UniProtKB - Q6PIZ9 (TRAT1_HUMAN)
Protein
T-cell receptor-associated transmembrane adapter 1
Gene
TRAT1
Organism
Homo sapiens (Human)
Status
Functioni
Stabilizes the TCR (T-cell antigen receptor)/CD3 complex at the surface of T-cells.1 Publication
GO - Molecular functioni
- transmembrane receptor protein tyrosine kinase adaptor activity Source: ProtInc
GO - Biological processi
- adaptive immune response Source: UniProtKB-KW
- cellular defense response Source: ProtInc
- negative regulation of receptor recycling Source: MGI
- negative regulation of transport Source: MGI
- positive regulation of calcium-mediated signaling Source: MGI
- positive regulation of protein kinase B signaling Source: Reactome
- positive regulation of T cell receptor signaling pathway Source: MGI
- signal transduction Source: ProtInc
- T cell receptor signaling pathway Source: Reactome
Keywordsi
Biological process | Adaptive immunity, Immunity |
Enzyme and pathway databases
PathwayCommonsi | Q6PIZ9 |
Reactomei | R-HSA-1257604, PIP3 activates AKT signaling R-HSA-202424, Downstream TCR signaling R-HSA-2219530, Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling |
SignaLinki | Q6PIZ9 |
Names & Taxonomyi
Protein namesi | Recommended name: T-cell receptor-associated transmembrane adapter 1Alternative name(s): T-cell receptor-interacting molecule Short name: TRIM pp29/30 |
Gene namesi | Name:TRAT1 Synonyms:TCRIM ORF Names:HSPC062 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:30698, TRAT1 |
MIMi | 604962, gene |
neXtProti | NX_Q6PIZ9 |
VEuPathDBi | HostDB:ENSG00000163519.13 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Single-pass type III membrane protein 1 Publication
Plasma Membrane
- integral component of plasma membrane Source: ProtInc
- plasma membrane Source: MGI
- T cell receptor complex Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 7 | ExtracellularSequence analysis | 7 | |
Transmembranei | 8 – 28 | Helical; Signal-anchor for type III membrane proteinSequence analysisAdd BLAST | 21 | |
Topological domaini | 29 – 186 | CytoplasmicSequence analysisAdd BLAST | 158 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 79 | Y → F: Abolishes interaction with PIK3R1. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 50852 |
OpenTargetsi | ENSG00000163519 |
PharmGKBi | PA128394655 |
Miscellaneous databases
Pharosi | Q6PIZ9, Tbio |
Genetic variation databases
BioMutai | TRAT1 |
DMDMi | 74749223 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000083344 | 1 – 186 | T-cell receptor-associated transmembrane adapter 1Add BLAST | 186 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 7 | InterchainCurated | ||
Modified residuei | 46 | PhosphoserineBy similarity | 1 | |
Modified residuei | 79 | Phosphotyrosine1 Publication | 1 |
Post-translational modificationi
Phosphorylated on tyrosines by LCK or FYN upon TCR activation.1 Publication
Keywords - PTMi
Disulfide bond, PhosphoproteinProteomic databases
MassIVEi | Q6PIZ9 |
MaxQBi | Q6PIZ9 |
PaxDbi | Q6PIZ9 |
PeptideAtlasi | Q6PIZ9 |
PRIDEi | Q6PIZ9 |
ProteomicsDBi | 67189 |
PTM databases
iPTMneti | Q6PIZ9 |
PhosphoSitePlusi | Q6PIZ9 |
Expressioni
Tissue specificityi
Strongly expressed in thymus, and to a lesser extent in spleen, lymph node and peripheral blood lymphocytes. Present in T-cells and NK cells, but not B-cells (at protein level).2 Publications
Developmental stagei
Strongly expressed in fetal thymus at weeks 17-24 of gestation. Undetectable in bone marrow and fetal liver.1 Publication
Gene expression databases
Bgeei | ENSG00000163519, Expressed in blood and 122 other tissues |
ExpressionAtlasi | Q6PIZ9, baseline and differential |
Genevisiblei | Q6PIZ9, HS |
Organism-specific databases
HPAi | ENSG00000163519, Group enriched (blood, lymphoid tissue) |
Interactioni
Subunit structurei
Homodimer; disulfide-linked.
Interacts with CD3Z. When phosphorylated, interacts with PIK3R1.
2 PublicationsBinary interactionsi
Q6PIZ9
With | #Exp. | IntAct |
---|---|---|
SEC22A [Q96IW7] | 3 | EBI-17710254,EBI-8652744 |
GO - Molecular functioni
- transmembrane receptor protein tyrosine kinase adaptor activity Source: ProtInc
Protein-protein interaction databases
BioGRIDi | 119154, 17 interactors |
IntActi | Q6PIZ9, 2 interactors |
MINTi | Q6PIZ9 |
STRINGi | 9606.ENSP00000295756 |
Miscellaneous databases
RNActi | Q6PIZ9, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 79 – 82 | Interaction with PIK3R11 Publication | 4 |
Keywords - Domaini
Signal-anchor, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502S7P1, Eukaryota |
GeneTreei | ENSGT00390000004910 |
HOGENOMi | CLU_125033_1_0_1 |
InParanoidi | Q6PIZ9 |
OMAi | VWAILAF |
OrthoDBi | 1572760at2759 |
PhylomeDBi | Q6PIZ9 |
TreeFami | TF336066 |
Family and domain databases
InterProi | View protein in InterPro IPR020399, T-cell_rcpt-assoc_TM_adapter-1 |
PANTHERi | PTHR15951, PTHR15951, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q6PIZ9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSGISGCPFF LWGLLALLGL ALVISLIFNI SHYVEKQRQD KMYSYSSDHT
60 70 80 90 100
RVDEYYIEDT PIYGNLDDMI SEPMDENCYE QMKARPEKSV NKMQEATPSA
110 120 130 140 150
QATNETQMCY ASLDHSVKGK RRKPRKQNTH FSDKDGDEQL HAIDASVSKT
160 170 180
TLVDSFSPES QAVEENIHDD PIRLFGLIRA KREPIN
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketC9JF66 | C9JF66_HUMAN | T-cell receptor-associated transmem... | TRAT1 | 149 | Annotation score: |
Sequence cautioni
The sequence AAF29034 differs from that shown. Reason: Frameshift.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_062195 | 137 | D → G. Corresponds to variant dbSNP:rs57744779Ensembl. | 1 | |
Natural variantiVAR_062196 | 148 | S → P. Corresponds to variant dbSNP:rs61585973Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF161547 mRNA Translation: AAF29034.1 Frameshift. BC025713 mRNA Translation: AAH25713.1 |
CCDSi | CCDS33813.1 |
RefSeqi | NP_001304676.1, NM_001317747.1 NP_057472.2, NM_016388.3 |
Genome annotation databases
Ensembli | ENST00000295756; ENSP00000295756; ENSG00000163519 |
GeneIDi | 50852 |
KEGGi | hsa:50852 |
UCSCi | uc003dxi.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF161547 mRNA Translation: AAF29034.1 Frameshift. BC025713 mRNA Translation: AAH25713.1 |
CCDSi | CCDS33813.1 |
RefSeqi | NP_001304676.1, NM_001317747.1 NP_057472.2, NM_016388.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 119154, 17 interactors |
IntActi | Q6PIZ9, 2 interactors |
MINTi | Q6PIZ9 |
STRINGi | 9606.ENSP00000295756 |
PTM databases
iPTMneti | Q6PIZ9 |
PhosphoSitePlusi | Q6PIZ9 |
Genetic variation databases
BioMutai | TRAT1 |
DMDMi | 74749223 |
Proteomic databases
MassIVEi | Q6PIZ9 |
MaxQBi | Q6PIZ9 |
PaxDbi | Q6PIZ9 |
PeptideAtlasi | Q6PIZ9 |
PRIDEi | Q6PIZ9 |
ProteomicsDBi | 67189 |
Protocols and materials databases
Antibodypediai | 1192, 251 antibodies |
DNASUi | 50852 |
Genome annotation databases
Ensembli | ENST00000295756; ENSP00000295756; ENSG00000163519 |
GeneIDi | 50852 |
KEGGi | hsa:50852 |
UCSCi | uc003dxi.2, human |
Organism-specific databases
CTDi | 50852 |
DisGeNETi | 50852 |
GeneCardsi | TRAT1 |
HGNCi | HGNC:30698, TRAT1 |
HPAi | ENSG00000163519, Group enriched (blood, lymphoid tissue) |
MIMi | 604962, gene |
neXtProti | NX_Q6PIZ9 |
OpenTargetsi | ENSG00000163519 |
PharmGKBi | PA128394655 |
VEuPathDBi | HostDB:ENSG00000163519.13 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S7P1, Eukaryota |
GeneTreei | ENSGT00390000004910 |
HOGENOMi | CLU_125033_1_0_1 |
InParanoidi | Q6PIZ9 |
OMAi | VWAILAF |
OrthoDBi | 1572760at2759 |
PhylomeDBi | Q6PIZ9 |
TreeFami | TF336066 |
Enzyme and pathway databases
PathwayCommonsi | Q6PIZ9 |
Reactomei | R-HSA-1257604, PIP3 activates AKT signaling R-HSA-202424, Downstream TCR signaling R-HSA-2219530, Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling |
SignaLinki | Q6PIZ9 |
Miscellaneous databases
BioGRID-ORCSi | 50852, 7 hits in 866 CRISPR screens |
GeneWikii | TRAT1 |
GenomeRNAii | 50852 |
Pharosi | Q6PIZ9, Tbio |
PROi | PR:Q6PIZ9 |
RNActi | Q6PIZ9, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000163519, Expressed in blood and 122 other tissues |
ExpressionAtlasi | Q6PIZ9, baseline and differential |
Genevisiblei | Q6PIZ9, HS |
Family and domain databases
InterProi | View protein in InterPro IPR020399, T-cell_rcpt-assoc_TM_adapter-1 |
PANTHERi | PTHR15951, PTHR15951, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TRAT1_HUMAN | |
Accessioni | Q6PIZ9Primary (citable) accession number: Q6PIZ9 Secondary accession number(s): Q9NZX5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 20, 2005 |
Last sequence update: | July 5, 2004 | |
Last modified: | February 10, 2021 | |
This is version 132 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM