Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Sodium/potassium-transporting ATPase subunit alpha-2

Gene

Atp1a2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients (By similarity).By similarity

Catalytic activityi

ATP + H2O + Na+(In) + K+(Out) = ADP + phosphate + Na+(Out) + K+(In).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei3744-aspartylphosphate intermediateBy similarity1
Metal bindingi714MagnesiumBy similarity1
Metal bindingi718MagnesiumBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processIon transport, Potassium transport, Sodium transport, Sodium/potassium transport, Transport
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium, Sodium

Enzyme and pathway databases

ReactomeiR-MMU-5578775 Ion homeostasis
R-MMU-936837 Ion transport by P-type ATPases

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/potassium-transporting ATPase subunit alpha-2 (EC:3.6.3.9)
Short name:
Na(+)/K(+) ATPase alpha-2 subunit
Alternative name(s):
Na(+)/K(+) ATPase alpha(+) subunit
Sodium pump subunit alpha-2
Gene namesi
Name:Atp1a2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:88106 Atp1a2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini6 – 85CytoplasmicSequence analysisAdd BLAST80
Transmembranei86 – 106HelicalSequence analysisAdd BLAST21
Topological domaini107 – 129ExtracellularSequence analysisAdd BLAST23
Transmembranei130 – 150HelicalSequence analysisAdd BLAST21
Topological domaini151 – 286CytoplasmicSequence analysisAdd BLAST136
Transmembranei287 – 306HelicalSequence analysisAdd BLAST20
Topological domaini307 – 318ExtracellularSequence analysisAdd BLAST12
Transmembranei319 – 336HelicalSequence analysisAdd BLAST18
Topological domaini337 – 769CytoplasmicSequence analysisAdd BLAST433
Transmembranei770 – 789HelicalSequence analysisAdd BLAST20
Topological domaini790 – 799ExtracellularSequence analysis10
Transmembranei800 – 820HelicalSequence analysisAdd BLAST21
Topological domaini821 – 840CytoplasmicSequence analysisAdd BLAST20
Transmembranei841 – 863HelicalSequence analysisAdd BLAST23
Topological domaini864 – 915ExtracellularSequence analysisAdd BLAST52
Transmembranei916 – 935HelicalSequence analysisAdd BLAST20
Topological domaini936 – 948CytoplasmicSequence analysisAdd BLAST13
Transmembranei949 – 967HelicalSequence analysisAdd BLAST19
Topological domaini968 – 982ExtracellularSequence analysisAdd BLAST15
Transmembranei983 – 1003HelicalSequence analysisAdd BLAST21
Topological domaini1004 – 1020CytoplasmicSequence analysisAdd BLAST17

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_00000025051 – 5By similarity5
ChainiPRO_00000025066 – 1020Sodium/potassium-transporting ATPase subunit alpha-2Add BLAST1015

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei10PhosphoserineCombined sources1
Modified residuei439PhosphoserineBy similarity1
Modified residuei450PhosphoserineCombined sources1
Modified residuei496PhosphoserineBy similarity1
Modified residuei559PhosphoserineCombined sources1
Modified residuei570PhosphothreonineBy similarity1
Modified residuei587PhosphoserineBy similarity1
Modified residuei672PhosphoserineCombined sources1
Modified residuei826PhosphoserineBy similarity1
Modified residuei940Phosphoserine; by PKABy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ6PIE5
PaxDbiQ6PIE5
PeptideAtlasiQ6PIE5
PRIDEiQ6PIE5

PTM databases

iPTMnetiQ6PIE5
PhosphoSitePlusiQ6PIE5
SwissPalmiQ6PIE5

Expressioni

Gene expression databases

BgeeiENSMUSG00000007097 Expressed in 294 organ(s), highest expression level in ciliary body
CleanExiMM_ATP1A2
ExpressionAtlasiQ6PIE5 baseline and differential
GenevisibleiQ6PIE5 MM

Interactioni

Subunit structurei

The sodium/potassium-transporting ATPase is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit. Interacts with regulatory subunit FXYD1.By similarity

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi221101, 4 interactors
DIPiDIP-48355N
IntActiQ6PIE5, 7 interactors
MINTiQ6PIE5
STRINGi10090.ENSMUSP00000083077

Structurei

3D structure databases

ProteinModelPortaliQ6PIE5
SMRiQ6PIE5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni80 – 82Interaction with phosphoinositide-3 kinaseBy similarity3

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0203 Eukaryota
COG0474 LUCA
GeneTreeiENSGT00890000139334
HOVERGENiHBG004298
InParanoidiQ6PIE5
KOiK01539
OMAiYVFGGFC
OrthoDBiEOG091G01BB
PhylomeDBiQ6PIE5
TreeFamiTF312838

Family and domain databases

CDDicd02608 P-type_ATPase_Na-K_like, 1 hit
Gene3Di3.40.1110.10, 1 hit
3.40.50.1000, 2 hits
InterProiView protein in InterPro
IPR006068 ATPase_P-typ_cation-transptr_C
IPR004014 ATPase_P-typ_cation-transptr_N
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR005775 P-type_ATPase_IIC
IPR001757 P_typ_ATPase
PfamiView protein in Pfam
PF00689 Cation_ATPase_C, 1 hit
PF00690 Cation_ATPase_N, 1 hit
SMARTiView protein in SMART
SM00831 Cation_ATPase_N, 1 hit
SUPFAMiSSF56784 SSF56784, 2 hits
SSF81653 SSF81653, 1 hit
SSF81660 SSF81660, 1 hit
SSF81665 SSF81665, 3 hits
TIGRFAMsiTIGR01106 ATPase-IIC_X-K, 1 hit
TIGR01494 ATPase_P-type, 2 hits
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

Q6PIE5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGRGAGREYS PAATTAENGG GKKKQKEKEL DELKKEVAMD DHKLSLDELG
60 70 80 90 100
RKYQVDLSKG LTNQRAQDIL ARDGPNALTP PPTTPEWVKF CRQLFGGFSI
110 120 130 140 150
LLWIGALLCF LAYGILAAME DEPSNDNLYL GIVLAAVVIV TGCFSYYQEA
160 170 180 190 200
KSSKIMDSFK NMVPQQALVI REGEKMQINA EEVVVGDLVE VKGGDRVPAD
210 220 230 240 250
LRIISSHGCK VDNSSLTGES EPQTRSPEFT HENPLETRNI CFFSTNCVEG
260 270 280 290 300
TARGIVIATG DRTVMGRIAT LASGLEVGQT PIAMEIEHFI QLITGVAVFL
310 320 330 340 350
GVSFFVLSLI LGYSWLEAVI FLIGIIVANV PEGLLATVTV CLTLTAKRMA
360 370 380 390 400
RKNCLVKNLE AVETLGSTST ICSDKTGTLT QNRMTVAHMW FDNQIHEADT
410 420 430 440 450
TEDQSGATFD KRSPTWTALS RIAGLCNRAV FKAGQENISV SKRDTAGDAS
460 470 480 490 500
ESALLKCIEL SCGSVRKMRD RNPKVAEIPF NSTNKYQLSI HEREDSPQSH
510 520 530 540 550
VLVMKGAPER ILDRCSTILV QGKEIPLDKE MQDAFQNAYM ELGGLGERVL
560 570 580 590 600
GFCQLNLPSG KFPRGFKFDT DELNFPTEKL CFVGLMSMID PPRAAVPDAV
610 620 630 640 650
GKCRSAGIKV IMVTGDHPIT AKAIAKGVGI ISEGNETVED IAARLNIPVS
660 670 680 690 700
QVNPREAKAC VVHGSDLKDM TSEQLDEILR DHTEIVFART SPQQKLIIVE
710 720 730 740 750
GCQRQGAIVA VTGDGVNDSP ALKKADIGIA MGISGSDVSK QAADMILLDD
760 770 780 790 800
NFASIVTGVE EGRLIFDNLK KSIAYTLTSN IPEITPFLLF IIANIPLPLG
810 820 830 840 850
TVTILCIDLG TDMVPAISLA YEAAESDIMK RQPRNSQTDK LVNERLISMA
860 870 880 890 900
YGQIGMIQAL GGFFTYFVIL AENGFLPSRL LGIRLDWDDR TTNDLEDSYG
910 920 930 940 950
QEWTYEQRKV VEFTCHTAFF ASIVVVQWAD LIICKTRRNS VFQQGMKNKI
960 970 980 990 1000
LIFGLLEETA LAAFLSYCPG MGVALRMYPL KVTWWFCAFP YSLLIFIYDE
1010 1020
VRKLILRRYP GGWVEKETYY
Length:1,020
Mass (Da):112,217
Last modified:July 5, 2004 - v1
Checksum:i5436E795BD5B4CFA
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3YYN7D3YYN7_MOUSE
Sodium/potassium-transporting ATPas...
Atp1a2
947Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC036127 mRNA Translation: AAH36127.1
BC041774 mRNA Translation: AAH41774.1
CCDSiCCDS35782.1
RefSeqiNP_848492.1, NM_178405.3
UniGeneiMm.207432

Genome annotation databases

EnsembliENSMUST00000085913; ENSMUSP00000083077; ENSMUSG00000007097
GeneIDi98660
KEGGimmu:98660
UCSCiuc007dqc.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC036127 mRNA Translation: AAH36127.1
BC041774 mRNA Translation: AAH41774.1
CCDSiCCDS35782.1
RefSeqiNP_848492.1, NM_178405.3
UniGeneiMm.207432

3D structure databases

ProteinModelPortaliQ6PIE5
SMRiQ6PIE5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi221101, 4 interactors
DIPiDIP-48355N
IntActiQ6PIE5, 7 interactors
MINTiQ6PIE5
STRINGi10090.ENSMUSP00000083077

PTM databases

iPTMnetiQ6PIE5
PhosphoSitePlusiQ6PIE5
SwissPalmiQ6PIE5

Proteomic databases

MaxQBiQ6PIE5
PaxDbiQ6PIE5
PeptideAtlasiQ6PIE5
PRIDEiQ6PIE5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000085913; ENSMUSP00000083077; ENSMUSG00000007097
GeneIDi98660
KEGGimmu:98660
UCSCiuc007dqc.1 mouse

Organism-specific databases

CTDi477
MGIiMGI:88106 Atp1a2

Phylogenomic databases

eggNOGiKOG0203 Eukaryota
COG0474 LUCA
GeneTreeiENSGT00890000139334
HOVERGENiHBG004298
InParanoidiQ6PIE5
KOiK01539
OMAiYVFGGFC
OrthoDBiEOG091G01BB
PhylomeDBiQ6PIE5
TreeFamiTF312838

Enzyme and pathway databases

ReactomeiR-MMU-5578775 Ion homeostasis
R-MMU-936837 Ion transport by P-type ATPases

Miscellaneous databases

ChiTaRSiAtp1a2 mouse
PROiPR:Q6PIE5
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000007097 Expressed in 294 organ(s), highest expression level in ciliary body
CleanExiMM_ATP1A2
ExpressionAtlasiQ6PIE5 baseline and differential
GenevisibleiQ6PIE5 MM

Family and domain databases

CDDicd02608 P-type_ATPase_Na-K_like, 1 hit
Gene3Di3.40.1110.10, 1 hit
3.40.50.1000, 2 hits
InterProiView protein in InterPro
IPR006068 ATPase_P-typ_cation-transptr_C
IPR004014 ATPase_P-typ_cation-transptr_N
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR005775 P-type_ATPase_IIC
IPR001757 P_typ_ATPase
PfamiView protein in Pfam
PF00689 Cation_ATPase_C, 1 hit
PF00690 Cation_ATPase_N, 1 hit
SMARTiView protein in SMART
SM00831 Cation_ATPase_N, 1 hit
SUPFAMiSSF56784 SSF56784, 2 hits
SSF81653 SSF81653, 1 hit
SSF81660 SSF81660, 1 hit
SSF81665 SSF81665, 3 hits
TIGRFAMsiTIGR01106 ATPase-IIC_X-K, 1 hit
TIGR01494 ATPase_P-type, 2 hits
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAT1A2_MOUSE
AccessioniPrimary (citable) accession number: Q6PIE5
Secondary accession number(s): Q80UZ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2005
Last sequence update: July 5, 2004
Last modified: September 12, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again