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Entry version 147 (13 Nov 2019)
Sequence version 2 (20 Mar 2007)
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Protein

GATOR complex protein WDR59

Gene

WDR59

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex (PubMed:23723238). It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1 (PubMed:25457612, PubMed:27487210).3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-9639288 Amino acids regulate mTORC1

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q6PJI9

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q6PJI9

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
GATOR complex protein WDR59Curated
Alternative name(s):
WD repeat-containing protein 59Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:WDR59Imported
Synonyms:KIAA1923Imported
ORF Names:FP977Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:25706 WDR59

Online Mendelian Inheritance in Man (OMIM)

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MIMi
617418 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6PJI9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Lysosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

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OpenTargetsi
ENSG00000103091

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA142670593

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q6PJI9

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
WDR59

Domain mapping of disease mutations (DMDM)

More...
DMDMi
134035358

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002807211 – 974GATOR complex protein WDR59Add BLAST974

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei564PhosphoserineCombined sources1
Modified residuei821PhosphoserineCombined sources1
Modified residuei822PhosphoserineCombined sources1
Modified residuei830PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q6PJI9

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q6PJI9

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q6PJI9

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6PJI9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6PJI9

PeptideAtlas

More...
PeptideAtlasi
Q6PJI9

PRoteomics IDEntifications database

More...
PRIDEi
Q6PJI9

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
67210 [Q6PJI9-1]
67211 [Q6PJI9-2]
67212 [Q6PJI9-3]
67213 [Q6PJI9-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6PJI9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6PJI9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000103091 Expressed in 226 organ(s), highest expression level in left lobe of thyroid gland

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q6PJI9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q6PJI9 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA041084
HPA048218

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with DDB1-CUL4A/B E3 ligase complexes (By similarity). Within the GATOR complex, component of the GATOR2 subcomplex, made of MIOS, SEC13, SEH1L, WDR24 and WDR59. The GATOR complex strongly interacts with RRAGA/RRAGC and RRAGB/RRAGC heterodimers. The GATOR2 complex interacts with CASTOR2 and CASTOR1; the interaction is negatively regulated by arginine (PubMed:26972053). The GATOR2 complex interacts with SESN1, SESN2 and SESN3; the interaction is negatively regulated by amino acids (PubMed:25263562, PubMed:25457612).

By similarity4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
Q96S158EBI-2515073,EBI-746424

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
122841, 50 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q6PJI9

Protein interaction database and analysis system

More...
IntActi
Q6PJI9, 39 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000262144

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati57 – 98WD 1Add BLAST42
Repeati103 – 143WD 2Add BLAST41
Repeati146 – 185WD 3Add BLAST40
Repeati189 – 229WD 4Add BLAST41
Repeati232 – 276WD 5Add BLAST45
Repeati278 – 318WD 6Add BLAST41
Repeati319 – 362WD 7Add BLAST44
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini393 – 494RWDPROSITE-ProRule annotationAdd BLAST102
Repeati668 – 706WD 8Add BLAST39

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the WD repeat WDR59 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0264 Eukaryota
KOG0309 Eukaryota
COG2319 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000157600

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000004834

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q6PJI9

KEGG Orthology (KO)

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KOi
K20409

Identification of Orthologs from Complete Genome Data

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OMAi
FQLCQGT

Database of Orthologous Groups

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OrthoDBi
590848at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q6PJI9

TreeFam database of animal gene trees

More...
TreeFami
TF314695

Family and domain databases

Conserved Domains Database

More...
CDDi
cd16692 mRING-H2-C3H3C2_WDR59, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.130.10.10, 2 hits
3.10.110.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR006575 RWD-domain
IPR016135 UBQ-conjugating_enzyme/RWD
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
IPR039456 WDR59_mRING-H2-C3H3C2

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00400 WD40, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00591 RWD, 1 hit
SM00320 WD40, 5 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50978 SSF50978, 1 hit
SSF54495 SSF54495, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50908 RWD, 1 hit
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 2 hits
PS50294 WD_REPEATS_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6PJI9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAARWSSENV VVEFRDSQAT AMSVDCLGQH AVLSGRRFLY IVNLDAPFEG
60 70 80 90 100
HRKISRQSKW DIGAVQWNPH DSFAHYFAAS SNQRVDLYKW KDGSGEVGTT
110 120 130 140 150
LQGHTRVISD LDWAVFEPDL LVTSSVDTYI YIWDIKDTRK PTVALSAVAG
160 170 180 190 200
ASQVKWNKKN ANCLATSHDG DVRIWDKRKP STAVEYLAAH LSKIHGLDWH
210 220 230 240 250
PDSEHILATS SQDNSVKFWD YRQPRKYLNI LPCQVPVWKA RYTPFSNGLV
260 270 280 290 300
TVMVPQLRRE NSLLLWNVFD LNTPVHTFVG HDDVVLEFQW RKQKEGSKDY
310 320 330 340 350
QLVTWSRDQT LRMWRVDSQM QRLCANDILD GVDEFIESIS LLPEPEKTLH
360 370 380 390 400
TEDTDHQHTA SHGEEEALKE DPPRNLLEER KSDQLGLPQT LQQEFSLINV
410 420 430 440 450
QIRNVNVEMD AADRSCTVSV HCSNHRVKML VKFPAQYPNN AAPSFQFINP
460 470 480 490 500
TTITSTMKAK LLKILKDTAL QKVKRGQSCL EPCLRQLVSC LESFVNQEDS
510 520 530 540 550
ASSNPFALPN SVTPPLPTFA RVTTAYGSYQ DANIPFPRTS GARFCGAGYL
560 570 580 590 600
VYFTRPMTMH RAVSPTEPTP RSLSALSAYH TGLIAPMKIR TEAPGNLRLY
610 620 630 640 650
SGSPTRSEKE QVSISSFYYK ERKSRRWKSK REGSDSGNRQ IKAAGKVIIQ
660 670 680 690 700
DIACLLPVHK SLGELYILNV NDIQETCQKN AASALLVGRK DLVQVWSLAT
710 720 730 740 750
VATDLCLGPK SDPDLETPWA RHPFGRQLLE SLLAHYCRLR DVQTLAMLCS
760 770 780 790 800
VFEAQSRPQG LPNPFGPFPN RSSNLVVSHS RYPSFTSSGS CSSMSDPGLN
810 820 830 840 850
TGGWNIAGRE AEHLSSPWGE SSPEELRFGS LTYSDPRERE RDQHDKNKRL
860 870 880 890 900
LDPANTQQFD DFKKCYGEIL YRWGLREKRA EVLKFVSCPP DPHKGIEFGV
910 920 930 940 950
YCSHCRSEVR GTQCAICKGF TFQCAICHVA VRGSSNFCLT CGHGGHTSHM
960 970
MEWFRTQEVC PTGCGCHCLL ESTF
Length:974
Mass (Da):109,793
Last modified:March 20, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i72F651A38EA51CBA
GO
Isoform 2 (identifier: Q6PJI9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     572-974: Missing.

Note: No experimental confirmation available.
Show »
Length:571
Mass (Da):64,848
Checksum:i9F0F69BD39E3FB60
GO
Isoform 3 (identifier: Q6PJI9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-408: Missing.

Show »
Length:566
Mass (Da):62,908
Checksum:i9FF9AC7DFEFB28FE
GO
Isoform 4 (identifier: Q6PJI9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-556: Missing.
     557-571: MTMHRAVSPTEPTPR → MTGLQPVWIIIIFNYR

Note: No experimental confirmation available.
Show »
Length:419
Mass (Da):46,909
Checksum:iD9E96013D5098D33
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B7Z7V6B7Z7V6_HUMAN
GATOR complex protein WDR59
WDR59
458Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BNY4H3BNY4_HUMAN
GATOR complex protein WDR59
WDR59
217Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BR95H3BR95_HUMAN
GATOR complex protein WDR59
WDR59
156Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BV71H3BV71_HUMAN
GATOR complex protein WDR59
WDR59
47Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BMH3H3BMH3_HUMAN
GATOR complex protein WDR59
WDR59
300Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BUE9H3BUE9_HUMAN
GATOR complex protein WDR59
WDR59
35Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB67816 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti441A → S in BAB67816 (PubMed:11572484).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_053436201P → T. Corresponds to variant dbSNP:rs11557260Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0238811 – 556Missing in isoform 4. 1 PublicationAdd BLAST556
Alternative sequenceiVSP_0238821 – 408Missing in isoform 3. 2 PublicationsAdd BLAST408
Alternative sequenceiVSP_023883557 – 571MTMHR…EPTPR → MTGLQPVWIIIIFNYR in isoform 4. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_023884572 – 974Missing in isoform 2. 1 PublicationAdd BLAST403

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK022332 mRNA Translation: BAB14015.1
AK091316 mRNA Translation: BAG52335.1
AF370390 mRNA Translation: AAQ15226.1
BC004519 mRNA Translation: AAH04519.1
BC014887 mRNA Translation: AAH14887.2
AB067510 mRNA Translation: BAB67816.1 Frameshift.

The Consensus CDS (CCDS) project

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CCDSi
CCDS32488.1 [Q6PJI9-1]
CCDS82011.1 [Q6PJI9-2]

NCBI Reference Sequences

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RefSeqi
NP_001311100.1, NM_001324171.1 [Q6PJI9-2]
NP_085058.3, NM_030581.3 [Q6PJI9-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000262144; ENSP00000262144; ENSG00000103091 [Q6PJI9-1]
ENST00000616369; ENSP00000482446; ENSG00000103091 [Q6PJI9-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
79726

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:79726

UCSC genome browser

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UCSCi
uc002fdh.2 human [Q6PJI9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022332 mRNA Translation: BAB14015.1
AK091316 mRNA Translation: BAG52335.1
AF370390 mRNA Translation: AAQ15226.1
BC004519 mRNA Translation: AAH04519.1
BC014887 mRNA Translation: AAH14887.2
AB067510 mRNA Translation: BAB67816.1 Frameshift.
CCDSiCCDS32488.1 [Q6PJI9-1]
CCDS82011.1 [Q6PJI9-2]
RefSeqiNP_001311100.1, NM_001324171.1 [Q6PJI9-2]
NP_085058.3, NM_030581.3 [Q6PJI9-1]

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi122841, 50 interactors
CORUMiQ6PJI9
IntActiQ6PJI9, 39 interactors
STRINGi9606.ENSP00000262144

PTM databases

iPTMnetiQ6PJI9
PhosphoSitePlusiQ6PJI9

Polymorphism and mutation databases

BioMutaiWDR59
DMDMi134035358

Proteomic databases

EPDiQ6PJI9
jPOSTiQ6PJI9
MassIVEiQ6PJI9
MaxQBiQ6PJI9
PaxDbiQ6PJI9
PeptideAtlasiQ6PJI9
PRIDEiQ6PJI9
ProteomicsDBi67210 [Q6PJI9-1]
67211 [Q6PJI9-2]
67212 [Q6PJI9-3]
67213 [Q6PJI9-4]

Genome annotation databases

EnsembliENST00000262144; ENSP00000262144; ENSG00000103091 [Q6PJI9-1]
ENST00000616369; ENSP00000482446; ENSG00000103091 [Q6PJI9-2]
GeneIDi79726
KEGGihsa:79726
UCSCiuc002fdh.2 human [Q6PJI9-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
79726

GeneCards: human genes, protein and diseases

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GeneCardsi
WDR59
HGNCiHGNC:25706 WDR59
HPAiHPA041084
HPA048218
MIMi617418 gene
neXtProtiNX_Q6PJI9
OpenTargetsiENSG00000103091
PharmGKBiPA142670593

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0264 Eukaryota
KOG0309 Eukaryota
COG2319 LUCA
GeneTreeiENSGT00940000157600
HOGENOMiHOG000004834
InParanoidiQ6PJI9
KOiK20409
OMAiFQLCQGT
OrthoDBi590848at2759
PhylomeDBiQ6PJI9
TreeFamiTF314695

Enzyme and pathway databases

ReactomeiR-HSA-9639288 Amino acids regulate mTORC1
SignaLinkiQ6PJI9
SIGNORiQ6PJI9

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
WDR59 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
79726
PharosiQ6PJI9

Protein Ontology

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PROi
PR:Q6PJI9

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000103091 Expressed in 226 organ(s), highest expression level in left lobe of thyroid gland
ExpressionAtlasiQ6PJI9 baseline and differential
GenevisibleiQ6PJI9 HS

Family and domain databases

CDDicd16692 mRING-H2-C3H3C2_WDR59, 1 hit
Gene3Di2.130.10.10, 2 hits
3.10.110.10, 1 hit
InterProiView protein in InterPro
IPR006575 RWD-domain
IPR016135 UBQ-conjugating_enzyme/RWD
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
IPR039456 WDR59_mRING-H2-C3H3C2
PfamiView protein in Pfam
PF00400 WD40, 2 hits
SMARTiView protein in SMART
SM00591 RWD, 1 hit
SM00320 WD40, 5 hits
SUPFAMiSSF50978 SSF50978, 1 hit
SSF54495 SSF54495, 1 hit
PROSITEiView protein in PROSITE
PS50908 RWD, 1 hit
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 2 hits
PS50294 WD_REPEATS_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiWDR59_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6PJI9
Secondary accession number(s): B3KRC3
, Q71RE7, Q96PW5, Q9BSW6, Q9HA43
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 20, 2007
Last modified: November 13, 2019
This is version 147 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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