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Protein

Kelch domain-containing protein 10

Gene

KLHDC10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Participates in the oxidative stress-induced cell death through MAP3K5 activation. Inhibits PPP5C phosphatase activity on MAP3K5.1 Publication

GO - Biological processi

  • positive regulation of stress-activated MAPK cascade Source: GO_Central

Names & Taxonomyi

Protein namesi
Recommended name:
Kelch domain-containing protein 10
Gene namesi
Name:KLHDC10
Synonyms:KIAA0265
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000128607.13
HGNCiHGNC:22194 KLHDC10
MIMi615152 gene
neXtProtiNX_Q6PID8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi409A → P: Loss of interaction with CUL2. No effect on MAP3K5 activation. 1 Publication1

Organism-specific databases

OpenTargetsiENSG00000128607
PharmGKBiPA164721976

Polymorphism and mutation databases

BioMutaiKLHDC10
DMDMi74737721

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003194361 – 442Kelch domain-containing protein 10Add BLAST442

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei13Omega-N-methylarginineBy similarity1

Keywords - PTMi

Methylation

Proteomic databases

EPDiQ6PID8
MaxQBiQ6PID8
PaxDbiQ6PID8
PeptideAtlasiQ6PID8
PRIDEiQ6PID8
ProteomicsDBi67150
67151 [Q6PID8-2]

PTM databases

iPTMnetiQ6PID8
PhosphoSitePlusiQ6PID8

Expressioni

Developmental stagei

Expressed in fetal brain, liver, lung, kidney and placenta.1 Publication

Gene expression databases

BgeeiENSG00000128607 Expressed in 243 organ(s), highest expression level in endothelial cell
CleanExiHS_KLHDC10
ExpressionAtlasiQ6PID8 baseline and differential
GenevisibleiQ6PID8 HS

Organism-specific databases

HPAiHPA020119

Interactioni

Subunit structurei

Interacts with CUL2, ELOB and ELOC; may be the substrate recognition component of an E3 ubiquitin ligase complex. Interacts (via the 6 Kelch repeats) with PPP5C.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
NUDCD3Q8IVD92EBI-3201175,EBI-744342

Protein-protein interaction databases

BioGridi116652, 19 interactors
IntActiQ6PID8, 5 interactors
STRINGi9606.ENSP00000334140

Structurei

3D structure databases

ProteinModelPortaliQ6PID8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati103 – 164Kelch 1Add BLAST62
Repeati166 – 217Kelch 2Add BLAST52
Repeati218 – 270Kelch 3Add BLAST53
Repeati271 – 319Kelch 4Add BLAST49
Repeati327 – 373Kelch 5Add BLAST47
Repeati376 – 419Kelch 6Add BLAST44

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni401 – 442Interaction with CUL21 PublicationAdd BLAST42

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi14 – 40Gly-richAdd BLAST27

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiKOG0379 Eukaryota
ENOG410Y5WM LUCA
GeneTreeiENSGT00760000119086
HOGENOMiHOG000008131
HOVERGENiHBG108065
InParanoidiQ6PID8
OMAiNLETNTW
OrthoDBiEOG091G09PK
PhylomeDBiQ6PID8
TreeFamiTF314081

Family and domain databases

Gene3Di2.120.10.80, 2 hits
InterProiView protein in InterPro
IPR015915 Kelch-typ_b-propeller
IPR006652 Kelch_1
PfamiView protein in Pfam
PF01344 Kelch_1, 2 hits
SMARTiView protein in SMART
SM00612 Kelch, 2 hits
SUPFAMiSSF117281 SSF117281, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6PID8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSAAQGWDRN RRRGGGAAGA GGGGSGAGGG SGGSGGRGTG QLNRFVQLSG
60 70 80 90 100
RPHLPGKKKI RWDPVRRRFI QSCPIIRIPN RFLRGHRPPP ARSGHRCVAD
110 120 130 140 150
NTNLYVFGGY NPDYDESGGP DNEDYPLFRE LWRYHFATGV WHQMGTDGYM
160 170 180 190 200
PRELASMSLV LHGNNLLVFG GTGIPFGESN GNDVHVCNVK YKRWALLSCR
210 220 230 240 250
GKKPSRIYGQ AMAIINGSLY VFGGTTGYIY STDLHKLDLN TREWTQLKPN
260 270 280 290 300
NLSCDLPEER YRHEIAHDGQ RIYILGGGTS WTAYSLNKIH AYNLETNAWE
310 320 330 340 350
EIATKPHEKI GFPAARRCHS CVQIKNDVFI CGGYNGEVIL GDIWKLNLQT
360 370 380 390 400
FQWVKLPATM PEPVYFHCAA VTPAGCMYIH GGVVNIHENK RTGSLFKIWL
410 420 430 440
VVPSLLELAW EKLLAAFPNL ANLSRTQLLH LGLTQGLIER LK
Length:442
Mass (Da):49,098
Last modified:July 5, 2004 - v1
Checksum:i8D8AF4A6302A7A86
GO
Isoform 2 (identifier: Q6PID8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-143: Missing.

Note: No experimental confirmation available.
Show »
Length:299
Mass (Da):33,488
Checksum:i3A4CA8E72358878A
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JRX2C9JRX2_HUMAN
Kelch domain-containing protein 10
KLHDC10
144Annotation score:
C9JRT7C9JRT7_HUMAN
Kelch domain-containing protein 10
KLHDC10
136Annotation score:

Sequence cautioni

The sequence BAA13395 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0390052S → L. Corresponds to variant dbSNP:rs3734928Ensembl.1
Natural variantiVAR_039006183D → G1 PublicationCorresponds to variant dbSNP:rs17854337Ensembl.1
Natural variantiVAR_039007274I → V1 PublicationCorresponds to variant dbSNP:rs17854336Ensembl.1
Natural variantiVAR_039008295E → G1 PublicationCorresponds to variant dbSNP:rs17857292Ensembl.1
Natural variantiVAR_039009437L → I. Corresponds to variant dbSNP:rs10241894Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0314841 – 143Missing in isoform 2. 1 PublicationAdd BLAST143

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87454 mRNA Translation: BAA13395.1 Different initiation.
CH236950 Genomic DNA Translation: EAL24096.1
CH471070 Genomic DNA Translation: EAW83744.1
BC036464 mRNA Translation: AAH36464.1
BC044884 mRNA Translation: AAH44884.1
CCDSiCCDS5815.1 [Q6PID8-1]
RefSeqiNP_055812.1, NM_014997.3 [Q6PID8-1]
UniGeneiHs.520710

Genome annotation databases

EnsembliENST00000335420; ENSP00000334140; ENSG00000128607 [Q6PID8-1]
GeneIDi23008
KEGGihsa:23008
UCSCiuc003vpj.3 human [Q6PID8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87454 mRNA Translation: BAA13395.1 Different initiation.
CH236950 Genomic DNA Translation: EAL24096.1
CH471070 Genomic DNA Translation: EAW83744.1
BC036464 mRNA Translation: AAH36464.1
BC044884 mRNA Translation: AAH44884.1
CCDSiCCDS5815.1 [Q6PID8-1]
RefSeqiNP_055812.1, NM_014997.3 [Q6PID8-1]
UniGeneiHs.520710

3D structure databases

ProteinModelPortaliQ6PID8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116652, 19 interactors
IntActiQ6PID8, 5 interactors
STRINGi9606.ENSP00000334140

PTM databases

iPTMnetiQ6PID8
PhosphoSitePlusiQ6PID8

Polymorphism and mutation databases

BioMutaiKLHDC10
DMDMi74737721

Proteomic databases

EPDiQ6PID8
MaxQBiQ6PID8
PaxDbiQ6PID8
PeptideAtlasiQ6PID8
PRIDEiQ6PID8
ProteomicsDBi67150
67151 [Q6PID8-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000335420; ENSP00000334140; ENSG00000128607 [Q6PID8-1]
GeneIDi23008
KEGGihsa:23008
UCSCiuc003vpj.3 human [Q6PID8-1]

Organism-specific databases

CTDi23008
EuPathDBiHostDB:ENSG00000128607.13
GeneCardsiKLHDC10
HGNCiHGNC:22194 KLHDC10
HPAiHPA020119
MIMi615152 gene
neXtProtiNX_Q6PID8
OpenTargetsiENSG00000128607
PharmGKBiPA164721976
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0379 Eukaryota
ENOG410Y5WM LUCA
GeneTreeiENSGT00760000119086
HOGENOMiHOG000008131
HOVERGENiHBG108065
InParanoidiQ6PID8
OMAiNLETNTW
OrthoDBiEOG091G09PK
PhylomeDBiQ6PID8
TreeFamiTF314081

Miscellaneous databases

ChiTaRSiKLHDC10 human
GenomeRNAii23008
PROiPR:Q6PID8
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000128607 Expressed in 243 organ(s), highest expression level in endothelial cell
CleanExiHS_KLHDC10
ExpressionAtlasiQ6PID8 baseline and differential
GenevisibleiQ6PID8 HS

Family and domain databases

Gene3Di2.120.10.80, 2 hits
InterProiView protein in InterPro
IPR015915 Kelch-typ_b-propeller
IPR006652 Kelch_1
PfamiView protein in Pfam
PF01344 Kelch_1, 2 hits
SMARTiView protein in SMART
SM00612 Kelch, 2 hits
SUPFAMiSSF117281 SSF117281, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKLD10_HUMAN
AccessioniPrimary (citable) accession number: Q6PID8
Secondary accession number(s): Q86Y99, Q92554
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: July 5, 2004
Last modified: November 7, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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