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Protein

Potassium voltage-gated channel subfamily V member 1

Gene

KCNV1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Potassium channel subunit that does not form functional channels by itself. Modulates KCNB1 and KCNB2 channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. Can down-regulate the channel activity of KCNB1, KCNB2, KCNC4 and KCND1, possibly by trapping them in intracellular membranes.2 Publications

GO - Molecular functioni

  • ion channel inhibitor activity Source: ProtInc
  • potassium channel regulator activity Source: ProtInc
  • voltage-gated potassium channel activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionIon channel, Potassium channel, Voltage-gated channel
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Enzyme and pathway databases

ReactomeiR-HSA-1296072 Voltage gated Potassium channels

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily V member 1
Alternative name(s):
Neuronal potassium channel alpha subunit HNKA
Voltage-gated potassium channel subunit Kv8.1
Gene namesi
Name:KCNV1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000164794.8
HGNCiHGNC:18861 KCNV1
MIMi608164 gene
neXtProtiNX_Q6PIU1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 210CytoplasmicSequence analysisAdd BLAST210
Transmembranei211 – 231Helical; Name=Segment S1Sequence analysisAdd BLAST21
Topological domaini232 – 238ExtracellularSequence analysis7
Transmembranei239 – 259Helical; Name=Segment S2Sequence analysisAdd BLAST21
Topological domaini260 – 276CytoplasmicSequence analysisAdd BLAST17
Transmembranei277 – 297Helical; Name=Segment S3Sequence analysisAdd BLAST21
Topological domaini298 – 309ExtracellularSequence analysisAdd BLAST12
Transmembranei310 – 331Helical; Voltage-sensor; Name=Segment S4Sequence analysisAdd BLAST22
Topological domaini332 – 345CytoplasmicSequence analysisAdd BLAST14
Transmembranei346 – 366Helical; Name=Segment S5Sequence analysisAdd BLAST21
Transmembranei407 – 427Helical; Name=Segment S6Sequence analysisAdd BLAST21
Topological domaini428 – 500CytoplasmicSequence analysisAdd BLAST73

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000164794
PharmGKBiPA38721

Chemistry databases

ChEMBLiCHEMBL2362996

Polymorphism and mutation databases

BioMutaiKCNV1
DMDMi160013825

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003083501 – 500Potassium voltage-gated channel subfamily V member 1Add BLAST500

Proteomic databases

PaxDbiQ6PIU1
PeptideAtlasiQ6PIU1
PRIDEiQ6PIU1
ProteomicsDBi67176

PTM databases

PhosphoSitePlusiQ6PIU1

Expressioni

Tissue specificityi

Detected in brain.1 Publication

Gene expression databases

BgeeiENSG00000164794
CleanExiHS_KCNV1
GenevisibleiQ6PIU1 HS

Interactioni

Subunit structurei

Heteromultimer with KCNB1 and KCNB2. Interacts with KCNC4 and KCND1.2 Publications

Protein-protein interaction databases

BioGridi117954, 2 interactors
IntActiQ6PIU1, 1 interactor
MINTiQ6PIU1
STRINGi9606.ENSP00000297404

Structurei

3D structure databases

ProteinModelPortaliQ6PIU1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi392 – 397Selectivity filterBy similarity6

Domaini

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3713 Eukaryota
COG1226 LUCA
GeneTreeiENSGT00760000118981
HOGENOMiHOG000231016
HOVERGENiHBG052230
InParanoidiQ6PIU1
KOiK04934
OMAiMTIAQCY
OrthoDBiEOG091G0FP3
PhylomeDBiQ6PIU1
TreeFamiTF313103

Family and domain databases

Gene3Di1.20.120.350, 1 hit
InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR005821 Ion_trans_dom
IPR003968 K_chnl_volt-dep_Kv
IPR003970 K_chnl_volt-dep_Kv8.1
IPR011333 SKP1/BTB/POZ_sf
IPR003131 T1-type_BTB
IPR028325 VG_K_chnl
IPR027359 Volt_channel_dom_sf
PANTHERiPTHR11537 PTHR11537, 1 hit
PTHR11537:SF38 PTHR11537:SF38, 1 hit
PfamiView protein in Pfam
PF02214 BTB_2, 1 hit
PF00520 Ion_trans, 1 hit
PRINTSiPR00169 KCHANNEL
PR01493 KV8CHANNEL
PR01491 KVCHANNEL
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SUPFAMiSSF54695 SSF54695, 1 hit

Sequencei

Sequence statusi: Complete.

Q6PIU1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSSGRALLD SPLDSGSLTS LDSSVFCSEG EGEPLALGDC FTVNVGGSRF
60 70 80 90 100
VLSQQALSCF PHTRLGKLAV VVASYRRPGA LAAVPSPLEL CDDANPVDNE
110 120 130 140 150
YFFDRSSQAF RYVLHYYRTG RLHVMEQLCA LSFLQEIQYW GIDELSIDSC
160 170 180 190 200
CRDRYFRRKE LSETLDFKKD TEDQESQHES EQDFSQGPCP TVRQKLWNIL
210 220 230 240 250
EKPGSSTAAR IFGVISIIFV VVSIINMALM SAELSWLDLQ LLEILEYVCI
260 270 280 290 300
SWFTGEFVLR FLCVRDRCRF LRKVPNIIDL LAILPFYITL LVESLSGSQT
310 320 330 340 350
TQELENVGRI VQVLRLLRAL RMLKLGRHST GLRSLGMTIT QCYEEVGLLL
360 370 380 390 400
LFLSVGISIF STVEYFAEQS IPDTTFTSVP CAWWWATTSM TTVGYGDIRP
410 420 430 440 450
DTTTGKIVAF MCILSGILVL ALPIAIINDR FSACYFTLKL KEAAVRQREA
460 470 480 490 500
LKKLTKNIAT DSYISVNLRD VYARSIMEML RLKGRERAST RSSGGDDFWF
Length:500
Mass (Da):56,304
Last modified:October 23, 2007 - v2
Checksum:iC229E21ABC869C73
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03680422D → G1 PublicationCorresponds to variant dbSNP:rs17852611Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB032013 Genomic DNA Translation: BAA92316.1
AF167082 mRNA Translation: AAD48031.2
BC028739 mRNA Translation: AAH28739.1
CCDSiCCDS6314.1
RefSeqiNP_055194.1, NM_014379.3
UniGeneiHs.13285

Genome annotation databases

EnsembliENST00000297404; ENSP00000297404; ENSG00000164794
ENST00000524391; ENSP00000435954; ENSG00000164794
GeneIDi27012
KEGGihsa:27012
UCSCiuc003ynr.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiKCNV1_HUMAN
AccessioniPrimary (citable) accession number: Q6PIU1
Secondary accession number(s): Q9UHJ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 23, 2007
Last modified: June 20, 2018
This is version 129 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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