UniProtKB - Q6PID8 (KLD10_HUMAN)
Protein
Kelch domain-containing protein 10
Gene
KLHDC10
Organism
Homo sapiens (Human)
Status
Functioni
Participates in the oxidative stress-induced cell death through MAP3K5 activation. Inhibits PPP5C phosphatase activity on MAP3K5.1 Publication
GO - Biological processi
- positive regulation of stress-activated MAPK cascade Source: GO_Central
Enzyme and pathway databases
PathwayCommonsi | Q6PID8 |
Names & Taxonomyi
Protein namesi | Recommended name: Kelch domain-containing protein 10 |
Gene namesi | Name:KLHDC10 Synonyms:KIAA0265 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:22194, KLHDC10 |
MIMi | 615152, gene |
neXtProti | NX_Q6PID8 |
VEuPathDBi | HostDB:ENSG00000128607.13 |
Subcellular locationi
Nucleus
- nucleoplasm Source: HPA
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 409 | A → P: Loss of interaction with CUL2. No effect on MAP3K5 activation. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 23008 |
OpenTargetsi | ENSG00000128607 |
PharmGKBi | PA164721976 |
Miscellaneous databases
Pharosi | Q6PID8, Tbio |
Genetic variation databases
BioMutai | KLHDC10 |
DMDMi | 74737721 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000319436 | 1 – 442 | Kelch domain-containing protein 10Add BLAST | 442 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 13 | Omega-N-methylarginineBy similarity | 1 |
Keywords - PTMi
MethylationProteomic databases
EPDi | Q6PID8 |
jPOSTi | Q6PID8 |
MassIVEi | Q6PID8 |
MaxQBi | Q6PID8 |
PaxDbi | Q6PID8 |
PeptideAtlasi | Q6PID8 |
PRIDEi | Q6PID8 |
ProteomicsDBi | 67150 [Q6PID8-1] 67151 [Q6PID8-2] |
PTM databases
iPTMneti | Q6PID8 |
PhosphoSitePlusi | Q6PID8 |
Expressioni
Developmental stagei
Expressed in fetal brain, liver, lung, kidney and placenta.1 Publication
Gene expression databases
Bgeei | ENSG00000128607, Expressed in endothelial cell and 253 other tissues |
ExpressionAtlasi | Q6PID8, baseline and differential |
Genevisiblei | Q6PID8, HS |
Organism-specific databases
HPAi | ENSG00000128607, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with CUL2, ELOB and ELOC; may be the substrate recognition component of an E3 ubiquitin ligase complex.
Interacts (via the 6 Kelch repeats) with PPP5C.
1 PublicationBinary interactionsi
Q6PID8
With | #Exp. | IntAct |
---|---|---|
NUDCD3 [Q8IVD9] | 2 | EBI-3201175,EBI-744342 |
Protein-protein interaction databases
BioGRIDi | 116652, 25 interactors |
IntActi | Q6PID8, 14 interactors |
MINTi | Q6PID8 |
STRINGi | 9606.ENSP00000334140 |
Miscellaneous databases
RNActi | Q6PID8, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 103 – 164 | Kelch 1Add BLAST | 62 | |
Repeati | 166 – 217 | Kelch 2Add BLAST | 52 | |
Repeati | 218 – 270 | Kelch 3Add BLAST | 53 | |
Repeati | 271 – 319 | Kelch 4Add BLAST | 49 | |
Repeati | 327 – 373 | Kelch 5Add BLAST | 47 | |
Repeati | 376 – 419 | Kelch 6Add BLAST | 44 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 401 – 442 | Interaction with CUL21 PublicationAdd BLAST | 42 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 14 – 40 | Gly-richAdd BLAST | 27 |
Keywords - Domaini
Kelch repeat, RepeatPhylogenomic databases
eggNOGi | KOG0379, Eukaryota |
GeneTreei | ENSGT00940000155977 |
HOGENOMi | CLU_030914_0_0_1 |
InParanoidi | Q6PID8 |
OMAi | VWENVYI |
OrthoDBi | 564212at2759 |
PhylomeDBi | Q6PID8 |
TreeFami | TF314081 |
Family and domain databases
Gene3Di | 2.120.10.80, 2 hits |
InterProi | View protein in InterPro IPR015915, Kelch-typ_b-propeller IPR006652, Kelch_1 |
Pfami | View protein in Pfam PF01344, Kelch_1, 1 hit |
SMARTi | View protein in SMART SM00612, Kelch, 2 hits |
SUPFAMi | SSF117281, SSF117281, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q6PID8-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSAAQGWDRN RRRGGGAAGA GGGGSGAGGG SGGSGGRGTG QLNRFVQLSG
60 70 80 90 100
RPHLPGKKKI RWDPVRRRFI QSCPIIRIPN RFLRGHRPPP ARSGHRCVAD
110 120 130 140 150
NTNLYVFGGY NPDYDESGGP DNEDYPLFRE LWRYHFATGV WHQMGTDGYM
160 170 180 190 200
PRELASMSLV LHGNNLLVFG GTGIPFGESN GNDVHVCNVK YKRWALLSCR
210 220 230 240 250
GKKPSRIYGQ AMAIINGSLY VFGGTTGYIY STDLHKLDLN TREWTQLKPN
260 270 280 290 300
NLSCDLPEER YRHEIAHDGQ RIYILGGGTS WTAYSLNKIH AYNLETNAWE
310 320 330 340 350
EIATKPHEKI GFPAARRCHS CVQIKNDVFI CGGYNGEVIL GDIWKLNLQT
360 370 380 390 400
FQWVKLPATM PEPVYFHCAA VTPAGCMYIH GGVVNIHENK RTGSLFKIWL
410 420 430 440
VVPSLLELAW EKLLAAFPNL ANLSRTQLLH LGLTQGLIER LK
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC9JRT7 | C9JRT7_HUMAN | Kelch domain-containing protein 10 | KLHDC10 | 136 | Annotation score: | ||
C9JRX2 | C9JRX2_HUMAN | Kelch domain-containing protein 10 | KLHDC10 | 144 | Annotation score: |
Sequence cautioni
The sequence BAA13395 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_039005 | 2 | S → L. Corresponds to variant dbSNP:rs3734928Ensembl. | 1 | |
Natural variantiVAR_039006 | 183 | D → G1 PublicationCorresponds to variant dbSNP:rs17854337Ensembl. | 1 | |
Natural variantiVAR_039007 | 274 | I → V1 PublicationCorresponds to variant dbSNP:rs17854336Ensembl. | 1 | |
Natural variantiVAR_039008 | 295 | E → G1 PublicationCorresponds to variant dbSNP:rs17857292Ensembl. | 1 | |
Natural variantiVAR_039009 | 437 | L → I. Corresponds to variant dbSNP:rs10241894Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_031484 | 1 – 143 | Missing in isoform 2. 1 PublicationAdd BLAST | 143 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D87454 mRNA Translation: BAA13395.1 Different initiation. CH236950 Genomic DNA Translation: EAL24096.1 CH471070 Genomic DNA Translation: EAW83744.1 BC036464 mRNA Translation: AAH36464.1 BC044884 mRNA Translation: AAH44884.1 |
CCDSi | CCDS5815.1 [Q6PID8-1] |
RefSeqi | NP_055812.1, NM_014997.3 [Q6PID8-1] |
Genome annotation databases
Ensembli | ENST00000335420; ENSP00000334140; ENSG00000128607 [Q6PID8-1] |
GeneIDi | 23008 |
KEGGi | hsa:23008 |
UCSCi | uc003vpj.3, human [Q6PID8-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D87454 mRNA Translation: BAA13395.1 Different initiation. CH236950 Genomic DNA Translation: EAL24096.1 CH471070 Genomic DNA Translation: EAW83744.1 BC036464 mRNA Translation: AAH36464.1 BC044884 mRNA Translation: AAH44884.1 |
CCDSi | CCDS5815.1 [Q6PID8-1] |
RefSeqi | NP_055812.1, NM_014997.3 [Q6PID8-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 116652, 25 interactors |
IntActi | Q6PID8, 14 interactors |
MINTi | Q6PID8 |
STRINGi | 9606.ENSP00000334140 |
PTM databases
iPTMneti | Q6PID8 |
PhosphoSitePlusi | Q6PID8 |
Genetic variation databases
BioMutai | KLHDC10 |
DMDMi | 74737721 |
Proteomic databases
EPDi | Q6PID8 |
jPOSTi | Q6PID8 |
MassIVEi | Q6PID8 |
MaxQBi | Q6PID8 |
PaxDbi | Q6PID8 |
PeptideAtlasi | Q6PID8 |
PRIDEi | Q6PID8 |
ProteomicsDBi | 67150 [Q6PID8-1] 67151 [Q6PID8-2] |
Protocols and materials databases
Antibodypediai | 17939, 24 antibodies |
Genome annotation databases
Ensembli | ENST00000335420; ENSP00000334140; ENSG00000128607 [Q6PID8-1] |
GeneIDi | 23008 |
KEGGi | hsa:23008 |
UCSCi | uc003vpj.3, human [Q6PID8-1] |
Organism-specific databases
CTDi | 23008 |
DisGeNETi | 23008 |
GeneCardsi | KLHDC10 |
HGNCi | HGNC:22194, KLHDC10 |
HPAi | ENSG00000128607, Low tissue specificity |
MIMi | 615152, gene |
neXtProti | NX_Q6PID8 |
OpenTargetsi | ENSG00000128607 |
PharmGKBi | PA164721976 |
VEuPathDBi | HostDB:ENSG00000128607.13 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0379, Eukaryota |
GeneTreei | ENSGT00940000155977 |
HOGENOMi | CLU_030914_0_0_1 |
InParanoidi | Q6PID8 |
OMAi | VWENVYI |
OrthoDBi | 564212at2759 |
PhylomeDBi | Q6PID8 |
TreeFami | TF314081 |
Enzyme and pathway databases
PathwayCommonsi | Q6PID8 |
Miscellaneous databases
BioGRID-ORCSi | 23008, 6 hits in 876 CRISPR screens |
ChiTaRSi | KLHDC10, human |
GenomeRNAii | 23008 |
Pharosi | Q6PID8, Tbio |
PROi | PR:Q6PID8 |
RNActi | Q6PID8, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000128607, Expressed in endothelial cell and 253 other tissues |
ExpressionAtlasi | Q6PID8, baseline and differential |
Genevisiblei | Q6PID8, HS |
Family and domain databases
Gene3Di | 2.120.10.80, 2 hits |
InterProi | View protein in InterPro IPR015915, Kelch-typ_b-propeller IPR006652, Kelch_1 |
Pfami | View protein in Pfam PF01344, Kelch_1, 1 hit |
SMARTi | View protein in SMART SM00612, Kelch, 2 hits |
SUPFAMi | SSF117281, SSF117281, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | KLD10_HUMAN | |
Accessioni | Q6PID8Primary (citable) accession number: Q6PID8 Secondary accession number(s): Q86Y99, Q92554 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 26, 2008 |
Last sequence update: | July 5, 2004 | |
Last modified: | February 10, 2021 | |
This is version 134 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM