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Protein

2-oxoglutarate and iron-dependent oxygenase domain-containing protein 3

Gene

OGFOD3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cofactori

Protein has several cofactor binding sites:
  • Fe2+PROSITE-ProRule annotationNote: Binds 1 Fe2+ ion per subunit.PROSITE-ProRule annotation
  • L-ascorbateBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi230IronPROSITE-ProRule annotation1
Metal bindingi232IronPROSITE-ProRule annotation1
Metal bindingi288IronPROSITE-ProRule annotation1
Active sitei298Sequence analysis1
Binding sitei2982-oxoglutaratePROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionDioxygenase, Oxidoreductase
LigandIron, Metal-binding, Vitamin C

Names & Taxonomyi

Protein namesi
Recommended name:
2-oxoglutarate and iron-dependent oxygenase domain-containing protein 3 (EC:1.14.11.-)
Gene namesi
Name:OGFOD3
Synonyms:C17orf101
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000181396.12
HGNCiHGNC:26174 OGFOD3
neXtProtiNX_Q6PK18

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 42CytoplasmicSequence analysisAdd BLAST42
Transmembranei43 – 65Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST23
Topological domaini66 – 319LumenalSequence analysisAdd BLAST254

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000181396
PharmGKBiPA164716907

Polymorphism and mutation databases

BioMutaiOGFOD3
DMDMi172046153

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003258851 – 3192-oxoglutarate and iron-dependent oxygenase domain-containing protein 3Add BLAST319

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi215N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ6PK18
MaxQBiQ6PK18
PaxDbiQ6PK18
PeptideAtlasiQ6PK18
PRIDEiQ6PK18
ProteomicsDBi67230
67231 [Q6PK18-2]

PTM databases

iPTMnetiQ6PK18
PhosphoSitePlusiQ6PK18

Expressioni

Gene expression databases

BgeeiENSG00000181396
ExpressionAtlasiQ6PK18 baseline and differential
GenevisibleiQ6PK18 HS

Organism-specific databases

HPAiHPA052099

Interactioni

Protein-protein interaction databases

BioGridi122821, 13 interactors
IntActiQ6PK18, 2 interactors
STRINGi9606.ENSP00000330075

Structurei

3D structure databases

ProteinModelPortaliQ6PK18
SMRiQ6PK18
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini207 – 309Fe2OG dioxygenasePROSITE-ProRule annotationAdd BLAST103

Sequence similaritiesi

Belongs to the OGFOD3 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHR9 Eukaryota
ENOG410ZI9Q LUCA
GeneTreeiENSGT00390000005895
HOGENOMiHOG000007407
InParanoidiQ6PK18
OMAiTIHDEYW
OrthoDBiEOG091G0JBD
PhylomeDBiQ6PK18
TreeFamiTF329031

Family and domain databases

InterProiView protein in InterPro
IPR039210 OGFOD3
IPR005123 Oxoglu/Fe-dep_dioxygenase
IPR006620 Pro_4_hyd_alph
PANTHERiPTHR14650 PTHR14650, 1 hit
PfamiView protein in Pfam
PF13640 2OG-FeII_Oxy_3, 1 hit
SMARTiView protein in SMART
SM00702 P4Hc, 1 hit
PROSITEiView protein in PROSITE
PS51471 FE2OG_OXY, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6PK18-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPQRRAATK APEGNGAAER RNRSSTKKDR APREVQRLWQ RPWLRTAGLG
60 70 80 90 100
AGFVLTALLL WSSLGADDGV AEVLARRGEV VAGRFIEVPC SEDYDSHRRF
110 120 130 140 150
EGCTPRKCGR GVTDVVITRE EAERIRSVAE KGLSLGGSDG GASILDLHSG
160 170 180 190 200
ALSVGKHFVN LYRYFGDKIQ NIFSEEDFRL YREVRQKVQL TIAEAFGISA
210 220 230 240 250
SSLHLTKPTF FSRINSTEAR TAHDEYWHAH VDKVTYGSFD YTSLLYLSNY
260 270 280 290 300
LEDFGGGRFM FMEEGANKTV EPRAGRVSFF TSGSENLHRV EKVHWGTRYA
310
ITIAFSCNPD HGIEDPAFP
Length:319
Mass (Da):35,646
Last modified:March 18, 2008 - v2
Checksum:i02F7FD0D5BA715B7
GO
Isoform 2 (identifier: Q6PK18-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     276-319: RVSFFTSGSE...DHGIEDPAFP → CFCFRMMSCG...ILEAESIAYC

Note: No experimental confirmation available.Curated
Show »
Length:331
Mass (Da):36,635
Checksum:i34B21A027FE805EE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Isoform 2 (identifier: Q6PK18-2)
Sequence conflicti314P → S in AAH08897 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03994867D → E. Corresponds to variant dbSNP:rs8072110Ensembl.1
Natural variantiVAR_039949272P → R1 PublicationCorresponds to variant dbSNP:rs17852152Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_032462276 – 319RVSFF…DPAFP → CFCFRMMSCGFQEVNGPRAS EAAGAKAGVRCPPGTHHPPE RGETHAILEAESIAYC in isoform 2. 1 PublicationAdd BLAST44

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK025875 mRNA Translation: BAB15267.1
AC132938 Genomic DNA No translation available.
BC008897 mRNA Translation: AAH08897.1
BC023602 mRNA Translation: AAH23602.1
CCDSiCCDS11811.1 [Q6PK18-1]
CCDS11812.1 [Q6PK18-2]
RefSeqiNP_078924.1, NM_024648.2 [Q6PK18-1]
NP_787098.3, NM_175902.4 [Q6PK18-2]
UniGeneiHs.187505

Genome annotation databases

EnsembliENST00000313056; ENSP00000320116; ENSG00000181396 [Q6PK18-1]
ENST00000329197; ENSP00000330075; ENSG00000181396 [Q6PK18-2]
GeneIDi79701
KEGGihsa:79701
UCSCiuc002ket.3 human [Q6PK18-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiOGFD3_HUMAN
AccessioniPrimary (citable) accession number: Q6PK18
Secondary accession number(s): C9JDC8, Q8IZ37, Q9H6J2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: July 18, 2018
This is version 112 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

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