UniProtKB - Q6PID8 (KLD10_HUMAN)

BLAST

>sp|Q6PID8|KLD10_HUMAN Kelch domain-containing protein 10 OS=Homo sapiens OX=9606 GN=KLHDC10 PE=1 SV=1
MSAAQGWDRNRRRGGGAAGAGGGGSGAGGGSGGSGGRGTGQLNRFVQLSGRPHLPGKKKI
RWDPVRRRFIQSCPIIRIPNRFLRGHRPPPARSGHRCVADNTNLYVFGGYNPDYDESGGP
DNEDYPLFRELWRYHFATGVWHQMGTDGYMPRELASMSLVLHGNNLLVFGGTGIPFGESN
GNDVHVCNVKYKRWALLSCRGKKPSRIYGQAMAIINGSLYVFGGTTGYIYSTDLHKLDLN
TREWTQLKPNNLSCDLPEERYRHEIAHDGQRIYILGGGTSWTAYSLNKIHAYNLETNAWE
EIATKPHEKIGFPAARRCHSCVQIKNDVFICGGYNGEVILGDIWKLNLQTFQWVKLPATM
PEPVYFHCAAVTPAGCMYIHGGVVNIHENKRTGSLFKIWLVVPSLLELAWEKLLAAFPNL
ANLSRTQLLHLGLTQGLIERLK

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History
Entry version 119 (07 Nov 2018)
Sequence version 1 (05 Jul 2004)
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Protein

Kelch domain-containing protein 10

Gene

KLHDC10

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Participates in the oxidative stress-induced cell death through MAP3K5 activation. Inhibits PPP5C phosphatase activity on MAP3K5.1 Publication

GO - Biological processⁱ

positive regulation of stress-activated MAPK cascade
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Kelch domain-containing protein 10
Gene namesⁱ	Name:KLHDC10 Synonyms:KIAA0265
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 7

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000128607.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:22194 KLHDC10
MIMⁱ	615152 gene
neXtProtⁱ	NX_Q6PID8

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	409	A → P: Loss of interaction with CUL2. No effect on MAP3K5 activation. 1 Publication		1

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000128607
PharmGKBⁱ	PA164721976

Polymorphism and mutation databases

BioMutaⁱ	KLHDC10
DMDMⁱ	74737721

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000319436	1 – 442	Kelch domain-containing protein 10Add BLAST		442

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	13	Omega-N-methylarginineBy similarity		1

Keywords - PTMⁱ

Methylation

Proteomic databases

EPDⁱ	Q6PID8
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q6PID8
PaxDbⁱ	Q6PID8
PeptideAtlas More...PeptideAtlasⁱ	Q6PID8
PRIDEⁱ	Q6PID8
ProteomicsDBⁱ	67150 67151 [Q6PID8-2]

PTM databases

iPTMnetⁱ	Q6PID8
PhosphoSitePlusⁱ	Q6PID8

Expressionⁱ

Developmental stageⁱ

Expressed in fetal brain, liver, lung, kidney and placenta.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000128607 Expressed in 243 organ(s), highest expression level in endothelial cell
CleanExⁱ	HS_KLHDC10
ExpressionAtlasⁱ	Q6PID8 baseline and differential
Genevisibleⁱ	Q6PID8 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA020119

HPAⁱ

HPA020119

Interactionⁱ

Subunit structureⁱ

Interacts with CUL2, ELOB and ELOC; may be the substrate recognition component of an E3 ubiquitin ligase complex. Interacts (via the 6 Kelch repeats) with PPP5C.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
NUDCD3	Q8IVD9	2	EBI-3201175,EBI-744342

With

Entry

#Exp.

IntAct

Notes

NUDCD3

Q8IVD9

EBI-3201175,EBI-744342

Protein-protein interaction databases

BioGridⁱ	116652, 19 interactors
IntActⁱ	Q6PID8, 5 interactors
STRINGⁱ	9606.ENSP00000334140

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q6PID8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	103 – 164	Kelch 1Add BLAST	62
Repeatⁱ	166 – 217	Kelch 2Add BLAST	52
Repeatⁱ	218 – 270	Kelch 3Add BLAST	53
Repeatⁱ	271 – 319	Kelch 4Add BLAST	49
Repeatⁱ	327 – 373	Kelch 5Add BLAST	47
Repeatⁱ	376 – 419	Kelch 6Add BLAST	44

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	401 – 442	Interaction with CUL21 PublicationAdd BLAST		42

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	14 – 40	Gly-richAdd BLAST		27

Keywords - Domainⁱ

Kelch repeat, Repeat

Phylogenomic databases

eggNOGⁱ	KOG0379 Eukaryota ENOG410Y5WM LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119086
HOGENOMⁱ	HOG000008131
HOVERGENⁱ	HBG108065
InParanoidⁱ	Q6PID8
OMAⁱ	NLETNTW
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G09PK
PhylomeDBⁱ	Q6PID8
TreeFamⁱ	TF314081

Family and domain databases

Gene3Dⁱ	2.120.10.80, 2 hits
InterProⁱ	View protein in InterPro IPR015915 Kelch-typ_b-propeller IPR006652 Kelch_1
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01344 Kelch_1, 2 hits
SMARTⁱ	View protein in SMART SM00612 Kelch, 2 hits
SUPFAMⁱ	SSF117281 SSF117281, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q6PID8-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSAAQGWDRN RRRGGGAAGA GGGGSGAGGG SGGSGGRGTG QLNRFVQLSG 
        60         70         80         90        100
RPHLPGKKKI RWDPVRRRFI QSCPIIRIPN RFLRGHRPPP ARSGHRCVAD 
       110        120        130        140        150
NTNLYVFGGY NPDYDESGGP DNEDYPLFRE LWRYHFATGV WHQMGTDGYM 
       160        170        180        190        200
PRELASMSLV LHGNNLLVFG GTGIPFGESN GNDVHVCNVK YKRWALLSCR 
       210        220        230        240        250
GKKPSRIYGQ AMAIINGSLY VFGGTTGYIY STDLHKLDLN TREWTQLKPN 
       260        270        280        290        300
NLSCDLPEER YRHEIAHDGQ RIYILGGGTS WTAYSLNKIH AYNLETNAWE 
       310        320        330        340        350
EIATKPHEKI GFPAARRCHS CVQIKNDVFI CGGYNGEVIL GDIWKLNLQT 
       360        370        380        390        400
FQWVKLPATM PEPVYFHCAA VTPAGCMYIH GGVVNIHENK RTGSLFKIWL 
       410        420        430        440 
VVPSLLELAW EKLLAAFPNL ANLSRTQLLH LGLTQGLIER LK

Length:442

Mass (Da):49,098

Last modified:July 5, 2004 - v1

Checksum:ⁱ8D8AF4A6302A7A86

Isoform 2 (identifier: Q6PID8-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-143: Missing.

« Hide

        10         20         30         40         50
MGTDGYMPRE LASMSLVLHG NNLLVFGGTG IPFGESNGND VHVCNVKYKR 
        60         70         80         90        100
WALLSCRGKK PSRIYGQAMA IINGSLYVFG GTTGYIYSTD LHKLDLNTRE 
       110        120        130        140        150
WTQLKPNNLS CDLPEERYRH EIAHDGQRIY ILGGGTSWTA YSLNKIHAYN 
       160        170        180        190        200
LETNAWEEIA TKPHEKIGFP AARRCHSCVQ IKNDVFICGG YNGEVILGDI 
       210        220        230        240        250
WKLNLQTFQW VKLPATMPEP VYFHCAAVTP AGCMYIHGGV VNIHENKRTG 
       260        270        280        290 
SLFKIWLVVP SLLELAWEKL LAAFPNLANL SRTQLLHLGL TQGLIERLK

Note: No experimental confirmation available.

Show »

Length:299

Mass (Da):33,488

Checksum:ⁱ3A4CA8E72358878A

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

C9JRX2	C9JRX2_HUMAN	Kelch domain-containing protein 10 Kelch domain-containing protein 10	KLHDC10	144	Annotation score:
C9JRT7	C9JRT7_HUMAN	Kelch domain-containing protein 10 Kelch domain-containing protein 10	KLHDC10	136	Annotation score:

Sequence cautionⁱ

The sequence BAA13395 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_039005	2	S → L. Corresponds to variant dbSNP:rs3734928Ensembl.	1
Natural variantⁱVAR_039006	183	D → G1 PublicationCorresponds to variant dbSNP:rs17854337Ensembl.	1
Natural variantⁱVAR_039007	274	I → V1 PublicationCorresponds to variant dbSNP:rs17854336Ensembl.	1
Natural variantⁱVAR_039008	295	E → G1 PublicationCorresponds to variant dbSNP:rs17857292Ensembl.	1
Natural variantⁱVAR_039009	437	L → I. Corresponds to variant dbSNP:rs10241894Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_031484	1 – 143	Missing in isoform 2. 1 PublicationAdd BLAST		143

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D87454 mRNA Translation: BAA13395.1 Different initiation. CH236950 Genomic DNA Translation: EAL24096.1 CH471070 Genomic DNA Translation: EAW83744.1 BC036464 mRNA Translation: AAH36464.1 BC044884 mRNA Translation: AAH44884.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS5815.1 [Q6PID8-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_055812.1, NM_014997.3 [Q6PID8-1]
UniGeneⁱ	Hs.520710

Genome annotation databases

Ensemblⁱ	ENST00000335420; ENSP00000334140; ENSG00000128607 [Q6PID8-1]
GeneIDⁱ	23008
KEGGⁱ	hsa:23008
UCSC genome browser More...UCSCⁱ	uc003vpj.3 human [Q6PID8-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q6PID8	KLHDC10 isoform 1		PANTR		442	UniRef100_Q6PID8
KLHDC10 isoform 1		PONAB		442
Uncharacterized protein		CALJA		442
Uncharacterized protein		Cebus capucinus imitator		442
Uncharacterized protein		CERAT		442
+8
Q6PID8-2	Kelch domain-containing protein 10		MYODS		299	UniRef100_L5LFM7
Kelch domain-containing protein 10 (Fragment)		MYOBR		387
Uncharacterized protein (Fragment)		AILME		387
Kelch domain-containing protein 10 (Fragment)		MACMU		367
UPI0003C89BA8		CAMFR		546

Protein	Similar proteins		Species	Score	Length	Source
Q6PID8	Kelch domain-containing protein 10		BOVIN		442	UniRef90_Q6PID8
Kelch domain-containing protein 10		MOUSE		439
KLHDC10 isoform 1		PANTR		442
KLHDC10 isoform 1		PONAB		442
Uncharacterized protein		CALJA		442
+84
Q6PID8-2	Kelch domain-containing protein 10		MYODS		299	UniRef90_L5LFM7
Kelch domain-containing protein 10 (Fragment)		MYOBR		387
Uncharacterized protein (Fragment)		AILME		387
Kelch domain-containing protein 10 (Fragment)		MACMU		367
UPI0003C89BA8		CAMFR		546

Protein	Similar proteins		Species	Score	Length	Source
Q6PID8	Kelch domain-containing protein 10		BOVIN		442	UniRef50_Q6PID8
Kelch domain-containing protein 10		MOUSE		439
KLHDC10 isoform 1		PANTR		442
KLHDC10 isoform 1		PONAB		442
Uncharacterized protein		CALJA		442
+231

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D87454 mRNA Translation: BAA13395.1 Different initiation. CH236950 Genomic DNA Translation: EAL24096.1 CH471070 Genomic DNA Translation: EAW83744.1 BC036464 mRNA Translation: AAH36464.1 BC044884 mRNA Translation: AAH44884.1
CCDSⁱ	CCDS5815.1 [Q6PID8-1]
RefSeqⁱ	NP_055812.1, NM_014997.3 [Q6PID8-1]
UniGeneⁱ	Hs.520710

3D structure databases

ProteinModelPortalⁱ	Q6PID8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	116652, 19 interactors
IntActⁱ	Q6PID8, 5 interactors
STRINGⁱ	9606.ENSP00000334140

PTM databases

iPTMnetⁱ	Q6PID8
PhosphoSitePlusⁱ	Q6PID8

Polymorphism and mutation databases

BioMutaⁱ	KLHDC10
DMDMⁱ	74737721

Proteomic databases

EPDⁱ	Q6PID8
MaxQBⁱ	Q6PID8
PaxDbⁱ	Q6PID8
PeptideAtlasⁱ	Q6PID8
PRIDEⁱ	Q6PID8
ProteomicsDBⁱ	67150 67151 [Q6PID8-2]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000335420; ENSP00000334140; ENSG00000128607 [Q6PID8-1]
GeneIDⁱ	23008
KEGGⁱ	hsa:23008
UCSCⁱ	uc003vpj.3 human [Q6PID8-1]

Organism-specific databases

CTDⁱ	23008
EuPathDBⁱ	HostDB:ENSG00000128607.13
GeneCardsⁱ	KLHDC10
HGNCⁱ	HGNC:22194 KLHDC10
HPAⁱ	HPA020119
MIMⁱ	615152 gene
neXtProtⁱ	NX_Q6PID8
OpenTargetsⁱ	ENSG00000128607
PharmGKBⁱ	PA164721976
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0379 Eukaryota ENOG410Y5WM LUCA
GeneTreeⁱ	ENSGT00760000119086
HOGENOMⁱ	HOG000008131
HOVERGENⁱ	HBG108065
InParanoidⁱ	Q6PID8
OMAⁱ	NLETNTW
OrthoDBⁱ	EOG091G09PK
PhylomeDBⁱ	Q6PID8
TreeFamⁱ	TF314081

Miscellaneous databases

ChiTaRSⁱ	KLHDC10 human
GenomeRNAiⁱ	23008
Protein Ontology More...PROⁱ	PR:Q6PID8
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000128607 Expressed in 243 organ(s), highest expression level in endothelial cell
CleanExⁱ	HS_KLHDC10
ExpressionAtlasⁱ	Q6PID8 baseline and differential
Genevisibleⁱ	Q6PID8 HS

Family and domain databases

Gene3Dⁱ	2.120.10.80, 2 hits
InterProⁱ	View protein in InterPro IPR015915 Kelch-typ_b-propeller IPR006652 Kelch_1
Pfamⁱ	View protein in Pfam PF01344 Kelch_1, 2 hits
SMARTⁱ	View protein in SMART SM00612 Kelch, 2 hits
SUPFAMⁱ	SSF117281 SSF117281, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	KLD10_HUMAN
Accessionⁱ	Q6PID8Primary (citable) accession number: Q6PID8 Secondary accession number(s): Q86Y99, Q92554
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
	Last sequence update:	July 5, 2004
	Last modified:	November 7, 2018
	This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM

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UniProtKB - Q6PID8 (KLD10_HUMAN)

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Kelch domain-containing protein 10

KLHDC10

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Nucleus

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Compositional bias

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ