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Protein

DNA cross-link repair 1A protein

Gene

DCLRE1A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be required for DNA interstrand cross-link repair. Also required for checkpoint mediated cell cycle arrest in early prophase in response to mitotic spindle poisons.1 Publication

GO - Molecular functioni

  • 5'-3' exodeoxyribonuclease activity Source: CACAO
  • damaged DNA binding Source: GO_Central

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, DNA damage, DNA repair, Mitosis

Enzyme and pathway databases

ReactomeiR-HSA-6783310 Fanconi Anemia Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
DNA cross-link repair 1A protein
Alternative name(s):
SNM1 homolog A
Short name:
hSNM1
Short name:
hSNM1A
Gene namesi
Name:DCLRE1A
Synonyms:KIAA0086, SNM1, SNM1A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000198924.7
HGNCiHGNC:17660 DCLRE1A
MIMi609682 gene
neXtProtiNX_Q6PJP8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi838D → N: Impaired nuclear focus formation, reduced interaction with PIAS and increased sensitivity to cisplatin. 1 Publication1
Mutagenesisi994H → A: Impaired nuclear focus formation, reduced interaction with PIAS and increased sensitivity to cisplatin. 1 Publication1

Organism-specific databases

DisGeNETi9937
OpenTargetsiENSG00000198924
PharmGKBiPA27174

Polymorphism and mutation databases

DMDMi311033461

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002091161 – 1040DNA cross-link repair 1A proteinAdd BLAST1040

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki202Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki236Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki269Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki353Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki361Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki429Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki488Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki508Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki517Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki533Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki536Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei590PhosphoserineBy similarity1
Cross-linki668Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki670Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki674Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ6PJP8
MaxQBiQ6PJP8
PaxDbiQ6PJP8
PeptideAtlasiQ6PJP8
PRIDEiQ6PJP8
ProteomicsDBi67214

PTM databases

iPTMnetiQ6PJP8
PhosphoSitePlusiQ6PJP8

Expressioni

Tissue specificityi

Expressed in brain, heart, kidney, liver, pancreas, placenta and skeletal muscle.1 Publication

Inductioni

During mitosis. The mRNA encoding this protein contains an internal ribosome entry site (IRES) in its 5'-UTR. This 5'-UTR generally suppresses translation while specifically promoting expression during mitosis, when cap-dependent translation may be impaired.1 Publication

Gene expression databases

BgeeiENSG00000198924 Expressed in 167 organ(s), highest expression level in secondary oocyte
CleanExiHS_DCLRE1A
GenevisibleiQ6PJP8 HS

Organism-specific databases

HPAiHPA036907

Interactioni

Subunit structurei

Binds constitutively to TP53BP1. Binds CDC27, which is itself a component of the anaphase promoting complex (APC). Binds PIAS1.

Protein-protein interaction databases

BioGridi115263, 6 interactors
IntActiQ6PJP8, 2 interactors
STRINGi9606.ENSP00000355185

Structurei

Secondary structure

11040
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ6PJP8
SMRiQ6PJP8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 190Nuclear localization regionAdd BLAST190
Regioni396 – 614Nuclear focus formationAdd BLAST219

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1361 Eukaryota
COG1236 LUCA
GeneTreeiENSGT00530000063183
HOGENOMiHOG000168450
HOVERGENiHBG081418
InParanoidiQ6PJP8
KOiK15340
OMAiPDGLLCT
OrthoDBiEOG091G0DBZ
PhylomeDBiQ6PJP8
TreeFamiTF314510

Family and domain databases

Gene3Di3.60.15.10, 1 hit
InterProiView protein in InterPro
IPR011084 DRMBL
IPR036866 RibonucZ/Hydroxyglut_hydro
PfamiView protein in Pfam
PF07522 DRMBL, 1 hit
SUPFAMiSSF56281 SSF56281, 1 hit

Sequencei

Sequence statusi: Complete.

Q6PJP8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLEDISEEDI WEYKSKRKPK RVDPNNGSKN ILKSVEKATD GKYQSKRSRN
60 70 80 90 100
RKRAAEAKEV KDHEVPLGNA GCQTSVASSQ NSSCGDGIQQ TQDKETTPGK
110 120 130 140 150
LCRTQKSQHV SPKIRPVYDG YCPNCQMPFS SLIGQTPRWH VFECLDSPPR
160 170 180 190 200
SETECPDGLL CTSTIPFHYK RYTHFLLAQS RAGDHPFSSP SPASGGSFSE
210 220 230 240 250
TKSGVLCSLE ERWSSYQNQT DNSVSNDPLL MTQYFKKSPS LTEASEKIST
260 270 280 290 300
HIQTSQQALQ FTDFVENDKL VGVALRLANN SEHINLPLPE NDFSDCEISY
310 320 330 340 350
SPLQSDEDTH DIDEKPDDSQ EQLFFTESSK DGSLEEDDDS CGFFKKRHGP
360 370 380 390 400
LLKDQDESCP KVNSFLTRDK YDEGLYRFNS LNDLSQPISQ NNESTLPYDL
410 420 430 440 450
ACTGGDFVLF PPALAGKLAA SVHQATKAKP DEPEFHSAQS NKQKQVIEES
460 470 480 490 500
SVYNQVSLPL VKSLMLKPFE SQVEGYLSSQ PTQNTIRKLS SENLNAKNNT
510 520 530 540 550
NSACFCRKAL EGVPVGKATI LNTENLSSTP APKYLKILPS GLKYNARHPS
560 570 580 590 600
TKVMKQMDIG VYFGLPPKRK EEKLLGESAL EGINLNPVPS PNQKRSSQCK
610 620 630 640 650
RKAEKSLSDL EFDASTLHES QLSVELSSER SQRQKKRCRK SNSLQEGACQ
660 670 680 690 700
KRSDHLINTE SEAVNLSKVK VFTKSAHGGL QRGNKKIPES SNVGGSRKKT
710 720 730 740 750
CPFYKKIPGT GFTVDAFQYG VVEGCTAYFL THFHSDHYAG LSKHFTFPVY
760 770 780 790 800
CSEITGNLLK NKLHVQEQYI HPLPLDTECI VNGVKVVLLD ANHCPGAVMI
810 820 830 840 850
LFYLPNGTVI LHTGDFRADP SMERSLLADQ KVHMLYLDTT YCSPEYTFPS
860 870 880 890 900
QQEVIRFAIN TAFEAVTLNP HALVVCGTYS IGKEKVFLAI ADVLGSKVGM
910 920 930 940 950
SQEKYKTLQC LNIPEINSLI TTDMCSSLVH LLPMMQINFK GLQSHLKKCG
960 970 980 990 1000
GKYNQILAFR PTGWTHSNKF TRIADVIPQT KGNISIYGIP YSEHSSYLEM
1010 1020 1030 1040
KRFVQWLKPQ KIIPTVNVGT WKSRSTMEKY FREWKLEAGY
Length:1,040
Mass (Da):116,400
Last modified:November 2, 2010 - v3
Checksum:i708FFA1F75451803
GO

Sequence cautioni

The sequence BAA07646 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02328658K → E1 PublicationCorresponds to variant dbSNP:rs17235066Ensembl.1
Natural variantiVAR_02328759E → D1 PublicationCorresponds to variant dbSNP:rs17228665Ensembl.1
Natural variantiVAR_02328871G → D1 PublicationCorresponds to variant dbSNP:rs17228672Ensembl.1
Natural variantiVAR_023289287P → L1 PublicationCorresponds to variant dbSNP:rs17235094Ensembl.1
Natural variantiVAR_023290317D → H3 PublicationsCorresponds to variant dbSNP:rs3750898Ensembl.1
Natural variantiVAR_030574582G → W1 PublicationCorresponds to variant dbSNP:rs17855759Ensembl.1
Natural variantiVAR_023291859I → F1 PublicationCorresponds to variant dbSNP:rs11196530Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D42045 mRNA Translation: BAA07646.2 Different initiation.
AY607842 Genomic DNA Translation: AAT09762.1
AL592546 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49489.1
CH471066 Genomic DNA Translation: EAW49490.1
BC013124 mRNA Translation: AAH13124.1
BC062582 mRNA Translation: AAH62582.1
CCDSiCCDS7584.1
RefSeqiNP_001258745.1, NM_001271816.1
NP_055696.3, NM_014881.4
XP_006718153.1, XM_006718090.1
XP_011538731.1, XM_011540429.1
UniGeneiHs.1560
Hs.703616

Genome annotation databases

EnsembliENST00000361384; ENSP00000355185; ENSG00000198924
ENST00000369305; ENSP00000358311; ENSG00000198924
GeneIDi9937
KEGGihsa:9937
UCSCiuc001law.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D42045 mRNA Translation: BAA07646.2 Different initiation.
AY607842 Genomic DNA Translation: AAT09762.1
AL592546 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49489.1
CH471066 Genomic DNA Translation: EAW49490.1
BC013124 mRNA Translation: AAH13124.1
BC062582 mRNA Translation: AAH62582.1
CCDSiCCDS7584.1
RefSeqiNP_001258745.1, NM_001271816.1
NP_055696.3, NM_014881.4
XP_006718153.1, XM_006718090.1
XP_011538731.1, XM_011540429.1
UniGeneiHs.1560
Hs.703616

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4B87X-ray2.16A676-1040[»]
5AHRX-ray2.19A700-1040[»]
5NZWX-ray2.70A698-1040[»]
5NZXX-ray1.47A698-1040[»]
5NZYX-ray1.55A698-1040[»]
5Q1JX-ray1.42A698-1040[»]
5Q1KX-ray1.42A698-1040[»]
5Q1LX-ray1.76A698-1040[»]
5Q1MX-ray1.56A698-1040[»]
5Q1NX-ray1.38A698-1040[»]
5Q1OX-ray1.25A698-1040[»]
5Q1PX-ray1.56A698-1040[»]
5Q1QX-ray1.44A698-1040[»]
5Q1RX-ray1.49A698-1040[»]
5Q1SX-ray1.62A698-1040[»]
5Q1TX-ray1.49A698-1040[»]
5Q1UX-ray1.50A698-1040[»]
5Q1VX-ray1.57A698-1040[»]
5Q1WX-ray1.68A698-1040[»]
5Q1XX-ray1.42A698-1040[»]
5Q1YX-ray1.42A698-1040[»]
5Q1ZX-ray1.41A698-1040[»]
5Q20X-ray1.76A698-1040[»]
5Q22X-ray1.18A698-1040[»]
5Q23X-ray1.32A698-1040[»]
5Q24X-ray1.35A698-1040[»]
5Q25X-ray1.43A698-1040[»]
5Q26X-ray1.66A698-1040[»]
5Q27X-ray1.83A698-1040[»]
5Q28X-ray1.52A698-1040[»]
5Q29X-ray1.46A698-1040[»]
5Q2AX-ray1.50A698-1040[»]
5Q2BX-ray1.33A698-1040[»]
5Q2CX-ray1.53A698-1040[»]
5Q2DX-ray1.40A698-1040[»]
5Q2EX-ray1.50A698-1040[»]
5Q2FX-ray1.47A698-1040[»]
5Q2GX-ray1.49A698-1040[»]
5Q2HX-ray1.72A698-1040[»]
5Q2IX-ray2.33A698-1040[»]
5Q2JX-ray1.30A698-1040[»]
5Q2KX-ray1.65A698-1040[»]
5Q2LX-ray1.42A698-1040[»]
5Q2MX-ray1.28A698-1040[»]
5Q2NX-ray1.38A698-1040[»]
5Q2OX-ray1.75A698-1040[»]
5Q2PX-ray1.55A698-1040[»]
5Q2QX-ray1.44A698-1040[»]
5Q2RX-ray1.37A698-1040[»]
5Q2SX-ray1.52A698-1040[»]
5Q2TX-ray1.52A698-1040[»]
5Q2UX-ray1.37A698-1040[»]
5Q2VX-ray1.58A698-1040[»]
5Q2WX-ray1.53A698-1040[»]
5Q2XX-ray1.50A698-1040[»]
5Q2YX-ray1.61A698-1040[»]
5Q2ZX-ray1.55A698-1040[»]
5Q30X-ray1.80A698-1040[»]
5Q31X-ray1.55A698-1040[»]
5Q32X-ray1.87A698-1040[»]
5Q33X-ray1.37A698-1040[»]
5Q34X-ray1.49A698-1040[»]
5Q35X-ray1.47A698-1040[»]
5Q36X-ray1.39A698-1040[»]
5Q37X-ray1.50A698-1040[»]
5Q38X-ray1.39A698-1040[»]
5Q39X-ray1.70A698-1040[»]
5Q3AX-ray1.48A698-1040[»]
5Q3BX-ray2.52A698-1040[»]
5Q3CX-ray1.41A698-1040[»]
5Q3DX-ray1.71A698-1040[»]
5Q3EX-ray1.49A698-1040[»]
5Q3FX-ray1.39A698-1040[»]
5Q3GX-ray1.29A698-1040[»]
5Q3HX-ray1.56A698-1040[»]
5Q3IX-ray1.53A698-1040[»]
5Q3JX-ray1.44A698-1040[»]
5Q3KX-ray1.39A698-1040[»]
5Q3LX-ray1.61A698-1040[»]
5Q3MX-ray1.34A698-1040[»]
5Q3NX-ray1.62A698-1040[»]
5Q3OX-ray1.60A698-1040[»]
5Q3PX-ray1.44A698-1040[»]
5Q3QX-ray1.39A698-1040[»]
5Q3RX-ray1.50A698-1040[»]
5Q3SX-ray1.72A698-1040[»]
5Q3TX-ray1.52A698-1040[»]
5Q3UX-ray1.49A698-1040[»]
5Q3VX-ray1.52A698-1040[»]
5Q3WX-ray1.50A698-1040[»]
5Q3XX-ray1.38A698-1040[»]
5Q3YX-ray1.45A698-1040[»]
5Q3ZX-ray1.84A698-1040[»]
5Q40X-ray2.04A698-1040[»]
5Q41X-ray1.95A698-1040[»]
5Q42X-ray1.68A698-1040[»]
5Q43X-ray1.47A698-1040[»]
5Q44X-ray1.55A698-1040[»]
5Q45X-ray1.64A698-1040[»]
5Q46X-ray2.01A698-1040[»]
5Q47X-ray1.38A698-1040[»]
5Q48X-ray1.44A698-1040[»]
5Q49X-ray1.38A698-1040[»]
5Q4AX-ray1.83A698-1040[»]
5Q4BX-ray1.60A698-1040[»]
5Q4CX-ray2.73A698-1040[»]
5Q4DX-ray1.80A698-1040[»]
5Q4EX-ray1.39A698-1040[»]
5Q4FX-ray1.97A698-1040[»]
5Q4GX-ray1.75A698-1040[»]
5Q4HX-ray1.53A698-1040[»]
5Q4IX-ray1.55A698-1040[»]
5Q4JX-ray1.55A698-1040[»]
5Q4KX-ray1.47A698-1040[»]
5Q4LX-ray1.60A698-1040[»]
5Q4MX-ray1.60A698-1040[»]
5Q4NX-ray1.71A698-1040[»]
5Q4OX-ray1.83A698-1040[»]
5Q4PX-ray1.40A698-1040[»]
5Q4QX-ray1.42A698-1040[»]
5Q4RX-ray2.00A698-1040[»]
5Q4SX-ray1.72A698-1040[»]
5Q4TX-ray1.77A698-1040[»]
5Q4UX-ray2.00A698-1040[»]
5Q4VX-ray1.59A698-1040[»]
5Q4WX-ray1.80A698-1040[»]
5Q4XX-ray1.66A698-1040[»]
5Q4YX-ray1.69A698-1040[»]
5Q4ZX-ray1.60A698-1040[»]
5Q50X-ray2.00A698-1040[»]
5Q51X-ray1.34A698-1040[»]
5Q52X-ray1.70A698-1040[»]
5Q53X-ray1.55A698-1040[»]
5Q54X-ray1.30A698-1040[»]
5Q55X-ray1.39A698-1040[»]
5Q56X-ray1.87A698-1040[»]
5Q57X-ray1.65A698-1040[»]
5Q58X-ray1.75A698-1040[»]
5Q59X-ray1.86A698-1040[»]
5Q5AX-ray2.26A698-1040[»]
5Q5BX-ray1.58A698-1040[»]
5Q5CX-ray1.38A698-1040[»]
5Q5DX-ray1.71A698-1040[»]
5Q5EX-ray1.49A698-1040[»]
5Q5FX-ray1.47A698-1040[»]
5Q5GX-ray2.00A698-1040[»]
5Q5HX-ray1.36A698-1040[»]
5Q5IX-ray1.65A698-1040[»]
5Q5JX-ray2.00A698-1040[»]
5Q5KX-ray2.81A698-1040[»]
5Q5LX-ray2.00A698-1040[»]
5Q5MX-ray1.57A698-1040[»]
5Q5NX-ray2.42A698-1040[»]
5Q5OX-ray2.07A698-1040[»]
5Q5PX-ray1.58A698-1040[»]
5Q5QX-ray1.45A698-1040[»]
5Q5RX-ray1.39A698-1040[»]
5Q5SX-ray1.70A698-1040[»]
5Q5TX-ray1.80A698-1040[»]
5Q5UX-ray1.88A698-1040[»]
5Q5VX-ray1.86A698-1040[»]
5Q5WX-ray1.42A698-1040[»]
5Q5XX-ray1.50A698-1040[»]
5Q5YX-ray1.82A698-1040[»]
5Q5ZX-ray1.48A698-1040[»]
5Q60X-ray1.40A698-1040[»]
5Q61X-ray1.71A698-1040[»]
5Q62X-ray1.52A698-1040[»]
5Q63X-ray1.82A698-1040[»]
5Q64X-ray1.42A698-1040[»]
5Q65X-ray1.78A698-1040[»]
5Q66X-ray1.51A698-1040[»]
5Q67X-ray1.65A698-1040[»]
5Q68X-ray1.86A698-1040[»]
5Q69X-ray1.84A698-1040[»]
5Q6AX-ray1.71A698-1040[»]
5Q6BX-ray2.62A698-1040[»]
5Q6CX-ray1.53A698-1040[»]
5Q6DX-ray1.48A698-1040[»]
5Q6EX-ray1.47A698-1040[»]
5Q6FX-ray1.55A698-1040[»]
5Q6GX-ray1.48A698-1040[»]
5Q6HX-ray1.42A698-1040[»]
5Q6IX-ray1.68A698-1040[»]
5Q6JX-ray1.70A698-1040[»]
5Q6KX-ray1.67A698-1040[»]
5Q6LX-ray1.82A698-1040[»]
5Q6MX-ray1.47A698-1040[»]
5Q6NX-ray1.52A698-1040[»]
5Q6OX-ray1.40A698-1040[»]
5Q6PX-ray1.54A698-1040[»]
5Q6QX-ray1.36A698-1040[»]
5Q6RX-ray1.42A698-1040[»]
5Q6SX-ray1.56A698-1040[»]
5Q6TX-ray1.59A698-1040[»]
5Q6UX-ray1.33A698-1040[»]
5Q6VX-ray1.29A698-1040[»]
5Q6WX-ray1.50A698-1040[»]
5Q6XX-ray1.43A698-1040[»]
5Q6YX-ray1.67A698-1040[»]
5Q6ZX-ray1.62A698-1040[»]
5Q70X-ray1.31A698-1040[»]
5Q71X-ray2.00A698-1040[»]
5Q72X-ray1.31A698-1040[»]
5Q73X-ray1.36A698-1040[»]
5Q74X-ray1.21A698-1040[»]
5Q75X-ray1.36A698-1040[»]
5Q76X-ray1.28A698-1040[»]
5Q77X-ray2.00A698-1040[»]
5Q78X-ray1.25A698-1040[»]
5Q79X-ray1.83A698-1040[»]
5Q7AX-ray1.39A698-1040[»]
5Q7BX-ray1.25A698-1040[»]
5Q7CX-ray1.20A698-1040[»]
5Q7DX-ray1.32A698-1040[»]
5Q7EX-ray1.50A698-1040[»]
5Q7FX-ray1.64A698-1040[»]
5Q7GX-ray2.00A698-1040[»]
5Q7HX-ray2.00A698-1040[»]
5Q7IX-ray1.26A698-1040[»]
5Q7JX-ray1.54A698-1040[»]
5Q7KX-ray2.00A698-1040[»]
5Q7LX-ray1.61A698-1040[»]
5Q7MX-ray1.26A698-1040[»]
5Q7NX-ray2.00A698-1040[»]
5Q7OX-ray1.32A698-1040[»]
5Q7PX-ray2.00A698-1040[»]
5Q7QX-ray1.76A698-1040[»]
5Q7RX-ray1.62A698-1040[»]
5Q7SX-ray1.31A698-1040[»]
5Q7TX-ray1.67A698-1040[»]
5Q7UX-ray2.11A698-1040[»]
5Q7VX-ray1.62A698-1040[»]
5Q7WX-ray1.27A698-1040[»]
5Q7XX-ray1.69A698-1040[»]
5Q7YX-ray1.39A698-1040[»]
5Q7ZX-ray1.65A698-1040[»]
5Q80X-ray1.43A698-1040[»]
5Q81X-ray1.51A698-1040[»]
5Q82X-ray1.20A698-1040[»]
5Q83X-ray1.28A698-1040[»]
5Q84X-ray1.88A698-1040[»]
5Q85X-ray1.80A698-1040[»]
5Q86X-ray1.31A698-1040[»]
5Q87X-ray1.34A698-1040[»]
5Q88X-ray1.78A698-1040[»]
5Q89X-ray1.91A698-1040[»]
5Q8AX-ray1.43A698-1040[»]
5Q8BX-ray1.63A698-1040[»]
5Q8CX-ray2.00A698-1040[»]
5Q8DX-ray1.23A698-1040[»]
5Q8EX-ray1.63A698-1040[»]
5Q8FX-ray1.36A698-1040[»]
5Q8GX-ray2.00A698-1040[»]
5Q8HX-ray1.90A698-1040[»]
5Q8IX-ray1.35A698-1040[»]
5Q8JX-ray1.79A698-1040[»]
5Q8KX-ray1.79A698-1040[»]
5Q8LX-ray1.42A698-1040[»]
5Q8MX-ray1.71A698-1040[»]
5Q8NX-ray1.41A698-1040[»]
5Q8OX-ray1.67A698-1040[»]
5Q8PX-ray1.45A698-1040[»]
5Q8QX-ray1.89A698-1040[»]
5Q8RX-ray1.90A698-1040[»]
5Q8SX-ray1.61A698-1040[»]
5Q8TX-ray2.00A698-1040[»]
5Q8UX-ray1.54A698-1040[»]
5Q8VX-ray1.32A698-1040[»]
5Q8WX-ray1.57A698-1040[»]
5Q8XX-ray1.23A698-1040[»]
5Q8YX-ray1.51A698-1040[»]
5Q8ZX-ray1.47A698-1040[»]
5Q90X-ray1.49A698-1040[»]
5Q91X-ray1.46A698-1040[»]
5Q92X-ray2.11A698-1040[»]
5Q93X-ray1.68A698-1040[»]
5Q94X-ray1.90A698-1040[»]
5Q95X-ray1.47A698-1040[»]
5Q96X-ray1.83A698-1040[»]
5Q97X-ray1.97A698-1040[»]
5Q98X-ray1.76A698-1040[»]
5Q99X-ray1.31A698-1040[»]
5Q9AX-ray1.67A698-1040[»]
5Q9BX-ray1.45A698-1040[»]
5Q9CX-ray1.46A698-1040[»]
5Q9DX-ray1.69A698-1040[»]
5Q9EX-ray1.45A698-1040[»]
5Q9FX-ray1.28A698-1040[»]
5Q9GX-ray1.60A698-1040[»]
5Q9HX-ray1.81A698-1040[»]
5Q9IX-ray1.46A698-1040[»]
5Q9JX-ray1.76A698-1040[»]
5Q9KX-ray1.78A698-1040[»]
5Q9LX-ray1.59A698-1040[»]
5Q9MX-ray1.30A698-1040[»]
5Q9NX-ray1.47A698-1040[»]
5Q9OX-ray1.37A698-1040[»]
5Q9PX-ray1.48A698-1040[»]
5Q9QX-ray1.50A698-1040[»]
5Q9RX-ray1.72A698-1040[»]
5Q9SX-ray1.43A698-1040[»]
5Q9TX-ray1.37A698-1040[»]
5Q9UX-ray1.49A698-1040[»]
5Q9VX-ray1.43A698-1040[»]
5Q9WX-ray1.53A698-1040[»]
5Q9XX-ray1.67A698-1040[»]
5Q9YX-ray1.64A698-1040[»]
5Q9ZX-ray1.77A698-1040[»]
5QA0X-ray1.47A698-1040[»]
5QA1X-ray1.46A698-1040[»]
5QA2X-ray1.56A698-1040[»]
ProteinModelPortaliQ6PJP8
SMRiQ6PJP8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115263, 6 interactors
IntActiQ6PJP8, 2 interactors
STRINGi9606.ENSP00000355185

PTM databases

iPTMnetiQ6PJP8
PhosphoSitePlusiQ6PJP8

Polymorphism and mutation databases

DMDMi311033461

Proteomic databases

EPDiQ6PJP8
MaxQBiQ6PJP8
PaxDbiQ6PJP8
PeptideAtlasiQ6PJP8
PRIDEiQ6PJP8
ProteomicsDBi67214

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361384; ENSP00000355185; ENSG00000198924
ENST00000369305; ENSP00000358311; ENSG00000198924
GeneIDi9937
KEGGihsa:9937
UCSCiuc001law.4 human

Organism-specific databases

CTDi9937
DisGeNETi9937
EuPathDBiHostDB:ENSG00000198924.7
GeneCardsiDCLRE1A
HGNCiHGNC:17660 DCLRE1A
HPAiHPA036907
MIMi609682 gene
neXtProtiNX_Q6PJP8
OpenTargetsiENSG00000198924
PharmGKBiPA27174
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1361 Eukaryota
COG1236 LUCA
GeneTreeiENSGT00530000063183
HOGENOMiHOG000168450
HOVERGENiHBG081418
InParanoidiQ6PJP8
KOiK15340
OMAiPDGLLCT
OrthoDBiEOG091G0DBZ
PhylomeDBiQ6PJP8
TreeFamiTF314510

Enzyme and pathway databases

ReactomeiR-HSA-6783310 Fanconi Anemia Pathway

Miscellaneous databases

ChiTaRSiDCLRE1A human
GeneWikiiDCLRE1A
GenomeRNAii9937
PROiPR:Q6PJP8
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000198924 Expressed in 167 organ(s), highest expression level in secondary oocyte
CleanExiHS_DCLRE1A
GenevisibleiQ6PJP8 HS

Family and domain databases

Gene3Di3.60.15.10, 1 hit
InterProiView protein in InterPro
IPR011084 DRMBL
IPR036866 RibonucZ/Hydroxyglut_hydro
PfamiView protein in Pfam
PF07522 DRMBL, 1 hit
SUPFAMiSSF56281 SSF56281, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDCR1A_HUMAN
AccessioniPrimary (citable) accession number: Q6PJP8
Secondary accession number(s): D3DRC1
, Q14701, Q6P5Y3, Q6PKL4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: November 2, 2010
Last modified: November 7, 2018
This is version 132 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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