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Entry version 125 (16 Oct 2019)
Sequence version 2 (05 Jul 2005)
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Protein

Telomere-associated protein RIF1

Gene

Rif1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:23333305, PubMed:23306437, PubMed:23306439). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333305, PubMed:23306437, PubMed:23306439). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (By similarity). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333305, PubMed:23306437). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333305, PubMed:23306437). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23333305, PubMed:23333306, PubMed:23306439). Promotes NHEJ of dysfunctional telomeres (PubMed:23333305).By similarity4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, DNA damage, DNA repair

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-5693571 Nonhomologous End-Joining (NHEJ)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Telomere-associated protein RIF1Curated
Alternative name(s):
Rap1-interacting factor 1 homolog1 Publication
Short name:
mRif11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Rif1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1098622 Rif1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Cytoplasm, Cytoskeleton, Nucleus, Telomere

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Embryonic lethality in inbred 129/Ola and outbred MF1 mouse strains: 7.5 dpc embryos display significant developmental retardation (PubMed:23333305). Female-specific lethality in a CD1 strain background, while males survive (PubMed:23333305). Surviving males grow normally, are fertile, but are subject to infections due to defects in the immune response (PubMed:23333305). Surviving males are severely compromised for TP53BP1-dependent class-switch recombination (CSR) and fusion of dysfunctional telomeres (PubMed:23333305).1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000973341 – 2419Telomere-associated protein RIF1Add BLAST2419

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei385PhosphoserineCombined sources1
Modified residuei391PhosphoserineCombined sources1
Modified residuei779PhosphoserineBy similarity1
Modified residuei976PhosphoserineBy similarity1
Modified residuei1005PhosphoserineBy similarity1
Modified residuei1044PhosphothreonineBy similarity1
Modified residuei1215PhosphothreonineBy similarity1
Modified residuei1231PhosphoserineBy similarity1
Modified residuei1233PhosphoserineBy similarity1
Modified residuei1407PhosphoserineCombined sources1
Modified residuei1439PhosphoserineBy similarity1
Modified residuei1457PhosphoserineCombined sources1
Modified residuei1498PhosphoserineBy similarity1
Modified residuei1504PhosphothreonineBy similarity1
Modified residuei1528PhosphoserineCombined sources1
Modified residuei1538PhosphoserineCombined sources1
Modified residuei1540PhosphoserineCombined sources1
Modified residuei1542PhosphoserineBy similarity1
Modified residuei1550PhosphoserineCombined sources1
Modified residuei1562PhosphoserineBy similarity1
Modified residuei1565PhosphoserineCombined sources1
Modified residuei1680PhosphoserineBy similarity1
Modified residuei1683PhosphoserineCombined sources1
Modified residuei1780PhosphothreonineBy similarity1
Modified residuei1784PhosphoserineBy similarity1
Modified residuei1842PhosphoserineBy similarity1
Modified residuei1931PhosphoserineBy similarity1
Modified residuei2094PhosphoserineBy similarity1
Modified residuei2109PhosphoserineBy similarity1
Modified residuei2121PhosphoserineBy similarity1
Modified residuei2125PhosphoserineBy similarity1
Modified residuei2144PhosphoserineCombined sources1
Modified residuei2153PhosphoserineBy similarity1
Modified residuei2208PhosphoserineBy similarity1
Modified residuei2287PhosphoserineBy similarity1
Modified residuei2341PhosphoserineBy similarity1
Modified residuei2413PhosphoserineBy similarity1
Modified residuei2419PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q6PR54

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q6PR54

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q6PR54

PeptideAtlas

More...
PeptideAtlasi
Q6PR54

PRoteomics IDEntifications database

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PRIDEi
Q6PR54

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q6PR54

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q6PR54

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q6PR54

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in Sertoli cells, prospermatagonia, early primary spermatocytes, and in oocytes at all stages of their growth. Expressed in embryonic stem (ES) and embryonic germ (EG) cells: expression is lost upon differentiation.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Found in the nucleus of germinal-vesicle (GV) stage oocytes prior to fertilization. Accumulates in the male and female pronucleus after fertilization. Expressed in the nuclei of all blastomeres from the two cell stage to the compacted morula stage, although absent from the polar body and inner cell mass (ICM). Found in the nuclei of polar and mural trophectoderm cells from 3.5 dpc, and at high levels in the epiblast from 5.5 dpc to 7.5 dpc. Expressed by primitive germ cells (PGCs) in both male and female from 9.5 dpc to 13.5 dpc, at which point expression declines. A low level is observed in Sertoli cells of the testis at 17.5 dpc.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSMUSG00000036202 Expressed in 281 organ(s), highest expression level in cleaving embryo

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q6PR54 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q6PR54 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with TP53BP1 (when phosphorylated by ATM) (PubMed:23333305, PubMed:23306437, PubMed:23306439). May interact with TRF2 (PubMed:15042697).

Interacts with SHLD2 (By similarity).

Interacts with ERCC6 (via WHD region) (By similarity).

By similarity1 Publication3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
206234, 10 interactors

Database of interacting proteins

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DIPi
DIP-54907N

Protein interaction database and analysis system

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IntActi
Q6PR54, 5 interactors

STRING: functional protein association networks

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STRINGi
10090.ENSMUSP00000108313

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1882 – 2419Interaction with condensed chromosomes in telophaseBy similarityAdd BLAST538
Regioni2119 – 2394Interaction with ERCC6By similarityAdd BLAST276

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RIF1 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IJ7R Eukaryota
ENOG410YNMC LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000012204

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000231777

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q6PR54

KEGG Orthology (KO)

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KOi
K11138

Identification of Orthologs from Complete Genome Data

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OMAi
NANKRLH

Database of Orthologous Groups

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OrthoDBi
10400at2759

TreeFam database of animal gene trees

More...
TreeFami
TF323789

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR016024 ARM-type_fold
IPR022031 Rif1_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12231 Rif1_N, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF48371 SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6PR54-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTAPGRSPLE PLLETWEDPS VPPGEQTDAY LTLTSRMTGE EGKEVIAEIE
60 70 80 90 100
KNLSRLYTVL KAHISSQNSE LSSAALQALG FCLYNPRITS GLSEANIQEL
110 120 130 140 150
LLTLNGIIKS SDKNVCTRAL WVISKQTFPA ELVSKMVSSI IDSLEVILSK
160 170 180 190 200
GEIHSAVVDF EALNVIIRLI EQAPVQMGEE SVRWAKLVIP LVVHSAQKVH
210 220 230 240 250
LRGATALEMG MPLLLQKQQE IALITEHLMT TKLISELQKL FKNKNETYVL
260 270 280 290 300
KLWPLFVKLL GKTLHRSGSF INSLLQLEEL GFRSGTPMIK KIAFIAWKSL
310 320 330 340 350
IDNFALNPDI LCSAKRLKLL MQPLSSIHVR TETLALTKLE VWWYLLMRLG
360 370 380 390 400
PQLPANFEQV CVPLIQSTIS VDSIPSPQGN SSRGSASPGL SPLTPGHKGA
410 420 430 440 450
SPYGSPRGNL SSNTGGMAAI PSIQLLGLEM MLHFLLGPEV LSFAKQHKIV
460 470 480 490 500
LSLEPLEHPL ISSPSFFSKY AHTLITAVHD SFVSVGKDAS DAVVSAIWKE
510 520 530 540 550
LISLVKSVTE AGNRKEKSGS EVLTLLLKSL ENIVKSEVFP VSKTLVLMEI
560 570 580 590 600
TVKGLPPKVL GSPAYQVANM DILNGTPALF LIQLIFNNNL LECGVEDEKF
610 620 630 640 650
FLNLETLVGC VLSGPTSPLA FSDSVLTVIN QNAKQLVNKE HLWRMWSMIV
660 670 680 690 700
SPLTDVIHQT NEVNQGDALE HNFSAIYGAL TLPINHIFSA QTFPTGTMKA
710 720 730 740 750
LLKTWSELYR AFTRCASLVA TAEENLCCEE LSSKIMCSLE DEVLSDLLFL
760 770 780 790 800
DRISHIIIVM VDCIDFSPYN KKYQPKIKSP QRSSDWSRKK KEPLGKLASL
810 820 830 840 850
FKLIVKVIDT FHTLSLKETF SDTLLAIGNS IISMLSNVFG HISLPSMIRE
860 870 880 890 900
IFATFTRPLA LLYENSKLDE APKVYTSLNN KLEKLLGEIV ACLQFSYLGA
910 920 930 940 950
YDSELLEHLS PLLCVIFLHK NKQIRKQSAL LWNATFAKAT ALVYPEELKP
960 970 980 990 1000
ILRQAKQKIL LLLPGLENVE MMDESSEPYS ESTENSQLNV KISGMERKSS
1010 1020 1030 1040 1050
GKRDSILAHT KDKKKKVKLS AKLKLESSSP KIKSGKLLEE EKSTDFVFIP
1060 1070 1080 1090 1100
PEGKETKARV LTEHQKEVLK TKRCDIPALY NNLDASQDTL FSAQFSQEES
1110 1120 1130 1140 1150
MESLTLTEKP KEDAKIIKEE QMESTIFIHQ DAPENCGIDE HSENASLPNC
1160 1170 1180 1190 1200
GGSVAETNPE TLITGFDARK EVLISSKILS AESSSSTETS VVSSSSVSNA
1210 1220 1230 1240 1250
TFSGTPPQPT SRRQTFITLE KFDGSETRPF SPSPLNNISS TVTVRNNQDN
1260 1270 1280 1290 1300
TTNTDMPPKA RKREVTNSKS DSENLANAGK KSSRRWSKAE QSVTKKSKPS
1310 1320 1330 1340 1350
LTSEQEEHSS ENNSPDLLSP TEHVSENDDH PSEATLEHKD GDPKPAVENA
1360 1370 1380 1390 1400
SLEDLTTEEK NVGINMESKE STASVVARTE QIVNEDSQAA ALAPNPKTLR
1410 1420 1430 1440 1450
RSSRRRSEAV DSCSDSQERE SGQQKKERRK EEEKIISKSP LRIKDDKLPT
1460 1470 1480 1490 1500
QKLTDESPIQ ENLTEKGNTL PERTSGEPSV NAEIDQNRRK PDLENVSSEG
1510 1520 1530 1540 1550
GGGTLDNLDK SSEKPLRGRT RYQTRRASQG LISAVENSES DSSEAKEEVS
1560 1570 1580 1590 1600
RKKRSGKWKN RSSDSVDIEE QEEKKAEEEV MKTANQTLDG QAVPDVDVNA
1610 1620 1630 1640 1650
AAQVCEKSTN NNRVILQDSA GPADSLQAPP KGEEKSKINK CVDSSFVSLP
1660 1670 1680 1690 1700
VPESNLRTRN ASKRLLYKQD NDSNVRVSDS SLSPEKFTQV ECQHKRSRRV
1710 1720 1730 1740 1750
RRSKSCDCCG EKSQSQEKSF IGLKNTESYA IKSVEKKKTD LQVPETAPET
1760 1770 1780 1790 1800
REARDHAETK LAGEEPLVNF HVGLKEENCT TGDSVKSEAE LQEASLPPEI
1810 1820 1830 1840 1850
VTVKEKTYDT DASEAVSEIQ GPCSENHSPA EDPGLSECKD ISQKQLSENG
1860 1870 1880 1890 1900
ELDISDVGKA CKVIAGSSPE GVETMELNVR NDAFVAADSE KSTQMDVSVD
1910 1920 1930 1940 1950
VATEEDNKKD ECEAVTTEVN VEGVATEDFN SGMDLSDTPI PVSKDVETEH
1960 1970 1980 1990 2000
AASGEIEGES NESDSGSCEE MNKEMGSHKA QMSTEIDSAR VKETDILASA
2010 2020 2030 2040 2050
SKSEEALIGR LDVNTQSFVS DIEMSSGERT VNCKTETSIE LNKLDEAKLS
2060 2070 2080 2090 2100
GNEATVGNDT LQEVCFTSEK VEKLPQCLLV QVASELGAES NTTSPEKLEL
2110 2120 2130 2140 2150
DSFGSVNESP SGMQQARCVW SPLASPSTSI LKRGLKRSQE DEISPVNKIR
2160 2170 2180 2190 2200
RVSFADPIYQ AGLADDIDRR CSVVRSHSSN SSPIIKSVKT SPTSHSKHNT
2210 2220 2230 2240 2250
TSAKGFLSPG SQSSKFKSPK KCLITEMAQE SMLSPTESVY PALVNCAASV
2260 2270 2280 2290 2300
DIILPQITSN MWARGLGQLI RAKNIKTIGD LSTLTASEIK TLPIRSPKVF
2310 2320 2330 2340 2350
NVKKALRVYH EQQMKSRGLE EIPIFDISEK AVNGVESRTV STDEERFASD
2360 2370 2380 2390 2400
LIEPVTLDTP LSKNLVAQIS ALALQLDSED LYSYTGSQLF EMHEKLGTMA
2410
NSIIRNLQSR WRSPAHENS
Length:2,419
Mass (Da):266,228
Last modified:July 5, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i016A1A4CEF25B8F9
GO
Isoform 2 (identifier: Q6PR54-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2198-2223: Missing.

Show »
Length:2,393
Mass (Da):263,480
Checksum:i97A1207A4F3AD637
GO
Isoform 3 (identifier: Q6PR54-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     167-167: I → ISHWFLHC

Note: May be due to a competing acceptor splice site. No experimental confirmation available.
Show »
Length:2,426
Mass (Da):267,139
Checksum:i72C0C38EBD54A556
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2I3BQI4A0A2I3BQI4_MOUSE
Telomere-associated protein RIF1
Rif1
740Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I3BQ21A0A2I3BQ21_MOUSE
Telomere-associated protein RIF1
Rif1
535Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I3BRD9A0A2I3BRD9_MOUSE
Telomere-associated protein RIF1
Rif1
731Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I3BQB0A0A2I3BQB0_MOUSE
Telomere-associated protein RIF1
Rif1
44Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB30843 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC38846 differs from that shown. Chimeric cDNA.Curated
The sequence BAC40506 differs from that shown. Intron retention.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti211M → V in AAR87833 (PubMed:15042697).Curated1
Sequence conflicti548M → V in AAR87833 (PubMed:15042697).Curated1
Sequence conflicti586F → L in AAR87833 (PubMed:15042697).Curated1
Sequence conflicti586F → L in BAC40506 (PubMed:16141072).Curated1
Sequence conflicti592E → G in AAR87833 (PubMed:15042697).Curated1
Sequence conflicti592E → G in BAC40506 (PubMed:16141072).Curated1
Sequence conflicti596E → G in AAR87833 (PubMed:15042697).Curated1
Sequence conflicti596E → G in BAC40506 (PubMed:16141072).Curated1
Sequence conflicti717S → A in AAR87833 (PubMed:15042697).Curated1
Sequence conflicti717S → A in BAC40506 (PubMed:16141072).Curated1
Sequence conflicti743V → A in AAR87833 (PubMed:15042697).Curated1
Sequence conflicti743V → A in BAC40506 (PubMed:16141072).Curated1
Sequence conflicti802K → E in BAC40506 (PubMed:16141072).Curated1
Sequence conflicti959I → S in AAR87833 (PubMed:15042697).Curated1
Sequence conflicti959I → S in BAC40506 (PubMed:16141072).Curated1
Sequence conflicti1066K → R in BAB30843 (PubMed:16141072).Curated1
Sequence conflicti1122M → T in AAR87833 (PubMed:15042697).Curated1
Sequence conflicti1179L → M in AAR87833 (PubMed:15042697).Curated1
Sequence conflicti1238I → M in AAR87833 (PubMed:15042697).Curated1
Sequence conflicti1527A → R in BAB30843 (PubMed:16141072).Curated1
Sequence conflicti1584A → S in AAR87833 (PubMed:15042697).Curated1
Sequence conflicti1671N → T in AAR87833 (PubMed:15042697).Curated1
Sequence conflicti1772V → L in AAR87833 (PubMed:15042697).Curated1
Sequence conflicti1798P → S in AAR87833 (PubMed:15042697).Curated1
Sequence conflicti1897V → I in AAR87833 (PubMed:15042697).Curated1
Sequence conflicti1918E → D in AAR87833 (PubMed:15042697).Curated1
Sequence conflicti1997L → F in AAR87833 (PubMed:15042697).Curated1
Sequence conflicti2018F → L in AAR87833 (PubMed:15042697).Curated1
Sequence conflicti2024M → T in AAR87833 (PubMed:15042697).Curated1
Sequence conflicti2052N → K in AAR87833 (PubMed:15042697).Curated1
Sequence conflicti2114Missing in AAR87833 (PubMed:15042697).Curated1
Sequence conflicti2394E → G in AAR87833 (PubMed:15042697).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_014432167I → ISHWFLHC in isoform 3. 1 Publication1
Alternative sequenceiVSP_0144332198 – 2223Missing in isoform 2. CuratedAdd BLAST26

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY428571 mRNA Translation: AAR87833.2
AY585206 mRNA Translation: AAS94124.1
AK017618 mRNA Translation: BAB30843.1 Different initiation.
AK083291 mRNA Translation: BAC38846.1 Sequence problems.
AK088688 mRNA Translation: BAC40506.1 Sequence problems.
BC055320 mRNA Translation: AAH55320.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS50583.1 [Q6PR54-3]

NCBI Reference Sequences

More...
RefSeqi
NP_780447.4, NM_175238.5 [Q6PR54-3]
XP_006498240.1, XM_006498177.2
XP_011237438.1, XM_011239136.1 [Q6PR54-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000112693; ENSMUSP00000108313; ENSMUSG00000036202 [Q6PR54-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
51869

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:51869

UCSC genome browser

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UCSCi
uc008jqq.1 mouse [Q6PR54-3]
uc008jqr.1 mouse [Q6PR54-1]
uc008jqt.1 mouse [Q6PR54-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY428571 mRNA Translation: AAR87833.2
AY585206 mRNA Translation: AAS94124.1
AK017618 mRNA Translation: BAB30843.1 Different initiation.
AK083291 mRNA Translation: BAC38846.1 Sequence problems.
AK088688 mRNA Translation: BAC40506.1 Sequence problems.
BC055320 mRNA Translation: AAH55320.1
CCDSiCCDS50583.1 [Q6PR54-3]
RefSeqiNP_780447.4, NM_175238.5 [Q6PR54-3]
XP_006498240.1, XM_006498177.2
XP_011237438.1, XM_011239136.1 [Q6PR54-2]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi206234, 10 interactors
DIPiDIP-54907N
IntActiQ6PR54, 5 interactors
STRINGi10090.ENSMUSP00000108313

PTM databases

iPTMnetiQ6PR54
PhosphoSitePlusiQ6PR54
SwissPalmiQ6PR54

Proteomic databases

EPDiQ6PR54
jPOSTiQ6PR54
PaxDbiQ6PR54
PeptideAtlasiQ6PR54
PRIDEiQ6PR54

Genome annotation databases

EnsembliENSMUST00000112693; ENSMUSP00000108313; ENSMUSG00000036202 [Q6PR54-3]
GeneIDi51869
KEGGimmu:51869
UCSCiuc008jqq.1 mouse [Q6PR54-3]
uc008jqr.1 mouse [Q6PR54-1]
uc008jqt.1 mouse [Q6PR54-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55183
MGIiMGI:1098622 Rif1

Phylogenomic databases

eggNOGiENOG410IJ7R Eukaryota
ENOG410YNMC LUCA
GeneTreeiENSGT00390000012204
HOGENOMiHOG000231777
InParanoidiQ6PR54
KOiK11138
OMAiNANKRLH
OrthoDBi10400at2759
TreeFamiTF323789

Enzyme and pathway databases

ReactomeiR-MMU-5693571 Nonhomologous End-Joining (NHEJ)

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Rif1 mouse

Protein Ontology

More...
PROi
PR:Q6PR54

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000036202 Expressed in 281 organ(s), highest expression level in cleaving embryo
ExpressionAtlasiQ6PR54 baseline and differential
GenevisibleiQ6PR54 MM

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR022031 Rif1_N
PfamiView protein in Pfam
PF12231 Rif1_N, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRIF1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6PR54
Secondary accession number(s): Q6T8D9
, Q7TPD8, Q8BTU2, Q8C408, Q9CS77
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: July 5, 2005
Last modified: October 16, 2019
This is version 125 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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