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Protein

Tetratricopeptide repeat protein 33

Gene

TTC33

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Tetratricopeptide repeat protein 33
Short name:
TPR repeat protein 33
Alternative name(s):
Osmosis-responsive factor
Gene namesi
Name:TTC33
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000113638.12
HGNCiHGNC:29959 TTC33
neXtProtiNX_Q6PID6

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000113638
PharmGKBiPA162407196

Polymorphism and mutation databases

BioMutaiTTC33
DMDMi147737109

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002875151 – 262Tetratricopeptide repeat protein 33Add BLAST262

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei197PhosphoserineCombined sources1
Modified residuei251PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6PID6
MaxQBiQ6PID6
PaxDbiQ6PID6
PeptideAtlasiQ6PID6
PRIDEiQ6PID6
ProteomicsDBi67149

PTM databases

iPTMnetiQ6PID6
PhosphoSitePlusiQ6PID6

Expressioni

Gene expression databases

BgeeiENSG00000113638
CleanExiHS_TTC33
ExpressionAtlasiQ6PID6 baseline and differential
GenevisibleiQ6PID6 HS

Organism-specific databases

HPAiHPA038252
HPA038253

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi117092, 17 interactors
IntActiQ6PID6, 8 interactors
MINTiQ6PID6
STRINGi9606.ENSP00000338533

Structurei

3D structure databases

ProteinModelPortaliQ6PID6
SMRiQ6PID6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati59 – 92TPR 1Add BLAST34
Repeati93 – 126TPR 2Add BLAST34
Repeati127 – 160TPR 3Add BLAST34

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiENOG410IMN5 Eukaryota
ENOG4111N4C LUCA
GeneTreeiENSGT00390000017462
HOGENOMiHOG000059551
HOVERGENiHBG053253
InParanoidiQ6PID6
OMAiKWDEAIQ
OrthoDBiEOG091G0H58
PhylomeDBiQ6PID6
TreeFamiTF332142

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
SMARTiView protein in SMART
SM00028 TPR, 2 hits
SUPFAMiSSF48452 SSF48452, 1 hit
PROSITEiView protein in PROSITE
PS50005 TPR, 3 hits
PS50293 TPR_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

Q6PID6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASFGWKRKI GEKVSKVTSQ QFEAEAADEK DVVDNDEGNW LHAIKRRKEI
60 70 80 90 100
LLEGCAEKSK QLKDEGASLA ENKRYREAIQ KWDEALQLTP NDATLYEMKS
110 120 130 140 150
QVLMSLHEMF PAVHAAEMAV QQNPHSWESW QTLGRAQLGL GEIILAIRSF
160 170 180 190 200
QVALHIYPMN PEIWKEDLSW ARTLQEQQKV AQRIKKSEAP AEVTHFSPKS
210 220 230 240 250
IPDYDFESDE IVAVCAAIAE KEKTVSANKT MVIVSASGAI ETVTEKEDGA
260
TPPDGSVFIK AR
Length:262
Mass (Da):29,411
Last modified:May 15, 2007 - v2
Checksum:iA5549AC3973FABC9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti13K → R in AAH36536 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03231769L → M. Corresponds to variant dbSNP:rs837105Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF023244 mRNA Translation: AAD09341.1
AK312560 mRNA Translation: BAG35457.1
CH471119 Genomic DNA Translation: EAW55998.1
BC015701 mRNA Translation: AAH15701.1
BC036536 mRNA Translation: AAH36536.1
CCDSiCCDS3931.1
RefSeqiNP_036514.1, NM_012382.2
XP_011512305.1, XM_011514003.2
UniGeneiHs.348915
Hs.621357

Genome annotation databases

EnsembliENST00000337702; ENSP00000338533; ENSG00000113638
GeneIDi23548
KEGGihsa:23548
UCSCiuc003jma.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTTC33_HUMAN
AccessioniPrimary (citable) accession number: Q6PID6
Secondary accession number(s): B2R6G0, O95105
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 15, 2007
Last modified: July 18, 2018
This is version 115 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

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