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UniProtKB - Q6PL18 (ATAD2_HUMAN)

Entry version 158 (25 May 2022)
Sequence version 1 (05 Jul 2004)
Previous versions | rss
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Protein

ATPase family AAA domain-containing protein 2

Gene

ATAD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells.

1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi467 – 474ATPSequence analysis8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Hydrolase
Biological processTranscription, Transcription regulation
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q6PL18

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-8866910, TFAP2 (AP-2) family regulates transcription of growth factors and their receptors

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q6PL18

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ATPase family AAA domain-containing protein 2 (EC:3.6.1.-)
Alternative name(s):
AAA nuclear coregulator cancer-associated protein
Short name:
ANCCA
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ATAD2
ORF Names:L16, PRO2000
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:30123, ATAD2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		611941, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q6PL18

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000156802

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi473K → T: Reduces the ability to mediate estradiol-dependent induction of CCND1 and E2F1; when associated with Q-532. 1 Publication1
Mutagenesisi532E → Q: Reduces the ability to mediate estradiol-dependent induction of CCND1 and E2F1; when associated with T-473. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		29028

Open Targets

More...OpenTargetsi		ENSG00000156802

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134895566

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q6PL18, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL2150837

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		2719

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ATAD2

Domain mapping of disease mutations (DMDM)

More...DMDMi		74762365

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000847961 – 1390ATPase family AAA domain-containing protein 2Add BLAST1390

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei60PhosphoserineCombined sources1
Modified residuei61PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki125Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei165PhosphoserineCombined sources1
Modified residuei170PhosphoserineCombined sources1
Cross-linki317Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei327PhosphoserineCombined sources1
Modified residuei337PhosphoserineCombined sources1
Modified residuei342PhosphoserineCombined sources1
Modified residuei410PhosphoserineCombined sources1
Modified residuei746PhosphoserineCombined sources1
Modified residuei751PhosphoserineCombined sources1
Cross-linki1128Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1139PhosphoserineCombined sources1
Cross-linki1148Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1149PhosphothreonineCombined sources1
Modified residuei1152PhosphothreonineCombined sources1
Modified residuei1176PhosphothreonineCombined sources1
Modified residuei1200PhosphoserineCombined sources1
Modified residuei1233PhosphoserineCombined sources1
Modified residuei1235PhosphoserineCombined sources1
Cross-linki1236Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1243PhosphoserineCombined sources1
Modified residuei1302PhosphoserineCombined sources1
Modified residuei1323PhosphothreonineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q6PL18

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q6PL18

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q6PL18

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q6PL18

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q6PL18

PeptideAtlas

More...PeptideAtlasi		Q6PL18

PRoteomics IDEntifications database

More...PRIDEi		Q6PL18

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		67248 [Q6PL18-1]
67249 [Q6PL18-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q6PL18

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q6PL18

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in estrogen receptor positive breast tumors and in osteosarcoma tumors.3 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated in breast, uterus, colon, ovary, and stomach tumors. Induced in breast cancer cells overexpressing NCOA3 or treated with estrogen. Down-regulated in 5-fluorouracil-resistant derivatives of the colon cancer cell line HCT 116.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000156802, Expressed in secondary oocyte and 189 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q6PL18, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q6PL18, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000156802, Tissue enhanced (lymphoid)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ESR1 and NCOA3 and these interactions are enhanced by estradiol.

Interacts with acetylated lysine residues on histone H1.4, H2A, H2B and H3 (in vitro).

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		118827, 41 interactors

Database of interacting proteins

More...DIPi		DIP-46197N

Protein interaction database and analysis system

More...IntActi		Q6PL18, 12 interactors

Molecular INTeraction database

More...MINTi		Q6PL18

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000287394

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q6PL18

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q6PL18, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11390
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q6PL18

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q6PL18

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q6PL18

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1001 – 1071BromoPROSITE-ProRule annotationAdd BLAST71

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni40 – 63DisorderedSequence analysisAdd BLAST24
Regioni216 – 380DisorderedSequence analysisAdd BLAST165
Regioni1124 – 1163DisorderedSequence analysisAdd BLAST40
Regioni1181 – 1242DisorderedSequence analysisAdd BLAST62

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili970 – 994Sequence analysisAdd BLAST25
Coiled coili1086 – 1112Sequence analysisAdd BLAST27

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi237 – 288Acidic residuesSequence analysisAdd BLAST52
Compositional biasi1181 – 1210Basic and acidic residuesSequence analysisAdd BLAST30
Compositional biasi1211 – 1226Polar residuesSequence analysisAdd BLAST16

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the AAA ATPase family.Curated

Keywords - Domaini

Bromodomain, Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0732, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00550000074694

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_001448_3_2_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q6PL18

Identification of Orthologs from Complete Genome Data

More...OMAi		RRKSKWY

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q6PL18

TreeFam database of animal gene trees

More...TreeFami		TF314783

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.920.10, 1 hit
3.40.50.300, 2 hits

Intrinsically Disordered proteins with Extensive Annotations and Literature

More...IDEALi		IID00570

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR003593, AAA+_ATPase
IPR041569, AAA_lid_3
IPR031252, ANCCA
IPR045199, ATAD2-like
IPR003959, ATPase_AAA_core
IPR003960, ATPase_AAA_CS
IPR001487, Bromodomain
IPR036427, Bromodomain-like_sf
IPR027417, P-loop_NTPase

The PANTHER Classification System

More...PANTHERi		PTHR23069, PTHR23069, 1 hit
PTHR23069:SF4, PTHR23069:SF4, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00004, AAA, 1 hit
PF17862, AAA_lid_3, 1 hit
PF00439, Bromodomain, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00503, BROMODOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00382, AAA, 1 hit
SM00297, BROMO, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47370, SSF47370, 1 hit
SSF52540, SSF52540, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00674, AAA, 1 hit
PS50014, BROMODOMAIN_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6PL18-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVVLRSSLEL HNHSAASATG SLDLSSDFLS LEHIGRRRLR SAGAAQKKPA 
        60         70         80         90        100
ATTAKAGDGS SVKEVETYHR TRALRSLRKD AQNSSDSSFE KNVEITEQLA 
       110        120        130        140        150
NGRHFTRQLA RQQADKKKEE HREDKVIPVT RSLRARNIVQ STEHLHEDNG 
       160        170        180        190        200
DVEVRRSCRI RSRYSGVNQS MLFDKLITNT AEAVLQKMDD MKKMRRQRMR 
       210        220        230        240        250
ELEDLGVFNE TEESNLNMYT RGKQKDIQRT DEETTDNQEG SVESSEEGED 
       260        270        280        290        300
QEHEDDGEDE DDEDDDDDDD DDDDDDDEDD EDEEDGEEEN QKRYYLRQRK 
       310        320        330        340        350
ATVYYQAPLE KPRHQRKPNI FYSGPASPAR PRYRLSSAGP RSPYCKRMNR 
       360        370        380        390        400
RRHAIHSSDS TSSSSSEDEQ HFERRRKRSR NRAINRCLPL NFRKDELKGI 
       410        420        430        440        450
YKDRMKIGAS LADVDPMQLD SSVRFDSVGG LSNHIAALKE MVVFPLLYPE 
       460        470        480        490        500
VFEKFKIQPP RGCLFYGPPG TGKTLVARAL ANECSQGDKR VAFFMRKGAD 
       510        520        530        540        550
CLSKWVGESE RQLRLLFDQA YQMRPSIIFF DEIDGLAPVR SSRQDQIHSS 
       560        570        580        590        600
IVSTLLALMD GLDSRGEIVV IGATNRLDSI DPALRRPGRF DREFLFSLPD 
       610        620        630        640        650
KEARKEILKI HTRDWNPKPL DTFLEELAEN CVGYCGADIK SICAEAALCA 
       660        670        680        690        700
LRRRYPQIYT TSEKLQLDLS SINISAKDFE VAMQKMIPAS QRAVTSPGQA 
       710        720        730        740        750
LSTVVKPLLQ NTVDKILEAL QRVFPHAEFR TNKTLDSDIS CPLLESDLAY 
       760        770        780        790        800
SDDDVPSVYE NGLSQKSSHK AKDNFNFLHL NRNACYQPMS FRPRILIVGE 
       810        820        830        840        850
PGFGQGSHLA PAVIHALEKF TVYTLDIPVL FGVSTTSPEE TCAQVIREAK 
       860        870        880        890        900
RTAPSIVYVP HIHVWWEIVG PTLKATFTTL LQNIPSFAPV LLLATSDKPH 
       910        920        930        940        950
SALPEEVQEL FIRDYGEIFN VQLPDKEERT KFFEDLILKQ AAKPPISKKK 
       960        970        980        990       1000
AVLQALEVLP VAPPPEPRSL TAEEVKRLEE QEEDTFRELR IFLRNVTHRL 
      1010       1020       1030       1040       1050
AIDKRFRVFT KPVDPDEVPD YVTVIKQPMD LSSVISKIDL HKYLTVKDYL 
      1060       1070       1080       1090       1100
RDIDLICSNA LEYNPDRDPG DRLIRHRACA LRDTAYAIIK EELDEDFEQL 
      1110       1120       1130       1140       1150
CEEIQESRKK RGCSSSKYAP SYYHVMPKQN STLVGDKRSD PEQNEKLKTP 
      1160       1170       1180       1190       1200
STPVACSTPA QLKRKIRKKS NWYLGTIKKR RKISQAKDDS QNAIDHKIES 
      1210       1220       1230       1240       1250
DTEETQDTSV DHNETGNTGE SSVEENEKQQ NASESKLELR NNSNTCNIEN 
      1260       1270       1280       1290       1300
ELEDSRKTTA CTELRDKIAC NGDASSSQII HISDENEGKE MCVLRMTRAR 
      1310       1320       1330       1340       1350
RSQVEQQQLI TVEKALAILS QPTPSLVVDH ERLKNLLKTV VKKSQNYNIF 
      1360       1370       1380       1390
QLENLYAVIS QCIYRHRKDH DKTSLIQKME QEVENFSCSR
Length:1,390
Mass (Da):158,554
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF43B30C77BB0F4BA
GO
Isoform 2 (identifier: Q6PL18-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-170: Missing.
     551-582: IVSTLLALMDGLDSRGEIVVIGATNRLDSIDP → YGWIGQQRGNCGHWCYEQARFYRSCFTKAWSL
     583-1390: Missing.

Note: Dubious isoform. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »
Length:412
Mass (Da):47,986
Checksum:i24E5F0638207B64A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0B4J211A0A0B4J211_HUMAN
ATPase family AAA domain-containing...
ATAD2
708Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RIP2E5RIP2_HUMAN
ATPase family AAA domain-containing...
ATAD2
64Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RHW7E5RHW7_HUMAN
ATPase family AAA domain-containing...
ATAD2
63Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF22032 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH10686 differs from that shown. Contaminating sequence. Sequence of unknown origin in the N-terminal part (676-679).Curated
The sequence AAH19909 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0476251280I → T. Corresponds to variant dbSNP:rs3758122Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0156331 – 170Missing in isoform 2. 1 PublicationAdd BLAST170
Alternative sequenceiVSP_015634551 – 582IVSTL…DSIDP → YGWIGQQRGNCGHWCYEQAR FYRSCFTKAWSL in isoform 2. 1 PublicationAdd BLAST32
Alternative sequenceiVSP_015635583 – 1390Missing in isoform 2. 1 PublicationAdd BLAST808

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY598335 mRNA Translation: AAT06746.1
CR749832 mRNA Translation: CAH18688.1
AL833653 mRNA Translation: CAH56229.1
BC010686 mRNA Translation: AAH10686.1 Sequence problems.
BC019909 mRNA Translation: AAH19909.1 Different initiation.
BC113656 mRNA Translation: AAI13657.1
AK097133 mRNA Translation: BAC04959.1
AF118088 mRNA Translation: AAF22032.1 Different initiation.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS6343.1 [Q6PL18-1]

NCBI Reference Sequences

More...RefSeqi		NP_054828.2, NM_014109.3 [Q6PL18-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000287394.10; ENSP00000287394.5; ENSG00000156802.13

Database of genes from NCBI RefSeq genomes

More...GeneIDi		29028

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:29028

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000287394.10; ENSP00000287394.5; NM_014109.4; NP_054828.2

UCSC genome browser

More...UCSCi		uc003yqh.5, human [Q6PL18-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY598335 mRNA Translation: AAT06746.1
CR749832 mRNA Translation: CAH18688.1
AL833653 mRNA Translation: CAH56229.1
BC010686 mRNA Translation: AAH10686.1 Sequence problems.
BC019909 mRNA Translation: AAH19909.1 Different initiation.
BC113656 mRNA Translation: AAI13657.1
AK097133 mRNA Translation: BAC04959.1
AF118088 mRNA Translation: AAF22032.1 Different initiation.
CCDSiCCDS6343.1 [Q6PL18-1]
RefSeqiNP_054828.2, NM_014109.3 [Q6PL18-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3DAIX-ray1.95A981-1108[»]
4QSPX-ray1.60A981-1108[»]
4QSQX-ray1.80A981-1108[»]
4QSRX-ray2.00A981-1108[»]
4QSSX-ray2.00A981-1108[»]
4QSTX-ray2.05A981-1108[»]
4QSUX-ray1.90A981-1108[»]
4QSVX-ray1.90A981-1108[»]
4QSWX-ray1.80A981-1108[»]
4QSXX-ray1.93A981-1108[»]
4QUTX-ray1.70A981-1108[»]
4QUUX-ray1.80A981-1108[»]
4TT2X-ray2.50A981-1108[»]
4TT4X-ray2.70A/B981-1108[»]
4TT6X-ray2.00A981-1108[»]
4TTEX-ray1.80A981-1108[»]
4TU4X-ray1.73A981-1108[»]
4TU6X-ray2.27A/B/C/D981-1108[»]
4TYLX-ray1.85A981-1108[»]
4TZ2X-ray1.70A981-1108[»]
4TZ8X-ray2.15A981-1108[»]
5A5NX-ray1.95A981-1108[»]
5A5OX-ray2.04A981-1108[»]
5A5PX-ray2.03A981-1108[»]
5A5QX-ray1.97A981-1108[»]
5A5RX-ray2.01A981-1108[»]
5A81X-ray2.03A981-1108[»]
5A82X-ray1.86A981-1108[»]
5A83X-ray2.09A981-1108[»]
5EPBX-ray1.50A981-1108[»]
5F36X-ray1.50A981-1108[»]
5F3AX-ray1.60A981-1108[»]
5LJ0X-ray1.82A981-1108[»]
5QXIX-ray1.64A981-1108[»]
5QXJX-ray1.46A981-1108[»]
5QXKX-ray1.72A981-1108[»]
5QXLX-ray1.57A981-1108[»]
5QXMX-ray1.50A981-1108[»]
5QXNX-ray1.41A981-1108[»]
5QXOX-ray1.47A981-1108[»]
5QXPX-ray1.41A981-1108[»]
5QXQX-ray1.55A981-1108[»]
5QXRX-ray1.66A981-1108[»]
5QXSX-ray1.62A981-1108[»]
5QXTX-ray1.55A981-1108[»]
5QXUX-ray1.65A981-1108[»]
5QXVX-ray1.74A981-1108[»]
5QXWX-ray1.78A981-1108[»]
5QXXX-ray1.58A981-1108[»]
5QXYX-ray1.54A981-1108[»]
5QXZX-ray1.64A981-1108[»]
5QY0X-ray1.89A981-1108[»]
5R4EX-ray1.83A981-1108[»]
5R4FX-ray1.44A981-1108[»]
5R4VX-ray1.29A981-1108[»]
5R4WX-ray1.47A981-1108[»]
5R4XX-ray1.40A981-1108[»]
5R4YX-ray1.84A981-1108[»]
5R4ZX-ray1.46A981-1108[»]
6CPSX-ray1.93A981-1108[»]
6EPJX-ray1.65A981-1108[»]
6EPRX-ray2.05A981-1108[»]
6EPSX-ray2.08A981-1108[»]
6EPTX-ray1.65A981-1108[»]
6EPUX-ray1.80A981-1108[»]
6EPVX-ray1.79A981-1108[»]
6EPWX-ray1.92A981-1108[»]
6EPXX-ray1.84A981-1108[»]
6HDNX-ray1.90A981-1108[»]
6HDOX-ray2.61A981-1108[»]
6HI3X-ray2.40A981-1108[»]
6HI4X-ray1.69A981-1108[»]
6HI5X-ray1.59A981-1108[»]
6HI6X-ray1.64A981-1108[»]
6HI7X-ray1.74A981-1108[»]
6HI8X-ray1.90A981-1108[»]
6HIAX-ray1.90A981-1108[»]
6HIBX-ray2.03A981-1108[»]
6HICX-ray1.77A981-1108[»]
6HIDX-ray1.77A981-1108[»]
6HIEX-ray2.05A981-1108[»]
6S55X-ray2.09A981-1108[»]
6S56X-ray2.01A981-1108[»]
6S57X-ray1.82A981-1108[»]
6YB4X-ray1.85AAA981-1108[»]
7M98X-ray1.60A966-1112[»]
7Q6TX-ray2.05A981-1108[»]
7Q6UX-ray1.95A981-1108[»]
7Q6VX-ray1.96A981-1108[»]
7Q6WX-ray1.96A981-1108[»]
AlphaFoldDBiQ6PL18
SMRiQ6PL18
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi118827, 41 interactors
DIPiDIP-46197N
IntActiQ6PL18, 12 interactors
MINTiQ6PL18
STRINGi9606.ENSP00000287394

Chemistry databases

BindingDBiQ6PL18
ChEMBLiCHEMBL2150837
GuidetoPHARMACOLOGYi2719

PTM databases

iPTMnetiQ6PL18
PhosphoSitePlusiQ6PL18

Genetic variation databases

BioMutaiATAD2
DMDMi74762365

Proteomic databases

EPDiQ6PL18
jPOSTiQ6PL18
MassIVEiQ6PL18
MaxQBiQ6PL18
PaxDbiQ6PL18
PeptideAtlasiQ6PL18
PRIDEiQ6PL18
ProteomicsDBi67248 [Q6PL18-1]
67249 [Q6PL18-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		13822, 166 antibodies from 28 providers

The DNASU plasmid repository

More...DNASUi		29028

Genome annotation databases

EnsembliENST00000287394.10; ENSP00000287394.5; ENSG00000156802.13
GeneIDi29028
KEGGihsa:29028
MANE-SelectiENST00000287394.10; ENSP00000287394.5; NM_014109.4; NP_054828.2
UCSCiuc003yqh.5, human [Q6PL18-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		29028
DisGeNETi29028

GeneCards: human genes, protein and diseases

More...GeneCardsi		ATAD2
HGNCiHGNC:30123, ATAD2
HPAiENSG00000156802, Tissue enhanced (lymphoid)
MIMi611941, gene
neXtProtiNX_Q6PL18
OpenTargetsiENSG00000156802
PharmGKBiPA134895566
VEuPathDBiHostDB:ENSG00000156802

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0732, Eukaryota
GeneTreeiENSGT00550000074694
HOGENOMiCLU_001448_3_2_1
InParanoidiQ6PL18
OMAiRRKSKWY
PhylomeDBiQ6PL18
TreeFamiTF314783

Enzyme and pathway databases

PathwayCommonsiQ6PL18
ReactomeiR-HSA-8866910, TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
SignaLinkiQ6PL18

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		29028, 37 hits in 1094 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ATAD2, human
EvolutionaryTraceiQ6PL18

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		29028
PharosiQ6PL18, Tchem

Protein Ontology

More...PROi		PR:Q6PL18
RNActiQ6PL18, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000156802, Expressed in secondary oocyte and 189 other tissues
ExpressionAtlasiQ6PL18, baseline and differential
GenevisibleiQ6PL18, HS

Family and domain databases

Gene3Di1.20.920.10, 1 hit
3.40.50.300, 2 hits
IDEALiIID00570
InterProiView protein in InterPro
IPR003593, AAA+_ATPase
IPR041569, AAA_lid_3
IPR031252, ANCCA
IPR045199, ATAD2-like
IPR003959, ATPase_AAA_core
IPR003960, ATPase_AAA_CS
IPR001487, Bromodomain
IPR036427, Bromodomain-like_sf
IPR027417, P-loop_NTPase
PANTHERiPTHR23069, PTHR23069, 1 hit
PTHR23069:SF4, PTHR23069:SF4, 1 hit
PfamiView protein in Pfam
PF00004, AAA, 1 hit
PF17862, AAA_lid_3, 1 hit
PF00439, Bromodomain, 1 hit
PRINTSiPR00503, BROMODOMAIN
SMARTiView protein in SMART
SM00382, AAA, 1 hit
SM00297, BROMO, 1 hit
SUPFAMiSSF47370, SSF47370, 1 hit
SSF52540, SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS00674, AAA, 1 hit
PS50014, BROMODOMAIN_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiATAD2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6PL18
Secondary accession number(s): Q14CR1
, Q658P2, Q68CQ0, Q6PJV6, Q8N890, Q9UHS5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: July 5, 2004
Last modified: May 25, 2022
This is version 158 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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