UniProtKB - Q6PL18 (ATAD2_HUMAN)
ATPase family AAA domain-containing protein 2
ATAD2
Functioni
Catalytic activityi
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 467 – 474 | ATPSequence analysis | 8 |
GO - Molecular functioni
- ATPase activity Source: UniProtKB
- ATP binding Source: UniProtKB-KW
- chromatin binding Source: GO_Central
- histone binding Source: GO_Central
GO - Biological processi
- chromatin organization Source: InterPro
- negative regulation of chromatin silencing Source: GO_Central
- positive regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: GO_Central
- regulation of transcription by RNA polymerase II Source: Reactome
Keywordsi
Molecular function | Activator, Hydrolase |
Biological process | Transcription, Transcription regulation |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | Q6PL18 |
Reactomei | R-HSA-8866910, TFAP2 (AP-2) family regulates transcription of growth factors and their receptors |
Names & Taxonomyi
Protein namesi | Recommended name: ATPase family AAA domain-containing protein 2 (EC:3.6.1.-)Alternative name(s): AAA nuclear coregulator cancer-associated protein Short name: ANCCA |
Gene namesi | Name:ATAD2 ORF Names:L16, PRO2000 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:30123, ATAD2 |
MIMi | 611941, gene |
neXtProti | NX_Q6PL18 |
VEuPathDBi | HostDB:ENSG00000156802.12 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 473 | K → T: Reduces the ability to mediate estradiol-dependent induction of CCND1 and E2F1; when associated with Q-532. 1 Publication | 1 | |
Mutagenesisi | 532 | E → Q: Reduces the ability to mediate estradiol-dependent induction of CCND1 and E2F1; when associated with T-473. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 29028 |
OpenTargetsi | ENSG00000156802 |
PharmGKBi | PA134895566 |
Miscellaneous databases
Pharosi | Q6PL18, Tchem |
Chemistry databases
ChEMBLi | CHEMBL2150837 |
GuidetoPHARMACOLOGYi | 2719 |
Genetic variation databases
BioMutai | ATAD2 |
DMDMi | 74762365 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000084796 | 1 – 1390 | ATPase family AAA domain-containing protein 2Add BLAST | 1390 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 60 | PhosphoserineCombined sources | 1 | |
Modified residuei | 61 | PhosphoserineCombined sources | 1 | |
Cross-linki | 125 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 165 | PhosphoserineCombined sources | 1 | |
Modified residuei | 170 | PhosphoserineCombined sources | 1 | |
Cross-linki | 317 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 327 | PhosphoserineCombined sources | 1 | |
Modified residuei | 337 | PhosphoserineCombined sources | 1 | |
Modified residuei | 342 | PhosphoserineCombined sources | 1 | |
Modified residuei | 410 | PhosphoserineCombined sources | 1 | |
Modified residuei | 746 | PhosphoserineCombined sources | 1 | |
Modified residuei | 751 | PhosphoserineCombined sources | 1 | |
Cross-linki | 1128 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 1139 | PhosphoserineCombined sources | 1 | |
Cross-linki | 1148 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 1149 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 1152 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 1176 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 1200 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1233 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1235 | PhosphoserineCombined sources | 1 | |
Cross-linki | 1236 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 1243 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1302 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1323 | PhosphothreonineCombined sources | 1 |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q6PL18 |
jPOSTi | Q6PL18 |
MassIVEi | Q6PL18 |
MaxQBi | Q6PL18 |
PaxDbi | Q6PL18 |
PeptideAtlasi | Q6PL18 |
PRIDEi | Q6PL18 |
ProteomicsDBi | 67248 [Q6PL18-1] 67249 [Q6PL18-2] |
PTM databases
iPTMneti | Q6PL18 |
PhosphoSitePlusi | Q6PL18 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000156802, Expressed in secondary oocyte and 188 other tissues |
ExpressionAtlasi | Q6PL18, baseline and differential |
Genevisiblei | Q6PL18, HS |
Organism-specific databases
HPAi | ENSG00000156802, Tissue enhanced (lymphoid) |
Interactioni
Subunit structurei
Interacts with ESR1 and NCOA3 and these interactions are enhanced by estradiol.
Interacts with acetylated lysine residues on histone H1.4, H2A, H2B and H3 (in vitro).
2 PublicationsBinary interactionsi
Hide detailsGO - Molecular functioni
- histone binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 118827, 33 interactors |
DIPi | DIP-46197N |
IntActi | Q6PL18, 10 interactors |
MINTi | Q6PL18 |
STRINGi | 9606.ENSP00000287394 |
Chemistry databases
BindingDBi | Q6PL18 |
Miscellaneous databases
RNActi | Q6PL18, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q6PL18 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q6PL18 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1001 – 1071 | BromoPROSITE-ProRule annotationAdd BLAST | 71 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 970 – 994 | Sequence analysisAdd BLAST | 25 | |
Coiled coili | 1086 – 1112 | Sequence analysisAdd BLAST | 27 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 250 – 285 | Asp-richAdd BLAST | 36 | |
Compositional biasi | 357 – 366 | Poly-Ser | 10 |
Sequence similaritiesi
Keywords - Domaini
Bromodomain, Coiled coilPhylogenomic databases
eggNOGi | KOG0732, Eukaryota |
GeneTreei | ENSGT00550000074694 |
HOGENOMi | CLU_001448_3_2_1 |
InParanoidi | Q6PL18 |
OMAi | DFVMAMQ |
PhylomeDBi | Q6PL18 |
TreeFami | TF314783 |
Family and domain databases
Gene3Di | 1.20.920.10, 1 hit |
IDEALi | IID00570 |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR041569, AAA_lid_3 IPR031252, ANCCA IPR003959, ATPase_AAA_core IPR003960, ATPase_AAA_CS IPR001487, Bromodomain IPR036427, Bromodomain-like_sf IPR027417, P-loop_NTPase |
PANTHERi | PTHR23069:SF4, PTHR23069:SF4, 1 hit |
Pfami | View protein in Pfam PF00004, AAA, 1 hit PF17862, AAA_lid_3, 1 hit PF00439, Bromodomain, 1 hit |
PRINTSi | PR00503, BROMODOMAIN |
SMARTi | View protein in SMART SM00382, AAA, 1 hit SM00297, BROMO, 1 hit |
SUPFAMi | SSF47370, SSF47370, 1 hit SSF52540, SSF52540, 2 hits |
PROSITEi | View protein in PROSITE PS00674, AAA, 1 hit PS50014, BROMODOMAIN_2, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MVVLRSSLEL HNHSAASATG SLDLSSDFLS LEHIGRRRLR SAGAAQKKPA
60 70 80 90 100
ATTAKAGDGS SVKEVETYHR TRALRSLRKD AQNSSDSSFE KNVEITEQLA
110 120 130 140 150
NGRHFTRQLA RQQADKKKEE HREDKVIPVT RSLRARNIVQ STEHLHEDNG
160 170 180 190 200
DVEVRRSCRI RSRYSGVNQS MLFDKLITNT AEAVLQKMDD MKKMRRQRMR
210 220 230 240 250
ELEDLGVFNE TEESNLNMYT RGKQKDIQRT DEETTDNQEG SVESSEEGED
260 270 280 290 300
QEHEDDGEDE DDEDDDDDDD DDDDDDDEDD EDEEDGEEEN QKRYYLRQRK
310 320 330 340 350
ATVYYQAPLE KPRHQRKPNI FYSGPASPAR PRYRLSSAGP RSPYCKRMNR
360 370 380 390 400
RRHAIHSSDS TSSSSSEDEQ HFERRRKRSR NRAINRCLPL NFRKDELKGI
410 420 430 440 450
YKDRMKIGAS LADVDPMQLD SSVRFDSVGG LSNHIAALKE MVVFPLLYPE
460 470 480 490 500
VFEKFKIQPP RGCLFYGPPG TGKTLVARAL ANECSQGDKR VAFFMRKGAD
510 520 530 540 550
CLSKWVGESE RQLRLLFDQA YQMRPSIIFF DEIDGLAPVR SSRQDQIHSS
560 570 580 590 600
IVSTLLALMD GLDSRGEIVV IGATNRLDSI DPALRRPGRF DREFLFSLPD
610 620 630 640 650
KEARKEILKI HTRDWNPKPL DTFLEELAEN CVGYCGADIK SICAEAALCA
660 670 680 690 700
LRRRYPQIYT TSEKLQLDLS SINISAKDFE VAMQKMIPAS QRAVTSPGQA
710 720 730 740 750
LSTVVKPLLQ NTVDKILEAL QRVFPHAEFR TNKTLDSDIS CPLLESDLAY
760 770 780 790 800
SDDDVPSVYE NGLSQKSSHK AKDNFNFLHL NRNACYQPMS FRPRILIVGE
810 820 830 840 850
PGFGQGSHLA PAVIHALEKF TVYTLDIPVL FGVSTTSPEE TCAQVIREAK
860 870 880 890 900
RTAPSIVYVP HIHVWWEIVG PTLKATFTTL LQNIPSFAPV LLLATSDKPH
910 920 930 940 950
SALPEEVQEL FIRDYGEIFN VQLPDKEERT KFFEDLILKQ AAKPPISKKK
960 970 980 990 1000
AVLQALEVLP VAPPPEPRSL TAEEVKRLEE QEEDTFRELR IFLRNVTHRL
1010 1020 1030 1040 1050
AIDKRFRVFT KPVDPDEVPD YVTVIKQPMD LSSVISKIDL HKYLTVKDYL
1060 1070 1080 1090 1100
RDIDLICSNA LEYNPDRDPG DRLIRHRACA LRDTAYAIIK EELDEDFEQL
1110 1120 1130 1140 1150
CEEIQESRKK RGCSSSKYAP SYYHVMPKQN STLVGDKRSD PEQNEKLKTP
1160 1170 1180 1190 1200
STPVACSTPA QLKRKIRKKS NWYLGTIKKR RKISQAKDDS QNAIDHKIES
1210 1220 1230 1240 1250
DTEETQDTSV DHNETGNTGE SSVEENEKQQ NASESKLELR NNSNTCNIEN
1260 1270 1280 1290 1300
ELEDSRKTTA CTELRDKIAC NGDASSSQII HISDENEGKE MCVLRMTRAR
1310 1320 1330 1340 1350
RSQVEQQQLI TVEKALAILS QPTPSLVVDH ERLKNLLKTV VKKSQNYNIF
1360 1370 1380 1390
QLENLYAVIS QCIYRHRKDH DKTSLIQKME QEVENFSCSR
The sequence of this isoform differs from the canonical sequence as follows:
1-170: Missing.
551-582: IVSTLLALMDGLDSRGEIVVIGATNRLDSIDP → YGWIGQQRGNCGHWCYEQARFYRSCFTKAWSL
583-1390: Missing.
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0B4J211 | A0A0B4J211_HUMAN | ATPase family AAA domain-containing... | ATAD2 | 708 | Annotation score: | ||
E5RIP2 | E5RIP2_HUMAN | ATPase family AAA domain-containing... | ATAD2 | 64 | Annotation score: | ||
E5RHW7 | E5RHW7_HUMAN | ATPase family AAA domain-containing... | ATAD2 | 63 | Annotation score: |
Sequence cautioni
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_047625 | 1280 | I → T. Corresponds to variant dbSNP:rs3758122Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_015633 | 1 – 170 | Missing in isoform 2. 1 PublicationAdd BLAST | 170 | |
Alternative sequenceiVSP_015634 | 551 – 582 | IVSTL…DSIDP → YGWIGQQRGNCGHWCYEQAR FYRSCFTKAWSL in isoform 2. 1 PublicationAdd BLAST | 32 | |
Alternative sequenceiVSP_015635 | 583 – 1390 | Missing in isoform 2. 1 PublicationAdd BLAST | 808 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY598335 mRNA Translation: AAT06746.1 CR749832 mRNA Translation: CAH18688.1 AL833653 mRNA Translation: CAH56229.1 BC010686 mRNA Translation: AAH10686.1 Sequence problems. BC019909 mRNA Translation: AAH19909.1 Different initiation. BC113656 mRNA Translation: AAI13657.1 AK097133 mRNA Translation: BAC04959.1 AF118088 mRNA Translation: AAF22032.1 Different initiation. |
CCDSi | CCDS6343.1 [Q6PL18-1] |
RefSeqi | NP_054828.2, NM_014109.3 [Q6PL18-1] |
Genome annotation databases
Ensembli | ENST00000287394; ENSP00000287394; ENSG00000156802 [Q6PL18-1] |
GeneIDi | 29028 |
KEGGi | hsa:29028 |
UCSCi | uc003yqh.5, human [Q6PL18-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY598335 mRNA Translation: AAT06746.1 CR749832 mRNA Translation: CAH18688.1 AL833653 mRNA Translation: CAH56229.1 BC010686 mRNA Translation: AAH10686.1 Sequence problems. BC019909 mRNA Translation: AAH19909.1 Different initiation. BC113656 mRNA Translation: AAI13657.1 AK097133 mRNA Translation: BAC04959.1 AF118088 mRNA Translation: AAF22032.1 Different initiation. |
CCDSi | CCDS6343.1 [Q6PL18-1] |
RefSeqi | NP_054828.2, NM_014109.3 [Q6PL18-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3DAI | X-ray | 1.95 | A | 981-1108 | [»] | |
4QSP | X-ray | 1.60 | A | 981-1108 | [»] | |
4QSQ | X-ray | 1.80 | A | 981-1108 | [»] | |
4QSR | X-ray | 2.00 | A | 981-1108 | [»] | |
4QSS | X-ray | 2.00 | A | 981-1108 | [»] | |
4QST | X-ray | 2.05 | A | 981-1108 | [»] | |
4QSU | X-ray | 1.90 | A | 981-1108 | [»] | |
4QSV | X-ray | 1.90 | A | 981-1108 | [»] | |
4QSW | X-ray | 1.80 | A | 981-1108 | [»] | |
4QSX | X-ray | 1.93 | A | 981-1108 | [»] | |
4QUT | X-ray | 1.70 | A | 981-1108 | [»] | |
4QUU | X-ray | 1.80 | A | 981-1108 | [»] | |
4TT2 | X-ray | 2.50 | A | 981-1108 | [»] | |
4TT4 | X-ray | 2.70 | A/B | 981-1108 | [»] | |
4TT6 | X-ray | 2.00 | A | 981-1108 | [»] | |
4TTE | X-ray | 1.80 | A | 981-1108 | [»] | |
4TU4 | X-ray | 1.73 | A | 981-1108 | [»] | |
4TU6 | X-ray | 2.27 | A/B/C/D | 981-1108 | [»] | |
4TYL | X-ray | 1.85 | A | 981-1108 | [»] | |
4TZ2 | X-ray | 1.70 | A | 981-1108 | [»] | |
4TZ8 | X-ray | 2.15 | A | 981-1108 | [»] | |
5A5N | X-ray | 1.95 | A | 981-1108 | [»] | |
5A5O | X-ray | 2.04 | A | 981-1108 | [»] | |
5A5P | X-ray | 2.03 | A | 981-1108 | [»] | |
5A5Q | X-ray | 1.97 | A | 981-1108 | [»] | |
5A5R | X-ray | 2.01 | A | 981-1108 | [»] | |
5A81 | X-ray | 2.03 | A | 981-1108 | [»] | |
5A82 | X-ray | 1.86 | A | 981-1108 | [»] | |
5A83 | X-ray | 2.09 | A | 981-1108 | [»] | |
5EPB | X-ray | 1.50 | A | 981-1108 | [»] | |
5F36 | X-ray | 1.50 | A | 981-1108 | [»] | |
5F3A | X-ray | 1.60 | A | 981-1108 | [»] | |
5LJ0 | X-ray | 1.82 | A | 981-1108 | [»] | |
5QXI | X-ray | 1.64 | A | 981-1108 | [»] | |
5QXJ | X-ray | 1.46 | A | 981-1108 | [»] | |
5QXK | X-ray | 1.72 | A | 981-1108 | [»] | |
5QXL | X-ray | 1.57 | A | 981-1108 | [»] | |
5QXM | X-ray | 1.50 | A | 981-1108 | [»] | |
5QXN | X-ray | 1.41 | A | 981-1108 | [»] | |
5QXO | X-ray | 1.47 | A | 981-1108 | [»] | |
5QXP | X-ray | 1.41 | A | 981-1108 | [»] | |
5QXQ | X-ray | 1.55 | A | 981-1108 | [»] | |
5QXR | X-ray | 1.66 | A | 981-1108 | [»] | |
5QXS | X-ray | 1.62 | A | 981-1108 | [»] | |
5QXT | X-ray | 1.55 | A | 981-1108 | [»] | |
5QXU | X-ray | 1.65 | A | 981-1108 | [»] | |
5QXV | X-ray | 1.74 | A | 981-1108 | [»] | |
5QXW | X-ray | 1.78 | A | 981-1108 | [»] | |
5QXX | X-ray | 1.58 | A | 981-1108 | [»] | |
5QXY | X-ray | 1.54 | A | 981-1108 | [»] | |
5QXZ | X-ray | 1.64 | A | 981-1108 | [»] | |
5QY0 | X-ray | 1.89 | A | 981-1108 | [»] | |
5R4E | X-ray | 1.83 | A | 981-1108 | [»] | |
5R4F | X-ray | 1.44 | A | 981-1108 | [»] | |
5R4V | X-ray | 1.29 | A | 981-1108 | [»] | |
5R4W | X-ray | 1.47 | A | 981-1108 | [»] | |
5R4X | X-ray | 1.40 | A | 981-1108 | [»] | |
5R4Y | X-ray | 1.84 | A | 981-1108 | [»] | |
5R4Z | X-ray | 1.46 | A | 981-1108 | [»] | |
6CPS | X-ray | 1.93 | A | 981-1108 | [»] | |
6EPJ | X-ray | 1.65 | A | 981-1108 | [»] | |
6EPR | X-ray | 2.05 | A | 981-1108 | [»] | |
6EPS | X-ray | 2.08 | A | 981-1108 | [»] | |
6EPT | X-ray | 1.65 | A | 981-1108 | [»] | |
6EPU | X-ray | 1.80 | A | 981-1108 | [»] | |
6EPV | X-ray | 1.79 | A | 981-1108 | [»] | |
6EPW | X-ray | 1.92 | A | 981-1108 | [»] | |
6EPX | X-ray | 1.84 | A | 981-1108 | [»] | |
6HDN | X-ray | 1.90 | A | 981-1108 | [»] | |
6HDO | X-ray | 2.61 | A | 981-1108 | [»] | |
6HI3 | X-ray | 2.40 | A | 981-1108 | [»] | |
6HI4 | X-ray | 1.69 | A | 981-1108 | [»] | |
6HI5 | X-ray | 1.59 | A | 981-1108 | [»] | |
6HI6 | X-ray | 1.64 | A | 981-1108 | [»] | |
6HI7 | X-ray | 1.74 | A | 981-1108 | [»] | |
6HI8 | X-ray | 1.90 | A | 981-1108 | [»] | |
6HIA | X-ray | 1.90 | A | 981-1108 | [»] | |
6HIB | X-ray | 2.03 | A | 981-1108 | [»] | |
6HIC | X-ray | 1.77 | A | 981-1108 | [»] | |
6HID | X-ray | 1.77 | A | 981-1108 | [»] | |
6HIE | X-ray | 2.05 | A | 981-1108 | [»] | |
6S55 | X-ray | 2.09 | A | 981-1108 | [»] | |
6S56 | X-ray | 2.01 | A | 981-1108 | [»] | |
6S57 | X-ray | 1.82 | A | 981-1108 | [»] | |
6YB4 | X-ray | 1.85 | AAA | 981-1108 | [»] | |
SMRi | Q6PL18 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 118827, 33 interactors |
DIPi | DIP-46197N |
IntActi | Q6PL18, 10 interactors |
MINTi | Q6PL18 |
STRINGi | 9606.ENSP00000287394 |
Chemistry databases
BindingDBi | Q6PL18 |
ChEMBLi | CHEMBL2150837 |
GuidetoPHARMACOLOGYi | 2719 |
PTM databases
iPTMneti | Q6PL18 |
PhosphoSitePlusi | Q6PL18 |
Genetic variation databases
BioMutai | ATAD2 |
DMDMi | 74762365 |
Proteomic databases
EPDi | Q6PL18 |
jPOSTi | Q6PL18 |
MassIVEi | Q6PL18 |
MaxQBi | Q6PL18 |
PaxDbi | Q6PL18 |
PeptideAtlasi | Q6PL18 |
PRIDEi | Q6PL18 |
ProteomicsDBi | 67248 [Q6PL18-1] 67249 [Q6PL18-2] |
Protocols and materials databases
Antibodypediai | 13822, 152 antibodies |
DNASUi | 29028 |
Genome annotation databases
Ensembli | ENST00000287394; ENSP00000287394; ENSG00000156802 [Q6PL18-1] |
GeneIDi | 29028 |
KEGGi | hsa:29028 |
UCSCi | uc003yqh.5, human [Q6PL18-1] |
Organism-specific databases
CTDi | 29028 |
DisGeNETi | 29028 |
GeneCardsi | ATAD2 |
HGNCi | HGNC:30123, ATAD2 |
HPAi | ENSG00000156802, Tissue enhanced (lymphoid) |
MIMi | 611941, gene |
neXtProti | NX_Q6PL18 |
OpenTargetsi | ENSG00000156802 |
PharmGKBi | PA134895566 |
VEuPathDBi | HostDB:ENSG00000156802.12 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0732, Eukaryota |
GeneTreei | ENSGT00550000074694 |
HOGENOMi | CLU_001448_3_2_1 |
InParanoidi | Q6PL18 |
OMAi | DFVMAMQ |
PhylomeDBi | Q6PL18 |
TreeFami | TF314783 |
Enzyme and pathway databases
PathwayCommonsi | Q6PL18 |
Reactomei | R-HSA-8866910, TFAP2 (AP-2) family regulates transcription of growth factors and their receptors |
Miscellaneous databases
BioGRID-ORCSi | 29028, 25 hits in 874 CRISPR screens |
ChiTaRSi | ATAD2, human |
EvolutionaryTracei | Q6PL18 |
GenomeRNAii | 29028 |
Pharosi | Q6PL18, Tchem |
PROi | PR:Q6PL18 |
RNActi | Q6PL18, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000156802, Expressed in secondary oocyte and 188 other tissues |
ExpressionAtlasi | Q6PL18, baseline and differential |
Genevisiblei | Q6PL18, HS |
Family and domain databases
Gene3Di | 1.20.920.10, 1 hit |
IDEALi | IID00570 |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR041569, AAA_lid_3 IPR031252, ANCCA IPR003959, ATPase_AAA_core IPR003960, ATPase_AAA_CS IPR001487, Bromodomain IPR036427, Bromodomain-like_sf IPR027417, P-loop_NTPase |
PANTHERi | PTHR23069:SF4, PTHR23069:SF4, 1 hit |
Pfami | View protein in Pfam PF00004, AAA, 1 hit PF17862, AAA_lid_3, 1 hit PF00439, Bromodomain, 1 hit |
PRINTSi | PR00503, BROMODOMAIN |
SMARTi | View protein in SMART SM00382, AAA, 1 hit SM00297, BROMO, 1 hit |
SUPFAMi | SSF47370, SSF47370, 1 hit SSF52540, SSF52540, 2 hits |
PROSITEi | View protein in PROSITE PS00674, AAA, 1 hit PS50014, BROMODOMAIN_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ATAD2_HUMAN | |
Accessioni | Q6PL18Primary (citable) accession number: Q6PL18 Secondary accession number(s): Q14CR1 Q9UHS5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 13, 2005 |
Last sequence update: | July 5, 2004 | |
Last modified: | February 10, 2021 | |
This is version 153 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human entries with genetic variants
List of human entries with genetic variants