UniProtKB - Q6PKG0 (LARP1_HUMAN)

BLAST

>sp|Q6PKG0|LARP1_HUMAN La-related protein 1 OS=Homo sapiens OX=9606 GN=LARP1 PE=1 SV=2
MATQVEPLLPGGATLLQAEEHGGLVRKKPPPAPEGKGEPGPNDVRGGEPDGSARRPRPPC
AKPHKEGTGQQERESPRPLQLPGAEGPAISDGEEGGGEPGAGGGAAGAAGAGRRDFVEAP
PPKVNPWTKNALPPVLTTVNGQSPPEHSAPAKVVRAAVPKQRKGSKVGDFGDAINWPTPG
EIAHKSVQPQSHKPQPTRKLPPKKDMKEQEKGEGSDSKESPKTKSDESGEEKNGDEDCQR
GGQKKKGNKHKWVPLQIDMKPEVPREKLASRPTRPPEPRHIPANRGEIKGSESATYVPVA
PPTPAWQPEIKPEPAWHDQDETSSVKSDGAGGARASFRGRGRGRGRGRGRGRGGTRTHFD
YQFGYRKFDGVEGPRTPKYMNNITYYFDNVSSTELYSVDQELLKDYIKRQIEYYFSVDNL
ERDFFLRRKMDADGFLPITLIASFHRVQALTTDISLIFAALKDSKVVEIVDEKVRRREEP
EKWPLPPIVDYSQTDFSQLLNCPEFVPRQHYQKETESAPGSPRAVTPVPTKTEEVSNLKT
LPKGLSASLPDLDSENWIEVKKRPRPSPARPKKSEESRFSHLTSLPQQLPSQQLMSKDQD
EQEELDFLFDEEMEQMDGRKNTFTAWSDEESDYEIDDRDVNKILIVTQTPHYMRRHPGGD
RTGNHTSRAKMSAELAKVINDGLFYYEQDLWAEKFEPEYSQIKQEVENFKKVNMISREQF
DTLTPEPPVDPNQEVPPGPPRFQQVPTDALANKLFGAPEPSTIARSLPTTVPESPNYRNT
RTPRTPRTPQLKDSSQTSRFYPVVKEGRTLDAKMPRKRKTRHSSNPPLESHVGWVMDSRE
HRPRTASISSSPSEGTPTVGSYGCTPQSLPKFQHPSHELLKENGFTQHVYHKYRRRCLNE
RKRLGIGQSQEMNTLFRFWSFFLRDHFNKKMYEEFKQLALEDAKEGYRYGLECLFRYYSY
GLEKKFRLDIFKDFQEETVKDYEAGQLYGLEKFWAFLKYSKAKNLDIDPKLQEYLGKFRR
LEDFRVDPPMGEEGNHKRHSVVAGGGGGEGRKRCPSQSSSRPAAMISQPPTPPTGQPVRE
DAKWTSQHSNTQTLGK

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History
Entry version 151 (07 Nov 2018)
Sequence version 2 (16 Aug 2005)
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Protein

La-related protein 1

Gene

LARP1

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

RNA-binding protein that promotes translation of specific classes of mRNAs downstream of the mTORC1 complex (PubMed:24532714, PubMed:25940091). Associates with the mRNA 5'cap in an MTOR-dependent manner and associates with mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding for ribosomal proteins and several components of the translation machinery (PubMed:24532714, PubMed:25940091, PubMed:26206669). Associates with actively translating ribosomes via interaction with PABPC1/PABP and stimulates translation of mRNAs containing a 5'TOP, thereby regulating cell growth and proliferation (PubMed:20430826, PubMed:25940091). Positively regulates the replication of dengue virus (DENV) (PubMed:26735137).4 Publications

GO - Molecular functionⁱ

cadherin binding
Source: BHF-UCL
Inferred from high throughput direct assayⁱ
- 25468996
eukaryotic initiation factor 4E binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 20430826
mRNA 3'-UTR binding
Source: UniProtKB
Inferred from direct assayⁱ
- 23711370
mRNA 5'-UTR binding
Source: UniProtKB
Inferred from direct assayⁱ
- 24532714
- 26206669
RNA binding
Source: UniProtKB
Inferred from high throughput direct assayⁱ
- 22658674
- 22681889
RNA cap binding
Source: UniProtKB
Inferred from direct assayⁱ
- 24532714
translation activator activity
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 24532714
translation initiation factor binding
Source: UniProtKB
Inferred from direct assayⁱ
- 24532714

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell proliferation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 24532714
cellular response to rapamycin
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 25940091
mRNA stabilization
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 25940091
negative regulation of translation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 25940091
positive regulation of macroautophagy
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 22354037
positive regulation of viral genome replication
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 26735137
response to amino acid starvation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 25940091
TORC1 signaling
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 25940091
TOR signaling
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 24532714
translational initiation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20430826
- 24532714

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Repressor, RNA-binding
Biological process	Protein biosynthesis, Translation regulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: La-related protein 1 Alternative name(s): La ribonucleoprotein domain family member 1
Gene namesⁱ	Name:LARP1 Synonyms:KIAA0731, LARP
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 5

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000155506.16
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:29531 LARP1
MIMⁱ	612059 gene
neXtProtⁱ	NX_Q6PKG0

Keywords - Cellular componentⁱ

Cytoplasm

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	917	R → E: Abolishes RNA binding. 1 Publication		1
Mutagenesisⁱ	960	Y → A: Abolishes RNA binding. 1 Publication		1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	23367
Open Targets More...OpenTargetsⁱ	ENSG00000155506
PharmGKBⁱ	PA142671564

Polymorphism and mutation databases

DMDMⁱ	73621135

DMDMⁱ

73621135

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources1 Publication
ChainⁱPRO_0000207609	2 – 1096	La-related protein 1Add BLAST		1095

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylalanineCombined sources1 Publication	1
Modified residueⁱ	75	PhosphoserineCombined sources	1
Modified residueⁱ	90	PhosphoserineCombined sources	1
Modified residueⁱ	143	PhosphoserineCombined sources	1
Modified residueⁱ	165	PhosphoserineCombined sources	1
Modified residueⁱ	215	PhosphoserineCombined sources	1
Modified residueⁱ	220	PhosphoserineCombined sources	1
Modified residueⁱ	223	PhosphothreonineBy similarity	1
Modified residueⁱ	225	PhosphoserineBy similarity	1
Modified residueⁱ	228	PhosphoserineBy similarity	1
Modified residueⁱ	240	Omega-N-methylarginineBy similarity	1
Cross-linkⁱ	260	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	311	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	324	PhosphoserineBy similarity	1
Modified residueⁱ	327	PhosphoserineBy similarity	1
Modified residueⁱ	376	PhosphothreonineCombined sources	1
Modified residueⁱ	517	PhosphoserineCombined sources	1
Modified residueⁱ	521	PhosphoserineCombined sources	1
Modified residueⁱ	526	PhosphothreonineCombined sources1 Publication	1
Cross-linkⁱ	531	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	548	PhosphoserineCombined sources	1
Modified residueⁱ	591	PhosphoserineCombined sources	1
Modified residueⁱ	627	PhosphoserineCombined sources	1
Modified residueⁱ	631	PhosphoserineCombined sources	1
Modified residueⁱ	649	PhosphothreonineCombined sources	1
Cross-linkⁱ	703	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	724	PhosphothreonineCombined sources	1
Modified residueⁱ	766	PhosphoserineCombined sources	1
Modified residueⁱ	774	PhosphoserineCombined sources1 Publication	1
Modified residueⁱ	777	PhosphotyrosineCombined sources	1
Modified residueⁱ	785	PhosphothreonineCombined sources	1
Modified residueⁱ	788	PhosphothreonineCombined sources	1
Modified residueⁱ	824	PhosphoserineCombined sources	1
Modified residueⁱ	845	PhosphothreonineCombined sources	1
Modified residueⁱ	851	PhosphoserineCombined sources	1
Modified residueⁱ	853	PhosphoserineBy similarity	1
Modified residueⁱ	865	PhosphothreonineBy similarity	1
Modified residueⁱ	868	PhosphoserineBy similarity	1
Modified residueⁱ	892	N6-acetyllysineCombined sources	1
Modified residueⁱ	1017	N6-acetyllysineCombined sources	1
Modified residueⁱ	1040	PhosphoserineCombined sources	1
Modified residueⁱ	1089	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q6PKG0
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q6PKG0
PaxDbⁱ	Q6PKG0
PeptideAtlas More...PeptideAtlasⁱ	Q6PKG0
PRIDEⁱ	Q6PKG0
ProteomicsDBⁱ	67242 67243 [Q6PKG0-3]

PTM databases

CarbonylDBⁱ	Q6PKG0
iPTMnetⁱ	Q6PKG0
PhosphoSitePlusⁱ	Q6PKG0
SwissPalmⁱ	Q6PKG0

Miscellaneous databases

PMAP-CutDBⁱ	Q6PKG0

PMAP-CutDBⁱ

Q6PKG0

Expressionⁱ

Inductionⁱ

Up-regulated in a number of hepatocellular carcinoma cell lines and liver cancer lesions, as well as in patients with hepatocellular carcinoma with a lower survival rate (at protein level).1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000155506 Expressed in 251 organ(s), highest expression level in female gonad
CleanExⁱ	HS_LARP1
ExpressionAtlasⁱ	Q6PKG0 baseline and differential
Genevisibleⁱ	Q6PKG0 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB015222 HPA051397 HPA054819

HPAⁱ

CAB015222
HPA051397
HPA054819

Interactionⁱ

Subunit structureⁱ

Interacts with PABPC1/PABP (PubMed:20430826, PubMed:24532714, PubMed:25940091). Associates with the mTORC1 complex via interaction with RPTOR (PubMed:25940091). Interacts with EIF4E (PubMed:20430826). Found in a complex with PABPC1 and RYDEN (PubMed:26735137).4 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
CCDC155	Q8N6L0	3	EBI-1052114,EBI-749265

With

Entry

#Exp.

IntAct

Notes

CCDC155

Q8N6L0

EBI-1052114,EBI-749265

GO - Molecular functionⁱ

cadherin binding
Source: BHF-UCL
Inferred from high throughput direct assayⁱ
- 25468996
eukaryotic initiation factor 4E binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 20430826
translation initiation factor binding
Source: UniProtKB
Inferred from direct assayⁱ
- 24532714

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	116947, 141 interactors
IntActⁱ	Q6PKG0, 62 interactors
Molecular INTeraction database More...MINTⁱ	Q6PKG0
STRINGⁱ	9606.ENSP00000336721

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	875 – 880	Combined sources	6
Turnⁱ	882 – 884	Combined sources	3
Helixⁱ	887 – 904	Combined sources	18
Helixⁱ	910 – 925	Combined sources	16
Helixⁱ	929 – 945	Combined sources	17
Helixⁱ	949 – 964	Combined sources	16
Helixⁱ	968 – 983	Combined sources	16
Helixⁱ	988 – 999	Combined sources	12
Helixⁱ	1001 – 1004	Combined sources	4
Helixⁱ	1009 – 1017	Combined sources	9

Show more details

3D structure databases

ProteinModelPortalⁱ	Q6PKG0
SMRⁱ	Q6PKG0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	397 – 487	HTH La-type RNA-bindingPROSITE-ProRule annotationAdd BLAST		91

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	873 – 1023	Interaction with mRNA1 PublicationAdd BLAST		151

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	1044 – 1050	Poly-Gly		7

Sequence similaritiesⁱ

Belongs to the LARP family.Curated

Phylogenomic databases

eggNOGⁱ	KOG2590 Eukaryota COG5193 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000000523
HOGENOMⁱ	HOG000113283
HOVERGENⁱ	HBG054322
InParanoidⁱ	Q6PKG0
KEGG Orthology (KO) More...KOⁱ	K18757
OMAⁱ	RAKMSSE
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G02X0
PhylomeDBⁱ	Q6PKG0
TreeFamⁱ	TF314516

Family and domain databases

Gene3Dⁱ	1.10.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR006607 DM15 IPR006630 La_HTH IPR036388 WH-like_DNA-bd_sf IPR036390 WH_DNA-bd_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF05383 La, 1 hit
SMARTⁱ	View protein in SMART SM00684 DM15, 3 hits SM00715 LA, 1 hit
SUPFAMⁱ	SSF46785 SSF46785, 1 hit
PROSITEⁱ	View protein in PROSITE PS50961 HTH_LA, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 11 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q6PKG0-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATQVEPLLP GGATLLQAEE HGGLVRKKPP PAPEGKGEPG PNDVRGGEPD 
        60         70         80         90        100
GSARRPRPPC AKPHKEGTGQ QERESPRPLQ LPGAEGPAIS DGEEGGGEPG 
       110        120        130        140        150
AGGGAAGAAG AGRRDFVEAP PPKVNPWTKN ALPPVLTTVN GQSPPEHSAP 
       160        170        180        190        200
AKVVRAAVPK QRKGSKVGDF GDAINWPTPG EIAHKSVQPQ SHKPQPTRKL 
       210        220        230        240        250
PPKKDMKEQE KGEGSDSKES PKTKSDESGE EKNGDEDCQR GGQKKKGNKH 
       260        270        280        290        300
KWVPLQIDMK PEVPREKLAS RPTRPPEPRH IPANRGEIKG SESATYVPVA 
       310        320        330        340        350
PPTPAWQPEI KPEPAWHDQD ETSSVKSDGA GGARASFRGR GRGRGRGRGR 
       360        370        380        390        400
GRGGTRTHFD YQFGYRKFDG VEGPRTPKYM NNITYYFDNV SSTELYSVDQ 
       410        420        430        440        450
ELLKDYIKRQ IEYYFSVDNL ERDFFLRRKM DADGFLPITL IASFHRVQAL 
       460        470        480        490        500
TTDISLIFAA LKDSKVVEIV DEKVRRREEP EKWPLPPIVD YSQTDFSQLL 
       510        520        530        540        550
NCPEFVPRQH YQKETESAPG SPRAVTPVPT KTEEVSNLKT LPKGLSASLP 
       560        570        580        590        600
DLDSENWIEV KKRPRPSPAR PKKSEESRFS HLTSLPQQLP SQQLMSKDQD 
       610        620        630        640        650
EQEELDFLFD EEMEQMDGRK NTFTAWSDEE SDYEIDDRDV NKILIVTQTP 
       660        670        680        690        700
HYMRRHPGGD RTGNHTSRAK MSAELAKVIN DGLFYYEQDL WAEKFEPEYS 
       710        720        730        740        750
QIKQEVENFK KVNMISREQF DTLTPEPPVD PNQEVPPGPP RFQQVPTDAL 
       760        770        780        790        800
ANKLFGAPEP STIARSLPTT VPESPNYRNT RTPRTPRTPQ LKDSSQTSRF 
       810        820        830        840        850
YPVVKEGRTL DAKMPRKRKT RHSSNPPLES HVGWVMDSRE HRPRTASISS 
       860        870        880        890        900
SPSEGTPTVG SYGCTPQSLP KFQHPSHELL KENGFTQHVY HKYRRRCLNE 
       910        920        930        940        950
RKRLGIGQSQ EMNTLFRFWS FFLRDHFNKK MYEEFKQLAL EDAKEGYRYG 
       960        970        980        990       1000
LECLFRYYSY GLEKKFRLDI FKDFQEETVK DYEAGQLYGL EKFWAFLKYS 
      1010       1020       1030       1040       1050
KAKNLDIDPK LQEYLGKFRR LEDFRVDPPM GEEGNHKRHS VVAGGGGGEG 
      1060       1070       1080       1090 
RKRCPSQSSS RPAAMISQPP TPPTGQPVRE DAKWTSQHSN TQTLGK

Length:1,096

Mass (Da):123,510

Last modified:August 16, 2005 - v2

Checksum:ⁱCA3E9D30BBC101B7

Isoform 2 (identifier: Q6PKG0-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-77: Missing.
78-144: PLQLPGAEGP...VLTTVNGQSP → MLWRVLLSKR...PFPVLAPFSN

« Hide

        10         20         30         40         50
MLWRVLLSKR PPFPHPELDF QEAPIPSCPG RLPGRKNSVA LAAAPRKEPT 
        60         70         80         90        100
GDREKPLPFP VLAPFSNPEH SAPAKVVRAA VPKQRKGSKV GDFGDAINWP 
       110        120        130        140        150
TPGEIAHKSV QPQSHKPQPT RKLPPKKDMK EQEKGEGSDS KESPKTKSDE 
       160        170        180        190        200
SGEEKNGDED CQRGGQKKKG NKHKWVPLQI DMKPEVPREK LASRPTRPPE 
       210        220        230        240        250
PRHIPANRGE IKGSESATYV PVAPPTPAWQ PEIKPEPAWH DQDETSSVKS 
       260        270        280        290        300
DGAGGARASF RGRGRGRGRG RGRGRGGTRT HFDYQFGYRK FDGVEGPRTP 
       310        320        330        340        350
KYMNNITYYF DNVSSTELYS VDQELLKDYI KRQIEYYFSV DNLERDFFLR 
       360        370        380        390        400
RKMDADGFLP ITLIASFHRV QALTTDISLI FAALKDSKVV EIVDEKVRRR 
       410        420        430        440        450
EEPEKWPLPP IVDYSQTDFS QLLNCPEFVP RQHYQKETES APGSPRAVTP 
       460        470        480        490        500
VPTKTEEVSN LKTLPKGLSA SLPDLDSENW IEVKKRPRPS PARPKKSEES 
       510        520        530        540        550
RFSHLTSLPQ QLPSQQLMSK DQDEQEELDF LFDEEMEQMD GRKNTFTAWS 
       560        570        580        590        600
DEESDYEIDD RDVNKILIVT QTPHYMRRHP GGDRTGNHTS RAKMSAELAK 
       610        620        630        640        650
VINDGLFYYE QDLWAEKFEP EYSQIKQEVE NFKKVNMISR EQFDTLTPEP 
       660        670        680        690        700
PVDPNQEVPP GPPRFQQVPT DALANKLFGA PEPSTIARSL PTTVPESPNY 
       710        720        730        740        750
RNTRTPRTPR TPQLKDSSQT SRFYPVVKEG RTLDAKMPRK RKTRHSSNPP 
       760        770        780        790        800
LESHVGWVMD SREHRPRTAS ISSSPSEGTP TVGSYGCTPQ SLPKFQHPSH 
       810        820        830        840        850
ELLKENGFTQ HVYHKYRRRC LNERKRLGIG QSQEMNTLFR FWSFFLRDHF 
       860        870        880        890        900
NKKMYEEFKQ LALEDAKEGY RYGLECLFRY YSYGLEKKFR LDIFKDFQEE 
       910        920        930        940        950
TVKDYEAGQL YGLEKFWAFL KYSKAKNLDI DPKLQEYLGK FRRLEDFRVD 
       960        970        980        990       1000
PPMGEEGNHK RHSVVAGGGG GEGRKRCPSQ SSSRPAAMIS QPPTPPTGQP 
      1010 
VREDAKWTSQ HSNTQTLGK

Show »

Length:1,019

Mass (Da):116,465

Checksum:ⁱ64982CA22171B0E6

Computationally mapped potential isoform sequencesⁱ

There are 11 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name	Protein names	Gene names	Length	Annotation

	H0YC73	H0YC73_HUMAN	La-related protein 1 La-related protein 1	LARP1	195	Annotation score:
	H0YBW1	H0YBW1_HUMAN	La-related protein 1 La-related protein 1	LARP1	281	Annotation score:
	E5RH50	E5RH50_HUMAN	La-related protein 1 La-related protein 1	LARP1	610	Annotation score:
	A0A0B4J210	A0A0B4J210_HUMAN	La-related protein 1 La-related protein 1	LARP1	815	Annotation score:
	H0YAN4	H0YAN4_HUMAN	La-related protein 1 La-related protein 1	LARP1	150	Annotation score:
	H0YC33	H0YC33_HUMAN	La-related protein 1 La-related protein 1	LARP1	183	Annotation score:
	H0YAX9	H0YAX9_HUMAN	La-related protein 1 La-related protein 1	LARP1	61	Annotation score:
	H0YBR8	H0YBR8_HUMAN	La-related protein 1 La-related protein 1	LARP1	36	Annotation score:
	E5RHK4	E5RHK4_HUMAN	La-related protein 1 La-related protein 1	LARP1	92	Annotation score:
	H0YBM7	H0YBM7_HUMAN	La-related protein 1 La-related protein 1	LARP1	167	Annotation score:
There is more potential isoformShow all

Sequence cautionⁱ

The sequence AAH33856 differs from that shown. Reason: Erroneous initiation.Curated

The sequence BAA34451 differs from that shown. Aberrant splicing.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	778 – 780	RNT → TRP in AAH33856 (PubMed:15489334).Curated		3
Sequence conflictⁱ	979	V → L in CAB61364 (PubMed:17974005).Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_015114	1 – 77	Missing in isoform 2. 1 PublicationAdd BLAST		77
Alternative sequenceⁱVSP_015115	78 – 144	PLQLP…NGQSP → MLWRVLLSKRPPFPHPELDF QEAPIPSCPGRLPGRKNSVA LAAAPRKEPTGDREKPLPFP VLAPFSN in isoform 2. 1 PublicationAdd BLAST		67

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC001460 mRNA Translation: AAH01460.2 BC033856 mRNA Translation: AAH33856.1 Different initiation. AK091465 mRNA Translation: BAC03668.1 AB018274 mRNA Translation: BAA34451.1 Sequence problems. AL133034 mRNA Translation: CAB61364.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS4328.1 [Q6PKG0-3]
PIRⁱ	T42646
NCBI Reference Sequences More...RefSeqⁱ	NP_056130.2, NM_015315.4 [Q6PKG0-3] XP_005268461.1, XM_005268404.3 [Q6PKG0-1]
UniGeneⁱ	Hs.292078

Genome annotation databases

Ensemblⁱ	ENST00000336314; ENSP00000336721; ENSG00000155506 [Q6PKG0-3]
GeneIDⁱ	23367
KEGGⁱ	hsa:23367
UCSC genome browser More...UCSCⁱ	uc003lvo.4 human [Q6PKG0-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q6PKG0	La-related protein 1 (Fragment)		HUMAN		815	UniRef100_Q6PKG0
LARP1 isoform 6 (Fragment)		PONAB		93
La-related protein 1 (Fragment)		HUMAN		610
La-related protein 1 (Fragment)		HUMAN		92
UPI0000D45F69		HUMAN		891

Protein	Similar proteins		Species	Score	Length	Source
Q6PKG0	La-related protein 1 (Fragment)		HUMAN		815	UniRef90_Q6PKG0
LARP1 isoform 6 (Fragment)		PONAB		93
la-related protein 1 isoform X1		PHYCD		1119
Putative rna-binding protein		DESRO		1116
la-related protein 1		Florida manatee		1105
+94
Q6PKG0-3	Uncharacterized protein		RHIBE		1034	UniRef90_Q6PKG0-3
Uncharacterized protein		MACMU		1021
Uncharacterized protein		MACNE		893
Uncharacterized protein		COLAP		1021
La ribonucleoprotein domain family member 1		CALJA		1021
+44

Protein	Similar proteins		Species	Score	Length	Source
Q6PKG0	La-related protein 1		MOUSE		1072	UniRef50_Q6PKG0
La-related protein 1 (Fragment)		HUMAN		815
LARP1 isoform 6 (Fragment)		PONAB		93
la-related protein 1 isoform X1		PHYCD		1119
Putative rna-binding protein		DESRO		1116
+743

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC001460 mRNA Translation: AAH01460.2 BC033856 mRNA Translation: AAH33856.1 Different initiation. AK091465 mRNA Translation: BAC03668.1 AB018274 mRNA Translation: BAA34451.1 Sequence problems. AL133034 mRNA Translation: CAB61364.1
CCDSⁱ	CCDS4328.1 [Q6PKG0-3]
PIRⁱ	T42646
RefSeqⁱ	NP_056130.2, NM_015315.4 [Q6PKG0-3] XP_005268461.1, XM_005268404.3 [Q6PKG0-1]
UniGeneⁱ	Hs.292078

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	4ZC4	X-ray	1.86	A/B/C/D	873-1023	[»]
	5C0V	X-ray	2.20	A/B/C/D	873-1023	[»]
	5V4R	X-ray	1.77	A/B	873-1023	[»]
	5V7C	X-ray	2.59	B	873-1023	[»]
	5V87	X-ray	1.69	A/B	873-1023	[»]
ProteinModelPortalⁱ	Q6PKG0
SMRⁱ	Q6PKG0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	116947, 141 interactors
IntActⁱ	Q6PKG0, 62 interactors
MINTⁱ	Q6PKG0
STRINGⁱ	9606.ENSP00000336721

PTM databases

CarbonylDBⁱ	Q6PKG0
iPTMnetⁱ	Q6PKG0
PhosphoSitePlusⁱ	Q6PKG0
SwissPalmⁱ	Q6PKG0

Polymorphism and mutation databases

DMDMⁱ	73621135

DMDMⁱ

73621135

Proteomic databases

EPDⁱ	Q6PKG0
MaxQBⁱ	Q6PKG0
PaxDbⁱ	Q6PKG0
PeptideAtlasⁱ	Q6PKG0
PRIDEⁱ	Q6PKG0
ProteomicsDBⁱ	67242 67243 [Q6PKG0-3]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	23367
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000336314; ENSP00000336721; ENSG00000155506 [Q6PKG0-3]
GeneIDⁱ	23367
KEGGⁱ	hsa:23367
UCSCⁱ	uc003lvo.4 human [Q6PKG0-1]

Organism-specific databases

CTDⁱ	23367
DisGeNETⁱ	23367
EuPathDBⁱ	HostDB:ENSG00000155506.16
GeneCardsⁱ	LARP1
HGNCⁱ	HGNC:29531 LARP1
HPAⁱ	CAB015222 HPA051397 HPA054819
MIMⁱ	612059 gene
neXtProtⁱ	NX_Q6PKG0
OpenTargetsⁱ	ENSG00000155506
PharmGKBⁱ	PA142671564
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2590 Eukaryota COG5193 LUCA
GeneTreeⁱ	ENSGT00390000000523
HOGENOMⁱ	HOG000113283
HOVERGENⁱ	HBG054322
InParanoidⁱ	Q6PKG0
KOⁱ	K18757
OMAⁱ	RAKMSSE
OrthoDBⁱ	EOG091G02X0
PhylomeDBⁱ	Q6PKG0
TreeFamⁱ	TF314516

Miscellaneous databases

ChiTaRSⁱ	LARP1 human
GeneWikiⁱ	LARP1
GenomeRNAiⁱ	23367
PMAP-CutDBⁱ	Q6PKG0
Protein Ontology More...PROⁱ	PR:Q6PKG0
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000155506 Expressed in 251 organ(s), highest expression level in female gonad
CleanExⁱ	HS_LARP1
ExpressionAtlasⁱ	Q6PKG0 baseline and differential
Genevisibleⁱ	Q6PKG0 HS

Family and domain databases

Gene3Dⁱ	1.10.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR006607 DM15 IPR006630 La_HTH IPR036388 WH-like_DNA-bd_sf IPR036390 WH_DNA-bd_sf
Pfamⁱ	View protein in Pfam PF05383 La, 1 hit
SMARTⁱ	View protein in SMART SM00684 DM15, 3 hits SM00715 LA, 1 hit
SUPFAMⁱ	SSF46785 SSF46785, 1 hit
PROSITEⁱ	View protein in PROSITE PS50961 HTH_LA, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	LARP1_HUMAN
Accessionⁱ	Q6PKG0Primary (citable) accession number: Q6PKG0 Secondary accession number(s): O94836 , Q8N4M2, Q8NB73, Q9UFD7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 16, 2005
	Last sequence update:	August 16, 2005
	Last modified:	November 7, 2018
	This is version 151 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM

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UniProtKB - Q6PKG0 (LARP1_HUMAN)

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La-related protein 1

LARP1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

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Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ