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Entry version 127 (02 Jun 2021)
Sequence version 2 (20 May 2008)
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Protein

Solute carrier family 23 member 3

Gene

SLC23A3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q6PIS1

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.40.6.4, the nucleobase/ascorbate transporter (nat) or nucleobase:cation symporter-2 (ncs2) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Solute carrier family 23 member 3
Alternative name(s):
HPC E2-binding protein 3
Na(+)/L-ascorbic acid transporter 3
Sodium-dependent vitamin C transporter 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC23A3
Synonyms:E2BP3, SVCT3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:20601, SLC23A3

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6PIS1

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000213901.10

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 49CytoplasmicSequence analysisAdd BLAST49
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei50 – 70HelicalSequence analysisAdd BLAST21
Topological domaini71 – 85ExtracellularSequence analysisAdd BLAST15
Transmembranei86 – 106HelicalSequence analysisAdd BLAST21
Topological domaini107 – 164CytoplasmicSequence analysisAdd BLAST58
Transmembranei165 – 185HelicalSequence analysisAdd BLAST21
Topological domaini186 – 187ExtracellularSequence analysis2
Transmembranei188 – 208HelicalSequence analysisAdd BLAST21
Topological domaini209 – 211CytoplasmicSequence analysis3
Transmembranei212 – 232HelicalSequence analysisAdd BLAST21
Topological domaini233 – 266ExtracellularSequence analysisAdd BLAST34
Transmembranei267 – 287HelicalSequence analysisAdd BLAST21
Topological domaini288 – 316CytoplasmicSequence analysisAdd BLAST29
Transmembranei317 – 337HelicalSequence analysisAdd BLAST21
Topological domaini338 – 355ExtracellularSequence analysisAdd BLAST18
Transmembranei356 – 376HelicalSequence analysisAdd BLAST21
Topological domaini377 – 394CytoplasmicSequence analysisAdd BLAST18
Transmembranei395 – 414HelicalSequence analysisAdd BLAST20
Topological domaini415 – 423ExtracellularSequence analysis9
Transmembranei424 – 446HelicalSequence analysisAdd BLAST23
Topological domaini447 – 452CytoplasmicSequence analysis6
Transmembranei453 – 472HelicalSequence analysisAdd BLAST20
Topological domaini473 – 486ExtracellularSequence analysisAdd BLAST14
Transmembranei487 – 507HelicalSequence analysisAdd BLAST21
Topological domaini508 – 610CytoplasmicSequence analysisAdd BLAST103

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
151295

Open Targets

More...
OpenTargetsi
ENSG00000213901

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134932069

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q6PIS1, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SLC23A3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
189046185

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003372031 – 610Solute carrier family 23 member 3Add BLAST610

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q6PIS1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6PIS1

PeptideAtlas

More...
PeptideAtlasi
Q6PIS1

PRoteomics IDEntifications database

More...
PRIDEi
Q6PIS1

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
67173 [Q6PIS1-1]
67174 [Q6PIS1-2]
67175 [Q6PIS1-5]

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6PIS1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000213901, Expressed in kidney epithelium and 152 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6PIS1, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6PIS1, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000213901, Group enriched (intestine, kidney)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
127365, 2 interactors

Protein interaction database and analysis system

More...
IntActi
Q6PIS1, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000406546

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6PIS1, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 32DisorderedSequence analysisAdd BLAST32
Regioni571 – 610DisorderedSequence analysisAdd BLAST40

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 16Polar residuesSequence analysisAdd BLAST16

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1292, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182953

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_017959_5_4_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6PIS1

Identification of Orthologs from Complete Genome Data

More...
OMAi
WNWPLLT

Database of Orthologous Groups

More...
OrthoDBi
387031at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6PIS1

TreeFam database of animal gene trees

More...
TreeFami
TF313272

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029957, SLC23A3
IPR006043, Xant/urac/vitC

The PANTHER Classification System

More...
PANTHERi
PTHR11119:SF57, PTHR11119:SF57, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00860, Xan_ur_permease, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6PIS1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSRSPLNPSQ LRSVGSQDAL APLPPPAPQN PSTHSWDPLC GSLPWGLSCL
60 70 80 90 100
LALQHVLVMA SLLCVSHLLL LCSLSPGGLS YSPSQLLASS FFSCGMSTIL
110 120 130 140 150
QTWMGSRLPL VQAPSLEFLI PALVLTSQKL PRAIQTPGNS SLMLHLCRGP
160 170 180 190 200
SCHGLGHWNT SLQEVSGAVV VSGLLQGMMG LLGSPGHVFP HCGPLVLAPS
210 220 230 240 250
LVVAGLSAHR EVAQFCFTHW GLALLVILLM VVCSQHLGSC QFHVCPWRRA
260 270 280 290 300
STSSTHTPLP VFRLLSVLIP VACVWIVSAF VGFSVIPQEL SAPTKAPWIW
310 320 330 340 350
LPHPGEWNWP LLTPRALAAG ISMALAASTS SLGCYALCGR LLHLPPPPPH
360 370 380 390 400
ACSRGLSLEG LGSVLAGLLG SPMGTASSFP NVGKVGLIQA GSQQVAHLVG
410 420 430 440 450
LLCVGLGLSP RLAQLLTTIP LPVVGGVLGV TQAVVLSAGF SSFYLADIDS
460 470 480 490 500
GRNIFIVGFS IFMALLLPRW FREAPVLFST GWSPLDVLLH SLLTQPIFLA
510 520 530 540 550
GLSGFLLENT IPGTQLERGL GQGLPSPFTA QEARMPQKPR EKAAQVYRLP
560 570 580 590 600
FPIQNLCPCI PQPLHCLCPL PEDPGDEEGG SSEPEEMADL LPGSGEPCPE
610
SSREGFRSQK
Length:610
Mass (Da):64,531
Last modified:May 20, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i962A3E1CBA895D10
GO
Isoform 2 (identifier: Q6PIS1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     226-388: VILLMVVCSQ...FPNVGKVGLI → TWAPASFMCA...PRHHGFGCLT

Show »
Length:493
Mass (Da):52,361
Checksum:i9D2C4F7331D7A12D
GO
Isoform 3 (identifier: Q6PIS1-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     140-140: S → CEHRARARA

Show »
Length:618
Mass (Da):65,495
Checksum:i07ACDE463CD90F4B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MSG3A0A0A0MSG3_HUMAN
Solute carrier family 23 member 3
SLC23A3
259Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JQ03C9JQ03_HUMAN
Solute carrier family 23 member 3
SLC23A3
179Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C2A2H7C2A2_HUMAN
Solute carrier family 23 member 3
SLC23A3
11Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence ABC17635 differs from that shown. Fragment of a potential novel isoform.Curated
The sequence BAB70999 differs from that shown. Intron retention.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti179M → V in ABC17635 (Ref. 4) Curated1
Sequence conflicti543Missing in AAH30243 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_043670140S → CEHRARARA in isoform 3. 1 Publication1
Alternative sequenceiVSP_033970226 – 388VILLM…KVGLI → TWAPASFMCAPGGELQRHQL TLLSLSSGSFRNCLPPPRHH GFGCLT in isoform 2. 1 PublicationAdd BLAST163

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK055730 mRNA Translation: BAB70999.1 Sequence problems.
AK298277 mRNA Translation: BAH12748.1
AC020575 Genomic DNA No translation available.
AC068946 Genomic DNA No translation available.
AC097468 Genomic DNA No translation available.
BC030243 mRNA Translation: AAH30243.1
DQ294736 mRNA Translation: ABC17635.1 Sequence problems.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS42819.1 [Q6PIS1-2]
CCDS46517.1 [Q6PIS1-5]
CCDS46518.1 [Q6PIS1-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001138361.1, NM_001144889.1 [Q6PIS1-1]
NP_001138362.1, NM_001144890.1 [Q6PIS1-5]
NP_653313.3, NM_144712.4 [Q6PIS1-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000295738; ENSP00000295738; ENSG00000213901 [Q6PIS1-2]
ENST00000409878; ENSP00000386473; ENSG00000213901 [Q6PIS1-1]
ENST00000455516; ENSP00000406546; ENSG00000213901 [Q6PIS1-5]

Database of genes from NCBI RefSeq genomes

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GeneIDi
151295

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:151295

UCSC genome browser

More...
UCSCi
uc010fwb.4, human [Q6PIS1-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055730 mRNA Translation: BAB70999.1 Sequence problems.
AK298277 mRNA Translation: BAH12748.1
AC020575 Genomic DNA No translation available.
AC068946 Genomic DNA No translation available.
AC097468 Genomic DNA No translation available.
BC030243 mRNA Translation: AAH30243.1
DQ294736 mRNA Translation: ABC17635.1 Sequence problems.
CCDSiCCDS42819.1 [Q6PIS1-2]
CCDS46517.1 [Q6PIS1-5]
CCDS46518.1 [Q6PIS1-1]
RefSeqiNP_001138361.1, NM_001144889.1 [Q6PIS1-1]
NP_001138362.1, NM_001144890.1 [Q6PIS1-5]
NP_653313.3, NM_144712.4 [Q6PIS1-2]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi127365, 2 interactors
IntActiQ6PIS1, 2 interactors
STRINGi9606.ENSP00000406546

Protein family/group databases

TCDBi2.A.40.6.4, the nucleobase/ascorbate transporter (nat) or nucleobase:cation symporter-2 (ncs2) family

PTM databases

PhosphoSitePlusiQ6PIS1

Genetic variation databases

BioMutaiSLC23A3
DMDMi189046185

Proteomic databases

MassIVEiQ6PIS1
PaxDbiQ6PIS1
PeptideAtlasiQ6PIS1
PRIDEiQ6PIS1
ProteomicsDBi67173 [Q6PIS1-1]
67174 [Q6PIS1-2]
67175 [Q6PIS1-5]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
11409, 62 antibodies

The DNASU plasmid repository

More...
DNASUi
151295

Genome annotation databases

EnsembliENST00000295738; ENSP00000295738; ENSG00000213901 [Q6PIS1-2]
ENST00000409878; ENSP00000386473; ENSG00000213901 [Q6PIS1-1]
ENST00000455516; ENSP00000406546; ENSG00000213901 [Q6PIS1-5]
GeneIDi151295
KEGGihsa:151295
UCSCiuc010fwb.4, human [Q6PIS1-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
151295
DisGeNETi151295

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SLC23A3
HGNCiHGNC:20601, SLC23A3
HPAiENSG00000213901, Group enriched (intestine, kidney)
neXtProtiNX_Q6PIS1
OpenTargetsiENSG00000213901
PharmGKBiPA134932069
VEuPathDBiHostDB:ENSG00000213901.10

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1292, Eukaryota
GeneTreeiENSGT00950000182953
HOGENOMiCLU_017959_5_4_1
InParanoidiQ6PIS1
OMAiWNWPLLT
OrthoDBi387031at2759
PhylomeDBiQ6PIS1
TreeFamiTF313272

Enzyme and pathway databases

PathwayCommonsiQ6PIS1

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
151295, 7 hits in 990 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SLC23A3, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
151295
PharosiQ6PIS1, Tdark

Protein Ontology

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PROi
PR:Q6PIS1
RNActiQ6PIS1, protein

Gene expression databases

BgeeiENSG00000213901, Expressed in kidney epithelium and 152 other tissues
ExpressionAtlasiQ6PIS1, baseline and differential
GenevisibleiQ6PIS1, HS

Family and domain databases

InterProiView protein in InterPro
IPR029957, SLC23A3
IPR006043, Xant/urac/vitC
PANTHERiPTHR11119:SF57, PTHR11119:SF57, 1 hit
PfamiView protein in Pfam
PF00860, Xan_ur_permease, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS23A3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6PIS1
Secondary accession number(s): B7Z512, Q2PYN6, Q96NA6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: June 2, 2021
This is version 127 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
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