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UniProtKB - Q6PKG0 (LARP1_HUMAN)

Entry version 168 (02 Dec 2020)
Sequence version 2 (16 Aug 2005)
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Protein

La-related protein 1

Gene

LARP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

RNA-binding protein that regulates the translation of specific target mRNA species downstream of the mTORC1 complex, in function of growth signals and nutrient availability (PubMed:20430826, PubMed:23711370, PubMed:24532714, PubMed:25940091, PubMed:28650797, PubMed:28673543, PubMed:29244122). Interacts on the one hand with the 3' poly-A tails that are present in all mRNA molecules, and on the other hand with the 7-methylguanosine cap structure of mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding ribosomal proteins and several components of the translation machinery (PubMed:23711370, PubMed:25940091, PubMed:28650797, PubMed:29244122, PubMed:26206669, PubMed:28379136). The interaction with the 5' end of mRNAs containing a 5'TOP motif leads to translational repression by preventing the binding of EIF4G1 (PubMed:25940091, PubMed:28650797, PubMed:29244122, PubMed:28379136). When mTORC1 is activated, LARP1 is phosphorylated and dissociates from the 5' untranslated region (UTR) of mRNA (PubMed:25940091, PubMed:28650797). Does not prevent binding of EIF4G1 to mRNAs that lack a 5'TOP motif (PubMed:28379136). Interacts with the free 40S ribosome subunit and with ribosomes, both monosomes and polysomes (PubMed:20430826, PubMed:24532714, PubMed:25940091, PubMed:28673543). Under normal nutrient availability, interacts primarily with the 3' untranslated region (UTR) of mRNAs encoding ribosomal proteins and increases protein synthesis (PubMed:23711370, PubMed:28650797). Associates with actively translating ribosomes and stimulates translation of mRNAs containing a 5'TOP motif, thereby regulating protein synthesis, and as a consequence, cell growth and proliferation (PubMed:20430826, PubMed:24532714). Stabilizes mRNAs species with a 5'TOP motif, which is required to prevent apoptosis (PubMed:20430826, PubMed:23711370, PubMed:25940091, PubMed:28673543).9 Publications
(Microbial infection) Positively regulates the replication of dengue virus (DENV).1 Publication

Caution

Conflicting results are reported regarding the interaction with PABPC1. Some studies found that the interaction depends on the presence of mRNA (PubMed:23711370, PubMed:28650797). Others found that the interaction is direct and does not depend on the presence of mRNA (PubMed:20430826, PubMed:24532714, PubMed:25940091).5 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRepressor, RNA-binding
Biological processProtein biosynthesis, Translation regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q6PKG0

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q6PKG0

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
La-related protein 1
Alternative name(s):
La ribonucleoprotein domain family member 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LARP1
Synonyms:KIAA0731, LARP
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000155506.16

Human Gene Nomenclature Database

More...HGNCi		HGNC:29531, LARP1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		612059, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q6PKG0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi497 – 507Missing : Strongly reduced interaction with PABPC1. 1 PublicationAdd BLAST11
Mutagenesisi505F → A: Strongly reduced interaction with PABPC1. 1 Publication1
Mutagenesisi766S → A: Loss of phosphorylation by MTOR; when associated with A-769. Decreased interaction with RPTOR and impaired dissociation from the 5'UTR of mRNA molecules; when associated with A-769; A-847 and A-1058. 1 Publication1
Mutagenesisi769T → A: Loss of phosphorylation by MTOR; when associated with A-766. Decreased interaction with RPTOR and impaired dissociation from the 5'UTR of mRNA molecules; when associated with A-766; A-847 and A-1058. 1 Publication1
Mutagenesisi847S → A: Strongly reduced phosphorylation mediated by Akt and RPS6KB1. Decreased interaction with RPTOR and impaired dissociation from the 5'UTR of mRNA molecules; when associated with A-766; A-769 and A-1058. 1 Publication1
Mutagenesisi917R → E: Abolishes RNA binding. Abolishes inhibition of EIF4G1 binding to mRNA molecules with a 5'TOP motif; when associated with A-960. 2 Publications1
Mutagenesisi960Y → A: Abolishes RNA binding. Abolishes translational repression of mRNAs with a 5'TOP motif. Abolishes inhibition of EIF4G1 binding to mRNA molecules with a 5'TOP motif; when associated with E-917. 3 Publications1
Mutagenesisi963E → R: Strongly decreased RNA binding. 1 Publication1
Mutagenesisi966 – 970Missing : Loss of interaction with RPTOR. 1 Publication5
Mutagenesisi966F → A: No effect on interaction with RPTOR. 1 Publication1
Mutagenesisi999Y → A: Strongly decreased RNA binding. 1 Publication1
Mutagenesisi1058S → A: Strongly reduced phosphorylation mediated by AKT and RPS6KB1. Decreased interaction with RPTOR and impaired dissociation from the 5'UTR of mRNA molecules; when associated with A-766; A-769 and A-847. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		23367

Open Targets

More...OpenTargetsi		ENSG00000155506

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA142671564

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q6PKG0, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		LARP1

Domain mapping of disease mutations (DMDM)

More...DMDMi		73621135

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources1 Publication
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002076092 – 1096La-related protein 1Add BLAST1095

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1 Publication1
Modified residuei75PhosphoserineCombined sources1
Modified residuei90PhosphoserineCombined sources1
Modified residuei143PhosphoserineCombined sources1
Modified residuei165PhosphoserineCombined sources1
Modified residuei215PhosphoserineCombined sources1
Modified residuei220PhosphoserineCombined sources1
Modified residuei223PhosphothreonineBy similarity1
Modified residuei225PhosphoserineBy similarity1
Modified residuei228PhosphoserineBy similarity1
Modified residuei240Omega-N-methylarginineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki260Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki311Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei324PhosphoserineBy similarity1
Modified residuei327PhosphoserineBy similarity1
Modified residuei376PhosphothreonineCombined sources1
Modified residuei517PhosphoserineCombined sources1
Modified residuei521PhosphoserineCombined sources1
Modified residuei526PhosphothreonineCombined sources1 Publication1
Cross-linki531Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei548PhosphoserineCombined sources1
Modified residuei591PhosphoserineCombined sources1
Modified residuei627PhosphoserineCombined sources1
Modified residuei631PhosphoserineCombined sources1
Modified residuei649PhosphothreonineCombined sources1
Cross-linki703Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei724PhosphothreonineCombined sources1
Modified residuei766PhosphoserineCombined sources1 Publication1
Modified residuei769Phosphothreonine1 Publication1
Modified residuei770Phosphothreonine1 Publication1
Modified residuei774PhosphoserineCombined sources1 Publication1
Modified residuei777PhosphotyrosineCombined sources1
Modified residuei782Phosphothreonine1 Publication1
Modified residuei785PhosphothreonineCombined sources1 Publication1
Modified residuei788PhosphothreonineCombined sources1
Modified residuei797Phosphothreonine1 Publication1
Modified residuei824PhosphoserineCombined sources1 Publication1
Modified residuei845PhosphothreonineCombined sources1
Modified residuei847Phosphoserine1 Publication1
Modified residuei851PhosphoserineCombined sources1 Publication1
Modified residuei853PhosphoserineBy similarity1
Modified residuei861Phosphoserine1 Publication1
Modified residuei865PhosphothreonineBy similarity1 Publication1
Modified residuei868Phosphoserine1 Publication1
Modified residuei892N6-acetyllysineCombined sources1
Modified residuei1017N6-acetyllysineCombined sources1
Modified residuei1040PhosphoserineCombined sources1
Modified residuei1058Phosphoserine1 Publication1
Modified residuei1089PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on multiple Ser and Thr residues in response to active mTORC1. Phosphorylation is important for interaction with RPTOR and the mTORC1 complex. Phosphorylation promotes dissociation from the 5'UTR of mRNA molecules with a 5'TOP motif.1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q6PKG0

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q6PKG0

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q6PKG0

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q6PKG0

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q6PKG0

PeptideAtlas

More...PeptideAtlasi		Q6PKG0

PRoteomics IDEntifications database

More...PRIDEi		Q6PKG0

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		67242 [Q6PKG0-1]
67243 [Q6PKG0-3]

PTM databases

CarbonylDB database of protein carbonylation sites

More...CarbonylDBi		Q6PKG0

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q6PKG0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q6PKG0

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q6PKG0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated in a number of hepatocellular carcinoma cell lines and liver cancer lesions, as well as in patients with hepatocellular carcinoma with a lower survival rate (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000155506, Expressed in female gonad and 263 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q6PKG0, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q6PKG0, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000155506, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PABPC1/PABP (PubMed:20430826, PubMed:24532714, PubMed:25940091, PubMed:23711370, PubMed:28650797).

Interacts with EIF4A1 (PubMed:24532714).

Interacts with RPTOR (PubMed:24532714, PubMed:25940091, PubMed:28650797). Recruited to the active mTORC1 complex via interaction with RPTOR (PubMed:25940091, PubMed:28650797). Inhibition of mTORC1 activity strongly reduces interaction with RPTOR and the mTORC1 complex (PubMed:25940091, PubMed:28650797).

Identified in a complex with mRNA, PABPC1, EIF4E and EIF4G1 (PubMed:20430826, PubMed:28650797).

Found in a complex with PABPC1 and SHFL (PubMed:26735137).

6 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		116947, 193 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q6PKG0

Protein interaction database and analysis system

More...IntActi		Q6PKG0, 131 interactors

Molecular INTeraction database

More...MINTi		Q6PKG0

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000336721

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q6PKG0, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11096
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q6PKG0

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini397 – 487HTH La-type RNA-bindingPROSITE-ProRule annotationAdd BLAST91

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni77 – 573Required for interaction with PABPC11 PublicationAdd BLAST497
Regioni574 – 1096Required for interaction with RPTOR and for repression of mRNAs with a 5'TOP motif1 PublicationAdd BLAST523
Regioni873 – 1023Interaction with mRNA2 PublicationsAdd BLAST151
Regioni956 – 999Interaction with 7-methylguanosine mRNA cap structureCombined sources1 PublicationAdd BLAST44

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1044 – 1050Poly-Gly7

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The C-terminal region mediates interaction with the mRNA and polysomes (PubMed:24532714, PubMed:26206669, PubMed:28379136). It is required for translational repression of mRNAs with a 5'TOP motif (PubMed:29244122).4 Publications
The N-terminal region mediates interaction with PABPC1.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the LARP family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2590, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159577

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_003957_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q6PKG0

Identification of Orthologs from Complete Genome Data

More...OMAi		PGWHPDN

Database of Orthologous Groups

More...OrthoDBi		258488at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q6PKG0

TreeFam database of animal gene trees

More...TreeFami		TF314516

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR006607, DM15
IPR006630, La_HTH
IPR036388, WH-like_DNA-bd_sf
IPR036390, WH_DNA-bd_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF05383, La, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00684, DM15, 3 hits
SM00715, LA, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF46785, SSF46785, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50961, HTH_LA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 11 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6PKG0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MATQVEPLLP GGATLLQAEE HGGLVRKKPP PAPEGKGEPG PNDVRGGEPD 
        60         70         80         90        100
GSARRPRPPC AKPHKEGTGQ QERESPRPLQ LPGAEGPAIS DGEEGGGEPG 
       110        120        130        140        150
AGGGAAGAAG AGRRDFVEAP PPKVNPWTKN ALPPVLTTVN GQSPPEHSAP 
       160        170        180        190        200
AKVVRAAVPK QRKGSKVGDF GDAINWPTPG EIAHKSVQPQ SHKPQPTRKL 
       210        220        230        240        250
PPKKDMKEQE KGEGSDSKES PKTKSDESGE EKNGDEDCQR GGQKKKGNKH 
       260        270        280        290        300
KWVPLQIDMK PEVPREKLAS RPTRPPEPRH IPANRGEIKG SESATYVPVA 
       310        320        330        340        350
PPTPAWQPEI KPEPAWHDQD ETSSVKSDGA GGARASFRGR GRGRGRGRGR 
       360        370        380        390        400
GRGGTRTHFD YQFGYRKFDG VEGPRTPKYM NNITYYFDNV SSTELYSVDQ 
       410        420        430        440        450
ELLKDYIKRQ IEYYFSVDNL ERDFFLRRKM DADGFLPITL IASFHRVQAL 
       460        470        480        490        500
TTDISLIFAA LKDSKVVEIV DEKVRRREEP EKWPLPPIVD YSQTDFSQLL 
       510        520        530        540        550
NCPEFVPRQH YQKETESAPG SPRAVTPVPT KTEEVSNLKT LPKGLSASLP 
       560        570        580        590        600
DLDSENWIEV KKRPRPSPAR PKKSEESRFS HLTSLPQQLP SQQLMSKDQD 
       610        620        630        640        650
EQEELDFLFD EEMEQMDGRK NTFTAWSDEE SDYEIDDRDV NKILIVTQTP 
       660        670        680        690        700
HYMRRHPGGD RTGNHTSRAK MSAELAKVIN DGLFYYEQDL WAEKFEPEYS 
       710        720        730        740        750
QIKQEVENFK KVNMISREQF DTLTPEPPVD PNQEVPPGPP RFQQVPTDAL 
       760        770        780        790        800
ANKLFGAPEP STIARSLPTT VPESPNYRNT RTPRTPRTPQ LKDSSQTSRF 
       810        820        830        840        850
YPVVKEGRTL DAKMPRKRKT RHSSNPPLES HVGWVMDSRE HRPRTASISS 
       860        870        880        890        900
SPSEGTPTVG SYGCTPQSLP KFQHPSHELL KENGFTQHVY HKYRRRCLNE 
       910        920        930        940        950
RKRLGIGQSQ EMNTLFRFWS FFLRDHFNKK MYEEFKQLAL EDAKEGYRYG 
       960        970        980        990       1000
LECLFRYYSY GLEKKFRLDI FKDFQEETVK DYEAGQLYGL EKFWAFLKYS 
      1010       1020       1030       1040       1050
KAKNLDIDPK LQEYLGKFRR LEDFRVDPPM GEEGNHKRHS VVAGGGGGEG 
      1060       1070       1080       1090 
RKRCPSQSSS RPAAMISQPP TPPTGQPVRE DAKWTSQHSN TQTLGK
Length:1,096
Mass (Da):123,510
Last modified:August 16, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCA3E9D30BBC101B7
GO
Isoform 2 (identifier: Q6PKG0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-77: Missing.
     78-144: PLQLPGAEGP...VLTTVNGQSP → MLWRVLLSKR...PFPVLAPFSN

Show »
Length:1,019
Mass (Da):116,465
Checksum:i64982CA22171B0E6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YC73H0YC73_HUMAN
La-related protein 1
LARP1
195Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YBW1H0YBW1_HUMAN
La-related protein 1
LARP1
281Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RH50E5RH50_HUMAN
La-related protein 1
LARP1
610Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4J210A0A0B4J210_HUMAN
La-related protein 1
LARP1
815Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YAN4H0YAN4_HUMAN
La-related protein 1
LARP1
150Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YBM7H0YBM7_HUMAN
La-related protein 1
LARP1
167Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YBR8H0YBR8_HUMAN
La-related protein 1
LARP1
36Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YC33H0YC33_HUMAN
La-related protein 1
LARP1
183Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RHK4E5RHK4_HUMAN
La-related protein 1
LARP1
92Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YBJ5H0YBJ5_HUMAN
La-related protein 1
LARP1
67Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There is more potential isoformShow all

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH33856 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAA34451 differs from that shown. Aberrant splicing.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti778 – 780RNT → TRP in AAH33856 (PubMed:15489334).Curated3
Sequence conflicti979V → L in CAB61364 (PubMed:17974005).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0151141 – 77Missing in isoform 2. 1 PublicationAdd BLAST77
Alternative sequenceiVSP_01511578 – 144PLQLP…NGQSP → MLWRVLLSKRPPFPHPELDF QEAPIPSCPGRLPGRKNSVA LAAAPRKEPTGDREKPLPFP VLAPFSN in isoform 2. 1 PublicationAdd BLAST67

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
BC001460 mRNA Translation: AAH01460.2
BC033856 mRNA Translation: AAH33856.1 Different initiation.
AK091465 mRNA Translation: BAC03668.1
AB018274 mRNA Translation: BAA34451.1 Sequence problems.
AL133034 mRNA Translation: CAB61364.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS4328.1 [Q6PKG0-3]

Protein sequence database of the Protein Information Resource

More...PIRi		T42646

NCBI Reference Sequences

More...RefSeqi		NP_056130.2, NM_015315.4 [Q6PKG0-3]
XP_005268461.1, XM_005268404.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000336314; ENSP00000336721; ENSG00000155506 [Q6PKG0-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		23367

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:23367

UCSC genome browser

More...UCSCi		uc003lvo.4, human [Q6PKG0-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC001460 mRNA Translation: AAH01460.2
BC033856 mRNA Translation: AAH33856.1 Different initiation.
AK091465 mRNA Translation: BAC03668.1
AB018274 mRNA Translation: BAA34451.1 Sequence problems.
AL133034 mRNA Translation: CAB61364.1
CCDSiCCDS4328.1 [Q6PKG0-3]
PIRiT42646
RefSeqiNP_056130.2, NM_015315.4 [Q6PKG0-3]
XP_005268461.1, XM_005268404.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4ZC4X-ray1.86A/B/C/D873-1023[»]
5C0VX-ray2.20A/B/C/D873-1023[»]
5V4RX-ray1.77A/B873-1023[»]
5V7CX-ray2.59B873-1023[»]
5V87X-ray1.69A/B873-1023[»]
6PW3X-ray2.34A/B/C/D873-1023[»]
SMRiQ6PKG0
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi116947, 193 interactors
CORUMiQ6PKG0
IntActiQ6PKG0, 131 interactors
MINTiQ6PKG0
STRINGi9606.ENSP00000336721

PTM databases

CarbonylDBiQ6PKG0
iPTMnetiQ6PKG0
PhosphoSitePlusiQ6PKG0
SwissPalmiQ6PKG0

Polymorphism and mutation databases

BioMutaiLARP1
DMDMi73621135

Proteomic databases

EPDiQ6PKG0
jPOSTiQ6PKG0
MassIVEiQ6PKG0
MaxQBiQ6PKG0
PaxDbiQ6PKG0
PeptideAtlasiQ6PKG0
PRIDEiQ6PKG0
ProteomicsDBi67242 [Q6PKG0-1]
67243 [Q6PKG0-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		28316, 125 antibodies

The DNASU plasmid repository

More...DNASUi		23367

Genome annotation databases

EnsembliENST00000336314; ENSP00000336721; ENSG00000155506 [Q6PKG0-3]
GeneIDi23367
KEGGihsa:23367
UCSCiuc003lvo.4, human [Q6PKG0-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		23367
DisGeNETi23367
EuPathDBiHostDB:ENSG00000155506.16

GeneCards: human genes, protein and diseases

More...GeneCardsi		LARP1
HGNCiHGNC:29531, LARP1
HPAiENSG00000155506, Low tissue specificity
MIMi612059, gene
neXtProtiNX_Q6PKG0
OpenTargetsiENSG00000155506
PharmGKBiPA142671564

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2590, Eukaryota
GeneTreeiENSGT00940000159577
HOGENOMiCLU_003957_1_0_1
InParanoidiQ6PKG0
OMAiPGWHPDN
OrthoDBi258488at2759
PhylomeDBiQ6PKG0
TreeFamiTF314516

Enzyme and pathway databases

PathwayCommonsiQ6PKG0
SIGNORiQ6PKG0

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		23367, 112 hits in 853 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		LARP1, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		LARP1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		23367
PharosiQ6PKG0, Tbio

Protein Ontology

More...PROi		PR:Q6PKG0
RNActiQ6PKG0, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000155506, Expressed in female gonad and 263 other tissues
ExpressionAtlasiQ6PKG0, baseline and differential
GenevisibleiQ6PKG0, HS

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR006607, DM15
IPR006630, La_HTH
IPR036388, WH-like_DNA-bd_sf
IPR036390, WH_DNA-bd_sf
PfamiView protein in Pfam
PF05383, La, 1 hit
SMARTiView protein in SMART
SM00684, DM15, 3 hits
SM00715, LA, 1 hit
SUPFAMiSSF46785, SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS50961, HTH_LA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLARP1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6PKG0
Secondary accession number(s): O94836
, Q8N4M2, Q8NB73, Q9UFD7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: August 16, 2005
Last modified: December 2, 2020
This is version 168 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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