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Protein

F-box only protein 38

Gene

FBXO38

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. May coactivate KLF7, but does not seem to promote KLF7 ubiquitination (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q6PIJ6

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
F-box only protein 38
Alternative name(s):
Modulator of KLF7 activity homolog
Short name:
MoKA
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FBXO38
ORF Names:SP329
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000145868.16

Human Gene Nomenclature Database

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HGNCi
HGNC:28844 FBXO38

Online Mendelian Inheritance in Man (OMIM)

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MIMi
608533 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q6PIJ6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Neuronopathy, distal hereditary motor, 2D (HMN2D)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by onset of slowly progressive distal lower limb weakness and atrophy between the second and fourth decades of life. Weakness usually begins in the calf muscles and later involves more proximal muscles. The severity is variable, and some patients have difficulty walking or running. Most also have upper limb involvement, particularly of the triceps and intrinsic hand muscles. Some patients may lose independent ambulation later in the disease course. Sensory impairment is typically not present, and cognition and bulbar function are normal.
See also OMIM:615575
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_070923206C → R in HMN2D; unable to promote activation of KLF7 target genes including CDKN1A and L1CAM in both cultured cells and patient-derived cells. 1 PublicationCorresponds to variant dbSNP:rs398122838EnsemblClinVar.1

Keywords - Diseasei

Disease mutation, Neurodegeneration, Neuropathy

Organism-specific databases

DisGeNET

More...
DisGeNETi
81545

MalaCards human disease database

More...
MalaCardsi
FBXO38
MIMi615575 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000145868

Orphanet; a database dedicated to information on rare diseases and orphan drugs

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Orphaneti
139525 Distal hereditary motor neuropathy type 2

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134929999

Polymorphism and mutation databases

Domain mapping of disease mutations (DMDM)

More...
DMDMi
116241362

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001199331 – 1188F-box only protein 38Add BLAST1188

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei591PhosphothreonineBy similarity1
Modified residuei598PhosphoserineBy similarity1
Modified residuei600PhosphoserineBy similarity1
Modified residuei606PhosphoserineBy similarity1
Modified residuei736PhosphoserineCombined sources1
Modified residuei740PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q6PIJ6

MaxQB - The MaxQuant DataBase

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MaxQBi
Q6PIJ6

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q6PIJ6

PeptideAtlas

More...
PeptideAtlasi
Q6PIJ6

PRoteomics IDEntifications database

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PRIDEi
Q6PIJ6

ProteomicsDB human proteome resource

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ProteomicsDBi
67162
67163 [Q6PIJ6-2]
67164 [Q6PIJ6-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q6PIJ6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q6PIJ6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000145868 Expressed in 222 organ(s), highest expression level in intestine

CleanEx database of gene expression profiles

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CleanExi
HS_FBXO38

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q6PIJ6 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA034821
HPA041444

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with KLF7. Part of a SCF (SKP1-cullin-F-box) protein ligase complex (By similarity).By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
123513, 22 interactors

Protein interaction database and analysis system

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IntActi
Q6PIJ6, 11 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000342023

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q6PIJ6

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini30 – 75F-boxAdd BLAST46

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni59 – 119Interaction with KLF7By similarityAdd BLAST61

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The N-terminal region aa 1-349 seems to be involved in cytoplasmic localization.By similarity
The C-terminal region aa 473-1194 seems to be involved in nuclear localization.By similarity

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IFU5 Eukaryota
ENOG410XS1U LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000013163

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG051579

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q6PIJ6

KEGG Orthology (KO)

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KOi
K10313

Identification of Orthologs from Complete Genome Data

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OMAi
PRCCCHR

Database of Orthologous Groups

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OrthoDBi
EOG091G00W1

Database for complete collections of gene phylogenies

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PhylomeDBi
Q6PIJ6

TreeFam database of animal gene trees

More...
TreeFami
TF331125

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.80.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
IPR032675 LRR_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00646 F-box, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF81383 SSF81383, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q6PIJ6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGPRKKSVKT CIMNNEIPEE MTADETKDYM NQLSHEVLCH IFRYLPLQDI
60 70 80 90 100
MCMECLSRKL KEAVTLYLRV VRVVDLCAGR WWEYMPSGFT DASFLTLLKK
110 120 130 140 150
MPDVEQLYGL HPRYLERRRV RGHEAFSIPG VLEALQACPN LVGVETSHLE
160 170 180 190 200
LVESIWTYMP HVHILGKFRN RNGAFPIPPE NKLKIPIGAK IQTLHLVGVN
210 220 230 240 250
VPEIPCIPML RHLYMKWVRL TKPQPFKDFL CISLRTFVMR NCAGPTNSLK
260 270 280 290 300
YVPLVTGLAS ARNLEHLEMV RVPFLGGLIQ HVVEDSWRSG GFRNLHTIVL
310 320 330 340 350
GACKNALEVD LGYLIITAAR RLHEVRIQPS LTKDGVFSAL KMAELEFPQF
360 370 380 390 400
ETLHLGYVDE FLLQSRMANA DLVKYGLADV VENPGIITDI GMKAVNEVFS
410 420 430 440 450
CIKYLAIYNC PHLHNPYNWI SDHSRWTRLV DINLVRCHAL KLDSFGQFIE
460 470 480 490 500
LLPSLEFISL DQMFREPPKG CARVGLSAGT GIGVSSALVS NQNSNNDDNN
510 520 530 540 550
AQNNNANIHD NNHHHPDDSD EENDFRQDLQ PGEQQFAADA LNEMEDIVQE
560 570 580 590 600
DGEVVAESGN NTPAHSQAII PVDVDEEQAG PSGLQRVVKP TSITVHDSES
610 620 630 640 650
DDEEDSLELQ EVWIPKNGTR RYSEREEKTG ESVQSRELSV SGKGKTPLRK
660 670 680 690 700
RYNSHQMGQS KQFPLEESSC EKGCQVTSEQ IKADMKAARD IPEKKKNKDV
710 720 730 740 750
YPSCSSTTAS TVGNSSSHNT ASQSPDFVRT VNSGGSSEPS PTEVDVSRQC
760 770 780 790 800
ACSPGGSEDS EAMEEGDAES SVCPRCCCHR PQESQRRTSR CSDEERPSTS
810 820 830 840 850
RACVVNGPDG TRSAFSFRTL PQGGSSGPAH DERTNGSGSG ATGEDRRGSS
860 870 880 890 900
QPESCDVQSN EDYPRRPLTR ARSRLSHVLL VSESEVAKTK PRHAMKRKRT
910 920 930 940 950
ADKSTSTSDP VIEDDHVQVL VLKSKNLVGV TMTNCGITDL VLKDCPKMMF
960 970 980 990 1000
IHATRCRVLK HLKVENAPIV NRFDYAQCKK LNMDQVLDQI LRMPPERNRI
1010 1020 1030 1040 1050
IYLRPMQQVD TLTLEQKLFS GPYPYHICII HEFSNPPNVR NKVRIRSWMD
1060 1070 1080 1090 1100
TIANINQELI KYEFFPEATR SEEDLKKYPK YPWGREIYTL EGVVDGAPYS
1110 1120 1130 1140 1150
MISDFPWLRS LRAAEPNSFA RYDFEDDEES TIYAPRRKGQ LSADICMETI
1160 1170 1180
GEEISEMRQM KKGVFQRVVA IFIHYCDVNG EPVEDDYI
Length:1,188
Mass (Da):133,944
Last modified:October 17, 2006 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i863A0F7333E95A0C
GO
Isoform 2 (identifier: Q6PIJ6-2) [UniParc]FASTAAdd to basket
Also known as: a

The sequence of this isoform differs from the canonical sequence as follows:
     810-884: Missing.

Show »
Length:1,113
Mass (Da):125,957
Checksum:i553F472DCB0C01A0
GO
Isoform 3 (identifier: Q6PIJ6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     640-809: Missing.
     810-884: Missing.

Show »
Length:943
Mass (Da):107,703
Checksum:i0AB4372A4BE9C91E
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAG17983 differs from that shown. Reason: Frameshift at position 783.Curated
The sequence AAH56147 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAK34945 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB14783 differs from that shown. Reason: Frameshift at position 349.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti137A → S in AAH33454 (PubMed:15489334).Curated1
Sequence conflicti264L → S in BAB14783 (PubMed:14702039).Curated1
Sequence conflicti315I → N in BAB14783 (PubMed:14702039).Curated1
Sequence conflicti480T → A in AAH33454 (PubMed:15489334).Curated1
Sequence conflicti498D → E in AAH33454 (PubMed:15489334).Curated1
Sequence conflicti775 – 776RC → DA in AAG17983 (PubMed:15498874).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_070923206C → R in HMN2D; unable to promote activation of KLF7 target genes including CDKN1A and L1CAM in both cultured cells and patient-derived cells. 1 PublicationCorresponds to variant dbSNP:rs398122838EnsemblClinVar.1
Natural variantiVAR_028099592S → P2 PublicationsCorresponds to variant dbSNP:rs10043775Ensembl.1
Natural variantiVAR_049049894A → T. Corresponds to variant dbSNP:rs11949133Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_011448640 – 809Missing in isoform 3. 1 PublicationAdd BLAST170
Alternative sequenceiVSP_011449810 – 884Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST75

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC005849 mRNA Translation: AAH05849.1
BC005873 mRNA Translation: AAH05873.1
BC033454 mRNA Translation: AAH33454.1
BC050424 mRNA Translation: AAH50424.1
BC056147 mRNA Translation: AAH56147.1 Different initiation.
AF251055 mRNA Translation: AAK34945.1 Different initiation.
AK024024 mRNA Translation: BAB14783.1 Frameshift.
AF177339 mRNA Translation: AAG17983.1 Frameshift.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS4290.1 [Q6PIJ6-1]
CCDS43384.1 [Q6PIJ6-2]
CCDS64285.1 [Q6PIJ6-3]

NCBI Reference Sequences

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RefSeqi
NP_001258652.1, NM_001271723.1 [Q6PIJ6-3]
NP_110420.3, NM_030793.4 [Q6PIJ6-2]
XP_005268570.1, XM_005268513.1

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.483772

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000296701; ENSP00000296701; ENSG00000145868 [Q6PIJ6-3]
ENST00000340253; ENSP00000342023; ENSG00000145868 [Q6PIJ6-1]
ENST00000394370; ENSP00000377895; ENSG00000145868 [Q6PIJ6-2]
ENST00000513826; ENSP00000426410; ENSG00000145868 [Q6PIJ6-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
81545

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:81545

UCSC genome browser

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UCSCi
uc003lpg.3 human [Q6PIJ6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC005849 mRNA Translation: AAH05849.1
BC005873 mRNA Translation: AAH05873.1
BC033454 mRNA Translation: AAH33454.1
BC050424 mRNA Translation: AAH50424.1
BC056147 mRNA Translation: AAH56147.1 Different initiation.
AF251055 mRNA Translation: AAK34945.1 Different initiation.
AK024024 mRNA Translation: BAB14783.1 Frameshift.
AF177339 mRNA Translation: AAG17983.1 Frameshift.
CCDSiCCDS4290.1 [Q6PIJ6-1]
CCDS43384.1 [Q6PIJ6-2]
CCDS64285.1 [Q6PIJ6-3]
RefSeqiNP_001258652.1, NM_001271723.1 [Q6PIJ6-3]
NP_110420.3, NM_030793.4 [Q6PIJ6-2]
XP_005268570.1, XM_005268513.1
UniGeneiHs.483772

3D structure databases

ProteinModelPortaliQ6PIJ6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123513, 22 interactors
IntActiQ6PIJ6, 11 interactors
STRINGi9606.ENSP00000342023

PTM databases

iPTMnetiQ6PIJ6
PhosphoSitePlusiQ6PIJ6

Polymorphism and mutation databases

DMDMi116241362

Proteomic databases

EPDiQ6PIJ6
MaxQBiQ6PIJ6
PaxDbiQ6PIJ6
PeptideAtlasiQ6PIJ6
PRIDEiQ6PIJ6
ProteomicsDBi67162
67163 [Q6PIJ6-2]
67164 [Q6PIJ6-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296701; ENSP00000296701; ENSG00000145868 [Q6PIJ6-3]
ENST00000340253; ENSP00000342023; ENSG00000145868 [Q6PIJ6-1]
ENST00000394370; ENSP00000377895; ENSG00000145868 [Q6PIJ6-2]
ENST00000513826; ENSP00000426410; ENSG00000145868 [Q6PIJ6-3]
GeneIDi81545
KEGGihsa:81545
UCSCiuc003lpg.3 human [Q6PIJ6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
81545
DisGeNETi81545
EuPathDBiHostDB:ENSG00000145868.16

GeneCards: human genes, protein and diseases

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GeneCardsi
FBXO38
HGNCiHGNC:28844 FBXO38
HPAiHPA034821
HPA041444
MalaCardsiFBXO38
MIMi608533 gene
615575 phenotype
neXtProtiNX_Q6PIJ6
OpenTargetsiENSG00000145868
Orphaneti139525 Distal hereditary motor neuropathy type 2
PharmGKBiPA134929999

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IFU5 Eukaryota
ENOG410XS1U LUCA
GeneTreeiENSGT00390000013163
HOVERGENiHBG051579
InParanoidiQ6PIJ6
KOiK10313
OMAiPRCCCHR
OrthoDBiEOG091G00W1
PhylomeDBiQ6PIJ6
TreeFamiTF331125

Enzyme and pathway databases

SIGNORiQ6PIJ6

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
FBXO38 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
81545

Protein Ontology

More...
PROi
PR:Q6PIJ6

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000145868 Expressed in 222 organ(s), highest expression level in intestine
CleanExiHS_FBXO38
GenevisibleiQ6PIJ6 HS

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF00646 F-box, 1 hit
SUPFAMiSSF81383 SSF81383, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFBX38_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6PIJ6
Secondary accession number(s): Q6PK72
, Q7Z2U0, Q86VN3, Q9BXY6, Q9H837, Q9HC40
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: October 17, 2006
Last modified: December 5, 2018
This is version 135 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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