SLC25A34

Functionⁱ

GO - Molecular functionⁱ

transmembrane transporter activity Source: GO_Central

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

mitochondrial transport Source: GO_Central

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Transport

Biological process

Transport

Protein family/group databases

TCDBⁱ	2.A.29.15.3 the mitochondrial carrier (mc) family

TCDBⁱ

2.A.29.15.3 the mitochondrial carrier (mc) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Solute carrier family 25 member 34
Gene namesⁱ	Name:SLC25A34
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000162461.7
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:27653 SLC25A34
MIMⁱ	610817 gene
neXtProtⁱ	NX_Q6PIV7

Topology

Feature key	Position(s)	DescriptionActions	Length
Transmembraneⁱ	7 – 27	Helical; Name=1Sequence analysisAdd BLAST	21
Transmembraneⁱ	45 – 65	Helical; Name=2Sequence analysisAdd BLAST	21
Transmembraneⁱ	98 – 120	Helical; Name=3Sequence analysisAdd BLAST	23
Transmembraneⁱ	170 – 191	Helical; Name=4Sequence analysisAdd BLAST	22
Transmembraneⁱ	206 – 226	Helical; Name=5Sequence analysisAdd BLAST	21
Transmembraneⁱ	278 – 301	Helical; Name=6Sequence analysisAdd BLAST	24

Keywords - Cellular componentⁱ

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000162461
PharmGKBⁱ	PA142670906

Polymorphism and mutation databases

BioMutaⁱ	SLC25A34
DMDMⁱ	74758372

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000291789	1 – 304	Solute carrier family 25 member 34Add BLAST		304

Proteomic databases

PaxDbⁱ	Q6PIV7
PRIDEⁱ	Q6PIV7
ProteomicsDBⁱ	67181

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000162461 Expressed in 139 organ(s), highest expression level in quadriceps femoris
CleanExⁱ	HS_SLC25A34
Genevisibleⁱ	Q6PIV7 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA069806

HPAⁱ

HPA069806

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000294454

STRINGⁱ

9606.ENSP00000294454

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q6PIV7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	4 – 97	Solcar 1Add BLAST	94
Repeatⁱ	101 – 194	Solcar 2Add BLAST	94
Repeatⁱ	204 – 295	Solcar 3Add BLAST	92

Sequence similaritiesⁱ

Belongs to the mitochondrial carrier (TC 2.A.29) family. [View classification]Curated

Keywords - Domainⁱ

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG0755 Eukaryota ENOG410XS37 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074760
HOGENOMⁱ	HOG000165141
HOVERGENⁱ	HBG108440
InParanoidⁱ	Q6PIV7
KEGG Orthology (KO) More...KOⁱ	K15117
OMAⁱ	DGLWGLQ
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0MCY
PhylomeDBⁱ	Q6PIV7
TreeFamⁱ	TF324506

Family and domain databases

Gene3Dⁱ	1.50.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR018108 Mitochondrial_sb/sol_carrier IPR023395 Mt_carrier_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00153 Mito_carr, 3 hits
SUPFAMⁱ	SSF103506 SSF103506, 1 hit
PROSITEⁱ	View protein in PROSITE PS50920 SOLCAR, 3 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

Q6PIV7-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
METVPPAVDL VLGASACCLA CVFTNPLEVV KTRLQLQGEL QARGTYPRPY 
        60         70         80         90        100
HGFIASVAAV ARADGLWGLQ KGLAAGLLYQ GLMNGVRFYC YSLACQAGLT 
       110        120        130        140        150
QQPGGTVVAG AVAGALGAFV GSPAYLIKTQ LQAQTVAAVA VGHQHNHQTV 
       160        170        180        190        200
LGALETIWRQ QGLLGLWQGV GGAVPRVMVG SAAQLATFAS AKAWVQKQQW 
       210        220        230        240        250
LPEDSWLVAL AGGMISSIAV VVVMTPFDVV STRLYNQPVD TAGRGQLYGG 
       260        270        280        290        300
LTDCMVKIWR QEGPLALYKG LGPAYLRLGP HTILSMLFWD ELRKLAGRAQ 

HKGT

Length:304

Mass (Da):32,224

Last modified:July 5, 2004 - v1

Checksum:ⁱ1C35741714D219ED

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	198	Q → P in CAH18120 (PubMed:17974005).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL450998 Genomic DNA No translation available. BC027998 mRNA Translation: AAH27998.1 CR749264 mRNA Translation: CAH18120.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS162.1
NCBI Reference Sequences More...RefSeqⁱ	NP_997231.1, NM_207348.2
UniGeneⁱ	Hs.631867

Genome annotation databases

Ensemblⁱ	ENST00000294454; ENSP00000294454; ENSG00000162461
GeneIDⁱ	284723
KEGGⁱ	hsa:284723
UCSC genome browser More...UCSCⁱ	uc001axb.2 human

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q6PIV7	Solute carrier family 25 member 34		TUPCH		318	UniRef90_Q6PIV7
solute carrier family 25 member 34 isoform X1		DIPOR		313
Solute carrier family 25 member 34		NOMLE		304
SLC25A34 isoform 1		PANTR		304
Solute carrier family 25 member 34		PANPA		304
+4

Protein	Similar proteins		Species	Score	Length	Source
Q6PIV7	Solute carrier family 25 member 34		TUPCH		318	UniRef50_Q6PIV7
solute carrier family 25 member 34 isoform X1		DIPOR		313
SLC25A34 isoform 1		PANTR		304
Solute carrier family 25 member 34		PANPA		304
Solute carrier family 25 member 34		NOMLE		304
+37

Entry informationⁱ

Entry nameⁱ	S2534_HUMAN
Accessionⁱ	Q6PIV7Primary (citable) accession number: Q6PIV7 Secondary accession number(s): Q68DV0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 26, 2007
	Last sequence update:	July 5, 2004
	Last modified:	September 12, 2018
	This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q6PIV7 (S2534_HUMAN)

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Solute carrier family 25 member 34

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Mitochondrion

Mitochondrion

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ