UniProtKB - Q6PL24 (TMED8_HUMAN)
Protein
Protein TMED8
Gene
TMED8
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Recommended name: Protein TMED8 |
Gene namesi | Name:TMED8 Synonyms:FAM15B ORF Names:L10 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:18633, TMED8 |
neXtProti | NX_Q6PL24 |
VEuPathDBi | HostDB:ENSG00000100580.7 |
Pathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000100580 |
PharmGKBi | PA134948632 |
Miscellaneous databases
Pharosi | Q6PL24, Tdark |
Genetic variation databases
BioMutai | TMED8 |
DMDMi | 62287887 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000055638 | 1 – 325 | Protein TMED8Add BLAST | 325 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 169 | N6-acetyllysineCombined sources | 1 |
Keywords - PTMi
AcetylationProteomic databases
EPDi | Q6PL24 |
jPOSTi | Q6PL24 |
MassIVEi | Q6PL24 |
MaxQBi | Q6PL24 |
PaxDbi | Q6PL24 |
PeptideAtlasi | Q6PL24 |
PRIDEi | Q6PL24 |
ProteomicsDBi | 67250 |
PTM databases
iPTMneti | Q6PL24 |
MetOSitei | Q6PL24 |
PhosphoSitePlusi | Q6PL24 |
Expressioni
Gene expression databases
Bgeei | ENSG00000100580, Expressed in endothelial cell and 216 other tissues |
Genevisiblei | Q6PL24, HS |
Organism-specific databases
HPAi | ENSG00000100580, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsQ6PL24
Protein-protein interaction databases
BioGRIDi | 129608, 56 interactors |
IntActi | Q6PL24, 40 interactors |
STRINGi | 9606.ENSP00000216468 |
Miscellaneous databases
RNActi | Q6PL24, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 159 – 323 | GOLDPROSITE-ProRule annotationAdd BLAST | 165 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 242 – 254 | Poly-GluAdd BLAST | 13 |
Phylogenomic databases
eggNOGi | KOG3878, Eukaryota |
GeneTreei | ENSGT00530000063651 |
HOGENOMi | CLU_053155_0_0_1 |
InParanoidi | Q6PL24 |
OMAi | LYFHVYY |
OrthoDBi | 733463at2759 |
PhylomeDBi | Q6PL24 |
TreeFami | TF321667 |
Family and domain databases
InterProi | View protein in InterPro IPR009038, GOLD_dom IPR036598, GOLD_dom_sf |
Pfami | View protein in Pfam PF13897, GOLD_2, 1 hit |
SUPFAMi | SSF101576, SSF101576, 1 hit |
PROSITEi | View protein in PROSITE PS50866, GOLD, 1 hit |
i Sequence
Sequence statusi: Complete.
Q6PL24-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSDLQAAEGP GSWSPTARPG SAGGVGDCQG VEGSQAAASE NEDLENKDTS
60 70 80 90 100
LLASATDPEP CSSPHRPQMV SPVSKDATED LRKATGPLEA QALVKQDLLP
110 120 130 140 150
ADQAQVLNEM AKYQVPQRSG DIVMIQSEHT GAIDVLSADL ESADLLGDHR
160 170 180 190 200
KVSPPLMAPP CIWTFAKVKE FKSKLGKEKN SRLVVKRGEV VTIRVPTHPE
210 220 230 240 250
GKRVCWEFAT DDYDIGFGVY FDWTPVTSTD ITVQVSDSSD DEDEEEEEEE
260 270 280 290 300
EIEEPVPAGD VERGSRSSLR GRYGEVMPVY RRDSHRDVQA GSHDYPGEGI
310 320
YLLKFDNSYS LLRNKTLYFH IYYTS
Sequence cautioni
The sequence AAF62560 differs from that shown. Reason: Erroneous gene model prediction.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_049112 | 5 | Q → K. Corresponds to variant dbSNP:rs3742737Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY598329 mRNA Translation: AAT06740.1 AK095650 mRNA Translation: BAG53098.1 AC007954 Genomic DNA Translation: AAF62560.1 Sequence problems. BC101510 mRNA Translation: AAI01511.1 |
CCDSi | CCDS32125.1 |
RefSeqi | NP_001333062.1, NM_001346133.1 NP_001333063.1, NM_001346134.1 NP_998766.1, NM_213601.2 |
Genome annotation databases
Ensembli | ENST00000216468; ENSP00000216468; ENSG00000100580 |
GeneIDi | 283578 |
KEGGi | hsa:283578 |
UCSCi | uc001xto.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY598329 mRNA Translation: AAT06740.1 AK095650 mRNA Translation: BAG53098.1 AC007954 Genomic DNA Translation: AAF62560.1 Sequence problems. BC101510 mRNA Translation: AAI01511.1 |
CCDSi | CCDS32125.1 |
RefSeqi | NP_001333062.1, NM_001346133.1 NP_001333063.1, NM_001346134.1 NP_998766.1, NM_213601.2 |
3D structure databases
SMRi | Q6PL24 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 129608, 56 interactors |
IntActi | Q6PL24, 40 interactors |
STRINGi | 9606.ENSP00000216468 |
PTM databases
iPTMneti | Q6PL24 |
MetOSitei | Q6PL24 |
PhosphoSitePlusi | Q6PL24 |
Genetic variation databases
BioMutai | TMED8 |
DMDMi | 62287887 |
Proteomic databases
EPDi | Q6PL24 |
jPOSTi | Q6PL24 |
MassIVEi | Q6PL24 |
MaxQBi | Q6PL24 |
PaxDbi | Q6PL24 |
PeptideAtlasi | Q6PL24 |
PRIDEi | Q6PL24 |
ProteomicsDBi | 67250 |
Protocols and materials databases
Antibodypediai | 27, 93 antibodies |
Genome annotation databases
Ensembli | ENST00000216468; ENSP00000216468; ENSG00000100580 |
GeneIDi | 283578 |
KEGGi | hsa:283578 |
UCSCi | uc001xto.2, human |
Organism-specific databases
CTDi | 283578 |
GeneCardsi | TMED8 |
HGNCi | HGNC:18633, TMED8 |
HPAi | ENSG00000100580, Low tissue specificity |
neXtProti | NX_Q6PL24 |
OpenTargetsi | ENSG00000100580 |
PharmGKBi | PA134948632 |
VEuPathDBi | HostDB:ENSG00000100580.7 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3878, Eukaryota |
GeneTreei | ENSGT00530000063651 |
HOGENOMi | CLU_053155_0_0_1 |
InParanoidi | Q6PL24 |
OMAi | LYFHVYY |
OrthoDBi | 733463at2759 |
PhylomeDBi | Q6PL24 |
TreeFami | TF321667 |
Enzyme and pathway databases
PathwayCommonsi | Q6PL24 |
Miscellaneous databases
BioGRID-ORCSi | 283578, 231 hits in 997 CRISPR screens |
ChiTaRSi | TMED8, human |
GenomeRNAii | 283578 |
Pharosi | Q6PL24, Tdark |
PROi | PR:Q6PL24 |
RNActi | Q6PL24, protein |
Gene expression databases
Bgeei | ENSG00000100580, Expressed in endothelial cell and 216 other tissues |
Genevisiblei | Q6PL24, HS |
Family and domain databases
InterProi | View protein in InterPro IPR009038, GOLD_dom IPR036598, GOLD_dom_sf |
Pfami | View protein in Pfam PF13897, GOLD_2, 1 hit |
SUPFAMi | SSF101576, SSF101576, 1 hit |
PROSITEi | View protein in PROSITE PS50866, GOLD, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TMED8_HUMAN | |
Accessioni | Q6PL24Primary (citable) accession number: Q6PL24 Secondary accession number(s): B3KTI6, Q3MJB0, Q9P1V9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 29, 2005 |
Last sequence update: | July 5, 2004 | |
Last modified: | April 7, 2021 | |
This is version 131 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports