UniProtKB - Q6PIV7 (S2534_HUMAN)
Protein
Solute carrier family 25 member 34
Gene
SLC25A34
Organism
Homo sapiens (Human)
Status
Functioni
GO - Biological processi
- blastocyst hatching Source: Ensembl
Keywordsi
Biological process | Transport |
Enzyme and pathway databases
PathwayCommonsi | Q6PIV7 |
Protein family/group databases
TCDBi | 2.A.29.15.3, the mitochondrial carrier (mc) family |
Names & Taxonomyi
Protein namesi | Recommended name: Solute carrier family 25 member 34 |
Gene namesi | Name:SLC25A34 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:27653, SLC25A34 |
MIMi | 610817, gene |
neXtProti | NX_Q6PIV7 |
VEuPathDBi | HostDB:ENSG00000162461.7 |
Subcellular locationi
Mitochondrion
- Mitochondrion inner membrane By similarity; Multi-pass membrane protein By similarity
Mitochondrion
- mitochondrial inner membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 7 – 27 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Transmembranei | 45 – 65 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Transmembranei | 98 – 120 | Helical; Name=3Sequence analysisAdd BLAST | 23 | |
Transmembranei | 170 – 191 | Helical; Name=4Sequence analysisAdd BLAST | 22 | |
Transmembranei | 206 – 226 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Transmembranei | 278 – 301 | Helical; Name=6Sequence analysisAdd BLAST | 24 |
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion inner membranePathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000162461 |
PharmGKBi | PA142670906 |
Miscellaneous databases
Pharosi | Q6PIV7, Tdark |
Genetic variation databases
BioMutai | SLC25A34 |
DMDMi | 74758372 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000291789 | 1 – 304 | Solute carrier family 25 member 34Add BLAST | 304 |
Proteomic databases
PaxDbi | Q6PIV7 |
PeptideAtlasi | Q6PIV7 |
PRIDEi | Q6PIV7 |
ProteomicsDBi | 67181 |
Expressioni
Gene expression databases
Bgeei | ENSG00000162461, Expressed in quadriceps femoris and 156 other tissues |
Genevisiblei | Q6PIV7, HS |
Organism-specific databases
HPAi | ENSG00000162461, Tissue enhanced (intestine, skeletal muscle) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 129941, 1 interactor |
STRINGi | 9606.ENSP00000294454 |
Miscellaneous databases
RNActi | Q6PIV7, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 4 – 97 | Solcar 1Add BLAST | 94 | |
Repeati | 101 – 194 | Solcar 2Add BLAST | 94 | |
Repeati | 204 – 295 | Solcar 3Add BLAST | 92 |
Sequence similaritiesi
Keywords - Domaini
Repeat, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0755, Eukaryota |
GeneTreei | ENSGT00940000160016 |
HOGENOMi | CLU_015166_14_3_1 |
InParanoidi | Q6PIV7 |
OMAi | ICQQEGP |
OrthoDBi | 1013743at2759 |
PhylomeDBi | Q6PIV7 |
TreeFami | TF324506 |
Family and domain databases
Gene3Di | 1.50.40.10, 1 hit |
InterProi | View protein in InterPro IPR018108, Mitochondrial_sb/sol_carrier IPR023395, Mt_carrier_dom_sf |
Pfami | View protein in Pfam PF00153, Mito_carr, 3 hits |
SUPFAMi | SSF103506, SSF103506, 1 hit |
PROSITEi | View protein in PROSITE PS50920, SOLCAR, 3 hits |
i Sequence
Sequence statusi: Complete.
Q6PIV7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
METVPPAVDL VLGASACCLA CVFTNPLEVV KTRLQLQGEL QARGTYPRPY
60 70 80 90 100
HGFIASVAAV ARADGLWGLQ KGLAAGLLYQ GLMNGVRFYC YSLACQAGLT
110 120 130 140 150
QQPGGTVVAG AVAGALGAFV GSPAYLIKTQ LQAQTVAAVA VGHQHNHQTV
160 170 180 190 200
LGALETIWRQ QGLLGLWQGV GGAVPRVMVG SAAQLATFAS AKAWVQKQQW
210 220 230 240 250
LPEDSWLVAL AGGMISSIAV VVVMTPFDVV STRLYNQPVD TAGRGQLYGG
260 270 280 290 300
LTDCMVKIWR QEGPLALYKG LGPAYLRLGP HTILSMLFWD ELRKLAGRAQ
HKGT
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 198 | Q → P in CAH18120 (PubMed:17974005).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL450998 Genomic DNA No translation available. BC027998 mRNA Translation: AAH27998.1 CR749264 mRNA Translation: CAH18120.1 |
CCDSi | CCDS162.1 |
RefSeqi | NP_997231.1, NM_207348.2 |
Genome annotation databases
Ensembli | ENST00000294454; ENSP00000294454; ENSG00000162461 |
GeneIDi | 284723 |
KEGGi | hsa:284723 |
UCSCi | uc001axb.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL450998 Genomic DNA No translation available. BC027998 mRNA Translation: AAH27998.1 CR749264 mRNA Translation: CAH18120.1 |
CCDSi | CCDS162.1 |
RefSeqi | NP_997231.1, NM_207348.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 129941, 1 interactor |
STRINGi | 9606.ENSP00000294454 |
Protein family/group databases
TCDBi | 2.A.29.15.3, the mitochondrial carrier (mc) family |
Genetic variation databases
BioMutai | SLC25A34 |
DMDMi | 74758372 |
Proteomic databases
PaxDbi | Q6PIV7 |
PeptideAtlasi | Q6PIV7 |
PRIDEi | Q6PIV7 |
ProteomicsDBi | 67181 |
Protocols and materials databases
Antibodypediai | 28971, 53 antibodies |
Genome annotation databases
Ensembli | ENST00000294454; ENSP00000294454; ENSG00000162461 |
GeneIDi | 284723 |
KEGGi | hsa:284723 |
UCSCi | uc001axb.2, human |
Organism-specific databases
CTDi | 284723 |
GeneCardsi | SLC25A34 |
HGNCi | HGNC:27653, SLC25A34 |
HPAi | ENSG00000162461, Tissue enhanced (intestine, skeletal muscle) |
MIMi | 610817, gene |
neXtProti | NX_Q6PIV7 |
OpenTargetsi | ENSG00000162461 |
PharmGKBi | PA142670906 |
VEuPathDBi | HostDB:ENSG00000162461.7 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0755, Eukaryota |
GeneTreei | ENSGT00940000160016 |
HOGENOMi | CLU_015166_14_3_1 |
InParanoidi | Q6PIV7 |
OMAi | ICQQEGP |
OrthoDBi | 1013743at2759 |
PhylomeDBi | Q6PIV7 |
TreeFami | TF324506 |
Enzyme and pathway databases
PathwayCommonsi | Q6PIV7 |
Miscellaneous databases
BioGRID-ORCSi | 284723, 5 hits in 875 CRISPR screens |
GenomeRNAii | 284723 |
Pharosi | Q6PIV7, Tdark |
PROi | PR:Q6PIV7 |
RNActi | Q6PIV7, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000162461, Expressed in quadriceps femoris and 156 other tissues |
Genevisiblei | Q6PIV7, HS |
Family and domain databases
Gene3Di | 1.50.40.10, 1 hit |
InterProi | View protein in InterPro IPR018108, Mitochondrial_sb/sol_carrier IPR023395, Mt_carrier_dom_sf |
Pfami | View protein in Pfam PF00153, Mito_carr, 3 hits |
SUPFAMi | SSF103506, SSF103506, 1 hit |
PROSITEi | View protein in PROSITE PS50920, SOLCAR, 3 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | S2534_HUMAN | |
Accessioni | Q6PIV7Primary (citable) accession number: Q6PIV7 Secondary accession number(s): Q68DV0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 26, 2007 |
Last sequence update: | July 5, 2004 | |
Last modified: | February 10, 2021 | |
This is version 129 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families