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Entry version 161 (25 May 2022)
Sequence version 2 (11 Sep 2007)
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Protein

Fidgetin-like protein 1

Gene

FIGNL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in DNA double-strand break (DBS) repair via homologous recombination (HR). Recruited at DSB sites independently of BRCA2, RAD51 and RAD51 paralogs in a H2AX-dependent manner. May regulate osteoblast proliferation and differentiation (PubMed:23754376).

May play a role in the control of male meiosis dynamic (By similarity).

By similarity1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei404ATP; via amide nitrogen and carbonyl oxygen1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi444 – 449ATP1 Publication6

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
Q6PIW4

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q6PIW4

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Fidgetin-like protein 1 (EC:3.6.4.-)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FIGNL1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:13286, FIGNL1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
615383, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6PIW4

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000132436

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi295F → E: Reduces interaction with RAD51 and inhibits HR-mediated DNA repair. Strongly reduce, but does abolish, interaction with RAD51; when associated with E-340. 1 Publication1
Mutagenesisi340F → E: Reduces weakly interaction with RAD51. Strongly reduce, but does abolish, interaction with RAD51; when associated with E-295. 1 Publication1
Mutagenesisi447K → A: Inhibits HR-mediated DNA repair. 1 Publication1
Mutagenesisi500D → A: Inhibits HR-mediated DNA repair. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
63979

Open Targets

More...
OpenTargetsi
ENSG00000132436

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA28148

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q6PIW4, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FIGNL1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
158563967

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003027231 – 674Fidgetin-like protein 1Add BLAST674

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki225Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei259PhosphoserineCombined sources1
Modified residuei339N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

The CPTAC Assay portal

More...
CPTACi
CPTAC-1608

Encyclopedia of Proteome Dynamics

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EPDi
Q6PIW4

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6PIW4

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q6PIW4

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6PIW4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6PIW4

PeptideAtlas

More...
PeptideAtlasi
Q6PIW4

PRoteomics IDEntifications database

More...
PRIDEi
Q6PIW4

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
67182 [Q6PIW4-1]
67183 [Q6PIW4-2]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q6PIW4, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6PIW4

MetOSite database of methionine sulfoxide sites

More...
MetOSitei
Q6PIW4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6PIW4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000132436, Expressed in secondary oocyte and 203 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6PIW4, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6PIW4, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000132436, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Hexamer (By similarity).

Interacts (via N-terminal one-half region) with RAD51; the interaction is direct.

Interacts (via N-terminal one-half region) with SPIDR (via the C-terminal region); the interaction is direct.

By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
122026, 74 interactors

Protein interaction database and analysis system

More...
IntActi
Q6PIW4, 36 interactors

Molecular INTeraction database

More...
MINTi
Q6PIW4

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000410811

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6PIW4, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1674
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...
AlphaFoldDBi
Q6PIW4

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6PIW4

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q6PIW4

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni157 – 179DisorderedSequence analysisAdd BLAST23
Regioni295 – 344Necessary and sufficient for interaction with RAD511 PublicationAdd BLAST50

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi164 – 178Basic and acidic residuesSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The N-terminus is necessary for its recruitment to DNA damage sites.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the AAA ATPase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0740, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161552

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000688_21_10_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6PIW4

Identification of Orthologs from Complete Genome Data

More...
OMAi
YSDKWES

Database of Orthologous Groups

More...
OrthoDBi
1176820at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6PIW4

TreeFam database of animal gene trees

More...
TreeFami
TF105013

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.300, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593, AAA+_ATPase
IPR003959, ATPase_AAA_core
IPR003960, ATPase_AAA_CS
IPR027417, P-loop_NTPase
IPR015415, Vps4_C

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00004, AAA, 1 hit
PF09336, Vps4_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382, AAA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00674, AAA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6PIW4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQTSSSRSVH LSEWQKNYFA ITSGICTGPK ADAYRAQILR IQYAWANSEI
60 70 80 90 100
SQVCATKLFK KYAEKYSAII DSDNVESGLN NYAENILTLA GSQQTDSDKW
110 120 130 140 150
QSGLSINNVF KMSSVQKMMQ AGKKFKDSLL EPALASVVIH KEATVFDLPK
160 170 180 190 200
FSVCGSSQES DSLPNSAHDR DRTQDFPESN RLKLLQNAQP PMVTNTARTC
210 220 230 240 250
PTFSAPVGES ATAKFHVTPL FGNVKKENHS SAKENIGLNV FLSNQSCFPA
260 270 280 290 300
ACENPQRKSF YGSGTIDALS NPILNKACSK TEDNGPKEDS SLPTFKTAKE
310 320 330 340 350
QLWVDQQKKY HQPQRASGSS YGGVKKSLGA SRSRGILGKF VPPIPKQDGG
360 370 380 390 400
EQNGGMQCKP YGAGPTEPAH PVDERLKNLE PKMIELIMNE IMDHGPPVNW
410 420 430 440 450
EDIAGVEFAK ATIKEIVVWP MLRPDIFTGL RGPPKGILLF GPPGTGKTLI
460 470 480 490 500
GKCIASQSGA TFFSISASSL TSKWVGEGEK MVRALFAVAR CQQPAVIFID
510 520 530 540 550
EIDSLLSQRG DGEHESSRRI KTEFLVQLDG ATTSSEDRIL VVGATNRPQE
560 570 580 590 600
IDEAARRRLV KRLYIPLPEA SARKQIVINL MSKEQCCLSE EEIEQIVQQS
610 620 630 640 650
DAFSGADMTQ LCREASLGPI RSLQTADIAT ITPDQVRPIA YIDFENAFRT
660 670
VRPSVSPKDL ELYENWNKTF GCGK
Length:674
Mass (Da):74,077
Last modified:September 11, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2EB812B407495BF2
GO
Isoform 2 (identifier: Q6PIW4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-111: Missing.

Show »
Length:563
Mass (Da):61,686
Checksum:iDD30D9C1EEC2DEA3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JHJ4C9JHJ4_HUMAN
Fidgetin-like protein 1
FIGNL1
102Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JKI6C9JKI6_HUMAN
Fidgetin-like protein 1
FIGNL1
125Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JP37C9JP37_HUMAN
Fidgetin-like protein 1
FIGNL1
35Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JSC4C9JSC4_HUMAN
Fidgetin-like protein 1
FIGNL1
67Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JTB2C9JTB2_HUMAN
Fidgetin-like protein 1
FIGNL1
97Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JTG6C9JTG6_HUMAN
Fidgetin-like protein 1
FIGNL1
53Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB14567 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti614E → G in BAB14426 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_034941137V → M1 PublicationCorresponds to variant dbSNP:rs10235371Ensembl.1
Natural variantiVAR_034942216H → Y. Corresponds to variant dbSNP:rs35929700Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0279371 – 111Missing in isoform 2. 1 PublicationAdd BLAST111

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK023142 mRNA Translation: BAB14426.1
AK023411 mRNA Translation: BAB14567.1 Different initiation.
AL834387 mRNA Translation: CAD39050.1
AC018705 Genomic DNA Translation: AAS01996.1
CH236955 Genomic DNA Translation: EAL23899.1
CH471128 Genomic DNA Translation: EAW60975.1
CH471128 Genomic DNA Translation: EAW60976.1
BC051867 mRNA Translation: AAH51867.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS5510.1 [Q6PIW4-1]

NCBI Reference Sequences

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RefSeqi
NP_001036227.1, NM_001042762.3 [Q6PIW4-1]
NP_001274421.1, NM_001287492.2 [Q6PIW4-1]
NP_001274422.1, NM_001287493.2 [Q6PIW4-1]
NP_001274423.1, NM_001287494.2 [Q6PIW4-1]
NP_001274424.1, NM_001287495.2 [Q6PIW4-1]
NP_001274425.1, NM_001287496.2 [Q6PIW4-2]
NP_001333487.1, NM_001346558.1 [Q6PIW4-2]
NP_001333488.1, NM_001346559.1 [Q6PIW4-2]
NP_001333489.1, NM_001346560.1 [Q6PIW4-1]
NP_001333490.1, NM_001346561.1 [Q6PIW4-1]
NP_001333491.1, NM_001346562.1 [Q6PIW4-1]
NP_001333492.1, NM_001346563.1 [Q6PIW4-1]
NP_001333493.1, NM_001346564.1 [Q6PIW4-1]
NP_001333494.1, NM_001346565.1 [Q6PIW4-1]
NP_071399.2, NM_022116.5 [Q6PIW4-1]
XP_011513772.1, XM_011515470.2 [Q6PIW4-1]
XP_016867990.1, XM_017012501.1 [Q6PIW4-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000356889.8; ENSP00000349356.4; ENSG00000132436.12
ENST00000395556.6; ENSP00000378924.2; ENSG00000132436.12
ENST00000419119.1; ENSP00000410811.1; ENSG00000132436.12
ENST00000433017.6; ENSP00000399997.1; ENSG00000132436.12
ENST00000611938.4; ENSP00000484551.1; ENSG00000132436.12
ENST00000613602.3; ENSP00000481751.1; ENSG00000132436.12
ENST00000615084.4; ENSP00000483543.1; ENSG00000132436.12
ENST00000617389.4; ENSP00000483126.1; ENSG00000132436.12

Database of genes from NCBI RefSeq genomes

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GeneIDi
63979

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:63979

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

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MANE-Selecti
ENST00000433017.6; ENSP00000399997.1; NM_001287492.4; NP_001274421.1

UCSC genome browser

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UCSCi
uc003tpc.5, human [Q6PIW4-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK023142 mRNA Translation: BAB14426.1
AK023411 mRNA Translation: BAB14567.1 Different initiation.
AL834387 mRNA Translation: CAD39050.1
AC018705 Genomic DNA Translation: AAS01996.1
CH236955 Genomic DNA Translation: EAL23899.1
CH471128 Genomic DNA Translation: EAW60975.1
CH471128 Genomic DNA Translation: EAW60976.1
BC051867 mRNA Translation: AAH51867.1
CCDSiCCDS5510.1 [Q6PIW4-1]
RefSeqiNP_001036227.1, NM_001042762.3 [Q6PIW4-1]
NP_001274421.1, NM_001287492.2 [Q6PIW4-1]
NP_001274422.1, NM_001287493.2 [Q6PIW4-1]
NP_001274423.1, NM_001287494.2 [Q6PIW4-1]
NP_001274424.1, NM_001287495.2 [Q6PIW4-1]
NP_001274425.1, NM_001287496.2 [Q6PIW4-2]
NP_001333487.1, NM_001346558.1 [Q6PIW4-2]
NP_001333488.1, NM_001346559.1 [Q6PIW4-2]
NP_001333489.1, NM_001346560.1 [Q6PIW4-1]
NP_001333490.1, NM_001346561.1 [Q6PIW4-1]
NP_001333491.1, NM_001346562.1 [Q6PIW4-1]
NP_001333492.1, NM_001346563.1 [Q6PIW4-1]
NP_001333493.1, NM_001346564.1 [Q6PIW4-1]
NP_001333494.1, NM_001346565.1 [Q6PIW4-1]
NP_071399.2, NM_022116.5 [Q6PIW4-1]
XP_011513772.1, XM_011515470.2 [Q6PIW4-1]
XP_016867990.1, XM_017012501.1 [Q6PIW4-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3D8BX-ray2.00A/B341-674[»]
AlphaFoldDBiQ6PIW4
SMRiQ6PIW4
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi122026, 74 interactors
IntActiQ6PIW4, 36 interactors
MINTiQ6PIW4
STRINGi9606.ENSP00000410811

PTM databases

GlyGeniQ6PIW4, 1 site, 1 O-linked glycan (1 site)
iPTMnetiQ6PIW4
MetOSiteiQ6PIW4
PhosphoSitePlusiQ6PIW4

Genetic variation databases

BioMutaiFIGNL1
DMDMi158563967

Proteomic databases

CPTACiCPTAC-1608
EPDiQ6PIW4
jPOSTiQ6PIW4
MassIVEiQ6PIW4
MaxQBiQ6PIW4
PaxDbiQ6PIW4
PeptideAtlasiQ6PIW4
PRIDEiQ6PIW4
ProteomicsDBi67182 [Q6PIW4-1]
67183 [Q6PIW4-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
27700, 143 antibodies from 26 providers

The DNASU plasmid repository

More...
DNASUi
63979

Genome annotation databases

EnsembliENST00000356889.8; ENSP00000349356.4; ENSG00000132436.12
ENST00000395556.6; ENSP00000378924.2; ENSG00000132436.12
ENST00000419119.1; ENSP00000410811.1; ENSG00000132436.12
ENST00000433017.6; ENSP00000399997.1; ENSG00000132436.12
ENST00000611938.4; ENSP00000484551.1; ENSG00000132436.12
ENST00000613602.3; ENSP00000481751.1; ENSG00000132436.12
ENST00000615084.4; ENSP00000483543.1; ENSG00000132436.12
ENST00000617389.4; ENSP00000483126.1; ENSG00000132436.12
GeneIDi63979
KEGGihsa:63979
MANE-SelectiENST00000433017.6; ENSP00000399997.1; NM_001287492.4; NP_001274421.1
UCSCiuc003tpc.5, human [Q6PIW4-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
63979
DisGeNETi63979

GeneCards: human genes, protein and diseases

More...
GeneCardsi
FIGNL1
HGNCiHGNC:13286, FIGNL1
HPAiENSG00000132436, Low tissue specificity
MIMi615383, gene
neXtProtiNX_Q6PIW4
OpenTargetsiENSG00000132436
PharmGKBiPA28148
VEuPathDBiHostDB:ENSG00000132436

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0740, Eukaryota
GeneTreeiENSGT00940000161552
HOGENOMiCLU_000688_21_10_1
InParanoidiQ6PIW4
OMAiYSDKWES
OrthoDBi1176820at2759
PhylomeDBiQ6PIW4
TreeFamiTF105013

Enzyme and pathway databases

PathwayCommonsiQ6PIW4
SignaLinkiQ6PIW4

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
63979, 15 hits in 1079 CRISPR screens
EvolutionaryTraceiQ6PIW4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
63979
PharosiQ6PIW4, Tbio

Protein Ontology

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PROi
PR:Q6PIW4
RNActiQ6PIW4, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000132436, Expressed in secondary oocyte and 203 other tissues
ExpressionAtlasiQ6PIW4, baseline and differential
GenevisibleiQ6PIW4, HS

Family and domain databases

Gene3Di3.40.50.300, 1 hit
InterProiView protein in InterPro
IPR003593, AAA+_ATPase
IPR003959, ATPase_AAA_core
IPR003960, ATPase_AAA_CS
IPR027417, P-loop_NTPase
IPR015415, Vps4_C
PfamiView protein in Pfam
PF00004, AAA, 1 hit
PF09336, Vps4_C, 1 hit
SMARTiView protein in SMART
SM00382, AAA, 1 hit
SUPFAMiSSF52540, SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00674, AAA, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFIGL1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6PIW4
Secondary accession number(s): D3DVM6
, Q86V18, Q8ND59, Q9H8P1, Q9H917
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 11, 2007
Last modified: May 25, 2022
This is version 161 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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