGLEP RTSLAPEPSL QEAESQSSSL TEDSGQVAFE
2360
AQYEEFTPPT VYPWDWE
Length:2,367
Mass (Da):257,363
Last modified:January 10, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i882ABAAED71B2EF0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087X0K8A0A087X0K8_HUMAN
Probable G-protein-coupled receptor...
GPR179
2,367Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WW83A0A087WW83_HUMAN
Probable G-protein-coupled receptor...
GPR179
2,368Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_067925126D → H in CSNB1E. 1 PublicationCorresponds to variant dbSNP:rs281875233EnsemblClinVar.1
Natural variantiVAR_067926220Y → C in CSNB1E. 1 PublicationCorresponds to variant dbSNP:rs281875236EnsemblClinVar.1
Natural variantiVAR_067927455G → D in CSNB1E. 1 PublicationCorresponds to variant dbSNP:rs281875235EnsemblClinVar.1
Natural variantiVAR_067928603H → Y in CSNB1E. 1 PublicationCorresponds to variant dbSNP:rs281875234EnsemblClinVar.1
Natural variantiVAR_0612041150K → E. Corresponds to variant dbSNP:rs55727040EnsemblClinVar.1
Natural variantiVAR_0492871176Q → E. Corresponds to variant dbSNP:rs4399578EnsemblClinVar.1
Natural variantiVAR_0492881381C → R. Corresponds to variant dbSNP:rs4398144Ensembl.1
Natural variantiVAR_0492891869Q → E. Corresponds to variant dbSNP:rs4399578EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY584611 mRNA Translation: AAS91740.1
AC115992 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

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CCDSi
CCDS42308.1

NCBI Reference Sequences

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RefSeqi
NP_001004334.3, NM_001004334.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000610650; ENSP00000484951; ENSG00000276469

Database of genes from NCBI RefSeq genomes

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GeneIDi
440435

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:440435

UCSC genome browser

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UCSCi
uc032gkv.1 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

G protein-coupled receptor 179 (GPR179)

Leiden Open Variation Database (LOVD)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY584611 mRNA Translation: AAS91740.1
AC115992 Genomic DNA No translation available.
CCDSiCCDS42308.1
RefSeqiNP_001004334.3, NM_001004334.3

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi136572, 1 interactor
IntActiQ6PRD1, 3 interactors
MINTiQ6PRD1
STRINGi9606.ENSP00000483469

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

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GPCRDBi
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PTM databases

iPTMnetiQ6PRD1
PhosphoSitePlusiQ6PRD1

Polymorphism and mutation databases

BioMutaiGPR179
DMDMi85540945

Proteomic databases

EPDiQ6PRD1
jPOSTiQ6PRD1
MassIVEiQ6PRD1
PaxDbiQ6PRD1
PeptideAtlasiQ6PRD1
PRIDEiQ6PRD1
ProteomicsDBi67258

Genome annotation databases

EnsembliENST00000610650; ENSP00000484951; ENSG00000276469
GeneIDi440435
KEGGihsa:440435
UCSCiuc032gkv.1 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
440435
DisGeNETi440435

GeneCards: human genes, protein and diseases

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GeneCardsi
GPR179
HGNCiHGNC:31371 GPR179
HPAiHPA017885
MalaCardsiGPR179
MIMi614515 gene
614565 phenotype
neXtProtiNX_Q6PRD1
Orphaneti215 Congenital stationary night blindness
PharmGKBiPA134900696

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG4418 Eukaryota
ENOG410XXEC LUCA
HOGENOMiHOG000015342
InParanoidiQ6PRD1
KOiK22961
OrthoDBi63351at2759
PhylomeDBiQ6PRD1
TreeFamiTF319114

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
GPR179

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
440435
PharosiQ6PRD1

Protein Ontology

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PROi
PR:Q6PRD1

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Family and domain databases

InterProiView protein in InterPro
IPR017978 GPCR_3_C
IPR032964 GPR179
PANTHERiPTHR32546:SF7 PTHR32546:SF7, 5 hits
PfamiView protein in Pfam
PF00003 7tm_3, 1 hit
PROSITEiView protein in PROSITE
PS50259 G_PROTEIN_RECEP_F3_4, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGP179_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6PRD1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: January 10, 2006
Last modified: October 16, 2019
This is version 118 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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