UniProtKB - Q6PJG2 (MDEAS_HUMAN)
Protein
Mitotic deacetylase-associated SANT domain protein
Gene
MIDEAS
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- transcription corepressor activity Source: GO_Central
GO - Biological processi
- histone deacetylation Source: GO_Central
- negative regulation of transcription, DNA-templated Source: GO_Central
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | Q6PJG2 |
Names & Taxonomyi
Protein namesi | Recommended name: Mitotic deacetylase-associated SANT domain proteinImportedAlternative name(s): ELM2 and SANT domain-containing protein 1 |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:19853, MIDEAS |
neXtProti | NX_Q6PJG2 |
VEuPathDBi | HostDB:ENSG00000156030.12 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation
Nucleus
- histone deacetylase complex Source: GO_Central
- nucleoplasm Source: HPA
Other locations
- transcription regulator complex Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 91748 |
OpenTargetsi | ENSG00000156030 |
PharmGKBi | PA134877876 |
Miscellaneous databases
Pharosi | Q6PJG2, Tdark |
Genetic variation databases
BioMutai | ELMSAN1 |
DMDMi | 118572229 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000259764 | 1 – 1045 | Mitotic deacetylase-associated SANT domain proteinAdd BLAST | 1045 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineCombined sources | 1 | |
Cross-linki | 166 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 193 | Asymmetric dimethylarginineCombined sources | 1 | |
Modified residuei | 447 | Omega-N-methylarginineCombined sources | 1 | |
Modified residuei | 461 | PhosphoserineCombined sources | 1 | |
Cross-linki | 590 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources | ||
Cross-linki | 590 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources | ||
Modified residuei | 655 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 661 | PhosphoserineCombined sources | 1 | |
Modified residuei | 704 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 709 | PhosphoserineCombined sources | 1 | |
Modified residuei | 715 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 923 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q6PJG2 |
jPOSTi | Q6PJG2 |
MassIVEi | Q6PJG2 |
MaxQBi | Q6PJG2 |
PaxDbi | Q6PJG2 |
PeptideAtlasi | Q6PJG2 |
PRIDEi | Q6PJG2 |
ProteomicsDBi | 67201 |
PTM databases
GlyGeni | Q6PJG2, 3 sites, 1 O-linked glycan (3 sites) |
iPTMneti | Q6PJG2 |
MetOSitei | Q6PJG2 |
PhosphoSitePlusi | Q6PJG2 |
Expressioni
Gene expression databases
Bgeei | ENSG00000156030, Expressed in sural nerve and 213 other tissues |
ExpressionAtlasi | Q6PJG2, baseline and differential |
Genevisiblei | Q6PJG2, HS |
Organism-specific databases
HPAi | ENSG00000156030, Low tissue specificity |
Interactioni
Subunit structurei
Protein-protein interaction databases
BioGRIDi | 124872, 46 interactors |
CORUMi | Q6PJG2 |
IntActi | Q6PJG2, 35 interactors |
STRINGi | 9606.ENSP00000286523 |
Miscellaneous databases
RNActi | Q6PJG2, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 721 – 813 | ELM2PROSITE-ProRule annotationAdd BLAST | 93 | |
Domaini | 828 – 879 | SANTPROSITE-ProRule annotationAdd BLAST | 52 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 111 – 115 | Poly-Gly | 5 | |
Compositional biasi | 210 – 291 | Gln-richAdd BLAST | 82 | |
Compositional biasi | 234 – 395 | Pro-richAdd BLAST | 162 | |
Compositional biasi | 455 – 459 | Poly-Arg | 5 | |
Compositional biasi | 1021 – 1024 | Poly-Lys | 4 |
Phylogenomic databases
eggNOGi | KOG4167, Eukaryota |
GeneTreei | ENSGT00940000157459 |
HOGENOMi | CLU_011395_0_0_1 |
InParanoidi | Q6PJG2 |
PhylomeDBi | Q6PJG2 |
TreeFami | TF106431 |
Family and domain databases
InterProi | View protein in InterPro IPR000949, ELM2_dom IPR009057, Homeobox-like_sf IPR001005, SANT/Myb IPR017884, SANT_dom |
Pfami | View protein in Pfam PF01448, ELM2, 1 hit |
SMARTi | View protein in SMART SM01189, ELM2, 1 hit SM00717, SANT, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS51156, ELM2, 1 hit PS51293, SANT, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
Q6PJG2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNLQAQPKAQ NKRKRCLFGG QEPAPKEQPP PLQPPQQSIR VKEEQYLGHE
60 70 80 90 100
GPGGAVSTSQ PVELPPPSSL ALLNSVVYGP ERTSAAMLSQ QVASVKWPNS
110 120 130 140 150
VMAPGRGPER GGGGGVSDSS WQQQPGQPPP HSTWNCHSLS LYSATKGSPH
160 170 180 190 200
PGVGVPTYYN HPEALKREKA GGPQLDRYVR PMMPQKVQLE VGRPQAPLNS
210 220 230 240 250
FHAAKKPPNQ SLPLQPFQLA FGHQVNRQVF RQGPPPPNPV AAFPPQKQQQ
260 270 280 290 300
QQQPQQQQQQ QQAALPQMPL FENFYSMPQQ PSQQPQDFGL QPAGPLGQSH
310 320 330 340 350
LAHHSMAPYP FPPNPDMNPE LRKALLQDSA PQPALPQVQI PFPRRSRRLS
360 370 380 390 400
KEGILPPSAL DGAGTQPGQE ATGNLFLHHW PLQQPPPGSL GQPHPEALGF
410 420 430 440 450
PLELRESQLL PDGERLAPNG REREAPAMGS EEGMRAVSTG DCGQVLRGGV
460 470 480 490 500
IQSTRRRRRA SQEANLLTLA QKAVELASLQ NAKDGSGSEE KRKSVLASTT
510 520 530 540 550
KCGVEFSEPS LATKRAREDS GMVPLIIPVS VPVRTVDPTE AAQAGGLDED
560 570 580 590 600
GKGPEQNPAE HKPSVIVTRR RSTRIPGTDA QAQAEDMNVK LEGEPSVRKP
610 620 630 640 650
KQRPRPEPLI IPTKAGTFIA PPVYSNITPY QSHLRSPVRL ADHPSERSFE
660 670 680 690 700
LPPYTPPPIL SPVREGSGLY FNAIISTSTI PAPPPITPKS AHRTLLRTNS
710 720 730 740 750
AEVTPPVLSV MGEATPVSIE PRINVGSRFQ AEIPLMRDRA LAAADPHKAD
760 770 780 790 800
LVWQPWEDLE SSREKQRQVE DLLTAACSSI FPGAGTNQEL ALHCLHESRG
810 820 830 840 850
DILETLNKLL LKKPLRPHNH PLATYHYTGS DQWKMAERKL FNKGIAIYKK
860 870 880 890 900
DFFLVQKLIQ TKTVAQCVEF YYTYKKQVKI GRNGTLTFGD VDTSDEKSAQ
910 920 930 940 950
EEVEVDIKTS QKFPRVPLPR RESPSEERLE PKREVKEPRK EGEEEVPEIQ
960 970 980 990 1000
EKEEQEEGRE RSRRAAAVKA TQTLQANESA SDILILRSHE SNAPGSAGGQ
1010 1020 1030 1040
ASEKPREGTG KSRRALPFSE KKKKTETFSK TQNQENTFPC KKCGR
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A1C7CYX1 | A0A1C7CYX1_HUMAN | Mitotic deacetylase-associated SANT... | MIDEAS | 1,099 | Annotation score: | ||
A0A0A0MSU2 | A0A0A0MSU2_HUMAN | Mitotic deacetylase-associated SANT... | MIDEAS | 1,018 | Annotation score: | ||
H7C1L3 | H7C1L3_HUMAN | Mitotic deacetylase-associated SANT... | MIDEAS | 445 | Annotation score: | ||
C9JYU7 | C9JYU7_HUMAN | Mitotic deacetylase-associated SANT... | MIDEAS | 65 | Annotation score: |
Sequence cautioni
The sequence AAH06511 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 626 | N → D in AAH09202 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 1020 | E → K in AAH09202 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 1020 | E → K in AAH15668 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_050182 | 86 | A → V. Corresponds to variant dbSNP:rs35302179Ensembl. | 1 | |
Natural variantiVAR_050183 | 554 | P → L1 PublicationCorresponds to variant dbSNP:rs17782124Ensembl. | 1 | |
Natural variantiVAR_061361 | 895 | D → N. Corresponds to variant dbSNP:rs35905570Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC006146 Genomic DNA No translation available. BC006511 mRNA Translation: AAH06511.1 Different initiation. BC009202 mRNA Translation: AAH09202.1 BC015668 mRNA Translation: AAH15668.1 AK127785 mRNA No translation available. |
CCDSi | CCDS9819.1 |
RefSeqi | NP_001036783.1, NM_001043318.2 NP_919254.2, NM_194278.3 |
Genome annotation databases
Ensembli | ENST00000286523; ENSP00000286523; ENSG00000156030 ENST00000394071; ENSP00000377634; ENSG00000156030 |
GeneIDi | 91748 |
KEGGi | hsa:91748 |
UCSCi | uc001xot.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC006146 Genomic DNA No translation available. BC006511 mRNA Translation: AAH06511.1 Different initiation. BC009202 mRNA Translation: AAH09202.1 BC015668 mRNA Translation: AAH15668.1 AK127785 mRNA No translation available. |
CCDSi | CCDS9819.1 |
RefSeqi | NP_001036783.1, NM_001043318.2 NP_919254.2, NM_194278.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6Z2J | electron microscopy | 4.00 | D/F | 717-887 | [»] | |
6Z2K | electron microscopy | 4.50 | D/F/J/L | 717-887 | [»] | |
SMRi | Q6PJG2 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 124872, 46 interactors |
CORUMi | Q6PJG2 |
IntActi | Q6PJG2, 35 interactors |
STRINGi | 9606.ENSP00000286523 |
PTM databases
GlyGeni | Q6PJG2, 3 sites, 1 O-linked glycan (3 sites) |
iPTMneti | Q6PJG2 |
MetOSitei | Q6PJG2 |
PhosphoSitePlusi | Q6PJG2 |
Genetic variation databases
BioMutai | ELMSAN1 |
DMDMi | 118572229 |
Proteomic databases
EPDi | Q6PJG2 |
jPOSTi | Q6PJG2 |
MassIVEi | Q6PJG2 |
MaxQBi | Q6PJG2 |
PaxDbi | Q6PJG2 |
PeptideAtlasi | Q6PJG2 |
PRIDEi | Q6PJG2 |
ProteomicsDBi | 67201 |
Protocols and materials databases
Antibodypediai | 167, 24 antibodies |
Genome annotation databases
Ensembli | ENST00000286523; ENSP00000286523; ENSG00000156030 ENST00000394071; ENSP00000377634; ENSG00000156030 |
GeneIDi | 91748 |
KEGGi | hsa:91748 |
UCSCi | uc001xot.4, human |
Organism-specific databases
CTDi | 91748 |
DisGeNETi | 91748 |
GeneCardsi | MIDEAS |
HGNCi | HGNC:19853, MIDEAS |
HPAi | ENSG00000156030, Low tissue specificity |
neXtProti | NX_Q6PJG2 |
OpenTargetsi | ENSG00000156030 |
PharmGKBi | PA134877876 |
VEuPathDBi | HostDB:ENSG00000156030.12 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4167, Eukaryota |
GeneTreei | ENSGT00940000157459 |
HOGENOMi | CLU_011395_0_0_1 |
InParanoidi | Q6PJG2 |
PhylomeDBi | Q6PJG2 |
TreeFami | TF106431 |
Enzyme and pathway databases
PathwayCommonsi | Q6PJG2 |
Miscellaneous databases
BioGRID-ORCSi | 91748, 29 hits in 1011 CRISPR screens |
ChiTaRSi | ELMSAN1, human |
GenomeRNAii | 91748 |
Pharosi | Q6PJG2, Tdark |
PROi | PR:Q6PJG2 |
RNActi | Q6PJG2, protein |
Gene expression databases
Bgeei | ENSG00000156030, Expressed in sural nerve and 213 other tissues |
ExpressionAtlasi | Q6PJG2, baseline and differential |
Genevisiblei | Q6PJG2, HS |
Family and domain databases
InterProi | View protein in InterPro IPR000949, ELM2_dom IPR009057, Homeobox-like_sf IPR001005, SANT/Myb IPR017884, SANT_dom |
Pfami | View protein in Pfam PF01448, ELM2, 1 hit |
SMARTi | View protein in SMART SM01189, ELM2, 1 hit SM00717, SANT, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS51156, ELM2, 1 hit PS51293, SANT, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MDEAS_HUMAN | |
Accessioni | Q6PJG2Primary (citable) accession number: Q6PJG2 Secondary accession number(s): Q6PK13, Q6PK59, Q6ZS23 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 28, 2006 |
Last sequence update: | November 28, 2006 | |
Last modified: | April 7, 2021 | |
This is version 143 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - PDB cross-references
Index of Protein Data Bank (PDB) cross-references