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Entry version 109 (17 Jun 2020)
Sequence version 2 (10 Jun 2008)
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Protein

Inactive rhomboid protein 1

Gene

Rhbdf1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Protein family/group databases

MEROPS protease database

More...
MEROPSi
S54.952

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Inactive rhomboid protein 1
Short name:
iRhom1
Alternative name(s):
Epidermal growth factor receptor-related protein
Rhomboid family member 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Rhbdf1
Synonyms:Dist1, Irhom1, Kiaa4242
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:104328 Rhbdf1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 412CytoplasmicSequence analysisAdd BLAST412
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei413 – 433HelicalSequence analysisAdd BLAST21
Topological domaini434 – 656LumenalSequence analysisAdd BLAST223
Transmembranei657 – 677HelicalSequence analysisAdd BLAST21
Topological domaini678 – 692CytoplasmicSequence analysisAdd BLAST15
Transmembranei693 – 713HelicalSequence analysisAdd BLAST21
Topological domaini714 – 715LumenalSequence analysis2
Transmembranei716 – 736HelicalSequence analysisAdd BLAST21
Topological domaini737 – 747CytoplasmicSequence analysisAdd BLAST11
Transmembranei748 – 768HelicalSequence analysisAdd BLAST21
Topological domaini769 – 773LumenalSequence analysis5
Transmembranei774 – 794HelicalSequence analysisAdd BLAST21
Topological domaini795 – 804CytoplasmicSequence analysis10
Transmembranei805 – 825HelicalSequence analysisAdd BLAST21
Topological domaini826 – 856LumenalSequence analysisAdd BLAST31

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003401081 – 856Inactive rhomboid protein 1Add BLAST856

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei76PhosphoserineBy similarity1
Modified residuei176PhosphoserineCombined sources1
Modified residuei180PhosphothreonineCombined sources1
Modified residuei183PhosphothreonineCombined sources1
Modified residuei391PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi584N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6PIX5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6PIX5

PeptideAtlas

More...
PeptideAtlasi
Q6PIX5

PRoteomics IDEntifications database

More...
PRIDEi
Q6PIX5

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
2388

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6PIX5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6PIX5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the duodenum, as well as in fetal liver and head.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000020282 Expressed in blood and 234 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6PIX5 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6PIX5 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer, or homooligomer.

Interacts with TGFA and HBEGF (By similarity).

Interacts with EGF; may retain EGF in the endoplasmic reticulum and regulates its degradation through the endoplasmic reticulum-associated degradation (ERAD) (PubMed:21439629).

Interacts (via cytoplasmic N-terminus) with FRMD8/iTAP; this interaction leads to mutual protein stabilization (By similarity).

Interacts with ADAM17/TACE (By similarity).

By similarity1 Publication

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000020524

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6PIX5 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6PIX5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase S54 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2290 Eukaryota
COG0705 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156278

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_011531_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6PIX5

Identification of Orthologs from Complete Genome Data

More...
OMAi
PHMDCAI

Database of Orthologous Groups

More...
OrthoDBi
1253228at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6PIX5

TreeFam database of animal gene trees

More...
TreeFami
TF312988

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1540.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR022764 Peptidase_S54_rhomboid_dom
IPR035952 Rhomboid-like_sf
IPR022241 Rhomboid_SP

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01694 Rhomboid, 1 hit
PF12595 Rhomboid_SP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6PIX5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSEARRDSTS SLQRKKPPWL KLDIPAAVPP AAEEPSFLQP LRRQAFLRSV
60 70 80 90 100
SMPAETARVP SPHHEPRRLV LQRQTSITQT IRRGTADWFG VSKDSDSTQK
110 120 130 140 150
WQRKSIRHCS QRYGKLKPQV IRELDLPSQD NVSLTSTETP PPLYVGPCQL
160 170 180 190 200
GMQKIIDPLA RGRAFRMADD TADGLSAPHT PVTPGAASLC SFSSSRSGFN
210 220 230 240 250
RLPRRRKRES VAKMSFRAAA ALVKGRSIRD GTLRRGQRRS FTPASFLEED
260 270 280 290 300
MVDFPDELDT SFFAREGVLH EEMSTYPDEV FESPSEAALK DWEKAPDQAD
310 320 330 340 350
LTGGALDRSE LERSHLMLPL ERGWRKQKEG GPLAPQPKVR LRQEVVSAAG
360 370 380 390 400
PRRGQRIAVP VRKLFAREKR PYGLGMVGRL TNRTYRKRID SYVKRQIEDM
410 420 430 440 450
DDHRPFFTYW LTFVHSLVTI LAVCIYGIAP VGFSQHETVD SVLRKRGVYE
460 470 480 490 500
NVKYVQQENF WIGPSSEALI HLGAKFSPCM RQDPQVHSFI LAAREREKHS
510 520 530 540 550
ACCVRNDRSG CVQTSKEECS STLAVWVKWP VHPSAPDLAG NKRQFGSVCH
560 570 580 590 600
QDPRVCDEPS SEDPHEWPED ITKWPICTKS SAGNHTNHPH MDCVITGRPC
610 620 630 640 650
CIGTKGRCEI TSREYCDFMR GYFHEEATLC SQVHCMDDVC GLLPFLNPEV
660 670 680 690 700
PDQFYRLWLS LFLHAGILHC LVSVCFQMTV LRDLEKLAGW HRIAIIYLLS
710 720 730 740 750
GITGNLASAI FLPYRAEVGP AGSQFGILAC LFVELFQSWQ ILARPWRAFF
760 770 780 790 800
KLLAVVLFLF AFGLLPWIDN FAHISGFVSG LFLSFAFLPY ISFGKFDLYR
810 820 830 840 850
KRCQIIIFQV VFLGLLAGLV VLFYFYPVRC EWCEFLTCIP FTDKFCEKYE

LDAQLH
Length:856
Mass (Da):97,292
Last modified:June 10, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBE8A3B32058793A5
GO
Isoform 2 (identifier: Q6PIX5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     266-282: EGVLHEEMSTYPDEVFE → VRRAWGVAPSPLSLDPP
     283-856: Missing.

Show »
Length:282
Mass (Da):31,555
Checksum:iDF73B1A9C8E5385E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A7M7T5A7M7T5_MOUSE
Inactive rhomboid protein 1
Rhbdf1
231Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2AVE5A2AVE5_MOUSE
Inactive rhomboid protein 1
Rhbdf1
57Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2AVE4A2AVE4_MOUSE
Inactive rhomboid protein 1
Rhbdf1
136Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F2Z3W3F2Z3W3_MOUSE
Inactive rhomboid protein 1
Rhbdf1
168Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA02574 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAL32367 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BAD90543 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti27A → V in AAH27346 (PubMed:15489334).Curated1
Sequence conflicti41L → V in AAH27346 (PubMed:15489334).Curated1
Sequence conflicti664 – 666HAG → LAA in AAA02574 (PubMed:8318735).Curated3
Sequence conflicti674V → I in AAH27346 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_034190266 – 282EGVLH…DEVFE → VRRAWGVAPSPLSLDPP in isoform 2. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_034191283 – 856Missing in isoform 2. 1 PublicationAdd BLAST574

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK220566 mRNA Translation: BAD90543.1 Different initiation.
AY016021 Genomic DNA Translation: AAL32367.1 Sequence problems.
AL929446 Genomic DNA No translation available.
BC023469 mRNA Translation: AAH23469.1
BC027346 mRNA Translation: AAH27346.1
M99623 mRNA Translation: AAA02574.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS24519.1 [Q6PIX5-1]

NCBI Reference Sequences

More...
RefSeqi
NP_034247.2, NM_010117.2 [Q6PIX5-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000020524; ENSMUSP00000020524; ENSMUSG00000020282 [Q6PIX5-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
13650

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:13650

UCSC genome browser

More...
UCSCi
uc007ijb.2 mouse [Q6PIX5-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK220566 mRNA Translation: BAD90543.1 Different initiation.
AY016021 Genomic DNA Translation: AAL32367.1 Sequence problems.
AL929446 Genomic DNA No translation available.
BC023469 mRNA Translation: AAH23469.1
BC027346 mRNA Translation: AAH27346.1
M99623 mRNA Translation: AAA02574.1 Different initiation.
CCDSiCCDS24519.1 [Q6PIX5-1]
RefSeqiNP_034247.2, NM_010117.2 [Q6PIX5-1]

3D structure databases

SMRiQ6PIX5
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020524

Protein family/group databases

MEROPSiS54.952

PTM databases

GlyConnecti2388
iPTMnetiQ6PIX5
PhosphoSitePlusiQ6PIX5

Proteomic databases

jPOSTiQ6PIX5
PaxDbiQ6PIX5
PeptideAtlasiQ6PIX5
PRIDEiQ6PIX5

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
22449 34 antibodies

Genome annotation databases

EnsembliENSMUST00000020524; ENSMUSP00000020524; ENSMUSG00000020282 [Q6PIX5-1]
GeneIDi13650
KEGGimmu:13650
UCSCiuc007ijb.2 mouse [Q6PIX5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
64285
MGIiMGI:104328 Rhbdf1

Rodent Unidentified Gene-Encoded large proteins database

More...
Rougei
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Phylogenomic databases

eggNOGiKOG2290 Eukaryota
COG0705 LUCA
GeneTreeiENSGT00940000156278
HOGENOMiCLU_011531_1_1_1
InParanoidiQ6PIX5
OMAiPHMDCAI
OrthoDBi1253228at2759
PhylomeDBiQ6PIX5
TreeFamiTF312988

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
13650 1 hit in 12 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Rhbdf1 mouse

Protein Ontology

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PROi
PR:Q6PIX5
RNActiQ6PIX5 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000020282 Expressed in blood and 234 other tissues
ExpressionAtlasiQ6PIX5 baseline and differential
GenevisibleiQ6PIX5 MM

Family and domain databases

Gene3Di1.20.1540.10, 1 hit
InterProiView protein in InterPro
IPR022764 Peptidase_S54_rhomboid_dom
IPR035952 Rhomboid-like_sf
IPR022241 Rhomboid_SP
PfamiView protein in Pfam
PF01694 Rhomboid, 1 hit
PF12595 Rhomboid_SP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRHDF1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6PIX5
Secondary accession number(s): A2AVE2
, Q04843, Q5DTF4, Q6PJ49, Q8VIK0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 10, 2008
Last modified: June 17, 2020
This is version 109 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. Peptidase families
    Classification of peptidase families and list of entries
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