UniProtKB - Q6PKG0 (LARP1_HUMAN)
La-related protein 1
LARP1
Functioni
Caution
GO - Molecular functioni
- cadherin binding Source: BHF-UCL
- eukaryotic initiation factor 4E binding Source: UniProtKB
- mRNA 3'-UTR binding Source: UniProtKB
- mRNA 5'-UTR binding Source: UniProtKB
- ribosomal small subunit binding Source: UniProtKB
- RNA 7-methylguanosine cap binding Source: UniProtKB
- RNA binding Source: UniProtKB
- RNA cap binding Source: UniProtKB
- translation activator activity Source: UniProtKB
- translation initiation factor binding Source: UniProtKB
GO - Biological processi
- cell population proliferation Source: UniProtKB
- cellular response to rapamycin Source: UniProtKB
- mRNA stabilization Source: UniProtKB
- negative regulation of translation Source: UniProtKB
- negative regulation of translational initiation Source: UniProtKB
- positive regulation of macroautophagy Source: BHF-UCL
- positive regulation of translational initiation Source: CACAO
- positive regulation of viral genome replication Source: UniProtKB
- response to amino acid starvation Source: UniProtKB
- TORC1 signaling Source: UniProtKB
- TOR signaling Source: UniProtKB
- translational initiation Source: UniProtKB
Keywordsi
Molecular function | Repressor, RNA-binding |
Biological process | Protein biosynthesis, Translation regulation |
Enzyme and pathway databases
PathwayCommonsi | Q6PKG0 |
SIGNORi | Q6PKG0 |
Names & Taxonomyi
Protein namesi | Recommended name: La-related protein 1Alternative name(s): La ribonucleoprotein domain family member 1 |
Gene namesi | Name:LARP1 Synonyms:KIAA0731, LARP |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000155506.16 |
HGNCi | HGNC:29531, LARP1 |
MIMi | 612059, gene |
neXtProti | NX_Q6PKG0 |
Subcellular locationi
Other locations
- Cytoplasm 3 Publications
- Cytoplasmic granule 2 Publications
Note: Colocalizes with RPTOR and PABPC1 in cytoplasmic granules that resemble stress granules.2 Publications
Other locations
- cytoplasm Source: UniProtKB
- cytoplasmic stress granule Source: UniProtKB
- membrane Source: UniProtKB
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 497 – 507 | Missing : Strongly reduced interaction with PABPC1. 1 PublicationAdd BLAST | 11 | |
Mutagenesisi | 505 | F → A: Strongly reduced interaction with PABPC1. 1 Publication | 1 | |
Mutagenesisi | 766 | S → A: Loss of phosphorylation by MTOR; when associated with A-769. Decreased interaction with RPTOR and impaired dissociation from the 5'UTR of mRNA molecules; when associated with A-769; A-847 and A-1058. 1 Publication | 1 | |
Mutagenesisi | 769 | T → A: Loss of phosphorylation by MTOR; when associated with A-766. Decreased interaction with RPTOR and impaired dissociation from the 5'UTR of mRNA molecules; when associated with A-766; A-847 and A-1058. 1 Publication | 1 | |
Mutagenesisi | 847 | S → A: Strongly reduced phosphorylation mediated by Akt and RPS6KB1. Decreased interaction with RPTOR and impaired dissociation from the 5'UTR of mRNA molecules; when associated with A-766; A-769 and A-1058. 1 Publication | 1 | |
Mutagenesisi | 917 | R → E: Abolishes RNA binding. Abolishes inhibition of EIF4G1 binding to mRNA molecules with a 5'TOP motif; when associated with A-960. 2 Publications | 1 | |
Mutagenesisi | 960 | Y → A: Abolishes RNA binding. Abolishes translational repression of mRNAs with a 5'TOP motif. Abolishes inhibition of EIF4G1 binding to mRNA molecules with a 5'TOP motif; when associated with E-917. 3 Publications | 1 | |
Mutagenesisi | 963 | E → R: Strongly decreased RNA binding. 1 Publication | 1 | |
Mutagenesisi | 966 – 970 | Missing : Loss of interaction with RPTOR. 1 Publication | 5 | |
Mutagenesisi | 966 | F → A: No effect on interaction with RPTOR. 1 Publication | 1 | |
Mutagenesisi | 999 | Y → A: Strongly decreased RNA binding. 1 Publication | 1 | |
Mutagenesisi | 1058 | S → A: Strongly reduced phosphorylation mediated by AKT and RPS6KB1. Decreased interaction with RPTOR and impaired dissociation from the 5'UTR of mRNA molecules; when associated with A-766; A-769 and A-847. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 23367 |
OpenTargetsi | ENSG00000155506 |
PharmGKBi | PA142671564 |
Miscellaneous databases
Pharosi | Q6PKG0, Tbio |
Polymorphism and mutation databases
BioMutai | LARP1 |
DMDMi | 73621135 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources1 Publication | |||
ChainiPRO_0000207609 | 2 – 1096 | La-related protein 1Add BLAST | 1095 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources1 Publication | 1 | |
Modified residuei | 75 | PhosphoserineCombined sources | 1 | |
Modified residuei | 90 | PhosphoserineCombined sources | 1 | |
Modified residuei | 143 | PhosphoserineCombined sources | 1 | |
Modified residuei | 165 | PhosphoserineCombined sources | 1 | |
Modified residuei | 215 | PhosphoserineCombined sources | 1 | |
Modified residuei | 220 | PhosphoserineCombined sources | 1 | |
Modified residuei | 223 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 225 | PhosphoserineBy similarity | 1 | |
Modified residuei | 228 | PhosphoserineBy similarity | 1 | |
Modified residuei | 240 | Omega-N-methylarginineBy similarity | 1 | |
Cross-linki | 260 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 311 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 324 | PhosphoserineBy similarity | 1 | |
Modified residuei | 327 | PhosphoserineBy similarity | 1 | |
Modified residuei | 376 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 517 | PhosphoserineCombined sources | 1 | |
Modified residuei | 521 | PhosphoserineCombined sources | 1 | |
Modified residuei | 526 | PhosphothreonineCombined sources1 Publication | 1 | |
Cross-linki | 531 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 548 | PhosphoserineCombined sources | 1 | |
Modified residuei | 591 | PhosphoserineCombined sources | 1 | |
Modified residuei | 627 | PhosphoserineCombined sources | 1 | |
Modified residuei | 631 | PhosphoserineCombined sources | 1 | |
Modified residuei | 649 | PhosphothreonineCombined sources | 1 | |
Cross-linki | 703 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 724 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 766 | PhosphoserineCombined sources1 Publication | 1 | |
Modified residuei | 769 | Phosphothreonine1 Publication | 1 | |
Modified residuei | 770 | Phosphothreonine1 Publication | 1 | |
Modified residuei | 774 | PhosphoserineCombined sources1 Publication | 1 | |
Modified residuei | 777 | PhosphotyrosineCombined sources | 1 | |
Modified residuei | 782 | Phosphothreonine1 Publication | 1 | |
Modified residuei | 785 | PhosphothreonineCombined sources1 Publication | 1 | |
Modified residuei | 788 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 797 | Phosphothreonine1 Publication | 1 | |
Modified residuei | 824 | PhosphoserineCombined sources1 Publication | 1 | |
Modified residuei | 845 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 847 | Phosphoserine1 Publication | 1 | |
Modified residuei | 851 | PhosphoserineCombined sources1 Publication | 1 | |
Modified residuei | 853 | PhosphoserineBy similarity | 1 | |
Modified residuei | 861 | Phosphoserine1 Publication | 1 | |
Modified residuei | 865 | PhosphothreonineBy similarity1 Publication | 1 | |
Modified residuei | 868 | Phosphoserine1 Publication | 1 | |
Modified residuei | 892 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 1017 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 1040 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1058 | Phosphoserine1 Publication | 1 | |
Modified residuei | 1089 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q6PKG0 |
jPOSTi | Q6PKG0 |
MassIVEi | Q6PKG0 |
MaxQBi | Q6PKG0 |
PaxDbi | Q6PKG0 |
PeptideAtlasi | Q6PKG0 |
PRIDEi | Q6PKG0 |
ProteomicsDBi | 67242 [Q6PKG0-1] 67243 [Q6PKG0-3] |
PTM databases
CarbonylDBi | Q6PKG0 |
iPTMneti | Q6PKG0 |
PhosphoSitePlusi | Q6PKG0 |
SwissPalmi | Q6PKG0 |
Expressioni
Inductioni
Gene expression databases
Bgeei | ENSG00000155506, Expressed in female gonad and 263 other tissues |
ExpressionAtlasi | Q6PKG0, baseline and differential |
Genevisiblei | Q6PKG0, HS |
Organism-specific databases
HPAi | ENSG00000155506, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with PABPC1/PABP (PubMed:20430826, PubMed:24532714, PubMed:25940091, PubMed:23711370, PubMed:28650797).
Interacts with EIF4A1 (PubMed:24532714).
Interacts with RPTOR (PubMed:24532714, PubMed:25940091, PubMed:28650797). Recruited to the active mTORC1 complex via interaction with RPTOR (PubMed:25940091, PubMed:28650797). Inhibition of mTORC1 activity strongly reduces interaction with RPTOR and the mTORC1 complex (PubMed:25940091, PubMed:28650797).
Identified in a complex with mRNA, PABPC1, EIF4E and EIF4G1 (PubMed:20430826, PubMed:28650797).
Found in a complex with PABPC1 and SHFL (PubMed:26735137).
6 PublicationsBinary interactionsi
Q6PKG0
With | #Exp. | IntAct |
---|---|---|
KASH5 [Q8N6L0] | 3 | EBI-1052114,EBI-749265 |
GO - Molecular functioni
- cadherin binding Source: BHF-UCL
- eukaryotic initiation factor 4E binding Source: UniProtKB
- translation initiation factor binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 116947, 193 interactors |
CORUMi | Q6PKG0 |
IntActi | Q6PKG0, 131 interactors |
MINTi | Q6PKG0 |
STRINGi | 9606.ENSP00000336721 |
Miscellaneous databases
RNActi | Q6PKG0, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q6PKG0 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 397 – 487 | HTH La-type RNA-bindingPROSITE-ProRule annotationAdd BLAST | 91 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 77 – 573 | Required for interaction with PABPC11 PublicationAdd BLAST | 497 | |
Regioni | 574 – 1096 | Required for interaction with RPTOR and for repression of mRNAs with a 5'TOP motif1 PublicationAdd BLAST | 523 | |
Regioni | 873 – 1023 | Interaction with mRNA2 PublicationsAdd BLAST | 151 | |
Regioni | 956 – 999 | Interaction with 7-methylguanosine mRNA cap structureCombined sources1 PublicationAdd BLAST | 44 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1044 – 1050 | Poly-Gly | 7 |
Domaini
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG2590, Eukaryota |
GeneTreei | ENSGT00940000159577 |
HOGENOMi | CLU_003957_1_0_1 |
InParanoidi | Q6PKG0 |
OMAi | PGWHPDN |
OrthoDBi | 258488at2759 |
PhylomeDBi | Q6PKG0 |
TreeFami | TF314516 |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR006607, DM15 IPR006630, La_HTH IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF05383, La, 1 hit |
SMARTi | View protein in SMART SM00684, DM15, 3 hits SM00715, LA, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS50961, HTH_LA, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 11 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MATQVEPLLP GGATLLQAEE HGGLVRKKPP PAPEGKGEPG PNDVRGGEPD
60 70 80 90 100
GSARRPRPPC AKPHKEGTGQ QERESPRPLQ LPGAEGPAIS DGEEGGGEPG
110 120 130 140 150
AGGGAAGAAG AGRRDFVEAP PPKVNPWTKN ALPPVLTTVN GQSPPEHSAP
160 170 180 190 200
AKVVRAAVPK QRKGSKVGDF GDAINWPTPG EIAHKSVQPQ SHKPQPTRKL
210 220 230 240 250
PPKKDMKEQE KGEGSDSKES PKTKSDESGE EKNGDEDCQR GGQKKKGNKH
260 270 280 290 300
KWVPLQIDMK PEVPREKLAS RPTRPPEPRH IPANRGEIKG SESATYVPVA
310 320 330 340 350
PPTPAWQPEI KPEPAWHDQD ETSSVKSDGA GGARASFRGR GRGRGRGRGR
360 370 380 390 400
GRGGTRTHFD YQFGYRKFDG VEGPRTPKYM NNITYYFDNV SSTELYSVDQ
410 420 430 440 450
ELLKDYIKRQ IEYYFSVDNL ERDFFLRRKM DADGFLPITL IASFHRVQAL
460 470 480 490 500
TTDISLIFAA LKDSKVVEIV DEKVRRREEP EKWPLPPIVD YSQTDFSQLL
510 520 530 540 550
NCPEFVPRQH YQKETESAPG SPRAVTPVPT KTEEVSNLKT LPKGLSASLP
560 570 580 590 600
DLDSENWIEV KKRPRPSPAR PKKSEESRFS HLTSLPQQLP SQQLMSKDQD
610 620 630 640 650
EQEELDFLFD EEMEQMDGRK NTFTAWSDEE SDYEIDDRDV NKILIVTQTP
660 670 680 690 700
HYMRRHPGGD RTGNHTSRAK MSAELAKVIN DGLFYYEQDL WAEKFEPEYS
710 720 730 740 750
QIKQEVENFK KVNMISREQF DTLTPEPPVD PNQEVPPGPP RFQQVPTDAL
760 770 780 790 800
ANKLFGAPEP STIARSLPTT VPESPNYRNT RTPRTPRTPQ LKDSSQTSRF
810 820 830 840 850
YPVVKEGRTL DAKMPRKRKT RHSSNPPLES HVGWVMDSRE HRPRTASISS
860 870 880 890 900
SPSEGTPTVG SYGCTPQSLP KFQHPSHELL KENGFTQHVY HKYRRRCLNE
910 920 930 940 950
RKRLGIGQSQ EMNTLFRFWS FFLRDHFNKK MYEEFKQLAL EDAKEGYRYG
960 970 980 990 1000
LECLFRYYSY GLEKKFRLDI FKDFQEETVK DYEAGQLYGL EKFWAFLKYS
1010 1020 1030 1040 1050
KAKNLDIDPK LQEYLGKFRR LEDFRVDPPM GEEGNHKRHS VVAGGGGGEG
1060 1070 1080 1090
RKRCPSQSSS RPAAMISQPP TPPTGQPVRE DAKWTSQHSN TQTLGK
Computationally mapped potential isoform sequencesi
There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0YC73 | H0YC73_HUMAN | La-related protein 1 | LARP1 | 195 | Annotation score: | ||
H0YBW1 | H0YBW1_HUMAN | La-related protein 1 | LARP1 | 281 | Annotation score: | ||
E5RH50 | E5RH50_HUMAN | La-related protein 1 | LARP1 | 610 | Annotation score: | ||
A0A0B4J210 | A0A0B4J210_HUMAN | La-related protein 1 | LARP1 | 815 | Annotation score: | ||
H0YAN4 | H0YAN4_HUMAN | La-related protein 1 | LARP1 | 150 | Annotation score: | ||
H0YBM7 | H0YBM7_HUMAN | La-related protein 1 | LARP1 | 167 | Annotation score: | ||
H0YBR8 | H0YBR8_HUMAN | La-related protein 1 | LARP1 | 36 | Annotation score: | ||
H0YC33 | H0YC33_HUMAN | La-related protein 1 | LARP1 | 183 | Annotation score: | ||
E5RHK4 | E5RHK4_HUMAN | La-related protein 1 | LARP1 | 92 | Annotation score: | ||
H0YBJ5 | H0YBJ5_HUMAN | La-related protein 1 | LARP1 | 67 | Annotation score: | ||
There is more potential isoformShow all |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 778 – 780 | RNT → TRP in AAH33856 (PubMed:15489334).Curated | 3 | |
Sequence conflicti | 979 | V → L in CAB61364 (PubMed:17974005).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_015114 | 1 – 77 | Missing in isoform 2. 1 PublicationAdd BLAST | 77 | |
Alternative sequenceiVSP_015115 | 78 – 144 | PLQLP…NGQSP → MLWRVLLSKRPPFPHPELDF QEAPIPSCPGRLPGRKNSVA LAAAPRKEPTGDREKPLPFP VLAPFSN in isoform 2. 1 PublicationAdd BLAST | 67 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC001460 mRNA Translation: AAH01460.2 BC033856 mRNA Translation: AAH33856.1 Different initiation. AK091465 mRNA Translation: BAC03668.1 AB018274 mRNA Translation: BAA34451.1 Sequence problems. AL133034 mRNA Translation: CAB61364.1 |
CCDSi | CCDS4328.1 [Q6PKG0-3] |
PIRi | T42646 |
RefSeqi | NP_056130.2, NM_015315.4 [Q6PKG0-3] XP_005268461.1, XM_005268404.3 |
Genome annotation databases
Ensembli | ENST00000336314; ENSP00000336721; ENSG00000155506 [Q6PKG0-3] |
GeneIDi | 23367 |
KEGGi | hsa:23367 |
UCSCi | uc003lvo.4, human [Q6PKG0-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC001460 mRNA Translation: AAH01460.2 BC033856 mRNA Translation: AAH33856.1 Different initiation. AK091465 mRNA Translation: BAC03668.1 AB018274 mRNA Translation: BAA34451.1 Sequence problems. AL133034 mRNA Translation: CAB61364.1 |
CCDSi | CCDS4328.1 [Q6PKG0-3] |
PIRi | T42646 |
RefSeqi | NP_056130.2, NM_015315.4 [Q6PKG0-3] XP_005268461.1, XM_005268404.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4ZC4 | X-ray | 1.86 | A/B/C/D | 873-1023 | [»] | |
5C0V | X-ray | 2.20 | A/B/C/D | 873-1023 | [»] | |
5V4R | X-ray | 1.77 | A/B | 873-1023 | [»] | |
5V7C | X-ray | 2.59 | B | 873-1023 | [»] | |
5V87 | X-ray | 1.69 | A/B | 873-1023 | [»] | |
6PW3 | X-ray | 2.34 | A/B/C/D | 873-1023 | [»] | |
SMRi | Q6PKG0 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 116947, 193 interactors |
CORUMi | Q6PKG0 |
IntActi | Q6PKG0, 131 interactors |
MINTi | Q6PKG0 |
STRINGi | 9606.ENSP00000336721 |
PTM databases
CarbonylDBi | Q6PKG0 |
iPTMneti | Q6PKG0 |
PhosphoSitePlusi | Q6PKG0 |
SwissPalmi | Q6PKG0 |
Polymorphism and mutation databases
BioMutai | LARP1 |
DMDMi | 73621135 |
Proteomic databases
EPDi | Q6PKG0 |
jPOSTi | Q6PKG0 |
MassIVEi | Q6PKG0 |
MaxQBi | Q6PKG0 |
PaxDbi | Q6PKG0 |
PeptideAtlasi | Q6PKG0 |
PRIDEi | Q6PKG0 |
ProteomicsDBi | 67242 [Q6PKG0-1] 67243 [Q6PKG0-3] |
Protocols and materials databases
Antibodypediai | 28316, 125 antibodies |
DNASUi | 23367 |
Genome annotation databases
Ensembli | ENST00000336314; ENSP00000336721; ENSG00000155506 [Q6PKG0-3] |
GeneIDi | 23367 |
KEGGi | hsa:23367 |
UCSCi | uc003lvo.4, human [Q6PKG0-1] |
Organism-specific databases
CTDi | 23367 |
DisGeNETi | 23367 |
EuPathDBi | HostDB:ENSG00000155506.16 |
GeneCardsi | LARP1 |
HGNCi | HGNC:29531, LARP1 |
HPAi | ENSG00000155506, Low tissue specificity |
MIMi | 612059, gene |
neXtProti | NX_Q6PKG0 |
OpenTargetsi | ENSG00000155506 |
PharmGKBi | PA142671564 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2590, Eukaryota |
GeneTreei | ENSGT00940000159577 |
HOGENOMi | CLU_003957_1_0_1 |
InParanoidi | Q6PKG0 |
OMAi | PGWHPDN |
OrthoDBi | 258488at2759 |
PhylomeDBi | Q6PKG0 |
TreeFami | TF314516 |
Enzyme and pathway databases
PathwayCommonsi | Q6PKG0 |
SIGNORi | Q6PKG0 |
Miscellaneous databases
BioGRID-ORCSi | 23367, 112 hits in 853 CRISPR screens |
ChiTaRSi | LARP1, human |
GeneWikii | LARP1 |
GenomeRNAii | 23367 |
Pharosi | Q6PKG0, Tbio |
PROi | PR:Q6PKG0 |
RNActi | Q6PKG0, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000155506, Expressed in female gonad and 263 other tissues |
ExpressionAtlasi | Q6PKG0, baseline and differential |
Genevisiblei | Q6PKG0, HS |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR006607, DM15 IPR006630, La_HTH IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF05383, La, 1 hit |
SMARTi | View protein in SMART SM00684, DM15, 3 hits SM00715, LA, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS50961, HTH_LA, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LARP1_HUMAN | |
Accessioni | Q6PKG0Primary (citable) accession number: Q6PKG0 Secondary accession number(s): O94836 Q9UFD7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 16, 2005 |
Last sequence update: | August 16, 2005 | |
Last modified: | December 2, 2020 | |
This is version 168 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families