BHLHB9

Functionⁱ

May play a role in the control of cellular aging and survival.

Caution

Despite its name, no basic helix-loop-helix (bHLH) domain is detected by any prediction tool.Curated

GO - Molecular functionⁱ

protein homodimerization activity Source: UniProtKB

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

learning or memory Source: UniProtKB
negative regulation of neuron apoptotic process Source: UniProtKB
positive regulation of dendritic spine morphogenesis Source: UniProtKB
positive regulation of neurogenesis Source: UniProtKB
positive regulation of synapse assembly Source: UniProtKB

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein BHLHb9 Short name: bHLHb9 Alternative name(s): Transcription regulator of 60 kDa Short name: p60TRP
Gene namesⁱ	Name:BHLHB9 Synonyms:KIAA1701
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome X

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000198908.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:29353 BHLHB9
MIMⁱ	300921 gene
neXtProtⁱ	NX_Q6PI77

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	80823
Open Targets More...OpenTargetsⁱ	ENSG00000198908
PharmGKBⁱ	PA134895992

Polymorphism and mutation databases

BioMutaⁱ	BHLHB9
DMDMⁱ	74749201

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000334662	1 – 547	Protein BHLHb9Add BLAST		547

Proteomic databases

EPDⁱ	Q6PI77
PaxDbⁱ	Q6PI77
PRIDEⁱ	Q6PI77
ProteomicsDBⁱ	67143

PTM databases

iPTMnetⁱ	Q6PI77
PhosphoSitePlusⁱ	Q6PI77

Expressionⁱ

Tissue specificityⁱ

Highly expressed in brain. Not expressed in lung or liver. Down-regulated in brain from patients suffering from Alzheimer disease.1 Publication

Inductionⁱ

Down-regulated in colon cancer cells, due to CpG hypermethylation of its promoter.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000198908
CleanExⁱ	HS_BHLHB9
Genevisibleⁱ	Q6PI77 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA000887

HPAⁱ

HPA000887

Interactionⁱ

GO - Molecular functionⁱ

protein homodimerization activity Source: UniProtKB

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	123320, 3 interactors
IntActⁱ	Q6PI77, 65 interactors
Molecular INTeraction database More...MINTⁱ	Q6PI77
STRINGⁱ	9606.ENSP00000354675

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q6PI77
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	166 – 171	Poly-Glu		6

Sequence similaritiesⁱ

Belongs to the GPRASP family.Curated

Phylogenomic databases

eggNOGⁱ	ENOG410IPU4 Eukaryota ENOG41115S9 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074488
HOGENOMⁱ	HOG000095228
HOVERGENⁱ	HBG098352
InParanoidⁱ	Q6PI77
OMAⁱ	SDPCIQT
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G01QA
PhylomeDBⁱ	Q6PI77
TreeFamⁱ	TF335652

Family and domain databases

Gene3Dⁱ	1.25.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR011989 ARM-like IPR006911 ARM-rpt_dom IPR016024 ARM-type_fold
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04826 Arm_2, 1 hit
SUPFAMⁱ	SSF48371 SSF48371, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q6PI77-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAGTKNKTRA QAKTEKKAAI QAKAGAEREA TGVVRPVAKT RAKAKAKTGS 
        60         70         80         90        100
KTDAVAEMKA VSKNKVVAET KEGALSEPKT LGKAMGDFTP KAGNESTSST 
       110        120        130        140        150
CKNEAGTDAW FWAGEEATIN SWFWNGEEAG NSFSTKNDKP EIGAQVCAEE 
       160        170        180        190        200
LEPAAGADCK PRSGAEEEEE ENVIGNWFWE GDDTSFDPNP KPVSRIVKPQ 
       210        220        230        240        250
PVYEINEKNR PKDWSEVTIW PNAPAVTPAV LGFRSQAPSE ASPPSYIVLA 
       260        270        280        290        300
SAEENACSLP VATACRPSRN TRSCSQPIPE CRFDSDPCIQ TIDEIRRQIR 
       310        320        330        340        350
IREVNGIKPF ACPCKMECYM DSEEFEKLVS LLKSTTDPLI HKIARIAMGV 
       360        370        380        390        400
HNVHPFAQEF INEVGVVTLI ESLLSFPSPE MRKKTVITLN PPSGDERQRK 
       410        420        430        440        450
IELHVKHMCK ETMSFPLNSP GQQSGLKILG QLTTDFVHHY IVANYFSELF 
       460        470        480        490        500
HLLSSGNCKT RNLVLKLLLN MSENPTAARD MINMKALAAL KLIFNQKEAK 
       510        520        530        540 
ANLVSGVAIF INIKEHIRKG SIVVVDHLSY NTLMAIFREV KEIIETM

Length:547

Mass (Da):60,291

Last modified:July 5, 2004 - v1

Checksum:ⁱEC0E8D95CC7CE09D

GO

Sequence cautionⁱ

The sequence BAB21792 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_049266	132	S → G. Corresponds to variant dbSNP:rs2179675Ensembl.		1
Natural variantⁱVAR_049267	318	C → R. Corresponds to variant dbSNP:rs4514179Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF547055 mRNA Translation: AAQ12077.1 AB051488 mRNA Translation: BAB21792.1 Different initiation. AL035427 Genomic DNA No translation available. CH471190 Genomic DNA Translation: EAW54726.1 BC041409 mRNA Translation: AAH41409.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS14502.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001135996.1, NM_001142524.1 NP_001135997.1, NM_001142525.1 NP_001135998.1, NM_001142526.1 NP_001135999.1, NM_001142527.1 NP_001136000.1, NM_001142528.1 NP_001136001.1, NM_001142529.1 NP_001136002.1, NM_001142530.1 NP_085142.1, NM_030639.2
UniGeneⁱ	Hs.4276 Hs.522729

Genome annotation databases

Ensemblⁱ	ENST00000361229; ENSP00000354675; ENSG00000198908 ENST00000372735; ENSP00000361820; ENSG00000198908 ENST00000447531; ENSP00000405893; ENSG00000198908 ENST00000448867; ENSP00000391722; ENSG00000198908 ENST00000457056; ENSP00000403226; ENSG00000198908
GeneIDⁱ	80823
KEGGⁱ	hsa:80823
UCSC genome browser More...UCSCⁱ	uc004ejo.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
Q6PI77	Protein BHLHb9		MACFA		547
Basic helix-loop-helix family member b9		CALJA		547
BHLHB9 isoform 1		PANTR		547
Basic helix-loop-helix family member b9		PANPA		547
Basic helix-loop-helix family member b9		MACMU		547
+17

Protein	Similar proteins		Species	Score	Length
Q6PI77	UPI00020AE2B0		NOMLE		547
Basic helix-loop-helix family member b9		CERAT		547
Protein BHLHb9		MACMU		547
Basic helix-loop-helix family member b9		CHLSB		547
Protein BHLHb9		MACFA		547
+94

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF547055 mRNA Translation: AAQ12077.1 AB051488 mRNA Translation: BAB21792.1 Different initiation. AL035427 Genomic DNA No translation available. CH471190 Genomic DNA Translation: EAW54726.1 BC041409 mRNA Translation: AAH41409.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS14502.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001135996.1, NM_001142524.1 NP_001135997.1, NM_001142525.1 NP_001135998.1, NM_001142526.1 NP_001135999.1, NM_001142527.1 NP_001136000.1, NM_001142528.1 NP_001136001.1, NM_001142529.1 NP_001136002.1, NM_001142530.1 NP_085142.1, NM_030639.2
UniGeneⁱ	Hs.4276 Hs.522729

3D structure databases

ProteinModelPortalⁱ	Q6PI77
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	123320, 3 interactors
IntActⁱ	Q6PI77, 65 interactors
Molecular INTeraction database More...MINTⁱ	Q6PI77
STRINGⁱ	9606.ENSP00000354675

PTM databases

iPTMnetⁱ	Q6PI77
PhosphoSitePlusⁱ	Q6PI77

Polymorphism and mutation databases

BioMutaⁱ	BHLHB9
DMDMⁱ	74749201

Proteomic databases

EPDⁱ	Q6PI77
PaxDbⁱ	Q6PI77
PRIDEⁱ	Q6PI77
ProteomicsDBⁱ	67143

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000361229; ENSP00000354675; ENSG00000198908 ENST00000372735; ENSP00000361820; ENSG00000198908 ENST00000447531; ENSP00000405893; ENSG00000198908 ENST00000448867; ENSP00000391722; ENSG00000198908 ENST00000457056; ENSP00000403226; ENSG00000198908
GeneIDⁱ	80823
KEGGⁱ	hsa:80823
UCSC genome browser More...UCSCⁱ	uc004ejo.4 human

Organism-specific databases

CTDⁱ	80823
DisGeNET More...DisGeNETⁱ	80823
EuPathDBⁱ	HostDB:ENSG00000198908.11
GeneCardsⁱ	BHLHB9
H-InvDBⁱ	HIX0176723
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:29353 BHLHB9
Human Protein Atlas More...HPAⁱ	HPA000887
MIMⁱ	300921 gene
neXtProtⁱ	NX_Q6PI77
Open Targets More...OpenTargetsⁱ	ENSG00000198908
PharmGKBⁱ	PA134895992
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IPU4 Eukaryota ENOG41115S9 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074488
HOGENOMⁱ	HOG000095228
HOVERGENⁱ	HBG098352
InParanoidⁱ	Q6PI77
OMAⁱ	SDPCIQT
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G01QA
PhylomeDBⁱ	Q6PI77
TreeFamⁱ	TF335652

Miscellaneous databases

GenomeRNAiⁱ	80823
Protein Ontology More...PROⁱ	PR:Q6PI77
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000198908
CleanExⁱ	HS_BHLHB9
Genevisibleⁱ	Q6PI77 HS

Family and domain databases

Gene3Dⁱ	1.25.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR011989 ARM-like IPR006911 ARM-rpt_dom IPR016024 ARM-type_fold
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04826 Arm_2, 1 hit
SUPFAMⁱ	SSF48371 SSF48371, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	BHLH9_HUMAN
Accessionⁱ	Q6PI77Primary (citable) accession number: Q6PI77 Secondary accession number(s): Q9C0G2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
	Last sequence update:	July 5, 2004
	Last modified:	July 18, 2018
	This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families

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UniRef

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Supporting data

UniProtKB - Q6PI77 (BHLH9_HUMAN)

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Protein BHLHb9

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Cytosol

Extracellular region or secreted

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ