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Protein

Synaptonemal complex central element protein 2

Gene

SYCE2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Requires SYCP1 in order to be incorporated into the central element. May have a role in the synaptonemal complex assembly, stabilization and recombination (By similarity).By similarity

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • synaptonemal complex assembly Source: BHF-UCL

Keywordsi

Biological processCell cycle, Cell division, Meiosis

Enzyme and pathway databases

ReactomeiR-HSA-1221632 Meiotic synapsis

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptonemal complex central element protein 2
Alternative name(s):
Central element synaptonemal complex protein 1
Gene namesi
Name:SYCE2
Synonyms:CESC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000161860.7
HGNCiHGNC:27411 SYCE2
MIMi611487 gene
neXtProtiNX_Q6PIF2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000161860
PharmGKBiPA142670849

Polymorphism and mutation databases

BioMutaiSYCE2
DMDMi118573898

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002625621 – 218Synaptonemal complex central element protein 2Add BLAST218

Proteomic databases

PaxDbiQ6PIF2
PeptideAtlasiQ6PIF2
PRIDEiQ6PIF2
ProteomicsDBi67154

PTM databases

iPTMnetiQ6PIF2
PhosphoSitePlusiQ6PIF2

Expressioni

Gene expression databases

BgeeiENSG00000161860 Expressed in 92 organ(s), highest expression level in testis
CleanExiHS_SYCE2
ExpressionAtlasiQ6PIF2 baseline and differential
GenevisibleiQ6PIF2 HS

Organism-specific databases

HPAiHPA042080
HPA062919

Interactioni

Subunit structurei

Homodimer. Found in a complex with SYCP1 and SYCE1. Interacts with SYCP1, SYCE1 and SYCE3 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
CCDC196A0A1B0GWI14EBI-11958386,EBI-10181422

Protein-protein interaction databases

IntActiQ6PIF2, 13 interactors
STRINGi9606.ENSP00000293695

Structurei

3D structure databases

ProteinModelPortaliQ6PIF2
SMRiQ6PIF2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili61 – 87Sequence analysisAdd BLAST27

Sequence similaritiesi

Belongs to the SYCE family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410J5YK Eukaryota
ENOG410XUQ9 LUCA
GeneTreeiENSGT00390000004872
HOGENOMiHOG000154464
HOVERGENiHBG080707
InParanoidiQ6PIF2
KOiK19535
OMAiQPLGESK
OrthoDBiEOG091G17DE
PhylomeDBiQ6PIF2
TreeFamiTF333776

Family and domain databases

InterProiView protein in InterPro
IPR034609 Syce2
PANTHERiPTHR28398 PTHR28398, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

Q6PIF2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MERQGVDVPH VKCKDQEPQP LGESKEHPRW EENCEEEAGG GPASASCQLT
60 70 80 90 100
VLEGKSGLYF SSLDSSIDIL QKRAQELIEN INKSRQKDHA LMTNFRNSLK
110 120 130 140 150
TKVSDLTEKL EERIYQIYND HNKIIQEKLQ EFTQKMAKIS HLETELKQVC
160 170 180 190 200
HSVETVYKDL CLQPEQSLRL RWGPDHSRGK SPPRPGNSQP PDVFVSSVAE
210
TTSQATASEV QTNRDGEC
Length:218
Mass (Da):24,690
Last modified:November 28, 2006 - v2
Checksum:i8E95680492B0E5C2
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EM50K7EM50_HUMAN
Synaptonemal complex central elemen...
SYCE2
54Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK302373 mRNA Translation: BAG63695.1
AD000092 Genomic DNA No translation available.
AC092069 Genomic DNA No translation available.
CR746484 mRNA No translation available.
BC035819 mRNA Translation: AAH35819.1
CCDSiCCDS42509.1
RefSeqiNP_001099048.1, NM_001105578.1
UniGeneiHs.655173

Genome annotation databases

EnsembliENST00000293695; ENSP00000293695; ENSG00000161860
GeneIDi256126
KEGGihsa:256126
UCSCiuc002mvr.3 human

Similar proteinsi

Entry informationi

Entry nameiSYCE2_HUMAN
AccessioniPrimary (citable) accession number: Q6PIF2
Secondary accession number(s): B4DYD3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: November 28, 2006
Last modified: September 12, 2018
This is version 104 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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