TRAT1

Functionⁱ

Stabilizes the TCR (T-cell antigen receptor)/CD3 complex at the surface of T-cells.1 Publication

GO - Molecular functionⁱ

phosphatidylinositol-4,5-bisphosphate 3-kinase activity Source: Reactome
transmembrane receptor protein tyrosine kinase adaptor activity
Source: ProtInc
Traceable author statementⁱ
- 9687533

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

adaptive immune response Source: UniProtKB-KW
cellular defense response
Source: ProtInc
Traceable author statementⁱ
- 9687533
negative regulation of receptor recycling
Source: MGI
Inferred from direct assayⁱ
- 11390434
negative regulation of transport
Source: MGI
Inferred from direct assayⁱ
- 11390434
positive regulation of calcium-mediated signaling
Source: MGI
Inferred from direct assayⁱ
- 11390434
positive regulation of protein kinase B signaling Source: Reactome
positive regulation of T cell receptor signaling pathway
Source: MGI
Inferred from direct assayⁱ
- 11390434
signal transduction
Source: ProtInc
Traceable author statementⁱ
- 9687533
T cell receptor signaling pathway Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Adaptive immunity, Immunity

Biological process

Adaptive immunity, Immunity

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1257604 PIP3 activates AKT signaling R-HSA-202424 Downstream TCR signaling R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
SignaLinkⁱ	Q6PIZ9

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: T-cell receptor-associated transmembrane adapter 1 Alternative name(s): T-cell receptor-interacting molecule Short name: TRIM pp29/30
Gene namesⁱ	Name:TRAT1 Synonyms:TCRIM ORF Names:HSPC062
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 3

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000163519.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:30698 TRAT1
MIMⁱ	604962 gene
neXtProtⁱ	NX_Q6PIZ9

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 7	ExtracellularSequence analysis	7
Transmembraneⁱ	8 – 28	Helical; Signal-anchor for type III membrane proteinSequence analysisAdd BLAST	21
Topological domainⁱ	29 – 186	CytoplasmicSequence analysisAdd BLAST	158

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	79	Y → F: Abolishes interaction with PIK3R1. 1 Publication		1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	50852
Open Targets More...OpenTargetsⁱ	ENSG00000163519
PharmGKBⁱ	PA128394655

Polymorphism and mutation databases

BioMutaⁱ	TRAT1
DMDMⁱ	74749223

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000083344	1 – 186	T-cell receptor-associated transmembrane adapter 1Add BLAST		186

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	7	InterchainCurated
Modified residueⁱ	46	PhosphoserineBy similarity	1
Modified residueⁱ	79	Phosphotyrosine1 Publication	1

Post-translational modificationⁱ

Phosphorylated on tyrosines by LCK or FYN upon TCR activation.1 Publication

Keywords - PTMⁱ

Disulfide bond, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q6PIZ9
PaxDbⁱ	Q6PIZ9
PeptideAtlas More...PeptideAtlasⁱ	Q6PIZ9
PRIDEⁱ	Q6PIZ9
ProteomicsDBⁱ	67189

PTM databases

iPTMnetⁱ	Q6PIZ9
PhosphoSitePlusⁱ	Q6PIZ9

Expressionⁱ

Tissue specificityⁱ

Strongly expressed in thymus, and to a lesser extent in spleen, lymph node and peripheral blood lymphocytes. Present in T-cells and NK cells, but not B-cells (at protein level).2 Publications

Developmental stageⁱ

Strongly expressed in fetal thymus at weeks 17-24 of gestation. Undetectable in bone marrow and fetal liver.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000163519 Expressed in 98 organ(s), highest expression level in blood
CleanExⁱ	HS_TRAT1
ExpressionAtlasⁱ	Q6PIZ9 baseline and differential
Genevisibleⁱ	Q6PIZ9 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB026130 HPA002356

HPAⁱ

CAB026130
HPA002356

Interactionⁱ

Subunit structureⁱ

Homodimer; disulfide-linked. Interacts with CD3Z. When phosphorylated, interacts with PIK3R1.2 Publications

GO - Molecular functionⁱ

transmembrane receptor protein tyrosine kinase adaptor activity
Source: ProtInc
Traceable author statementⁱ
- 9687533

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	119154, 16 interactors
IntActⁱ	Q6PIZ9, 1 interactor
STRINGⁱ	9606.ENSP00000295756

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q6PIZ9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	79 – 82	Interaction with PIK3R11 Publication		4

Keywords - Domainⁱ

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IW4V Eukaryota ENOG410ZB8K LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000004910
HOGENOMⁱ	HOG000129918
HOVERGENⁱ	HBG083932
InParanoidⁱ	Q6PIZ9
OMAⁱ	PVDENCY
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0RRV
PhylomeDBⁱ	Q6PIZ9
TreeFamⁱ	TF336066

Family and domain databases

InterProⁱ	View protein in InterPro IPR020399 T-cell_rcpt-assoc_TM_adapter-1
PANTHERⁱ	PTHR15951 PTHR15951, 1 hit
ProDomⁱ	View protein in ProDom or Entries sharing at least one domain PD306446 T-cell_rcpt-assoc_TM_adapter-1, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

Q6PIZ9-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSGISGCPFF LWGLLALLGL ALVISLIFNI SHYVEKQRQD KMYSYSSDHT 
        60         70         80         90        100
RVDEYYIEDT PIYGNLDDMI SEPMDENCYE QMKARPEKSV NKMQEATPSA 
       110        120        130        140        150
QATNETQMCY ASLDHSVKGK RRKPRKQNTH FSDKDGDEQL HAIDASVSKT 
       160        170        180 
TLVDSFSPES QAVEENIHDD PIRLFGLIRA KREPIN

Length:186

Mass (Da):21,211

Last modified:July 5, 2004 - v1

Checksum:ⁱ236A4BEFF427EA3E

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	C9JF66	C9JF66_HUMAN		T-cell receptor-associated transmem... T-cell receptor-associated transmembrane adapter 1	TRAT1	149	Annotation score:

Sequence cautionⁱ

The sequence AAF29034 differs from that shown. Reason: Frameshift at position 166.Curated

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_062195	137	D → G. Corresponds to variant dbSNP:rs57744779Ensembl.		1
Natural variantⁱVAR_062196	148	S → P. Corresponds to variant dbSNP:rs61585973Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF161547 mRNA Translation: AAF29034.1 Frameshift. BC025713 mRNA Translation: AAH25713.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS33813.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001304676.1, NM_001317747.1 NP_057472.2, NM_016388.3
UniGeneⁱ	Hs.138701

Genome annotation databases

Ensemblⁱ	ENST00000295756; ENSP00000295756; ENSG00000163519
GeneIDⁱ	50852
KEGGⁱ	hsa:50852
UCSC genome browser More...UCSCⁱ	uc003dxi.2 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q6PIZ9	T cell receptor associated transmembrane adaptor 1		GORGO		186	UniRef100_Q6PIZ9

Protein	Similar proteins		Species	Score	Length	Source
Q6PIZ9	T cell receptor associated transmembrane adaptor 1		GORGO		186	UniRef90_Q6PIZ9
T cell receptor associated transmembrane adaptor 1		SAIBB		195
Uncharacterized protein		AOTNA		190
Uncharacterized protein (Fragment)		MACMU		187
Uncharacterized protein (Fragment)		MACFA		187
+19

Protein	Similar proteins		Species	Score	Length	Source
Q6PIZ9	T cell receptor associated transmembrane adaptor 1		GORGO		186	UniRef50_Q6PIZ9
T cell receptor associated transmembrane adaptor 1		SAIBB		195
Uncharacterized protein		AOTNA		190
Uncharacterized protein		CHLSB		187
Uncharacterized protein (Fragment)		MACMU		187
+91

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF161547 mRNA Translation: AAF29034.1 Frameshift. BC025713 mRNA Translation: AAH25713.1
CCDSⁱ	CCDS33813.1
RefSeqⁱ	NP_001304676.1, NM_001317747.1 NP_057472.2, NM_016388.3
UniGeneⁱ	Hs.138701

3D structure databases

ProteinModelPortalⁱ	Q6PIZ9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	119154, 16 interactors
IntActⁱ	Q6PIZ9, 1 interactor
STRINGⁱ	9606.ENSP00000295756

PTM databases

iPTMnetⁱ	Q6PIZ9
PhosphoSitePlusⁱ	Q6PIZ9

Polymorphism and mutation databases

BioMutaⁱ	TRAT1
DMDMⁱ	74749223

Proteomic databases

MaxQBⁱ	Q6PIZ9
PaxDbⁱ	Q6PIZ9
PeptideAtlasⁱ	Q6PIZ9
PRIDEⁱ	Q6PIZ9
ProteomicsDBⁱ	67189

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	50852
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000295756; ENSP00000295756; ENSG00000163519
GeneIDⁱ	50852
KEGGⁱ	hsa:50852
UCSCⁱ	uc003dxi.2 human

Organism-specific databases

CTDⁱ	50852
DisGeNETⁱ	50852
EuPathDBⁱ	HostDB:ENSG00000163519.13
GeneCardsⁱ	TRAT1
HGNCⁱ	HGNC:30698 TRAT1
HPAⁱ	CAB026130 HPA002356
MIMⁱ	604962 gene
neXtProtⁱ	NX_Q6PIZ9
OpenTargetsⁱ	ENSG00000163519
PharmGKBⁱ	PA128394655
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IW4V Eukaryota ENOG410ZB8K LUCA
GeneTreeⁱ	ENSGT00390000004910
HOGENOMⁱ	HOG000129918
HOVERGENⁱ	HBG083932
InParanoidⁱ	Q6PIZ9
OMAⁱ	PVDENCY
OrthoDBⁱ	EOG091G0RRV
PhylomeDBⁱ	Q6PIZ9
TreeFamⁱ	TF336066

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1257604 PIP3 activates AKT signaling R-HSA-202424 Downstream TCR signaling R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
SignaLinkⁱ	Q6PIZ9

Miscellaneous databases

GeneWikiⁱ	TRAT1
GenomeRNAiⁱ	50852
Protein Ontology More...PROⁱ	PR:Q6PIZ9
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000163519 Expressed in 98 organ(s), highest expression level in blood
CleanExⁱ	HS_TRAT1
ExpressionAtlasⁱ	Q6PIZ9 baseline and differential
Genevisibleⁱ	Q6PIZ9 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR020399 T-cell_rcpt-assoc_TM_adapter-1
PANTHERⁱ	PTHR15951 PTHR15951, 1 hit
ProDomⁱ	View protein in ProDom or Entries sharing at least one domain PD306446 T-cell_rcpt-assoc_TM_adapter-1, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TRAT1_HUMAN
Accessionⁱ	Q6PIZ9Primary (citable) accession number: Q6PIZ9 Secondary accession number(s): Q9NZX5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 20, 2005
	Last sequence update:	July 5, 2004
	Last modified:	September 12, 2018
	This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniParc

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UniRef

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UniProtKB - Q6PIZ9 (TRAT1_HUMAN)

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T-cell receptor-associated transmembrane adapter 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma Membrane

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ