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Protein

Nuclear factor related to kappa-B-binding protein

Gene

Nfrkb

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds to the DNA consensus sequence 5'-GGGGAATCTCC-3'.By similarity
Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Modulates the deubiquitinase activity of UCHL5 in the INO80 complex (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processDNA damage, DNA recombination, DNA repair, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-5689603 UCH proteinases
R-MMU-5696394 DNA Damage Recognition in GG-NER

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear factor related to kappa-B-binding protein
Alternative name(s):
DNA-binding protein R kappa-B
Gene namesi
Name:Nfrkb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:2442410 Nfrkb

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002278081 – 1296Nuclear factor related to kappa-B-binding proteinAdd BLAST1296

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei228PhosphoserineBy similarity1
Modified residuei298PhosphoserineCombined sources1
Cross-linki327Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei351PhosphoserineBy similarity1
Cross-linki469Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki488Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity
Cross-linki488Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei1019PhosphoserineBy similarity1
Modified residuei1234N6-acetyllysineBy similarity1
Modified residuei1288PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ6PIJ4
MaxQBiQ6PIJ4
PaxDbiQ6PIJ4
PeptideAtlasiQ6PIJ4
PRIDEiQ6PIJ4

PTM databases

iPTMnetiQ6PIJ4
PhosphoSitePlusiQ6PIJ4

Expressioni

Gene expression databases

BgeeiENSMUSG00000042185 Expressed in 264 organ(s), highest expression level in embryo
CleanExiMM_NFRKB
ExpressionAtlasiQ6PIJ4 baseline and differential
GenevisibleiQ6PIJ4 MM

Interactioni

Subunit structurei

Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the N-terminus of INO80. Interacts with UCHL5 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi231624, 1 interactor
ComplexPortaliCPX-878 INO80 chromatin remodeling complex
IntActiQ6PIJ4, 2 interactors
MINTiQ6PIJ4
STRINGi10090.ENSMUSP00000083341

Structurei

3D structure databases

ProteinModelPortaliQ6PIJ4
SMRiQ6PIJ4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni370 – 495Winged-helix like domainBy similarityAdd BLAST126

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi309 – 327Lys-richAdd BLAST19
Compositional biasi664 – 671Poly-Ala8
Compositional biasi683 – 796Ser-richAdd BLAST114
Compositional biasi714 – 736Pro-richAdd BLAST23
Compositional biasi1242 – 1268Gln-richAdd BLAST27

Domaini

NFRKB seems to be mostly disordered. The wing-helix like domain doesn't bind DNA (By similarity).By similarity

Sequence similaritiesi

Belongs to the NFRKB family.Curated

Phylogenomic databases

eggNOGiKOG1927 Eukaryota
ENOG410YHF2 LUCA
GeneTreeiENSGT00390000016213
HOGENOMiHOG000113775
HOVERGENiHBG082022
InParanoidiQ6PIJ4
KOiK11671
OMAiVKCPPVP
OrthoDBiEOG091G03IX
PhylomeDBiQ6PIJ4
TreeFamiTF324944

Family and domain databases

Gene3Di1.10.10.2430, 1 hit
InterProiView protein in InterPro
IPR024867 NFRKB
IPR025220 NFRKB_winged_dom
IPR038106 NFRKB_winged_sf
PANTHERiPTHR13052 PTHR13052, 1 hit
PfamiView protein in Pfam
PF14465 NFRKB_winged, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q6PIJ4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDSLDHMLTD PLELGPCGDG HSTGIMEDCL LGGTRVSLPE DLLEDPEIFF
60 70 80 90 100
DVVSLSTWQE VLSDSQREHL QQFLPRFPAD SVEQQRELIL ALFSGENFRF
110 120 130 140 150
GNPLHIAQKL FRDGHFNPEV VKYRQLCFKS QYKRYLNSQQ QYFHRLLKQI
160 170 180 190 200
LASRSDLLEM ARRSGPALPF PHKHHSPSRS PEEREWRTQQ RYLKVLREVK
210 220 230 240 250
EECGDTALSS DEEDLSSWLP SSPARSPSPA VPLRVVPTLS TTDMKTADKI
260 270 280 290 300
ELGDSDLKLM LKKHHEKRKH QPDHPDLLTG DLTLSDIMTR VNAGRKGSLA
310 320 330 340 350
ALYDLAVLKK KVKEKEEKKK KKIKLIKSEA EDLAEPLSST EGVPTLSQAP
360 370 380 390 400
SPLAISSIKE EPLEDIKPCL GINEISSSFF SLLLEILLLE SQASLPMLED
410 420 430 440 450
RVLDWQSSPA SSLNSWFSAA PNWAELVLPA LQYLAGESRA VPSSFSPFVE
460 470 480 490 500
FKEKTQQWKL LGQSQDNEKE LAALFHLWLE TKDQAFCKEN EDSSDAMTPV
510 520 530 540 550
PRVRTDYVVR PSTGEEKRVF QEQERYRYSQ PHKAFTFRMH GFESVVGPVK
560 570 580 590 600
GVFDKETSLN KAREHSLLRS DRPAYVTILS LVRDAAARLP NGEGTRAEIC
610 620 630 640 650
ELLKDSQFLA PDVTSTQVNT VVSGALDRLH YEKDPCVKYD IGRKLWIYLH
660 670 680 690 700
RDRSEEEFER IHQAQAAAAK ARKALQQKPK PPSKVKSSNK EGSTKGLSGP
710 720 730 740 750
SEQSQMSLSD SSMPPTPVTP VTPTTPALPT PISPPPVSAV NRSGSSTVSE
760 770 780 790 800
PAQSSSGVLL VSSPTMPQLG TMLSPASIQT PPSSQATARV VSHSSSAGLP
810 820 830 840 850
QVRVVAQPSL PAVSQQSVGP AQPLPQMPAG PQIRVPVTAT QTKVVPQAVM
860 870 880 890 900
ATVPVKGQTA AASVQRPGPG QTGLTVTNLP AAVSPVSKTA MSSPGNSAPS
910 920 930 940 950
ASTTAVIQNV TGQNIIKQVS ITGQLGVKPQ TGSSIPLTAT NFRIQGKDVL
960 970 980 990 1000
RLPPSSITTD AKGQTVLRIT PDMMATLAKS QVTTVKLTQD LFGAGSGTAG
1010 1020 1030 1040 1050
KGISATLHVT SNPVHAADSP AKAPSASVPS SAPAGTTVVK VTPDLKPTET
1060 1070 1080 1090 1100
ANSAFRLMPA LGVSVADQKG KNTVASSEAK PAATIRIVQG LGVMPPKAGQ
1110 1120 1130 1140 1150
TITVAAHAKQ GASVAGGSGT VHSSTVSLPS INAAVSKTVA VASGATSTPI
1160 1170 1180 1190 1200
SIGTGAPTVR QVPVNTTVVS TSQSGKLPTR ITVPLSVISQ PMKGKSVVTA
1210 1220 1230 1240 1250
PIIKGNLGAN LSGLGRNIIL TTMPAGTKLI AGNKPVSFLT AQQLQQLQQQ
1260 1270 1280 1290
GQATQVRIQT VPASHLQQGT ASGSSKAVST VVVTTAPSPK QAPEQQ
Length:1,296
Mass (Da):138,764
Last modified:July 5, 2004 - v1
Checksum:iED6A42FE704DED1B
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RIN8D6RIN8_MOUSE
Nuclear factor-related to kappa-B-b...
Nfrkb
114Annotation score:
D6RD05D6RD05_MOUSE
Nuclear factor-related to kappa-B-b...
Nfrkb
258Annotation score:
D6RHP5D6RHP5_MOUSE
Nuclear factor-related to kappa-B-b...
Nfrkb
215Annotation score:
A0A1L1SSC9A0A1L1SSC9_MOUSE
Nuclear factor-related to kappa-B-b...
Nfrkb
324Annotation score:

Sequence cautioni

The sequence BAC33927 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC029701 mRNA Translation: AAH29701.1
BC033595 mRNA Translation: AAH33595.1
AK049804 mRNA Translation: BAC33927.1 Different initiation.
CCDSiCCDS22949.1
RefSeqiNP_766354.2, NM_172766.3
UniGeneiMm.238146

Genome annotation databases

EnsembliENSMUST00000086167; ENSMUSP00000083341; ENSMUSG00000042185
GeneIDi235134
KEGGimmu:235134
UCSCiuc009orr.3 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC029701 mRNA Translation: AAH29701.1
BC033595 mRNA Translation: AAH33595.1
AK049804 mRNA Translation: BAC33927.1 Different initiation.
CCDSiCCDS22949.1
RefSeqiNP_766354.2, NM_172766.3
UniGeneiMm.238146

3D structure databases

ProteinModelPortaliQ6PIJ4
SMRiQ6PIJ4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi231624, 1 interactor
ComplexPortaliCPX-878 INO80 chromatin remodeling complex
IntActiQ6PIJ4, 2 interactors
MINTiQ6PIJ4
STRINGi10090.ENSMUSP00000083341

PTM databases

iPTMnetiQ6PIJ4
PhosphoSitePlusiQ6PIJ4

Proteomic databases

EPDiQ6PIJ4
MaxQBiQ6PIJ4
PaxDbiQ6PIJ4
PeptideAtlasiQ6PIJ4
PRIDEiQ6PIJ4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000086167; ENSMUSP00000083341; ENSMUSG00000042185
GeneIDi235134
KEGGimmu:235134
UCSCiuc009orr.3 mouse

Organism-specific databases

CTDi4798
MGIiMGI:2442410 Nfrkb

Phylogenomic databases

eggNOGiKOG1927 Eukaryota
ENOG410YHF2 LUCA
GeneTreeiENSGT00390000016213
HOGENOMiHOG000113775
HOVERGENiHBG082022
InParanoidiQ6PIJ4
KOiK11671
OMAiVKCPPVP
OrthoDBiEOG091G03IX
PhylomeDBiQ6PIJ4
TreeFamiTF324944

Enzyme and pathway databases

ReactomeiR-MMU-5689603 UCH proteinases
R-MMU-5696394 DNA Damage Recognition in GG-NER

Miscellaneous databases

PROiPR:Q6PIJ4
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000042185 Expressed in 264 organ(s), highest expression level in embryo
CleanExiMM_NFRKB
ExpressionAtlasiQ6PIJ4 baseline and differential
GenevisibleiQ6PIJ4 MM

Family and domain databases

Gene3Di1.10.10.2430, 1 hit
InterProiView protein in InterPro
IPR024867 NFRKB
IPR025220 NFRKB_winged_dom
IPR038106 NFRKB_winged_sf
PANTHERiPTHR13052 PTHR13052, 1 hit
PfamiView protein in Pfam
PF14465 NFRKB_winged, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNFRKB_MOUSE
AccessioniPrimary (citable) accession number: Q6PIJ4
Secondary accession number(s): Q8BWV5, Q8K0X6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: July 5, 2004
Last modified: November 7, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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