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UniProtKB - Q6PL24 (TMED8_HUMAN)

Entry version 131 (07 Apr 2021)
Sequence version 1 (05 Jul 2004)
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Protein

Protein TMED8

Gene

TMED8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q6PL24

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein TMED8
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TMED8
Synonyms:FAM15B
ORF Names:L10
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:18633, TMED8

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q6PL24

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000100580.7

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000100580

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134948632

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q6PL24, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TMED8

Domain mapping of disease mutations (DMDM)

More...DMDMi		62287887

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000556381 – 325Protein TMED8Add BLAST325

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei169N6-acetyllysineCombined sources1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q6PL24

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q6PL24

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q6PL24

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q6PL24

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q6PL24

PeptideAtlas

More...PeptideAtlasi		Q6PL24

PRoteomics IDEntifications database

More...PRIDEi		Q6PL24

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		67250

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q6PL24

MetOSite database of methionine sulfoxide sites

More...MetOSitei		Q6PL24

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q6PL24

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000100580, Expressed in endothelial cell and 216 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q6PL24, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000100580, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		129608, 56 interactors

Protein interaction database and analysis system

More...IntActi		Q6PL24, 40 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000216468

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q6PL24, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q6PL24

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini159 – 323GOLDPROSITE-ProRule annotationAdd BLAST165

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi242 – 254Poly-GluAdd BLAST13

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3878, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00530000063651

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_053155_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q6PL24

Identification of Orthologs from Complete Genome Data

More...OMAi		LYFHVYY

Database of Orthologous Groups

More...OrthoDBi		733463at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q6PL24

TreeFam database of animal gene trees

More...TreeFami		TF321667

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR009038, GOLD_dom
IPR036598, GOLD_dom_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF13897, GOLD_2, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF101576, SSF101576, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50866, GOLD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6PL24-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSDLQAAEGP GSWSPTARPG SAGGVGDCQG VEGSQAAASE NEDLENKDTS 
        60         70         80         90        100
LLASATDPEP CSSPHRPQMV SPVSKDATED LRKATGPLEA QALVKQDLLP 
       110        120        130        140        150
ADQAQVLNEM AKYQVPQRSG DIVMIQSEHT GAIDVLSADL ESADLLGDHR 
       160        170        180        190        200
KVSPPLMAPP CIWTFAKVKE FKSKLGKEKN SRLVVKRGEV VTIRVPTHPE 
       210        220        230        240        250
GKRVCWEFAT DDYDIGFGVY FDWTPVTSTD ITVQVSDSSD DEDEEEEEEE 
       260        270        280        290        300
EIEEPVPAGD VERGSRSSLR GRYGEVMPVY RRDSHRDVQA GSHDYPGEGI 
       310        320 
YLLKFDNSYS LLRNKTLYFH IYYTS
Length:325
Mass (Da):35,740
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5E4880F39E5145E9
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF62560 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0491125Q → K. Corresponds to variant dbSNP:rs3742737Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY598329 mRNA Translation: AAT06740.1
AK095650 mRNA Translation: BAG53098.1
AC007954 Genomic DNA Translation: AAF62560.1 Sequence problems.
BC101510 mRNA Translation: AAI01511.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS32125.1

NCBI Reference Sequences

More...RefSeqi		NP_001333062.1, NM_001346133.1
NP_001333063.1, NM_001346134.1
NP_998766.1, NM_213601.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000216468; ENSP00000216468; ENSG00000100580

Database of genes from NCBI RefSeq genomes

More...GeneIDi		283578

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:283578

UCSC genome browser

More...UCSCi		uc001xto.2, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY598329 mRNA Translation: AAT06740.1
AK095650 mRNA Translation: BAG53098.1
AC007954 Genomic DNA Translation: AAF62560.1 Sequence problems.
BC101510 mRNA Translation: AAI01511.1
CCDSiCCDS32125.1
RefSeqiNP_001333062.1, NM_001346133.1
NP_001333063.1, NM_001346134.1
NP_998766.1, NM_213601.2

3D structure databases

SMRiQ6PL24
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi129608, 56 interactors
IntActiQ6PL24, 40 interactors
STRINGi9606.ENSP00000216468

PTM databases

iPTMnetiQ6PL24
MetOSiteiQ6PL24
PhosphoSitePlusiQ6PL24

Genetic variation databases

BioMutaiTMED8
DMDMi62287887

Proteomic databases

EPDiQ6PL24
jPOSTiQ6PL24
MassIVEiQ6PL24
MaxQBiQ6PL24
PaxDbiQ6PL24
PeptideAtlasiQ6PL24
PRIDEiQ6PL24
ProteomicsDBi67250

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		27, 93 antibodies

Genome annotation databases

EnsembliENST00000216468; ENSP00000216468; ENSG00000100580
GeneIDi283578
KEGGihsa:283578
UCSCiuc001xto.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		283578

GeneCards: human genes, protein and diseases

More...GeneCardsi		TMED8
HGNCiHGNC:18633, TMED8
HPAiENSG00000100580, Low tissue specificity
neXtProtiNX_Q6PL24
OpenTargetsiENSG00000100580
PharmGKBiPA134948632
VEuPathDBiHostDB:ENSG00000100580.7

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3878, Eukaryota
GeneTreeiENSGT00530000063651
HOGENOMiCLU_053155_0_0_1
InParanoidiQ6PL24
OMAiLYFHVYY
OrthoDBi733463at2759
PhylomeDBiQ6PL24
TreeFamiTF321667

Enzyme and pathway databases

PathwayCommonsiQ6PL24

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		283578, 231 hits in 997 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		TMED8, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		283578
PharosiQ6PL24, Tdark

Protein Ontology

More...PROi		PR:Q6PL24
RNActiQ6PL24, protein

Gene expression databases

BgeeiENSG00000100580, Expressed in endothelial cell and 216 other tissues
GenevisibleiQ6PL24, HS

Family and domain databases

InterProiView protein in InterPro
IPR009038, GOLD_dom
IPR036598, GOLD_dom_sf
PfamiView protein in Pfam
PF13897, GOLD_2, 1 hit
SUPFAMiSSF101576, SSF101576, 1 hit
PROSITEiView protein in PROSITE
PS50866, GOLD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTMED8_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6PL24
Secondary accession number(s): B3KTI6, Q3MJB0, Q9P1V9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: July 5, 2004
Last modified: April 7, 2021
This is version 131 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
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