UniProtKB - Q6PKX4 (DOK6_HUMAN)
Protein
Docking protein 6
Gene
DOK6
Organism
Homo sapiens (Human)
Status
Functioni
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK6 promotes Ret-mediated neurite growth. May have a role in brain development and/or maintenance.1 Publication
GO - Biological processi
- axon guidance Source: Reactome
Enzyme and pathway databases
PathwayCommonsi | Q6PKX4 |
Reactomei | R-HSA-8853659, RET signaling |
SignaLinki | Q6PKX4 |
SIGNORi | Q6PKX4 |
Names & Taxonomyi
Protein namesi | Recommended name: Docking protein 6Alternative name(s): Downstream of tyrosine kinase 6 |
Gene namesi | Name:DOK6 Synonyms:DOK5L |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000206052.10 |
HGNCi | HGNC:28301, DOK6 |
MIMi | 611402, gene |
neXtProti | NX_Q6PKX4 |
Subcellular locationi
Cytosol
- cytosol Source: Reactome
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 220164 |
OpenTargetsi | ENSG00000206052 |
PharmGKBi | PA134866995 |
Miscellaneous databases
Pharosi | Q6PKX4, Tbio |
Polymorphism and mutation databases
BioMutai | DOK6 |
DMDMi | 84029601 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000187279 | 1 – 331 | Docking protein 6Add BLAST | 331 |
Post-translational modificationi
On Ret activation, phosphorylated on one or more C-terminal tyrosine residues by an Src family kinase.1 Publication
Keywords - PTMi
PhosphoproteinProteomic databases
MassIVEi | Q6PKX4 |
PaxDbi | Q6PKX4 |
PeptideAtlasi | Q6PKX4 |
PRIDEi | Q6PKX4 |
ProteomicsDBi | 67247 |
PTM databases
iPTMneti | Q6PKX4 |
PhosphoSitePlusi | Q6PKX4 |
Expressioni
Tissue specificityi
Highly expressed in fetal and adult brain. Highly expressed in the cerebellum. Weak expression in kidney, spinal cord and testis.1 Publication
Gene expression databases
Bgeei | ENSG00000206052, Expressed in substantia nigra and 173 other tissues |
ExpressionAtlasi | Q6PKX4, baseline and differential |
Genevisiblei | Q6PKX4, HS |
Organism-specific databases
HPAi | ENSG00000206052, Tissue enhanced (brain) |
Interactioni
Subunit structurei
Interacts via its PTB domain with phosphorylated RET.
1 PublicationBinary interactionsi
Hide detailsQ6PKX4
Protein-protein interaction databases
BioGRIDi | 128636, 22 interactors |
IntActi | Q6PKX4, 19 interactors |
MINTi | Q6PKX4 |
STRINGi | 9606.ENSP00000372160 |
Miscellaneous databases
RNActi | Q6PKX4, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 8 – 112 | PHAdd BLAST | 105 | |
Domaini | 132 – 237 | IRS-type PTBPROSITE-ProRule annotationAdd BLAST | 106 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 263 – 273 | DKFBH motifAdd BLAST | 11 |
Domaini
PTB domain mediates receptor interaction.By similarity
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG4047, Eukaryota |
GeneTreei | ENSGT00940000158760 |
HOGENOMi | CLU_057256_0_0_1 |
InParanoidi | Q6PKX4 |
OMAi | MEQKARX |
OrthoDBi | 1224728at2759 |
PhylomeDBi | Q6PKX4 |
TreeFami | TF324994 |
Family and domain databases
CDDi | cd14678, PH_DOK4_DOK5_DOK6, 1 hit |
Gene3Di | 2.30.29.30, 2 hits |
InterProi | View protein in InterPro IPR037816, DOK4/5/6_PH IPR002404, IRS_PTB IPR011993, PH-like_dom_sf IPR001849, PH_domain |
Pfami | View protein in Pfam PF02174, IRS, 1 hit |
SMARTi | View protein in SMART SM00233, PH, 1 hit SM00310, PTBI, 1 hit |
PROSITEi | View protein in PROSITE PS51064, IRS_PTB, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q6PKX4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASNFNDIVK QGYVKIRSRK LGIFRRCWLV FKKASSKGPR RLEKFPDEKA
60 70 80 90 100
AYFRNFHKVT ELHNIKNITR LPRETKKHAV AIIFHDETSK TFACESELEA
110 120 130 140 150
EEWCKHLCME CLGTRLNDIS LGEPDLLAAG VQREQNERFN VYLMPTPNLD
160 170 180 190 200
IYGECTMQIT HENIYLWDIH NAKVKLVMWP LSSLRRYGRD STWFTFESGR
210 220 230 240 250
MCDTGEGLFT FQTREGEMIY QKVHSATLAI AEQHERLMLE MEQKARLQTS
260 270 280 290 300
LTEPMTLSKS ISLPRSAYWH HITRQNSVGE IYSLQGHGFG SSKMSRAQTF
310 320 330
PSYAPEQSEE AQQPLSRSSS YGFSYSSSLI Q
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketJ3KTH4 | J3KTH4_HUMAN | Docking protein 6 | DOK6 | 156 | Annotation score: |
Sequence cautioni
The sequence BAB71577 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 238 | M → V in BAB71577 (PubMed:14702039).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY599248 mRNA Translation: AAT09770.1 AC026585 Genomic DNA No translation available. CH471117 Genomic DNA Translation: EAW66514.1 BC008583 mRNA Translation: AAH08583.3 BC019045 mRNA Translation: AAH19045.2 BC096744 mRNA Translation: AAH96744.1 AK057795 mRNA Translation: BAB71577.1 Different initiation. |
CCDSi | CCDS32841.1 |
RefSeqi | NP_689934.2, NM_152721.5 |
Genome annotation databases
Ensembli | ENST00000382713; ENSP00000372160; ENSG00000206052 |
GeneIDi | 220164 |
KEGGi | hsa:220164 |
UCSCi | uc002lkl.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY599248 mRNA Translation: AAT09770.1 AC026585 Genomic DNA No translation available. CH471117 Genomic DNA Translation: EAW66514.1 BC008583 mRNA Translation: AAH08583.3 BC019045 mRNA Translation: AAH19045.2 BC096744 mRNA Translation: AAH96744.1 AK057795 mRNA Translation: BAB71577.1 Different initiation. |
CCDSi | CCDS32841.1 |
RefSeqi | NP_689934.2, NM_152721.5 |
3D structure databases
SMRi | Q6PKX4 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 128636, 22 interactors |
IntActi | Q6PKX4, 19 interactors |
MINTi | Q6PKX4 |
STRINGi | 9606.ENSP00000372160 |
PTM databases
iPTMneti | Q6PKX4 |
PhosphoSitePlusi | Q6PKX4 |
Polymorphism and mutation databases
BioMutai | DOK6 |
DMDMi | 84029601 |
Proteomic databases
MassIVEi | Q6PKX4 |
PaxDbi | Q6PKX4 |
PeptideAtlasi | Q6PKX4 |
PRIDEi | Q6PKX4 |
ProteomicsDBi | 67247 |
Protocols and materials databases
Antibodypediai | 23216, 157 antibodies |
Genome annotation databases
Ensembli | ENST00000382713; ENSP00000372160; ENSG00000206052 |
GeneIDi | 220164 |
KEGGi | hsa:220164 |
UCSCi | uc002lkl.4, human |
Organism-specific databases
CTDi | 220164 |
DisGeNETi | 220164 |
EuPathDBi | HostDB:ENSG00000206052.10 |
GeneCardsi | DOK6 |
HGNCi | HGNC:28301, DOK6 |
HPAi | ENSG00000206052, Tissue enhanced (brain) |
MIMi | 611402, gene |
neXtProti | NX_Q6PKX4 |
OpenTargetsi | ENSG00000206052 |
PharmGKBi | PA134866995 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4047, Eukaryota |
GeneTreei | ENSGT00940000158760 |
HOGENOMi | CLU_057256_0_0_1 |
InParanoidi | Q6PKX4 |
OMAi | MEQKARX |
OrthoDBi | 1224728at2759 |
PhylomeDBi | Q6PKX4 |
TreeFami | TF324994 |
Enzyme and pathway databases
PathwayCommonsi | Q6PKX4 |
Reactomei | R-HSA-8853659, RET signaling |
SignaLinki | Q6PKX4 |
SIGNORi | Q6PKX4 |
Miscellaneous databases
BioGRID-ORCSi | 220164, 2 hits in 841 CRISPR screens |
ChiTaRSi | DOK6, human |
GenomeRNAii | 220164 |
Pharosi | Q6PKX4, Tbio |
PROi | PR:Q6PKX4 |
RNActi | Q6PKX4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000206052, Expressed in substantia nigra and 173 other tissues |
ExpressionAtlasi | Q6PKX4, baseline and differential |
Genevisiblei | Q6PKX4, HS |
Family and domain databases
CDDi | cd14678, PH_DOK4_DOK5_DOK6, 1 hit |
Gene3Di | 2.30.29.30, 2 hits |
InterProi | View protein in InterPro IPR037816, DOK4/5/6_PH IPR002404, IRS_PTB IPR011993, PH-like_dom_sf IPR001849, PH_domain |
Pfami | View protein in Pfam PF02174, IRS, 1 hit |
SMARTi | View protein in SMART SM00233, PH, 1 hit SM00310, PTBI, 1 hit |
PROSITEi | View protein in PROSITE PS51064, IRS_PTB, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DOK6_HUMAN | |
Accessioni | Q6PKX4Primary (citable) accession number: Q6PKX4 Secondary accession number(s): A6NNG3 Q96LU2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 10, 2005 |
Last sequence update: | July 5, 2004 | |
Last modified: | December 2, 2020 | |
This is version 136 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 18
Human chromosome 18: entries, gene names and cross-references to MIM