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Protein

La-related protein 1

Gene

LARP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

RNA-binding protein that promotes translation of specific classes of mRNAs downstream of the mTORC1 complex (PubMed:24532714, PubMed:25940091). Associates with the mRNA 5'cap in an MTOR-dependent manner and associates with mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding for ribosomal proteins and several components of the translation machinery (PubMed:24532714, PubMed:25940091, PubMed:26206669). Associates with actively translating ribosomes via interaction with PABPC1/PABP and stimulates translation of mRNAs containing a 5'TOP, thereby regulating cell growth and proliferation (PubMed:20430826, PubMed:25940091). Positively regulates the replication of dengue virus (DENV) (PubMed:26735137).4 Publications

GO - Molecular functioni

  • cadherin binding Source: BHF-UCL
  • eukaryotic initiation factor 4E binding Source: UniProtKB
  • mRNA 3'-UTR binding Source: UniProtKB
  • mRNA 5'-UTR binding Source: UniProtKB
  • RNA binding Source: UniProtKB
  • RNA cap binding Source: UniProtKB
  • translation activator activity Source: UniProtKB
  • translation initiation factor binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionRepressor, RNA-binding
Biological processProtein biosynthesis, Translation regulation

Names & Taxonomyi

Protein namesi
Recommended name:
La-related protein 1
Alternative name(s):
La ribonucleoprotein domain family member 1
Gene namesi
Name:LARP1
Synonyms:KIAA0731, LARP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000155506.16
HGNCiHGNC:29531 LARP1
MIMi612059 gene
neXtProtiNX_Q6PKG0

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi917R → E: Abolishes RNA binding. 1 Publication1
Mutagenesisi960Y → A: Abolishes RNA binding. 1 Publication1

Organism-specific databases

DisGeNETi23367
OpenTargetsiENSG00000155506
PharmGKBiPA142671564

Polymorphism and mutation databases

DMDMi73621135

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00002076092 – 1096La-related protein 1Add BLAST1095

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1 Publication1
Modified residuei75PhosphoserineCombined sources1
Modified residuei90PhosphoserineCombined sources1
Modified residuei143PhosphoserineCombined sources1
Modified residuei165PhosphoserineCombined sources1
Modified residuei215PhosphoserineCombined sources1
Modified residuei220PhosphoserineCombined sources1
Modified residuei223PhosphothreonineBy similarity1
Modified residuei225PhosphoserineBy similarity1
Modified residuei228PhosphoserineBy similarity1
Modified residuei240Omega-N-methylarginineBy similarity1
Cross-linki260Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki311Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei324PhosphoserineBy similarity1
Modified residuei327PhosphoserineBy similarity1
Modified residuei376PhosphothreonineCombined sources1
Modified residuei517PhosphoserineCombined sources1
Modified residuei521PhosphoserineCombined sources1
Modified residuei526PhosphothreonineCombined sources1 Publication1
Cross-linki531Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei548PhosphoserineCombined sources1
Modified residuei591PhosphoserineCombined sources1
Modified residuei627PhosphoserineCombined sources1
Modified residuei631PhosphoserineCombined sources1
Modified residuei649PhosphothreonineCombined sources1
Cross-linki703Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei724PhosphothreonineCombined sources1
Modified residuei766PhosphoserineCombined sources1
Modified residuei774PhosphoserineCombined sources1 Publication1
Modified residuei777PhosphotyrosineCombined sources1
Modified residuei785PhosphothreonineCombined sources1
Modified residuei788PhosphothreonineCombined sources1
Modified residuei824PhosphoserineCombined sources1
Modified residuei845PhosphothreonineCombined sources1
Modified residuei851PhosphoserineCombined sources1
Modified residuei853PhosphoserineBy similarity1
Modified residuei865PhosphothreonineBy similarity1
Modified residuei868PhosphoserineBy similarity1
Modified residuei892N6-acetyllysineCombined sources1
Modified residuei1017N6-acetyllysineCombined sources1
Modified residuei1040PhosphoserineCombined sources1
Modified residuei1089PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ6PKG0
MaxQBiQ6PKG0
PaxDbiQ6PKG0
PeptideAtlasiQ6PKG0
PRIDEiQ6PKG0
ProteomicsDBi67242
67243 [Q6PKG0-3]

PTM databases

CarbonylDBiQ6PKG0
iPTMnetiQ6PKG0
PhosphoSitePlusiQ6PKG0
SwissPalmiQ6PKG0

Miscellaneous databases

PMAP-CutDBiQ6PKG0

Expressioni

Inductioni

Up-regulated in a number of hepatocellular carcinoma cell lines and liver cancer lesions, as well as in patients with hepatocellular carcinoma with a lower survival rate (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000155506 Expressed in 251 organ(s), highest expression level in female gonad
CleanExiHS_LARP1
ExpressionAtlasiQ6PKG0 baseline and differential
GenevisibleiQ6PKG0 HS

Organism-specific databases

HPAiCAB015222
HPA051397
HPA054819

Interactioni

Subunit structurei

Interacts with PABPC1/PABP (PubMed:20430826, PubMed:24532714, PubMed:25940091). Associates with the mTORC1 complex via interaction with RPTOR (PubMed:25940091). Interacts with EIF4E (PubMed:20430826). Found in a complex with PABPC1 and RYDEN (PubMed:26735137).4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CCDC155Q8N6L03EBI-1052114,EBI-749265

GO - Molecular functioni

Protein-protein interaction databases

BioGridi116947, 141 interactors
IntActiQ6PKG0, 62 interactors
MINTiQ6PKG0
STRINGi9606.ENSP00000336721

Structurei

Secondary structure

11096
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ6PKG0
SMRiQ6PKG0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini397 – 487HTH La-type RNA-bindingPROSITE-ProRule annotationAdd BLAST91

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni873 – 1023Interaction with mRNA1 PublicationAdd BLAST151

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1044 – 1050Poly-Gly7

Sequence similaritiesi

Belongs to the LARP family.Curated

Phylogenomic databases

eggNOGiKOG2590 Eukaryota
COG5193 LUCA
GeneTreeiENSGT00390000000523
HOGENOMiHOG000113283
HOVERGENiHBG054322
InParanoidiQ6PKG0
KOiK18757
OMAiRAKMSSE
OrthoDBiEOG091G02X0
PhylomeDBiQ6PKG0
TreeFamiTF314516

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR006607 DM15
IPR006630 La_HTH
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF05383 La, 1 hit
SMARTiView protein in SMART
SM00684 DM15, 3 hits
SM00715 LA, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS50961 HTH_LA, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 11 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6PKG0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MATQVEPLLP GGATLLQAEE HGGLVRKKPP PAPEGKGEPG PNDVRGGEPD
60 70 80 90 100
GSARRPRPPC AKPHKEGTGQ QERESPRPLQ LPGAEGPAIS DGEEGGGEPG
110 120 130 140 150
AGGGAAGAAG AGRRDFVEAP PPKVNPWTKN ALPPVLTTVN GQSPPEHSAP
160 170 180 190 200
AKVVRAAVPK QRKGSKVGDF GDAINWPTPG EIAHKSVQPQ SHKPQPTRKL
210 220 230 240 250
PPKKDMKEQE KGEGSDSKES PKTKSDESGE EKNGDEDCQR GGQKKKGNKH
260 270 280 290 300
KWVPLQIDMK PEVPREKLAS RPTRPPEPRH IPANRGEIKG SESATYVPVA
310 320 330 340 350
PPTPAWQPEI KPEPAWHDQD ETSSVKSDGA GGARASFRGR GRGRGRGRGR
360 370 380 390 400
GRGGTRTHFD YQFGYRKFDG VEGPRTPKYM NNITYYFDNV SSTELYSVDQ
410 420 430 440 450
ELLKDYIKRQ IEYYFSVDNL ERDFFLRRKM DADGFLPITL IASFHRVQAL
460 470 480 490 500
TTDISLIFAA LKDSKVVEIV DEKVRRREEP EKWPLPPIVD YSQTDFSQLL
510 520 530 540 550
NCPEFVPRQH YQKETESAPG SPRAVTPVPT KTEEVSNLKT LPKGLSASLP
560 570 580 590 600
DLDSENWIEV KKRPRPSPAR PKKSEESRFS HLTSLPQQLP SQQLMSKDQD
610 620 630 640 650
EQEELDFLFD EEMEQMDGRK NTFTAWSDEE SDYEIDDRDV NKILIVTQTP
660 670 680 690 700
HYMRRHPGGD RTGNHTSRAK MSAELAKVIN DGLFYYEQDL WAEKFEPEYS
710 720 730 740 750
QIKQEVENFK KVNMISREQF DTLTPEPPVD PNQEVPPGPP RFQQVPTDAL
760 770 780 790 800
ANKLFGAPEP STIARSLPTT VPESPNYRNT RTPRTPRTPQ LKDSSQTSRF
810 820 830 840 850
YPVVKEGRTL DAKMPRKRKT RHSSNPPLES HVGWVMDSRE HRPRTASISS
860 870 880 890 900
SPSEGTPTVG SYGCTPQSLP KFQHPSHELL KENGFTQHVY HKYRRRCLNE
910 920 930 940 950
RKRLGIGQSQ EMNTLFRFWS FFLRDHFNKK MYEEFKQLAL EDAKEGYRYG
960 970 980 990 1000
LECLFRYYSY GLEKKFRLDI FKDFQEETVK DYEAGQLYGL EKFWAFLKYS
1010 1020 1030 1040 1050
KAKNLDIDPK LQEYLGKFRR LEDFRVDPPM GEEGNHKRHS VVAGGGGGEG
1060 1070 1080 1090
RKRCPSQSSS RPAAMISQPP TPPTGQPVRE DAKWTSQHSN TQTLGK
Length:1,096
Mass (Da):123,510
Last modified:August 16, 2005 - v2
Checksum:iCA3E9D30BBC101B7
GO
Isoform 2 (identifier: Q6PKG0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-77: Missing.
     78-144: PLQLPGAEGP...VLTTVNGQSP → MLWRVLLSKR...PFPVLAPFSN

Show »
Length:1,019
Mass (Da):116,465
Checksum:i64982CA22171B0E6
GO

Computationally mapped potential isoform sequencesi

There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YC73H0YC73_HUMAN
La-related protein 1
LARP1
195Annotation score:
H0YBW1H0YBW1_HUMAN
La-related protein 1
LARP1
281Annotation score:
E5RH50E5RH50_HUMAN
La-related protein 1
LARP1
610Annotation score:
A0A0B4J210A0A0B4J210_HUMAN
La-related protein 1
LARP1
815Annotation score:
H0YAN4H0YAN4_HUMAN
La-related protein 1
LARP1
150Annotation score:
H0YC33H0YC33_HUMAN
La-related protein 1
LARP1
183Annotation score:
H0YAX9H0YAX9_HUMAN
La-related protein 1
LARP1
61Annotation score:
H0YBR8H0YBR8_HUMAN
La-related protein 1
LARP1
36Annotation score:
E5RHK4E5RHK4_HUMAN
La-related protein 1
LARP1
92Annotation score:
H0YBM7H0YBM7_HUMAN
La-related protein 1
LARP1
167Annotation score:
There is more potential isoformShow all

Sequence cautioni

The sequence AAH33856 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA34451 differs from that shown. Aberrant splicing.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti778 – 780RNT → TRP in AAH33856 (PubMed:15489334).Curated3
Sequence conflicti979V → L in CAB61364 (PubMed:17974005).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0151141 – 77Missing in isoform 2. 1 PublicationAdd BLAST77
Alternative sequenceiVSP_01511578 – 144PLQLP…NGQSP → MLWRVLLSKRPPFPHPELDF QEAPIPSCPGRLPGRKNSVA LAAAPRKEPTGDREKPLPFP VLAPFSN in isoform 2. 1 PublicationAdd BLAST67

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC001460 mRNA Translation: AAH01460.2
BC033856 mRNA Translation: AAH33856.1 Different initiation.
AK091465 mRNA Translation: BAC03668.1
AB018274 mRNA Translation: BAA34451.1 Sequence problems.
AL133034 mRNA Translation: CAB61364.1
CCDSiCCDS4328.1 [Q6PKG0-3]
PIRiT42646
RefSeqiNP_056130.2, NM_015315.4 [Q6PKG0-3]
XP_005268461.1, XM_005268404.3 [Q6PKG0-1]
UniGeneiHs.292078

Genome annotation databases

EnsembliENST00000336314; ENSP00000336721; ENSG00000155506 [Q6PKG0-3]
GeneIDi23367
KEGGihsa:23367
UCSCiuc003lvo.4 human [Q6PKG0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC001460 mRNA Translation: AAH01460.2
BC033856 mRNA Translation: AAH33856.1 Different initiation.
AK091465 mRNA Translation: BAC03668.1
AB018274 mRNA Translation: BAA34451.1 Sequence problems.
AL133034 mRNA Translation: CAB61364.1
CCDSiCCDS4328.1 [Q6PKG0-3]
PIRiT42646
RefSeqiNP_056130.2, NM_015315.4 [Q6PKG0-3]
XP_005268461.1, XM_005268404.3 [Q6PKG0-1]
UniGeneiHs.292078

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4ZC4X-ray1.86A/B/C/D873-1023[»]
5C0VX-ray2.20A/B/C/D873-1023[»]
5V4RX-ray1.77A/B873-1023[»]
5V7CX-ray2.59B873-1023[»]
5V87X-ray1.69A/B873-1023[»]
ProteinModelPortaliQ6PKG0
SMRiQ6PKG0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116947, 141 interactors
IntActiQ6PKG0, 62 interactors
MINTiQ6PKG0
STRINGi9606.ENSP00000336721

PTM databases

CarbonylDBiQ6PKG0
iPTMnetiQ6PKG0
PhosphoSitePlusiQ6PKG0
SwissPalmiQ6PKG0

Polymorphism and mutation databases

DMDMi73621135

Proteomic databases

EPDiQ6PKG0
MaxQBiQ6PKG0
PaxDbiQ6PKG0
PeptideAtlasiQ6PKG0
PRIDEiQ6PKG0
ProteomicsDBi67242
67243 [Q6PKG0-3]

Protocols and materials databases

DNASUi23367
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000336314; ENSP00000336721; ENSG00000155506 [Q6PKG0-3]
GeneIDi23367
KEGGihsa:23367
UCSCiuc003lvo.4 human [Q6PKG0-1]

Organism-specific databases

CTDi23367
DisGeNETi23367
EuPathDBiHostDB:ENSG00000155506.16
GeneCardsiLARP1
HGNCiHGNC:29531 LARP1
HPAiCAB015222
HPA051397
HPA054819
MIMi612059 gene
neXtProtiNX_Q6PKG0
OpenTargetsiENSG00000155506
PharmGKBiPA142671564
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2590 Eukaryota
COG5193 LUCA
GeneTreeiENSGT00390000000523
HOGENOMiHOG000113283
HOVERGENiHBG054322
InParanoidiQ6PKG0
KOiK18757
OMAiRAKMSSE
OrthoDBiEOG091G02X0
PhylomeDBiQ6PKG0
TreeFamiTF314516

Miscellaneous databases

ChiTaRSiLARP1 human
GeneWikiiLARP1
GenomeRNAii23367
PMAP-CutDBiQ6PKG0
PROiPR:Q6PKG0
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000155506 Expressed in 251 organ(s), highest expression level in female gonad
CleanExiHS_LARP1
ExpressionAtlasiQ6PKG0 baseline and differential
GenevisibleiQ6PKG0 HS

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR006607 DM15
IPR006630 La_HTH
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF05383 La, 1 hit
SMARTiView protein in SMART
SM00684 DM15, 3 hits
SM00715 LA, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS50961 HTH_LA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLARP1_HUMAN
AccessioniPrimary (citable) accession number: Q6PKG0
Secondary accession number(s): O94836
, Q8N4M2, Q8NB73, Q9UFD7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: August 16, 2005
Last modified: November 7, 2018
This is version 151 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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