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Entry version 130 (02 Dec 2020)
Sequence version 3 (11 Jan 2011)
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Protein

Consortin

Gene

CNST

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for targeting of connexins to the plasma membrane.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q6PJW8

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Consortin
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CNST
Synonyms:C1orf71
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

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EuPathDBi
HostDB:ENSG00000162852.13

Human Gene Nomenclature Database

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HGNCi
HGNC:26486, CNST

Online Mendelian Inheritance in Man (OMIM)

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MIMi
613439, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6PJW8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 664CytoplasmicSequence analysisAdd BLAST664
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei665 – 685HelicalSequence analysisAdd BLAST21
Topological domaini686 – 725ExtracellularSequence analysisAdd BLAST40

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
163882

Open Targets

More...
OpenTargetsi
ENSG00000162852

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA165751017

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q6PJW8, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CNST

Domain mapping of disease mutations (DMDM)

More...
DMDMi
317373449

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002889061 – 725ConsortinAdd BLAST725

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q6PJW8

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6PJW8

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q6PJW8

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6PJW8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6PJW8

PeptideAtlas

More...
PeptideAtlasi
Q6PJW8

PRoteomics IDEntifications database

More...
PRIDEi
Q6PJW8

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
67225 [Q6PJW8-1]
67226 [Q6PJW8-2]
67227 [Q6PJW8-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6PJW8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6PJW8

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q6PJW8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000162852, Expressed in quadriceps femoris and 215 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6PJW8, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q6PJW8, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000162852, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with connexins GJA1/CX43, GJB1/CX32, GJB2/CX26, GJB3/CX31, GJB6/CX30 and GJC1/CX45.

Also interacts with GGA1 and GGA2. Does not interact with PANX1 (By similarity).

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
127882, 17 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
Q6PJW8

Protein interaction database and analysis system

More...
IntActi
Q6PJW8, 10 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000355470

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6PJW8, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CNST family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QSMS, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000005861

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_023107_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6PJW8

Identification of Orthologs from Complete Genome Data

More...
OMAi
IAPLMQE

Database of Orthologous Groups

More...
OrthoDBi
1451496at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6PJW8

TreeFam database of animal gene trees

More...
TreeFami
TF351172

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR042318, Consortin
IPR028129, Consortin_C

The PANTHER Classification System

More...
PANTHERi
PTHR28581, PTHR28581, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15281, Consortin_C, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6PJW8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDDSDTPTYY LQIEPQDGCH PGDSVERSVT CLPSASDENE NQLDGDGHEH
60 70 80 90 100
LTSSDSAMGK PQVSEQDSLN NNESCTLSCE VAAGENLQNT LCEASRDEQA
110 120 130 140 150
FLGKDKKIPG KRSPRSKKGT AKKIPPGLFS GDIAPLMQEK VLSAVTYAVD
160 170 180 190 200
DEEAAEVNAN EQPEAPKLVL QSLFSLIRGE VEQLDSRALP LCLHQIAESY
210 220 230 240 250
FQEEDYEKAM KFIQLERLYH EQLLANLSAI QEQWETKWKT VQPHTVTALR
260 270 280 290 300
NSEKGFNGED FERLTKICAT HQDPLLSKHK IAAVEKSQER KCSTQLLVSE
310 320 330 340 350
DPKEGGATTK ESESKTCLGT ESSKESQHTV EPLGSSPCCH QMDVQTDSPS
360 370 380 390 400
LSVTAGKDHM EELLCSAEAT LALHTQSSET AGSPSGPDSS EDACEDDSRL
410 420 430 440 450
QLAQTEACQD VARIEGIAED PKVFLSSKSK TEPLISPGCD RIPPALISEG
460 470 480 490 500
KYSQAQRKEL RLPLRDASEA LPTDQLENNE LNELQQPDLT DSDGKSPQAQ
510 520 530 540 550
ADSDGSENVL CGNNQISDLG ILLPEVCMAP EEKGDKDDQL NKETEDYLNS
560 570 580 590 600
LLEGCLKDTE DSLSYEDNQD DDSDLLQDLS PEEASYSLQE NLPSDESCLS
610 620 630 640 650
LDDLAKRIEI AEVVPTEGLV SILKKRNDTV GDHPAQMQHK PSKRRVRFQE
660 670 680 690 700
IDDSLDQDEV GGGSCILLVL LCIATVFLSV GGTALYCTFG DMESPVCTDF
710 720
ADNMDFYYTK LLQGVAELKH WIYLS
Length:725
Mass (Da):79,597
Last modified:January 11, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC32AF9E17D98C389
GO
Isoform 2 (identifier: Q6PJW8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     614-616: VPT → NQR
     617-725: Missing.

Show »
Length:616
Mass (Da):67,541
Checksum:i393E0FF7F5443B97
GO
Isoform 3 (identifier: Q6PJW8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     235-263: ETKWKTVQPHTVTALRNSEKGFNGEDFER → GKYRPTWNVELAVIQQVTIYKINIFDLVL
     264-725: Missing.

Show »
Length:263
Mass (Da):29,306
Checksum:i0766B36B9C03DB68
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1AQM9B1AQM9_HUMAN
Consortin
CNST
137Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB84968 differs from that shown. Reason: Frameshift.Curated
The sequence BAC03735 differs from that shown. Reason: Frameshift.Curated
The sequence CAD38922 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti246V → L in BAB84968 (PubMed:14702039).Curated1
Sequence conflicti331E → Q in CAD38922 (PubMed:17974005).Curated1
Sequence conflicti393 – 394AC → GR in CAD38922 (PubMed:17974005).Curated2
Sequence conflicti689F → L in BAC03735 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03253028S → N. Corresponds to variant dbSNP:rs35286882Ensembl.1
Natural variantiVAR_03253187L → S3 PublicationsCorresponds to variant dbSNP:rs6702823Ensembl.1
Natural variantiVAR_056762183Q → R. Corresponds to variant dbSNP:rs12091148Ensembl.1
Natural variantiVAR_032532399R → C. Corresponds to variant dbSNP:rs12075111Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_025817235 – 263ETKWK…EDFER → GKYRPTWNVELAVIQQVTIY KINIFDLVL in isoform 3. 1 PublicationAdd BLAST29
Alternative sequenceiVSP_025818264 – 725Missing in isoform 3. 1 PublicationAdd BLAST462
Alternative sequenceiVSP_025819614 – 616VPT → NQR in isoform 2. 1 Publication3
Alternative sequenceiVSP_025820617 – 725Missing in isoform 2. 1 PublicationAdd BLAST109

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK056563 mRNA Translation: BAB71218.1
AK074142 mRNA Translation: BAB84968.1 Frameshift.
AK091739 mRNA Translation: BAC03735.1 Frameshift.
AL834246 mRNA Translation: CAD38922.2 Different initiation.
AL591623 Genomic DNA No translation available.
AL646019 Genomic DNA No translation available.
BC010228 mRNA Translation: AAH10228.1
BC036200 mRNA Translation: AAH36200.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS1628.1 [Q6PJW8-1]
CCDS44343.1 [Q6PJW8-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001132931.1, NM_001139459.1 [Q6PJW8-2]
NP_689822.2, NM_152609.2 [Q6PJW8-1]
XP_005273138.2, XM_005273081.3 [Q6PJW8-1]
XP_011542412.1, XM_011544110.2 [Q6PJW8-1]
XP_011542413.1, XM_011544111.1 [Q6PJW8-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000366512; ENSP00000355469; ENSG00000162852 [Q6PJW8-2]
ENST00000366513; ENSP00000355470; ENSG00000162852 [Q6PJW8-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
163882

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:163882

UCSC genome browser

More...
UCSCi
uc001ibo.5, human [Q6PJW8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056563 mRNA Translation: BAB71218.1
AK074142 mRNA Translation: BAB84968.1 Frameshift.
AK091739 mRNA Translation: BAC03735.1 Frameshift.
AL834246 mRNA Translation: CAD38922.2 Different initiation.
AL591623 Genomic DNA No translation available.
AL646019 Genomic DNA No translation available.
BC010228 mRNA Translation: AAH10228.1
BC036200 mRNA Translation: AAH36200.1
CCDSiCCDS1628.1 [Q6PJW8-1]
CCDS44343.1 [Q6PJW8-2]
RefSeqiNP_001132931.1, NM_001139459.1 [Q6PJW8-2]
NP_689822.2, NM_152609.2 [Q6PJW8-1]
XP_005273138.2, XM_005273081.3 [Q6PJW8-1]
XP_011542412.1, XM_011544110.2 [Q6PJW8-1]
XP_011542413.1, XM_011544111.1 [Q6PJW8-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi127882, 17 interactors
ELMiQ6PJW8
IntActiQ6PJW8, 10 interactors
STRINGi9606.ENSP00000355470

PTM databases

iPTMnetiQ6PJW8
PhosphoSitePlusiQ6PJW8
SwissPalmiQ6PJW8

Polymorphism and mutation databases

BioMutaiCNST
DMDMi317373449

Proteomic databases

EPDiQ6PJW8
jPOSTiQ6PJW8
MassIVEiQ6PJW8
MaxQBiQ6PJW8
PaxDbiQ6PJW8
PeptideAtlasiQ6PJW8
PRIDEiQ6PJW8
ProteomicsDBi67225 [Q6PJW8-1]
67226 [Q6PJW8-2]
67227 [Q6PJW8-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
2026, 17 antibodies

The DNASU plasmid repository

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DNASUi
163882

Genome annotation databases

EnsembliENST00000366512; ENSP00000355469; ENSG00000162852 [Q6PJW8-2]
ENST00000366513; ENSP00000355470; ENSG00000162852 [Q6PJW8-1]
GeneIDi163882
KEGGihsa:163882
UCSCiuc001ibo.5, human [Q6PJW8-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
163882
DisGeNETi163882
EuPathDBiHostDB:ENSG00000162852.13

GeneCards: human genes, protein and diseases

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GeneCardsi
CNST
HGNCiHGNC:26486, CNST
HPAiENSG00000162852, Low tissue specificity
MIMi613439, gene
neXtProtiNX_Q6PJW8
OpenTargetsiENSG00000162852
PharmGKBiPA165751017

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG502QSMS, Eukaryota
GeneTreeiENSGT00390000005861
HOGENOMiCLU_023107_0_0_1
InParanoidiQ6PJW8
OMAiIAPLMQE
OrthoDBi1451496at2759
PhylomeDBiQ6PJW8
TreeFamiTF351172

Enzyme and pathway databases

PathwayCommonsiQ6PJW8

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
163882, 4 hits in 844 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CNST, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
C1orf71

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
163882
PharosiQ6PJW8, Tdark

Protein Ontology

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PROi
PR:Q6PJW8
RNActiQ6PJW8, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000162852, Expressed in quadriceps femoris and 215 other tissues
ExpressionAtlasiQ6PJW8, baseline and differential
GenevisibleiQ6PJW8, HS

Family and domain databases

InterProiView protein in InterPro
IPR042318, Consortin
IPR028129, Consortin_C
PANTHERiPTHR28581, PTHR28581, 1 hit
PfamiView protein in Pfam
PF15281, Consortin_C, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCNST_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6PJW8
Secondary accession number(s): Q5VSY9
, Q5VTM7, Q8IYA9, Q8N3L5, Q8NB09, Q8TEI2, Q96MR5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: January 11, 2011
Last modified: December 2, 2020
This is version 130 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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