Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Coiled-coil domain-containing protein 137

Gene

CCDC137

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 137
Gene namesi
Name:CCDC137
Synonyms:cPERP-B1 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000185298.12
HGNCiHGNC:33451 CCDC137
neXtProtiNX_Q6PK04

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome

Pathology & Biotechi

Organism-specific databases

DisGeNETi339230
OpenTargetsiENSG00000185298
PharmGKBiPA162381422

Polymorphism and mutation databases

BioMutaiCCDC137
DMDMi74737969

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002884521 – 289Coiled-coil domain-containing protein 137Add BLAST289

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei19PhosphoserineCombined sources1
Modified residuei233PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6PK04
MaxQBiQ6PK04
PaxDbiQ6PK04
PeptideAtlasiQ6PK04
PRIDEiQ6PK04
ProteomicsDBi67229

PTM databases

iPTMnetiQ6PK04
PhosphoSitePlusiQ6PK04

Expressioni

Gene expression databases

BgeeiENSG00000185298 Expressed in 173 organ(s), highest expression level in lower esophagus mucosa
CleanExiHS_CCDC137
ExpressionAtlasiQ6PK04 baseline and differential
GenevisibleiQ6PK04 HS

Organism-specific databases

HPAiHPA052637
HPA053914

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TERF2Q155542EBI-714654,EBI-706637

Protein-protein interaction databases

BioGridi130846, 43 interactors
IntActiQ6PK04, 9 interactors
STRINGi9606.ENSP00000329360

Structurei

3D structure databases

ProteinModelPortaliQ6PK04
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili155 – 197Sequence analysisAdd BLAST43
Coiled coili247 – 273Sequence analysisAdd BLAST27

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IENS Eukaryota
ENOG4111TSW LUCA
GeneTreeiENSGT00390000004169
HOGENOMiHOG000111387
HOVERGENiHBG090761
InParanoidiQ6PK04
PhylomeDBiQ6PK04
TreeFamiTF332311

Family and domain databases

InterProiView protein in InterPro
IPR026680 CCDC137
PANTHERiPTHR21838 PTHR21838, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.iShow all

Q6PK04-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGAGRGAAV SRVQAGPGSP RRARGRQQVQ PLGKQRPAPW PGLRSKEKKK
60 70 80 90 100
VNCKPKNQDE QEIPFRLREI MRSRQEMKNP ISNKKRKKAA QVTFRKTLEK
110 120 130 140 150
EAKGEEPDIA VPKFKQRKGE SDGAYIHRMQ QEAQHVLFLS KNQAIRQPEV
160 170 180 190 200
QAAPKEKSEQ KKAKKAFQKR RLDKVRRKKE EKAADRLEQE LLRDTVKFGE
210 220 230 240 250
VVLQPPELTA RPQRSVSKDQ PGRRSQMLRM LLSPGGVSQP LTASLARQRI
260 270 280
VEEERERAVQ AYRALKQRQQ QLHGERPHLT SRKKPEPQL
Length:289
Mass (Da):33,231
Last modified:July 5, 2004 - v1
Checksum:iB8C4E6EC64360771
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I3L0U5I3L0U5_HUMAN
Coiled-coil domain-containing prote...
CCDC137
292Annotation score:
I3L4F6I3L4F6_HUMAN
Coiled-coil domain-containing prote...
CCDC137
44Annotation score:
I3L385I3L385_HUMAN
Coiled-coil domain-containing prote...
CCDC137
61Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050739127H → Q. Corresponds to variant dbSNP:rs7226091Ensembl.1
Natural variantiVAR_050740177R → W. Corresponds to variant dbSNP:rs11150805Ensembl.1
Natural variantiVAR_050741229R → Q. Corresponds to variant dbSNP:rs11546630Ensembl.1
Natural variantiVAR_061582282R → W. Corresponds to variant dbSNP:rs11546631Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC009369 mRNA Translation: AAH09369.1
CCDSiCCDS42400.1
RefSeqiNP_954981.1, NM_199287.2
UniGeneiHs.744125

Genome annotation databases

EnsembliENST00000329214; ENSP00000329360; ENSG00000185298
ENST00000575223; ENSP00000458884; ENSG00000185298
GeneIDi339230
KEGGihsa:339230
UCSCiuc002kbc.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCC137_HUMAN
AccessioniPrimary (citable) accession number: Q6PK04
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: July 5, 2004
Last modified: September 12, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again