UniProtKB - Q6PIL6 (KCIP4_HUMAN)
Kv channel-interacting protein 4
KCNIP4
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Calcium bindingi | 133 – 144 | 1PROSITE-ProRule annotationAdd BLAST | 12 | |
Calcium bindingi | 169 – 180 | 2PROSITE-ProRule annotationAdd BLAST | 12 | |
Calcium bindingi | 217 – 228 | 3PROSITE-ProRule annotationAdd BLAST | 12 |
GO - Molecular functioni
- calcium ion binding Source: UniProtKB
- potassium channel activity Source: UniProtKB-KW
- potassium channel regulator activity Source: UniProtKB
- voltage-gated ion channel activity Source: UniProtKB-KW
GO - Biological processi
- cardiac conduction Source: Reactome
- protein localization to plasma membrane Source: UniProtKB
- regulation of potassium ion transmembrane transport Source: UniProtKB
Keywordsi
Molecular function | Ion channel, Potassium channel, Voltage-gated channel |
Biological process | Ion transport, Potassium transport, Transport |
Ligand | Calcium, Metal-binding, Potassium |
Enzyme and pathway databases
PathwayCommonsi | Q6PIL6 |
Reactomei | R-HSA-5576894, Phase 1 - inactivation of fast Na+ channels |
Protein family/group databases
TCDBi | 8.A.82.2.2, the calmodulin calcium binding protein (calmodulin) family |
Names & Taxonomyi
Protein namesi | Recommended name: Kv channel-interacting protein 4Short name: KChIP41 Publication Alternative name(s): A-type potassium channel modulatory protein 4 Calsenilin-like protein1 Publication Potassium channel-interacting protein 4 |
Gene namesi | Name:KCNIP4 Synonyms:CALP, KCHIP4 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000185774.14 |
HGNCi | HGNC:30083, KCNIP4 |
MIMi | 608182, gene |
neXtProti | NX_Q6PIL6 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Peripheral membrane protein 1 Publication
Other locations
- Cytoplasm 2 Publications
Endoplasmic reticulum
- Endoplasmic reticulum 1 Publication
Cytosol
- cytosol Source: UniProtKB
Endoplasmic reticulum
- endoplasmic reticulum Source: UniProtKB-SubCell
Plasma Membrane
- plasma membrane Source: UniProtKB
- voltage-gated potassium channel complex Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
Keywords - Cellular componenti
Cell membrane, Cytoplasm, Endoplasmic reticulum, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 80333 |
OpenTargetsi | ENSG00000185774 |
PharmGKBi | PA134893552 |
Miscellaneous databases
Pharosi | Q6PIL6, Tbio |
Polymorphism and mutation databases
BioMutai | KCNIP4 |
DMDMi | 73621129 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000073825 | 1 – 250 | Kv channel-interacting protein 4Add BLAST | 250 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 17 | PhosphoserineBy similarity | 1 | |
Modified residuei | 56 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q6PIL6 |
MassIVEi | Q6PIL6 |
PaxDbi | Q6PIL6 |
PeptideAtlasi | Q6PIL6 |
PRIDEi | Q6PIL6 |
ProteomicsDBi | 67166 [Q6PIL6-1] 67167 [Q6PIL6-2] 67168 [Q6PIL6-3] 67169 [Q6PIL6-4] 67170 [Q6PIL6-5] |
PTM databases
iPTMneti | Q6PIL6 |
PhosphoSitePlusi | Q6PIL6 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000185774, Expressed in frontal cortex and 168 other tissues |
ExpressionAtlasi | Q6PIL6, baseline and differential |
Genevisiblei | Q6PIL6, HS |
Organism-specific databases
HPAi | ENSG00000185774, Tissue enhanced (brain) |
Interactioni
Subunit structurei
Component of heteromultimeric potassium channels (PubMed:23576435). Identified in potassium channel complexes containing KCND1, KCND2, KCND3, KCNIP1, KCNIP2, KCNIP3, KCNIP4, DPP6 and DPP10 (By similarity).
Interacts with KCND2 (PubMed:11847232, PubMed:18957440).
Interacts with KCND3 (By similarity).
Interacts with the C-terminus of PSEN2 and probably PSEN1 (PubMed:11847232).
By similarity4 PublicationsBinary interactionsi
Hide detailsQ6PIL6
Protein-protein interaction databases
BioGRIDi | 123244, 22 interactors |
CORUMi | Q6PIL6 |
IntActi | Q6PIL6, 17 interactors |
STRINGi | 9606.ENSP00000371587 |
Miscellaneous databases
RNActi | Q6PIL6, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 61 – 117 | EF-hand 1; degeneratePROSITE-ProRule annotationAdd BLAST | 57 | |
Domaini | 120 – 155 | EF-hand 2PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 156 – 191 | EF-hand 3PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 204 – 239 | EF-hand 4PROSITE-ProRule annotationAdd BLAST | 36 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 2 – 44 | KISBy similarityAdd BLAST | 43 | |
Regioni | 237 – 250 | Interaction with KCND2By similarityAdd BLAST | 14 |
Domaini
Sequence similaritiesi
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG0044, Eukaryota |
GeneTreei | ENSGT00940000158985 |
HOGENOMi | CLU_072366_5_0_1 |
InParanoidi | Q6PIL6 |
OMAi | KNAMRPP |
OrthoDBi | 1513542at2759 |
PhylomeDBi | Q6PIL6 |
TreeFami | TF318560 |
Family and domain databases
CDDi | cd00051, EFh, 2 hits |
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom IPR028846, Recoverin |
PANTHERi | PTHR23055, PTHR23055, 1 hit |
Pfami | View protein in Pfam PF13499, EF-hand_7, 1 hit PF13833, EF-hand_8, 1 hit |
SMARTi | View protein in SMART SM00054, EFh, 3 hits |
SUPFAMi | SSF47473, SSF47473, 1 hit |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 3 hits PS50222, EF_HAND_2, 3 hits |
s (5+)i Sequence
Sequence statusi: Complete.
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MNVRRVESIS AQLEEASSTG GFLYAQNSTK RSIKERLMKL LPCSAAKTSS
60 70 80 90 100
PAIQNSVEDE LEMATVRHRP EALELLEAQS KFTKKELQIL YRGFKNECPS
110 120 130 140 150
GVVNEETFKE IYSQFFPQGD STTYAHFLFN AFDTDHNGAV SFEDFIKGLS
160 170 180 190 200
ILLRGTVQEK LNWAFNLYDI NKDGYITKEE MLDIMKAIYD MMGKCTYPVL
210 220 230 240 250
KEDAPRQHVE TFFQKMDKNK DGVVTIDEFI ESCQKDENIM RSMQLFENVI
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ3YAB7 | Q3YAB7_HUMAN | Kv channel-interacting protein 4 | KCNIP4 | 233 | Annotation score: | ||
F5H395 | F5H395_HUMAN | Kv channel-interacting protein 4 | KCNIP4 | 34 | Annotation score: | ||
A0A0G2JRL8 | A0A0G2JRL8_HUMAN | Kv channel-interacting protein 4 | KCNIP4 | 29 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 29 | T → I in AAG36974 (PubMed:11847232).Curated | 1 | |
Sequence conflicti | 29 | T → I in AAK53713 (Ref. 3) Curated | 1 | |
Sequence conflicti | 32 | S → N in AAG36974 (PubMed:11847232).Curated | 1 | |
Sequence conflicti | 32 | S → N in AAK53713 (Ref. 3) Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_015066 | 1 – 62 | Missing in isoform 3. 3 PublicationsAdd BLAST | 62 | |
Alternative sequenceiVSP_015067 | 1 – 55 | MNVRR…PAIQN → MNLEGLEMIAVLIVIVLFVK LLEQFGLIEAGLED in isoform 4. 2 PublicationsAdd BLAST | 55 | |
Alternative sequenceiVSP_043321 | 1 – 55 | MNVRR…PAIQN → MSGCRKRCKREILKFAQYLL RLLTGSLHTD in isoform 5. 1 PublicationAdd BLAST | 55 | |
Alternative sequenceiVSP_015068 | 21 – 55 | GFLYA…PAIQN → D in isoform 2. 3 PublicationsAdd BLAST | 35 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF302044 mRNA Translation: AAG36974.1 AF305072 mRNA Translation: AAG36977.1 AF453246 mRNA Translation: AAL86769.1 AF367023 mRNA Translation: AAK53712.1 AF367024 mRNA Translation: AAK53713.1 AY029176 mRNA Translation: AAK31594.1 AY118170 mRNA Translation: AAM81578.1 DQ148487 mRNA Translation: AAZ77804.1 DQ148488 mRNA Translation: AAZ77805.1 DQ148489 mRNA Translation: AAZ77806.1 DQ148490 mRNA Translation: AAZ77807.1 DQ148491 mRNA Translation: AAZ77808.1 AK289922 mRNA Translation: BAF82611.1 AC096576 Genomic DNA No translation available. AC097505 Genomic DNA No translation available. AC098597 Genomic DNA No translation available. AC104065 Genomic DNA Translation: AAY40911.1 AC107462 Genomic DNA No translation available. AC108147 Genomic DNA No translation available. AC109360 Genomic DNA No translation available. AC109636 Genomic DNA No translation available. AC110296 Genomic DNA No translation available. AC110612 Genomic DNA No translation available. AC113606 Genomic DNA No translation available. AC116641 Genomic DNA No translation available. CH471069 Genomic DNA Translation: EAW92798.1 BC032520 mRNA Translation: AAH32520.1 |
CCDSi | CCDS3428.1 [Q6PIL6-4] CCDS43215.1 [Q6PIL6-2] CCDS43216.1 [Q6PIL6-1] CCDS43217.1 [Q6PIL6-5] CCDS47035.1 [Q6PIL6-3] |
RefSeqi | NP_001030175.1, NM_001035003.1 [Q6PIL6-5] NP_001030176.1, NM_001035004.1 [Q6PIL6-3] NP_079497.2, NM_025221.5 [Q6PIL6-1] NP_671710.1, NM_147181.3 [Q6PIL6-2] NP_671711.1, NM_147182.3 [Q6PIL6-3] NP_671712.1, NM_147183.3 [Q6PIL6-4] XP_016864142.1, XM_017008653.1 [Q6PIL6-3] |
Genome annotation databases
Ensembli | ENST00000359001; ENSP00000351892; ENSG00000185774 [Q6PIL6-3] ENST00000382148; ENSP00000371583; ENSG00000185774 [Q6PIL6-5] ENST00000382150; ENSP00000371585; ENSG00000185774 [Q6PIL6-4] ENST00000382152; ENSP00000371587; ENSG00000185774 [Q6PIL6-1] ENST00000447367; ENSP00000399080; ENSG00000185774 [Q6PIL6-2] ENST00000509207; ENSP00000423257; ENSG00000185774 [Q6PIL6-3] |
GeneIDi | 80333 |
KEGGi | hsa:80333 |
UCSCi | uc003gqf.2, human [Q6PIL6-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF302044 mRNA Translation: AAG36974.1 AF305072 mRNA Translation: AAG36977.1 AF453246 mRNA Translation: AAL86769.1 AF367023 mRNA Translation: AAK53712.1 AF367024 mRNA Translation: AAK53713.1 AY029176 mRNA Translation: AAK31594.1 AY118170 mRNA Translation: AAM81578.1 DQ148487 mRNA Translation: AAZ77804.1 DQ148488 mRNA Translation: AAZ77805.1 DQ148489 mRNA Translation: AAZ77806.1 DQ148490 mRNA Translation: AAZ77807.1 DQ148491 mRNA Translation: AAZ77808.1 AK289922 mRNA Translation: BAF82611.1 AC096576 Genomic DNA No translation available. AC097505 Genomic DNA No translation available. AC098597 Genomic DNA No translation available. AC104065 Genomic DNA Translation: AAY40911.1 AC107462 Genomic DNA No translation available. AC108147 Genomic DNA No translation available. AC109360 Genomic DNA No translation available. AC109636 Genomic DNA No translation available. AC110296 Genomic DNA No translation available. AC110612 Genomic DNA No translation available. AC113606 Genomic DNA No translation available. AC116641 Genomic DNA No translation available. CH471069 Genomic DNA Translation: EAW92798.1 BC032520 mRNA Translation: AAH32520.1 |
CCDSi | CCDS3428.1 [Q6PIL6-4] CCDS43215.1 [Q6PIL6-2] CCDS43216.1 [Q6PIL6-1] CCDS43217.1 [Q6PIL6-5] CCDS47035.1 [Q6PIL6-3] |
RefSeqi | NP_001030175.1, NM_001035003.1 [Q6PIL6-5] NP_001030176.1, NM_001035004.1 [Q6PIL6-3] NP_079497.2, NM_025221.5 [Q6PIL6-1] NP_671710.1, NM_147181.3 [Q6PIL6-2] NP_671711.1, NM_147182.3 [Q6PIL6-3] NP_671712.1, NM_147183.3 [Q6PIL6-4] XP_016864142.1, XM_017008653.1 [Q6PIL6-3] |
3D structure databases
BMRBi | Q6PIL6 |
SMRi | Q6PIL6 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 123244, 22 interactors |
CORUMi | Q6PIL6 |
IntActi | Q6PIL6, 17 interactors |
STRINGi | 9606.ENSP00000371587 |
Protein family/group databases
TCDBi | 8.A.82.2.2, the calmodulin calcium binding protein (calmodulin) family |
PTM databases
iPTMneti | Q6PIL6 |
PhosphoSitePlusi | Q6PIL6 |
Polymorphism and mutation databases
BioMutai | KCNIP4 |
DMDMi | 73621129 |
Proteomic databases
EPDi | Q6PIL6 |
MassIVEi | Q6PIL6 |
PaxDbi | Q6PIL6 |
PeptideAtlasi | Q6PIL6 |
PRIDEi | Q6PIL6 |
ProteomicsDBi | 67166 [Q6PIL6-1] 67167 [Q6PIL6-2] 67168 [Q6PIL6-3] 67169 [Q6PIL6-4] 67170 [Q6PIL6-5] |
Protocols and materials databases
ABCDi | Q6PIL6, 2 sequenced antibodies |
Antibodypediai | 10064, 186 antibodies |
DNASUi | 80333 |
Genome annotation databases
Ensembli | ENST00000359001; ENSP00000351892; ENSG00000185774 [Q6PIL6-3] ENST00000382148; ENSP00000371583; ENSG00000185774 [Q6PIL6-5] ENST00000382150; ENSP00000371585; ENSG00000185774 [Q6PIL6-4] ENST00000382152; ENSP00000371587; ENSG00000185774 [Q6PIL6-1] ENST00000447367; ENSP00000399080; ENSG00000185774 [Q6PIL6-2] ENST00000509207; ENSP00000423257; ENSG00000185774 [Q6PIL6-3] |
GeneIDi | 80333 |
KEGGi | hsa:80333 |
UCSCi | uc003gqf.2, human [Q6PIL6-1] |
Organism-specific databases
CTDi | 80333 |
DisGeNETi | 80333 |
EuPathDBi | HostDB:ENSG00000185774.14 |
GeneCardsi | KCNIP4 |
HGNCi | HGNC:30083, KCNIP4 |
HPAi | ENSG00000185774, Tissue enhanced (brain) |
MIMi | 608182, gene |
neXtProti | NX_Q6PIL6 |
OpenTargetsi | ENSG00000185774 |
PharmGKBi | PA134893552 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0044, Eukaryota |
GeneTreei | ENSGT00940000158985 |
HOGENOMi | CLU_072366_5_0_1 |
InParanoidi | Q6PIL6 |
OMAi | KNAMRPP |
OrthoDBi | 1513542at2759 |
PhylomeDBi | Q6PIL6 |
TreeFami | TF318560 |
Enzyme and pathway databases
PathwayCommonsi | Q6PIL6 |
Reactomei | R-HSA-5576894, Phase 1 - inactivation of fast Na+ channels |
Miscellaneous databases
BioGRID-ORCSi | 80333, 6 hits in 846 CRISPR screens |
ChiTaRSi | KCNIP4, human |
GenomeRNAii | 80333 |
Pharosi | Q6PIL6, Tbio |
PROi | PR:Q6PIL6 |
RNActi | Q6PIL6, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000185774, Expressed in frontal cortex and 168 other tissues |
ExpressionAtlasi | Q6PIL6, baseline and differential |
Genevisiblei | Q6PIL6, HS |
Family and domain databases
CDDi | cd00051, EFh, 2 hits |
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom IPR028846, Recoverin |
PANTHERi | PTHR23055, PTHR23055, 1 hit |
Pfami | View protein in Pfam PF13499, EF-hand_7, 1 hit PF13833, EF-hand_8, 1 hit |
SMARTi | View protein in SMART SM00054, EFh, 3 hits |
SUPFAMi | SSF47473, SSF47473, 1 hit |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 3 hits PS50222, EF_HAND_2, 3 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | KCIP4_HUMAN | |
Accessioni | Q6PIL6Primary (citable) accession number: Q6PIL6 Secondary accession number(s): Q3YAB8 Q9H2A4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 16, 2005 |
Last sequence update: | July 5, 2004 | |
Last modified: | December 2, 2020 | |
This is version 148 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families