UniProtKB - Q6PK18 (OGFD3_HUMAN)
Protein
2-oxoglutarate and iron-dependent oxygenase domain-containing protein 3
Gene
OGFOD3
Organism
Homo sapiens (Human)
Status
Functioni
Cofactori
Protein has several cofactor binding sites:- Fe2+PROSITE-ProRule annotationNote: Binds 1 Fe2+ ion per subunit.PROSITE-ProRule annotation
- L-ascorbateBy similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 230 | IronPROSITE-ProRule annotation | 1 | |
Metal bindingi | 232 | IronPROSITE-ProRule annotation | 1 | |
Metal bindingi | 288 | IronPROSITE-ProRule annotation | 1 | |
Active sitei | 298 | Sequence analysis | 1 | |
Binding sitei | 298 | 2-oxoglutaratePROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- dioxygenase activity Source: UniProtKB-KW
- iron ion binding Source: InterPro
- L-ascorbic acid binding Source: UniProtKB-KW
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Source: InterPro
Keywordsi
Molecular function | Dioxygenase, Oxidoreductase |
Ligand | Iron, Metal-binding, Vitamin C |
Enzyme and pathway databases
PathwayCommonsi | Q6PK18 |
Names & Taxonomyi
Protein namesi | Recommended name: 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 3 (EC:1.14.11.-) |
Gene namesi | Name:OGFOD3 Synonyms:C17orf101 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000181396.12 |
HGNCi | HGNC:26174, OGFOD3 |
neXtProti | NX_Q6PK18 |
Subcellular locationi
Other locations
- Membrane Curated; Single-pass type II membrane protein Curated
Other locations
- integral component of membrane Source: UniProtKB-KW
- membrane Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 42 | CytoplasmicSequence analysisAdd BLAST | 42 | |
Transmembranei | 43 – 65 | Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST | 23 | |
Topological domaini | 66 – 319 | LumenalSequence analysisAdd BLAST | 254 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 79701 |
OpenTargetsi | ENSG00000181396 |
PharmGKBi | PA164716907 |
Miscellaneous databases
Pharosi | Q6PK18, Tdark |
Polymorphism and mutation databases
BioMutai | OGFOD3 |
DMDMi | 172046153 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000325885 | 1 – 319 | 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 3Add BLAST | 319 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 215 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
EPDi | Q6PK18 |
jPOSTi | Q6PK18 |
MassIVEi | Q6PK18 |
MaxQBi | Q6PK18 |
PaxDbi | Q6PK18 |
PeptideAtlasi | Q6PK18 |
PRIDEi | Q6PK18 |
ProteomicsDBi | 67230 [Q6PK18-1] 67231 [Q6PK18-2] |
PTM databases
GlyConnecti | 981, 3 N-Linked glycans (2 sites) |
GlyGeni | Q6PK18, 2 sites |
iPTMneti | Q6PK18 |
PhosphoSitePlusi | Q6PK18 |
Expressioni
Gene expression databases
Bgeei | ENSG00000181396, Expressed in parotid gland and 223 other tissues |
ExpressionAtlasi | Q6PK18, baseline and differential |
Genevisiblei | Q6PK18, HS |
Organism-specific databases
HPAi | ENSG00000181396, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 122821, 13 interactors |
IntActi | Q6PK18, 7 interactors |
STRINGi | 9606.ENSP00000330075 |
Miscellaneous databases
RNActi | Q6PK18, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 207 – 309 | Fe2OG dioxygenasePROSITE-ProRule annotationAdd BLAST | 103 |
Sequence similaritiesi
Belongs to the OGFOD3 family.Curated
Keywords - Domaini
Signal-anchor, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QR2P, Eukaryota |
GeneTreei | ENSGT00390000005895 |
HOGENOMi | CLU_042482_0_0_1 |
InParanoidi | Q6PK18 |
OMAi | SFTCNPD |
OrthoDBi | 674380at2759 |
PhylomeDBi | Q6PK18 |
TreeFami | TF329031 |
Family and domain databases
InterProi | View protein in InterPro IPR039210, OGFOD3 IPR005123, Oxoglu/Fe-dep_dioxygenase IPR006620, Pro_4_hyd_alph |
PANTHERi | PTHR14650, PTHR14650, 1 hit |
Pfami | View protein in Pfam PF13640, 2OG-FeII_Oxy_3, 1 hit |
SMARTi | View protein in SMART SM00702, P4Hc, 1 hit |
PROSITEi | View protein in PROSITE PS51471, FE2OG_OXY, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q6PK18-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAPQRRAATK APEGNGAAER RNRSSTKKDR APREVQRLWQ RPWLRTAGLG
60 70 80 90 100
AGFVLTALLL WSSLGADDGV AEVLARRGEV VAGRFIEVPC SEDYDSHRRF
110 120 130 140 150
EGCTPRKCGR GVTDVVITRE EAERIRSVAE KGLSLGGSDG GASILDLHSG
160 170 180 190 200
ALSVGKHFVN LYRYFGDKIQ NIFSEEDFRL YREVRQKVQL TIAEAFGISA
210 220 230 240 250
SSLHLTKPTF FSRINSTEAR TAHDEYWHAH VDKVTYGSFD YTSLLYLSNY
260 270 280 290 300
LEDFGGGRFM FMEEGANKTV EPRAGRVSFF TSGSENLHRV EKVHWGTRYA
310
ITIAFSCNPD HGIEDPAFP
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketJ3QLI8 | J3QLI8_HUMAN | 2-oxoglutarate and iron-dependent o... | OGFOD3 | 126 | Annotation score: | ||
J3QRG1 | J3QRG1_HUMAN | 2-oxoglutarate and iron-dependent o... | OGFOD3 | 241 | Annotation score: | ||
K7ELK1 | K7ELK1_HUMAN | 2-oxoglutarate and iron-dependent o... | OGFOD3 | 95 | Annotation score: | ||
K7ENS7 | K7ENS7_HUMAN | 2-oxoglutarate and iron-dependent o... | OGFOD3 | 219 | Annotation score: | ||
K7ELR2 | K7ELR2_HUMAN | 2-oxoglutarate and iron-dependent o... | OGFOD3 | 15 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Isoform 2 (identifier: Q6PK18-2) | |||||
Sequence conflicti | 314 | P → S in AAH08897 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_039948 | 67 | D → E. Corresponds to variant dbSNP:rs8072110Ensembl. | 1 | |
Natural variantiVAR_039949 | 272 | P → R1 PublicationCorresponds to variant dbSNP:rs17852152Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_032462 | 276 – 319 | RVSFF…DPAFP → CFCFRMMSCGFQEVNGPRAS EAAGAKAGVRCPPGTHHPPE RGETHAILEAESIAYC in isoform 2. 1 PublicationAdd BLAST | 44 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK025875 mRNA Translation: BAB15267.1 AC132938 Genomic DNA No translation available. BC008897 mRNA Translation: AAH08897.1 BC023602 mRNA Translation: AAH23602.1 |
CCDSi | CCDS11811.1 [Q6PK18-1] CCDS11812.1 [Q6PK18-2] |
RefSeqi | NP_078924.1, NM_024648.2 [Q6PK18-1] NP_787098.3, NM_175902.4 [Q6PK18-2] |
Genome annotation databases
Ensembli | ENST00000313056; ENSP00000320116; ENSG00000181396 [Q6PK18-1] ENST00000329197; ENSP00000330075; ENSG00000181396 [Q6PK18-2] |
GeneIDi | 79701 |
KEGGi | hsa:79701 |
UCSCi | uc002ket.3, human [Q6PK18-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK025875 mRNA Translation: BAB15267.1 AC132938 Genomic DNA No translation available. BC008897 mRNA Translation: AAH08897.1 BC023602 mRNA Translation: AAH23602.1 |
CCDSi | CCDS11811.1 [Q6PK18-1] CCDS11812.1 [Q6PK18-2] |
RefSeqi | NP_078924.1, NM_024648.2 [Q6PK18-1] NP_787098.3, NM_175902.4 [Q6PK18-2] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 122821, 13 interactors |
IntActi | Q6PK18, 7 interactors |
STRINGi | 9606.ENSP00000330075 |
PTM databases
GlyConnecti | 981, 3 N-Linked glycans (2 sites) |
GlyGeni | Q6PK18, 2 sites |
iPTMneti | Q6PK18 |
PhosphoSitePlusi | Q6PK18 |
Polymorphism and mutation databases
BioMutai | OGFOD3 |
DMDMi | 172046153 |
Proteomic databases
EPDi | Q6PK18 |
jPOSTi | Q6PK18 |
MassIVEi | Q6PK18 |
MaxQBi | Q6PK18 |
PaxDbi | Q6PK18 |
PeptideAtlasi | Q6PK18 |
PRIDEi | Q6PK18 |
ProteomicsDBi | 67230 [Q6PK18-1] 67231 [Q6PK18-2] |
Protocols and materials databases
Antibodypediai | 63655, 14 antibodies |
Genome annotation databases
Ensembli | ENST00000313056; ENSP00000320116; ENSG00000181396 [Q6PK18-1] ENST00000329197; ENSP00000330075; ENSG00000181396 [Q6PK18-2] |
GeneIDi | 79701 |
KEGGi | hsa:79701 |
UCSCi | uc002ket.3, human [Q6PK18-1] |
Organism-specific databases
CTDi | 79701 |
DisGeNETi | 79701 |
EuPathDBi | HostDB:ENSG00000181396.12 |
GeneCardsi | OGFOD3 |
HGNCi | HGNC:26174, OGFOD3 |
HPAi | ENSG00000181396, Low tissue specificity |
neXtProti | NX_Q6PK18 |
OpenTargetsi | ENSG00000181396 |
PharmGKBi | PA164716907 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QR2P, Eukaryota |
GeneTreei | ENSGT00390000005895 |
HOGENOMi | CLU_042482_0_0_1 |
InParanoidi | Q6PK18 |
OMAi | SFTCNPD |
OrthoDBi | 674380at2759 |
PhylomeDBi | Q6PK18 |
TreeFami | TF329031 |
Enzyme and pathway databases
PathwayCommonsi | Q6PK18 |
Miscellaneous databases
BioGRID-ORCSi | 79701, 5 hits in 840 CRISPR screens |
ChiTaRSi | OGFOD3, human |
GenomeRNAii | 79701 |
Pharosi | Q6PK18, Tdark |
PROi | PR:Q6PK18 |
RNActi | Q6PK18, protein |
Gene expression databases
Bgeei | ENSG00000181396, Expressed in parotid gland and 223 other tissues |
ExpressionAtlasi | Q6PK18, baseline and differential |
Genevisiblei | Q6PK18, HS |
Family and domain databases
InterProi | View protein in InterPro IPR039210, OGFOD3 IPR005123, Oxoglu/Fe-dep_dioxygenase IPR006620, Pro_4_hyd_alph |
PANTHERi | PTHR14650, PTHR14650, 1 hit |
Pfami | View protein in Pfam PF13640, 2OG-FeII_Oxy_3, 1 hit |
SMARTi | View protein in SMART SM00702, P4Hc, 1 hit |
PROSITEi | View protein in PROSITE PS51471, FE2OG_OXY, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | OGFD3_HUMAN | |
Accessioni | Q6PK18Primary (citable) accession number: Q6PK18 Secondary accession number(s): C9JDC8, Q8IZ37, Q9H6J2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 18, 2008 |
Last sequence update: | March 18, 2008 | |
Last modified: | December 2, 2020 | |
This is version 126 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - SIMILARITY comments
Index of protein domains and families - Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations