UniProtKB - Q6PID9 (Q6PID9_HUMAN)
Protein
Submitted name:
Aggrecan
Gene
ACAN
Organism
Homo sapiens (Human)
Status
Functioni
Caution
Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
GO - Molecular functioni
- hyaluronic acid binding Source: InterPro
GO - Biological processi
- cell adhesion Source: InterPro
Names & Taxonomyi
Protein namesi | Submitted name: AggrecanImportedSubmitted name: Aggrecan core proteinImported |
Gene namesi | Name:ACANImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000157766.15 |
HGNCi | HGNC:319, ACAN |
Subcellular locationi
Extracellular region or secreted
- extracellular matrix ARBA annotation
Extracellular region or secreted
- extracellular region Source: UniProtKB-KW
Keywords - Cellular componenti
Extracellular matrixARBA annotation, SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 16 | Sequence analysisAdd BLAST | 16 | |
ChainiPRO_5014310604 | 17 – 721 | Sequence analysisAdd BLAST | 705 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 199 ↔ 220 | PROSITE-ProRule annotation | ||
Disulfide bondi | 297 ↔ 318 | PROSITE-ProRule annotation | ||
Disulfide bondi | 524 ↔ 545 | PROSITE-ProRule annotation | ||
Disulfide bondi | 622 ↔ 643 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bondPROSITE-ProRule annotationProteomic databases
PRIDEi | Q6PID9 |
ProteomicsDBi | 67152 |
Expressioni
Gene expression databases
Bgeei | ENSG00000157766, Expressed in tibia and 179 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 34 – 147 | Ig-likeInterPro annotationAdd BLAST | 114 | |
Domaini | 153 – 248 | LinkInterPro annotationAdd BLAST | 96 | |
Domaini | 254 – 350 | LinkInterPro annotationAdd BLAST | 97 | |
Domaini | 478 – 573 | LinkInterPro annotationAdd BLAST | 96 | |
Domaini | 579 – 675 | LinkInterPro annotationAdd BLAST | 97 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 692 – 721 | DisorderedSequence analysisAdd BLAST | 30 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 696 – 721 | PolarSequence analysisAdd BLAST | 26 |
Sequence similaritiesi
Belongs to the aggrecan/versican proteoglycan family.ARBA annotation
Keywords - Domaini
Immunoglobulin domainARBA annotation, SignalSequence analysisPhylogenomic databases
GeneTreei | ENSGT00940000155971 |
HOGENOMi | CLU_413670_0_0_1 |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit 3.10.100.10, 4 hits |
InterProi | View protein in InterPro IPR016186, C-type_lectin-like/link_sf IPR016187, CTDL_fold IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003006, Ig/MHC_CS IPR003599, Ig_sub IPR013106, Ig_V-set IPR000538, Link_dom |
Pfami | View protein in Pfam PF07686, V-set, 1 hit PF00193, Xlink, 4 hits |
PRINTSi | PR01265, LINKMODULE |
SMARTi | View protein in SMART SM00409, IG, 1 hit SM00406, IGv, 1 hit SM00445, LINK, 4 hits |
SUPFAMi | SSF48726, SSF48726, 1 hit SSF56436, SSF56436, 4 hits |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit PS00290, IG_MHC, 1 hit PS01241, LINK_1, 3 hits PS50963, LINK_2, 4 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All
Q6PID9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTTLLWVFVT LRVITAAVTV ETSDHDNSLS VSIPQPSPLR VLLGTSLTIP
60 70 80 90 100
CYFIDPMHPV TTAPSTAPLA PRIKWSRVSK EKEVVLLVAT EGRVRVNSAY
110 120 130 140 150
QDKVSLPNYP AIPSDATLEV QSLRSNDSGV YRCEVMHGIE DSEATLEVVV
160 170 180 190 200
KGIVFHYRAI STRYTLDFDR AQRACLQNSA IIATPEQLQA AYEDGFHQCD
210 220 230 240 250
AGWLADQTVR YPIHTPREGC YGDKDEFPGV RTYGIRDTNE TYDVYCFAEE
260 270 280 290 300
MEGEVFYATS PEKFTFQEAA NECRRLGARL ATTGQLYLAW QAGMDMCSAG
310 320 330 340 350
WLADRSVRYP ISKARPNCGG NLLGVRTVYV HANQTGYPDP SSRYDAICYT
360 370 380 390 400
GEDFVDIPEN FFGVGGEEDI TVQTVTWPDM ELPLPRNITE GEARGSVILT
410 420 430 440 450
VKPIFEVSPS PLEPEEPFTF APEIGATAFA EVENETGEAT RPWGFPTPGL
460 470 480 490 500
GPATAFTSED LVVQVTAVPG QPHLPGGVVF HYRPGPTRYS LTFEEAQQAC
510 520 530 540 550
LRTGAVIASP EQLQAAYEAG YEQCDAGWLR DQTVRYPIVS PRTPCVGDKD
560 570 580 590 600
SSPGVRTYGV RPSTETYDVY CFVDRLEGEV FFATRLEQFT FQEALEFCES
610 620 630 640 650
HNATLATTGQ LYAAWSRGLD KCYAGWLADG SLRYPIVTPR PACGGDKPGV
660 670 680 690 700
RTVYLYPNQT GLPDPLSRHH AFCFRGMQPH FGSNSPFCLE RTPLGSPDPA
710 720
TTQYPIHQSK KMSVPLGQSQ L
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP16112 | PGCA_HUMAN | Aggrecan core protein | ACAN AGC1, CSPG1, MSK16 | 2,530 | Annotation score: | ||
H0YMF1 | H0YMF1_HUMAN | Aggrecan core protein | ACAN | 2,568 | Annotation score: | ||
A0A087X1T7 | A0A087X1T7_HUMAN | Aggrecan core protein | ACAN | 2,473 | Annotation score: | ||
A0A5K1VW97 | A0A5K1VW97_HUMAN | Aggrecan core protein | ACAN | 2,054 | Annotation score: | ||
H0YK70 | H0YK70_HUMAN | Aggrecan core protein | ACAN | 156 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC103982 Genomic DNA No translation available. BC036445 mRNA Translation: AAH36445.1 |
Genome annotation databases
Ensembli | ENST00000558207; ENSP00000453003; ENSG00000157766 |
UCSCi | uc002bmx.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC103982 Genomic DNA No translation available. BC036445 mRNA Translation: AAH36445.1 |
3D structure databases
SMRi | Q6PID9 |
ModBasei | Search... |
Proteomic databases
PRIDEi | Q6PID9 |
ProteomicsDBi | 67152 |
Protocols and materials databases
Antibodypediai | 4288, 521 antibodies |
Genome annotation databases
Ensembli | ENST00000558207; ENSP00000453003; ENSG00000157766 |
UCSCi | uc002bmx.4, human |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000157766.15 |
HGNCi | HGNC:319, ACAN |
OpenTargetsi | ENSG00000157766 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000155971 |
HOGENOMi | CLU_413670_0_0_1 |
Miscellaneous databases
ChiTaRSi | ACAN, human |
Gene expression databases
Bgeei | ENSG00000157766, Expressed in tibia and 179 other tissues |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit 3.10.100.10, 4 hits |
InterProi | View protein in InterPro IPR016186, C-type_lectin-like/link_sf IPR016187, CTDL_fold IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003006, Ig/MHC_CS IPR003599, Ig_sub IPR013106, Ig_V-set IPR000538, Link_dom |
Pfami | View protein in Pfam PF07686, V-set, 1 hit PF00193, Xlink, 4 hits |
PRINTSi | PR01265, LINKMODULE |
SMARTi | View protein in SMART SM00409, IG, 1 hit SM00406, IGv, 1 hit SM00445, LINK, 4 hits |
SUPFAMi | SSF48726, SSF48726, 1 hit SSF56436, SSF56436, 4 hits |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit PS00290, IG_MHC, 1 hit PS01241, LINK_1, 3 hits PS50963, LINK_2, 4 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q6PID9_HUMAN | |
Accessioni | Q6PID9Primary (citable) accession number: Q6PID9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 5, 2004 |
Last sequence update: | July 5, 2004 | |
Last modified: | December 2, 2020 | |
This is version 145 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |