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UniProtKB - Q6PJG2 (MDEAS_HUMAN)

Entry version 139 (12 Aug 2020)
Sequence version 2 (28 Nov 2006)
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Protein

Mitotic deacetylase-associated SANT domain protein

Gene

MIDEAS

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q6PJG2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Mitotic deacetylase-associated SANT domain proteinImported
Alternative name(s):
ELM2 and SANT domain-containing protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MIDEAS1 PublicationImported
Synonyms:C14orf117Imported, C14orf43Imported, ELMSAN1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000156030.12

Human Gene Nomenclature Database

More...HGNCi		HGNC:19853, MIDEAS

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q6PJG2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		91748

Open Targets

More...OpenTargetsi		ENSG00000156030

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134877876

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q6PJG2, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ELMSAN1

Domain mapping of disease mutations (DMDM)

More...DMDMi		118572229

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002597641 – 1045Mitotic deacetylase-associated SANT domain proteinAdd BLAST1045

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki166Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei193Asymmetric dimethylarginineCombined sources1
Modified residuei447Omega-N-methylarginineCombined sources1
Modified residuei461PhosphoserineCombined sources1
Cross-linki590Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki590Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei655PhosphothreonineCombined sources1
Modified residuei661PhosphoserineCombined sources1
Modified residuei704PhosphothreonineCombined sources1
Modified residuei709PhosphoserineCombined sources1
Modified residuei715PhosphothreonineCombined sources1
Modified residuei923PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q6PJG2

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q6PJG2

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q6PJG2

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q6PJG2

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q6PJG2

PeptideAtlas

More...PeptideAtlasi		Q6PJG2

PRoteomics IDEntifications database

More...PRIDEi		Q6PJG2

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		67201

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q6PJG2, 3 sites, 1 O-linked glycan (3 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q6PJG2

MetOSite database of methionine sulfoxide sites

More...MetOSitei		Q6PJG2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q6PJG2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000156030, Expressed in sural nerve and 213 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q6PJG2, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q6PJG2, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000156030, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with DNTTIP1 (PubMed:21573134, PubMed:25653165).

Identified in a histone deacetylase complex that contains DNTTIP1, HDAC1 and MIDEAS; this complex assembles into a tetramer that contains four copies of each protein chain (PubMed:25653165).

2 Publications

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		124872, 45 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q6PJG2

Protein interaction database and analysis system

More...IntActi		Q6PJG2, 35 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000286523

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q6PJG2, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q6PJG2

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini721 – 813ELM2PROSITE-ProRule annotationAdd BLAST93
Domaini828 – 879SANTPROSITE-ProRule annotationAdd BLAST52

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi111 – 115Poly-Gly5
Compositional biasi210 – 291Gln-richAdd BLAST82
Compositional biasi234 – 395Pro-richAdd BLAST162
Compositional biasi455 – 459Poly-Arg5
Compositional biasi1021 – 1024Poly-Lys4

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4167, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000157459

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_011395_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q6PJG2

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q6PJG2

TreeFam database of animal gene trees

More...TreeFami		TF106431

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000949, ELM2_dom
IPR009057, Homeobox-like_sf
IPR001005, SANT/Myb
IPR017884, SANT_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01448, ELM2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01189, ELM2, 1 hit
SM00717, SANT, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF46689, SSF46689, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51156, ELM2, 1 hit
PS51293, SANT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q6PJG2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNLQAQPKAQ NKRKRCLFGG QEPAPKEQPP PLQPPQQSIR VKEEQYLGHE 
        60         70         80         90        100
GPGGAVSTSQ PVELPPPSSL ALLNSVVYGP ERTSAAMLSQ QVASVKWPNS 
       110        120        130        140        150
VMAPGRGPER GGGGGVSDSS WQQQPGQPPP HSTWNCHSLS LYSATKGSPH 
       160        170        180        190        200
PGVGVPTYYN HPEALKREKA GGPQLDRYVR PMMPQKVQLE VGRPQAPLNS 
       210        220        230        240        250
FHAAKKPPNQ SLPLQPFQLA FGHQVNRQVF RQGPPPPNPV AAFPPQKQQQ 
       260        270        280        290        300
QQQPQQQQQQ QQAALPQMPL FENFYSMPQQ PSQQPQDFGL QPAGPLGQSH 
       310        320        330        340        350
LAHHSMAPYP FPPNPDMNPE LRKALLQDSA PQPALPQVQI PFPRRSRRLS 
       360        370        380        390        400
KEGILPPSAL DGAGTQPGQE ATGNLFLHHW PLQQPPPGSL GQPHPEALGF 
       410        420        430        440        450
PLELRESQLL PDGERLAPNG REREAPAMGS EEGMRAVSTG DCGQVLRGGV 
       460        470        480        490        500
IQSTRRRRRA SQEANLLTLA QKAVELASLQ NAKDGSGSEE KRKSVLASTT 
       510        520        530        540        550
KCGVEFSEPS LATKRAREDS GMVPLIIPVS VPVRTVDPTE AAQAGGLDED 
       560        570        580        590        600
GKGPEQNPAE HKPSVIVTRR RSTRIPGTDA QAQAEDMNVK LEGEPSVRKP 
       610        620        630        640        650
KQRPRPEPLI IPTKAGTFIA PPVYSNITPY QSHLRSPVRL ADHPSERSFE 
       660        670        680        690        700
LPPYTPPPIL SPVREGSGLY FNAIISTSTI PAPPPITPKS AHRTLLRTNS 
       710        720        730        740        750
AEVTPPVLSV MGEATPVSIE PRINVGSRFQ AEIPLMRDRA LAAADPHKAD 
       760        770        780        790        800
LVWQPWEDLE SSREKQRQVE DLLTAACSSI FPGAGTNQEL ALHCLHESRG 
       810        820        830        840        850
DILETLNKLL LKKPLRPHNH PLATYHYTGS DQWKMAERKL FNKGIAIYKK 
       860        870        880        890        900
DFFLVQKLIQ TKTVAQCVEF YYTYKKQVKI GRNGTLTFGD VDTSDEKSAQ 
       910        920        930        940        950
EEVEVDIKTS QKFPRVPLPR RESPSEERLE PKREVKEPRK EGEEEVPEIQ 
       960        970        980        990       1000
EKEEQEEGRE RSRRAAAVKA TQTLQANESA SDILILRSHE SNAPGSAGGQ 
      1010       1020       1030       1040 
ASEKPREGTG KSRRALPFSE KKKKTETFSK TQNQENTFPC KKCGR
Length:1,045
Mass (Da):114,989
Last modified:November 28, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1FFD4CE7557D026F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1C7CYX1A0A1C7CYX1_HUMAN
Mitotic deacetylase-associated SANT...
MIDEAS
1,099Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MSU2A0A0A0MSU2_HUMAN
Mitotic deacetylase-associated SANT...
MIDEAS
1,018Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C1L3H7C1L3_HUMAN
Mitotic deacetylase-associated SANT...
MIDEAS
445Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JYU7C9JYU7_HUMAN
Mitotic deacetylase-associated SANT...
MIDEAS
65Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH06511 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti626N → D in AAH09202 (PubMed:15489334).Curated1
Sequence conflicti1020E → K in AAH09202 (PubMed:15489334).Curated1
Sequence conflicti1020E → K in AAH15668 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05018286A → V. Corresponds to variant dbSNP:rs35302179Ensembl.1
Natural variantiVAR_050183554P → L1 PublicationCorresponds to variant dbSNP:rs17782124Ensembl.1
Natural variantiVAR_061361895D → N. Corresponds to variant dbSNP:rs35905570Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AC006146 Genomic DNA No translation available.
BC006511 mRNA Translation: AAH06511.1 Different initiation.
BC009202 mRNA Translation: AAH09202.1
BC015668 mRNA Translation: AAH15668.1
AK127785 mRNA No translation available.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS9819.1

NCBI Reference Sequences

More...RefSeqi		NP_001036783.1, NM_001043318.2
NP_919254.2, NM_194278.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000286523; ENSP00000286523; ENSG00000156030
ENST00000394071; ENSP00000377634; ENSG00000156030

Database of genes from NCBI RefSeq genomes

More...GeneIDi		91748

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:91748

UCSC genome browser

More...UCSCi		uc001xot.4, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006146 Genomic DNA No translation available.
BC006511 mRNA Translation: AAH06511.1 Different initiation.
BC009202 mRNA Translation: AAH09202.1
BC015668 mRNA Translation: AAH15668.1
AK127785 mRNA No translation available.
CCDSiCCDS9819.1
RefSeqiNP_001036783.1, NM_001043318.2
NP_919254.2, NM_194278.3

3D structure databases

SMRiQ6PJG2
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi124872, 45 interactors
CORUMiQ6PJG2
IntActiQ6PJG2, 35 interactors
STRINGi9606.ENSP00000286523

PTM databases

GlyGeniQ6PJG2, 3 sites, 1 O-linked glycan (3 sites)
iPTMnetiQ6PJG2
MetOSiteiQ6PJG2
PhosphoSitePlusiQ6PJG2

Polymorphism and mutation databases

BioMutaiELMSAN1
DMDMi118572229

Proteomic databases

EPDiQ6PJG2
jPOSTiQ6PJG2
MassIVEiQ6PJG2
MaxQBiQ6PJG2
PaxDbiQ6PJG2
PeptideAtlasiQ6PJG2
PRIDEiQ6PJG2
ProteomicsDBi67201

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		167, 23 antibodies

Genome annotation databases

EnsembliENST00000286523; ENSP00000286523; ENSG00000156030
ENST00000394071; ENSP00000377634; ENSG00000156030
GeneIDi91748
KEGGihsa:91748
UCSCiuc001xot.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		91748
DisGeNETi91748
EuPathDBiHostDB:ENSG00000156030.12

GeneCards: human genes, protein and diseases

More...GeneCardsi		MIDEAS
HGNCiHGNC:19853, MIDEAS
HPAiENSG00000156030, Low tissue specificity
neXtProtiNX_Q6PJG2
OpenTargetsiENSG00000156030
PharmGKBiPA134877876

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4167, Eukaryota
GeneTreeiENSGT00940000157459
HOGENOMiCLU_011395_0_0_1
InParanoidiQ6PJG2
PhylomeDBiQ6PJG2
TreeFamiTF106431

Enzyme and pathway databases

PathwayCommonsiQ6PJG2

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		91748, 20 hits in 886 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ELMSAN1, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		91748
PharosiQ6PJG2, Tdark

Protein Ontology

More...PROi		PR:Q6PJG2
RNActiQ6PJG2, protein

Gene expression databases

BgeeiENSG00000156030, Expressed in sural nerve and 213 other tissues
ExpressionAtlasiQ6PJG2, baseline and differential
GenevisibleiQ6PJG2, HS

Family and domain databases

InterProiView protein in InterPro
IPR000949, ELM2_dom
IPR009057, Homeobox-like_sf
IPR001005, SANT/Myb
IPR017884, SANT_dom
PfamiView protein in Pfam
PF01448, ELM2, 1 hit
SMARTiView protein in SMART
SM01189, ELM2, 1 hit
SM00717, SANT, 1 hit
SUPFAMiSSF46689, SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS51156, ELM2, 1 hit
PS51293, SANT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMDEAS_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6PJG2
Secondary accession number(s): Q6PK13, Q6PK59, Q6ZS23
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: November 28, 2006
Last modified: August 12, 2020
This is version 139 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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