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Protein

Solute carrier family 25 member 34

Gene

SLC25A34

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Protein family/group databases

TCDBi2.A.29.15.3 the mitochondrial carrier (mc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 25 member 34
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000162461.7
HGNCiHGNC:27653 SLC25A34
MIMi610817 gene
neXtProtiNX_Q6PIV7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei7 – 27Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei45 – 65Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei98 – 120Helical; Name=3Sequence analysisAdd BLAST23
Transmembranei170 – 191Helical; Name=4Sequence analysisAdd BLAST22
Transmembranei206 – 226Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei278 – 301Helical; Name=6Sequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000162461
PharmGKBiPA142670906

Polymorphism and mutation databases

BioMutaiSLC25A34
DMDMi74758372

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002917891 – 304Solute carrier family 25 member 34Add BLAST304

Proteomic databases

PaxDbiQ6PIV7
PRIDEiQ6PIV7
ProteomicsDBi67181

Expressioni

Gene expression databases

BgeeiENSG00000162461 Expressed in 139 organ(s), highest expression level in quadriceps femoris
CleanExiHS_SLC25A34
GenevisibleiQ6PIV7 HS

Organism-specific databases

HPAiHPA069806

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000294454

Structurei

3D structure databases

ProteinModelPortaliQ6PIV7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati4 – 97Solcar 1Add BLAST94
Repeati101 – 194Solcar 2Add BLAST94
Repeati204 – 295Solcar 3Add BLAST92

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0755 Eukaryota
ENOG410XS37 LUCA
GeneTreeiENSGT00550000074760
HOGENOMiHOG000165141
HOVERGENiHBG108440
InParanoidiQ6PIV7
KOiK15117
OMAiDGLWGLQ
OrthoDBiEOG091G0MCY
PhylomeDBiQ6PIV7
TreeFamiTF324506

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

Q6PIV7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
METVPPAVDL VLGASACCLA CVFTNPLEVV KTRLQLQGEL QARGTYPRPY
60 70 80 90 100
HGFIASVAAV ARADGLWGLQ KGLAAGLLYQ GLMNGVRFYC YSLACQAGLT
110 120 130 140 150
QQPGGTVVAG AVAGALGAFV GSPAYLIKTQ LQAQTVAAVA VGHQHNHQTV
160 170 180 190 200
LGALETIWRQ QGLLGLWQGV GGAVPRVMVG SAAQLATFAS AKAWVQKQQW
210 220 230 240 250
LPEDSWLVAL AGGMISSIAV VVVMTPFDVV STRLYNQPVD TAGRGQLYGG
260 270 280 290 300
LTDCMVKIWR QEGPLALYKG LGPAYLRLGP HTILSMLFWD ELRKLAGRAQ

HKGT
Length:304
Mass (Da):32,224
Last modified:July 5, 2004 - v1
Checksum:i1C35741714D219ED
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti198Q → P in CAH18120 (PubMed:17974005).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL450998 Genomic DNA No translation available.
BC027998 mRNA Translation: AAH27998.1
CR749264 mRNA Translation: CAH18120.1
CCDSiCCDS162.1
RefSeqiNP_997231.1, NM_207348.2
UniGeneiHs.631867

Genome annotation databases

EnsembliENST00000294454; ENSP00000294454; ENSG00000162461
GeneIDi284723
KEGGihsa:284723
UCSCiuc001axb.2 human

Similar proteinsi

Entry informationi

Entry nameiS2534_HUMAN
AccessioniPrimary (citable) accession number: Q6PIV7
Secondary accession number(s): Q68DV0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: July 5, 2004
Last modified: September 12, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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