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Entry version 151 (16 Oct 2019)
Sequence version 1 (05 Jul 2004)
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Protein

Zinc finger CCCH domain-containing protein 14

Gene

ZC3H14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in poly(A) tail length control in neuronal cells. Binds the polyadenosine RNA oligonucleotides.2 Publications

Miscellaneous

ZC3H14 can functionally substitute for Nab2 in fly neurons and can rescue defects in development and locomotion that are present in dNab2 null flies.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri595 – 620C3H1-type 1PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri621 – 640C3H1-type 2PROSITE-ProRule annotationAdd BLAST20
Zinc fingeri641 – 656C3H1-type 3PROSITE-ProRule annotationAdd BLAST16
Zinc fingeri682 – 699C3H1-type 4PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri701 – 719C3H1-type 5PROSITE-ProRule annotationAdd BLAST19

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger CCCH domain-containing protein 14
Alternative name(s):
Mammalian suppressor of tau pathology-2
Short name:
MSUT-2
Renal carcinoma antigen NY-REN-37
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZC3H14
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:20509 ZC3H14

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
613279 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6PJT7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Mental retardation, autosomal recessive 56 (MRT56)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of mental retardation, a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period.
Related information in OMIM

Keywords - Diseasei

Mental retardation

Organism-specific databases

DisGeNET

More...
DisGeNETi
79882

MalaCards human disease database

More...
MalaCardsi
ZC3H14
MIMi617125 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000100722

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
88616 Autosomal recessive non-syndromic intellectual disability

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA145007270

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q6PJT7

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZC3H14

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74737935

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003313111 – 736Zinc finger CCCH domain-containing protein 14Add BLAST736

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei85PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki99Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki139Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki175Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki198Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei240PhosphoserineCombined sources1
Cross-linki245Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei281PhosphoserineCombined sources1
Cross-linki283Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki295Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei327PhosphoserineCombined sources1
Modified residuei343PhosphoserineCombined sources1
Modified residuei357N6-acetyllysine; alternateCombined sources1
Cross-linki357Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Cross-linki378Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei390PhosphoserineCombined sources1
Modified residuei409PhosphoserineCombined sources1
Cross-linki413Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei421PhosphoserineCombined sources1
Cross-linki489Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei498PhosphoserineCombined sources1
Modified residuei515PhosphoserineCombined sources1
Modified residuei527PhosphoserineBy similarity1
Modified residuei620PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q6PJT7

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6PJT7

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q6PJT7

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6PJT7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6PJT7

PeptideAtlas

More...
PeptideAtlasi
Q6PJT7

PRoteomics IDEntifications database

More...
PRIDEi
Q6PJT7

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
33599
67217 [Q6PJT7-1]
67218 [Q6PJT7-2]
67219 [Q6PJT7-3]
67220 [Q6PJT7-4]
67221 [Q6PJT7-5]
67222 [Q6PJT7-6]
67223 [Q6PJT7-8]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6PJT7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6PJT7

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q6PJT7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 1 and isoform 6 are expressed in fetal and adult brain. Isoform 1 and isoform 6 are expressed in fetal and adult temporal lobe.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000100722 Expressed in 227 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6PJT7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6PJT7 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA049798
HPA053510

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with HOOK2 (PubMed:19273536).

Interacts with ZFC3H1 in a RNase-sensitive manner (PubMed:27871484).

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
DDIT3P35638-23EBI-740660,EBI-10173632

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
122967, 69 interactors

Protein interaction database and analysis system

More...
IntActi
Q6PJT7, 48 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000251038

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6PJT7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ZC3H14 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri595 – 620C3H1-type 1PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri621 – 640C3H1-type 2PROSITE-ProRule annotationAdd BLAST20
Zinc fingeri641 – 656C3H1-type 3PROSITE-ProRule annotationAdd BLAST16
Zinc fingeri682 – 699C3H1-type 4PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri701 – 719C3H1-type 5PROSITE-ProRule annotationAdd BLAST19

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3702 Eukaryota
ENOG410YE77 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00440000038430

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000074062

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6PJT7

KEGG Orthology (KO)

More...
KOi
K23038

Identification of Orthologs from Complete Genome Data

More...
OMAi
ESMVHTD

Database of Orthologous Groups

More...
OrthoDBi
893844at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6PJT7

TreeFam database of animal gene trees

More...
TreeFami
TF329509

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR040366 Nab2/ZC3H14
IPR000571 Znf_CCCH

The PANTHER Classification System

More...
PANTHERi
PTHR14738 PTHR14738, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00356 ZnF_C3H1, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50103 ZF_C3H1, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (10+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 10 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 10 described isoforms and 15 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6PJT7-1) [UniParc]FASTAAdd to basket
Also known as: Isoform 1

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEIGTEISRK IRSAIKGKLQ ELGAYVDEEL PDYIMVMVAN KKSQDQMTED
60 70 80 90 100
LSLFLGNNTI RFTVWLHGVL DKLRSVTTEP SSLKSSDTNI FDSNVPSNKS
110 120 130 140 150
NFSRGDERRH EAAVPPLAIP SARPEKRDSR VSTSSQESKT TNVRQTYDDG
160 170 180 190 200
AATRLMSTVK PLREPAPSED VIDIKPEPDD LIDEDLNFVQ ENPLSQKKPT
210 220 230 240 250
VTLTYGSSRP SIEIYRPPAS RNADSGVHLN RLQFQQQQNS IHAAKQLDMQ
260 270 280 290 300
SSWVYETGRL CEPEVLNSLE ETYSPFFRNN SEKMSMEDEN FRKRKLPVVS
310 320 330 340 350
SVVKVKKFNH DGEEEEEDDD YGSRTGSISS SVSVPAKPER RPSLPPSKQA
360 370 380 390 400
NKNLILKAIS EAQESVTKTT NYSTVPQKQT LPVAPRTRTS QEELLAEVVQ
410 420 430 440 450
GQSRTPRISP PIKEEETKGD SVEKNQGTQQ RQLLSRLQID PVMAETLQMS
460 470 480 490 500
QDYYDMESMV HADTRSFILK KPKLSEEVVV APNQESGMKT ADSLRVLSGH
510 520 530 540 550
LMQTRDLVQP DKPASPKFIV TLDGVPSPPG YMSDQEEDMC FEGMKPVNQT
560 570 580 590 600
AASNKGLRGL LHPQQLHLLS RQLEDPNGSF SNAEMSELSV AQKPEKLLER
610 620 630 640 650
CKYWPACKNG DECAYHHPIS PCKAFPNCKF AEKCLFVHPN CKYDAKCTKP
660 670 680 690 700
DCPFTHVSRR IPVLSPKPAV APPAPPSSSQ LCRYFPACKK MECPFYHPKH
710 720 730
CRFNTQCTRP DCTFYHPTIN VPPRHALKWI RPQTSE
Length:736
Mass (Da):82,876
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBCF3E36CBA66170A
GO
Isoform 2 (identifier: Q6PJT7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     669-669: Missing.

Show »
Length:735
Mass (Da):82,805
Checksum:i23DE4F1ECFAB49DE
GO
Isoform 3 (identifier: Q6PJT7-3) [UniParc]FASTAAdd to basket
Also known as: Isoform 2

The sequence of this isoform differs from the canonical sequence as follows:
     427-582: Missing.
     669-669: Missing.

Show »
Length:579
Mass (Da):65,425
Checksum:i9F97392E74A1F612
GO
Isoform 4 (identifier: Q6PJT7-4) [UniParc]FASTAAdd to basket
Also known as: Isoform 3 short

The sequence of this isoform differs from the canonical sequence as follows:
     1-34: Missing.
     452-582: Missing.

Show »
Length:571
Mass (Da):64,502
Checksum:i95D7DEA373BCA94B
GO
Isoform 5 (identifier: Q6PJT7-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     427-451: Missing.

Show »
Length:711
Mass (Da):80,021
Checksum:i9D8B3AF17DC0FB13
GO
Isoform 6 (identifier: Q6PJT7-6) [UniParc]FASTAAdd to basket
Also known as: Isoform 4

The sequence of this isoform differs from the canonical sequence as follows:
     1-298: Missing.
     299-426: VSSVVKVKKF...TKGDSVEKNQ → MRMSSKFPSP...IIGFLRNVEK
     452-582: Missing.
     669-669: Missing.

Show »
Length:306
Mass (Da):34,867
Checksum:i6122BC10CFCE1D25
GO
Isoform 8 (identifier: Q6PJT7-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-454: Missing.
     455-582: DMESMVHADT...LEDPNGSFSN → MRMSSKFPSP...IIGFLRNVEK

Show »
Length:282
Mass (Da):32,084
Checksum:iD32BB78C85628238
GO
Isoform 9 (identifier: Q6PJT7-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     577-581: Missing.
     669-669: Missing.

Note: No experimental confirmation available.
Show »
Length:730
Mass (Da):82,312
Checksum:i667DAF346CBEB6A4
GO
Isoform 10 (identifier: Q6PJT7-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     123-159: Missing.
     427-582: Missing.

Note: No experimental confirmation available.
Show »
Length:543
Mass (Da):61,354
Checksum:i1FC746F7E0BB614C
GO
Isoform 11 (identifier: Q6PJT7-11) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     95-113: Missing.
     452-582: Missing.
     669-669: Missing.

Note: No experimental confirmation available.
Show »
Length:585
Mass (Da):66,140
Checksum:iE62A6DB4F267FEEE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 15 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V256G3V256_HUMAN
Zinc finger CCCH domain-containing ...
ZC3H14
605Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V5I6G3V5I6_HUMAN
Zinc finger CCCH domain-containing ...
ZC3H14
420Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YJA2H0YJA2_HUMAN
Zinc finger CCCH domain-containing ...
ZC3H14
651Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WTC9A0A087WTC9_HUMAN
Zinc finger CCCH domain-containing ...
ZC3H14
148Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V411G3V411_HUMAN
Nuclear protein UKp68, isoform CRA_...
ZC3H14 FLJ11806, hCG_21080
438Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YJ51H0YJ51_HUMAN
Zinc finger CCCH domain-containing ...
ZC3H14
151Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V240G3V240_HUMAN
Zinc finger CCCH domain-containing ...
ZC3H14
94Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V3Y4G3V3Y4_HUMAN
Zinc finger CCCH domain-containing ...
ZC3H14
215Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YJ87H0YJ87_HUMAN
Zinc finger CCCH domain-containing ...
ZC3H14
81Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V3R9G3V3R9_HUMAN
Zinc finger CCCH domain-containing ...
ZC3H14
209Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAL83289 differs from that shown. Several sequencing errors.Curated
The sequence AAS90302 differs from that shown. Aberrant splicing.Curated
The sequence AAS90302 differs from that shown. Reason: Frameshift.Curated
The sequence AK021868 differs from that shown. Reason: Frameshift.Curated
The sequence CAE45933 differs from that shown. Aberrant splicing.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti113A → V in BAG63510 (PubMed:14702039).Curated1
Sequence conflicti323S → P in BAG64229 (PubMed:14702039).Curated1
Sequence conflicti532M → V in BAG65136 (PubMed:14702039).Curated1
Sequence conflicti674A → V in AAH23641 (PubMed:15489334).Curated1
Sequence conflicti712C → F in AAS90302 (Ref. 2) Curated1
Sequence conflicti712C → F in CAE45933 (PubMed:17974005).Curated1
Sequence conflicti718T → P in BAG65136 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0331621 – 454Missing in isoform 8. 1 PublicationAdd BLAST454
Alternative sequenceiVSP_0331631 – 298Missing in isoform 6. 1 PublicationAdd BLAST298
Alternative sequenceiVSP_0331641 – 34Missing in isoform 4. 2 PublicationsAdd BLAST34
Alternative sequenceiVSP_05509695 – 113Missing in isoform 11. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_055097123 – 159Missing in isoform 10. 1 PublicationAdd BLAST37
Alternative sequenceiVSP_033165299 – 426VSSVV…VEKNQ → MRMSSKFPSPPLPIFLPPEP VDLGSITSSSCSLNELDNIS HLLRKISADINEIKGMKAAI LTVEANLFDLNVRVSKNEAK ISSLEVKMNEYSTTYECNRQ FEDQEEDTESQSRTTDVKII GFLRNVEK in isoform 6. 1 PublicationAdd BLAST128
Alternative sequenceiVSP_033166427 – 582Missing in isoform 3 and isoform 10. 2 PublicationsAdd BLAST156
Alternative sequenceiVSP_033167427 – 451Missing in isoform 5. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_033168452 – 582Missing in isoform 4, isoform 6 and isoform 11. 4 PublicationsAdd BLAST131
Alternative sequenceiVSP_033169455 – 582DMESM…GSFSN → MRMSSKFPSPPLPIFLPPEP VDLGSITSSSCSLNELDNIS HLLRKISADINEIKGMKAAI LTVEANLFDLNVRVSKNEAK ISSLEVKMNEYSTTYECNRQ FEDQEEDTESQSRTTDVKII GFLRNVEK in isoform 8. 1 PublicationAdd BLAST128
Alternative sequenceiVSP_044645577 – 581Missing in isoform 9. 1 Publication5
Alternative sequenceiVSP_033171669Missing in isoform 2, isoform 3, isoform 6, isoform 9 and isoform 11. 5 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF474376 mRNA Translation: AAL83289.1 Sequence problems.
AY578060 mRNA Translation: AAS90299.1
AY578061 mRNA Translation: AAS90300.1
AY578062 mRNA Translation: AAS90301.1
AY578063 mRNA Translation: AAS90302.1 Sequence problems.
AK021868 mRNA No translation available.
AK302136 mRNA Translation: BAG63510.1
AK303123 mRNA Translation: BAG64229.1
AK304275 mRNA Translation: BAG65136.1
AL834215 mRNA Translation: CAD38897.1
BX640716 mRNA Translation: CAE45835.1
BX640876 mRNA Translation: CAE45933.1 Sequence problems.
AL162171 Genomic DNA No translation available.
CH471061 Genomic DNA Translation: EAW81385.1
CH471061 Genomic DNA Translation: EAW81388.1
CH471061 Genomic DNA Translation: EAW81389.1
CH471061 Genomic DNA Translation: EAW81390.1
BC011793 mRNA Translation: AAH11793.1
BC023641 mRNA Translation: AAH23641.1
BC027607 mRNA Translation: AAH27607.1
BX248265 mRNA Translation: CAD62593.1
BX248281 mRNA Translation: CAD62609.1
BX248769 mRNA Translation: CAD66576.1
AF155107 mRNA Translation: AAD42873.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS32133.1 [Q6PJT7-1]
CCDS32134.1 [Q6PJT7-3]
CCDS32135.1 [Q6PJT7-4]
CCDS32136.1 [Q6PJT7-6]
CCDS55938.1 [Q6PJT7-9]
CCDS86418.1 [Q6PJT7-5]

NCBI Reference Sequences

More...
RefSeqi
NP_001153575.1, NM_001160103.1 [Q6PJT7-2]
NP_001153576.1, NM_001160104.1 [Q6PJT7-9]
NP_001313236.1, NM_001326307.1 [Q6PJT7-5]
NP_079100.2, NM_024824.4 [Q6PJT7-1]
NP_997543.1, NM_207660.3 [Q6PJT7-3]
NP_997544.1, NM_207661.2 [Q6PJT7-4]
NP_997545.2, NM_207662.3 [Q6PJT7-6]
XP_005268125.1, XM_005268068.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000251038; ENSP00000251038; ENSG00000100722 [Q6PJT7-1]
ENST00000302216; ENSP00000307025; ENSG00000100722 [Q6PJT7-3]
ENST00000318308; ENSP00000327176; ENSG00000100722 [Q6PJT7-6]
ENST00000336693; ENSP00000338002; ENSG00000100722 [Q6PJT7-4]
ENST00000393514; ENSP00000377150; ENSG00000100722 [Q6PJT7-5]
ENST00000406216; ENSP00000384682; ENSG00000100722 [Q6PJT7-8]
ENST00000555755; ENSP00000452475; ENSG00000100722 [Q6PJT7-9]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
79882

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:79882

UCSC genome browser

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UCSCi
uc001xww.4 human [Q6PJT7-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF474376 mRNA Translation: AAL83289.1 Sequence problems.
AY578060 mRNA Translation: AAS90299.1
AY578061 mRNA Translation: AAS90300.1
AY578062 mRNA Translation: AAS90301.1
AY578063 mRNA Translation: AAS90302.1 Sequence problems.
AK021868 mRNA No translation available.
AK302136 mRNA Translation: BAG63510.1
AK303123 mRNA Translation: BAG64229.1
AK304275 mRNA Translation: BAG65136.1
AL834215 mRNA Translation: CAD38897.1
BX640716 mRNA Translation: CAE45835.1
BX640876 mRNA Translation: CAE45933.1 Sequence problems.
AL162171 Genomic DNA No translation available.
CH471061 Genomic DNA Translation: EAW81385.1
CH471061 Genomic DNA Translation: EAW81388.1
CH471061 Genomic DNA Translation: EAW81389.1
CH471061 Genomic DNA Translation: EAW81390.1
BC011793 mRNA Translation: AAH11793.1
BC023641 mRNA Translation: AAH23641.1
BC027607 mRNA Translation: AAH27607.1
BX248265 mRNA Translation: CAD62593.1
BX248281 mRNA Translation: CAD62609.1
BX248769 mRNA Translation: CAD66576.1
AF155107 mRNA Translation: AAD42873.1
CCDSiCCDS32133.1 [Q6PJT7-1]
CCDS32134.1 [Q6PJT7-3]
CCDS32135.1 [Q6PJT7-4]
CCDS32136.1 [Q6PJT7-6]
CCDS55938.1 [Q6PJT7-9]
CCDS86418.1 [Q6PJT7-5]
RefSeqiNP_001153575.1, NM_001160103.1 [Q6PJT7-2]
NP_001153576.1, NM_001160104.1 [Q6PJT7-9]
NP_001313236.1, NM_001326307.1 [Q6PJT7-5]
NP_079100.2, NM_024824.4 [Q6PJT7-1]
NP_997543.1, NM_207660.3 [Q6PJT7-3]
NP_997544.1, NM_207661.2 [Q6PJT7-4]
NP_997545.2, NM_207662.3 [Q6PJT7-6]
XP_005268125.1, XM_005268068.4

3D structure databases

SMRiQ6PJT7
ModBaseiSearch...

Protein-protein interaction databases

BioGridi122967, 69 interactors
IntActiQ6PJT7, 48 interactors
STRINGi9606.ENSP00000251038

PTM databases

iPTMnetiQ6PJT7
PhosphoSitePlusiQ6PJT7
SwissPalmiQ6PJT7

Polymorphism and mutation databases

BioMutaiZC3H14
DMDMi74737935

Proteomic databases

EPDiQ6PJT7
jPOSTiQ6PJT7
MassIVEiQ6PJT7
MaxQBiQ6PJT7
PaxDbiQ6PJT7
PeptideAtlasiQ6PJT7
PRIDEiQ6PJT7
ProteomicsDBi33599
67217 [Q6PJT7-1]
67218 [Q6PJT7-2]
67219 [Q6PJT7-3]
67220 [Q6PJT7-4]
67221 [Q6PJT7-5]
67222 [Q6PJT7-6]
67223 [Q6PJT7-8]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
79882

Genome annotation databases

EnsembliENST00000251038; ENSP00000251038; ENSG00000100722 [Q6PJT7-1]
ENST00000302216; ENSP00000307025; ENSG00000100722 [Q6PJT7-3]
ENST00000318308; ENSP00000327176; ENSG00000100722 [Q6PJT7-6]
ENST00000336693; ENSP00000338002; ENSG00000100722 [Q6PJT7-4]
ENST00000393514; ENSP00000377150; ENSG00000100722 [Q6PJT7-5]
ENST00000406216; ENSP00000384682; ENSG00000100722 [Q6PJT7-8]
ENST00000555755; ENSP00000452475; ENSG00000100722 [Q6PJT7-9]
GeneIDi79882
KEGGihsa:79882
UCSCiuc001xww.4 human [Q6PJT7-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
79882
DisGeNETi79882

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ZC3H14
HGNCiHGNC:20509 ZC3H14
HPAiHPA049798
HPA053510
MalaCardsiZC3H14
MIMi613279 gene
617125 phenotype
neXtProtiNX_Q6PJT7
OpenTargetsiENSG00000100722
Orphaneti88616 Autosomal recessive non-syndromic intellectual disability
PharmGKBiPA145007270

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3702 Eukaryota
ENOG410YE77 LUCA
GeneTreeiENSGT00440000038430
HOGENOMiHOG000074062
InParanoidiQ6PJT7
KOiK23038
OMAiESMVHTD
OrthoDBi893844at2759
PhylomeDBiQ6PJT7
TreeFamiTF329509

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ZC3H14 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
79882
PharosiQ6PJT7

Protein Ontology

More...
PROi
PR:Q6PJT7

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000100722 Expressed in 227 organ(s), highest expression level in testis
ExpressionAtlasiQ6PJT7 baseline and differential
GenevisibleiQ6PJT7 HS

Family and domain databases

InterProiView protein in InterPro
IPR040366 Nab2/ZC3H14
IPR000571 Znf_CCCH
PANTHERiPTHR14738 PTHR14738, 2 hits
SMARTiView protein in SMART
SM00356 ZnF_C3H1, 3 hits
PROSITEiView protein in PROSITE
PS50103 ZF_C3H1, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZC3HE_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6PJT7
Secondary accession number(s): A8MY46
, B4DXU8, B4DZW7, B4E2H4, G3V5R4, Q6MZU4, Q6PJ32, Q6PUI6, Q6PUI8, Q86TQ5, Q86TW0, Q86TW1, Q8NCT6, Q8NCZ3, Q8TDE2, Q9HAC9, Q9Y5A0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: July 5, 2004
Last modified: October 16, 2019
This is version 151 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
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