UniProtKB - Q6PI77 (BHLH9_HUMAN)
Protein
Protein BHLHb9
Gene
BHLHB9
Organism
Homo sapiens (Human)
Status
Functioni
May play a role in the control of cellular aging and survival.
Caution
Despite its name, no basic helix-loop-helix (bHLH) domain is detected by any prediction tool.Curated
GO - Molecular functioni
- protein homodimerization activity Source: UniProtKB
GO - Biological processi
- learning or memory Source: UniProtKB
- negative regulation of neuron apoptotic process Source: UniProtKB
- positive regulation of dendritic spine morphogenesis Source: UniProtKB
- positive regulation of neurogenesis Source: UniProtKB
- positive regulation of synapse assembly Source: UniProtKB
Enzyme and pathway databases
PathwayCommonsi | Q6PI77 |
Names & Taxonomyi
Protein namesi | Recommended name: Protein BHLHb9Short name: bHLHb9 Alternative name(s): Transcription regulator of 60 kDa Short name: p60TRP |
Gene namesi | Name:BHLHB9 Synonyms:KIAA1701 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:29353, BHLHB9 |
MIMi | 300921, gene |
neXtProti | NX_Q6PI77 |
VEuPathDBi | HostDB:ENSG00000198908.11 |
Subcellular locationi
Cytosol
- cytosol Source: HPA
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Nucleus
- nucleoplasm Source: HPA
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 80823 |
OpenTargetsi | ENSG00000198908 |
PharmGKBi | PA134895992 |
Miscellaneous databases
Pharosi | Q6PI77, Tdark |
Genetic variation databases
BioMutai | BHLHB9 |
DMDMi | 74749201 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000334662 | 1 – 547 | Protein BHLHb9Add BLAST | 547 |
Proteomic databases
EPDi | Q6PI77 |
MassIVEi | Q6PI77 |
PaxDbi | Q6PI77 |
PeptideAtlasi | Q6PI77 |
PRIDEi | Q6PI77 |
ProteomicsDBi | 67143 |
PTM databases
iPTMneti | Q6PI77 |
PhosphoSitePlusi | Q6PI77 |
Expressioni
Tissue specificityi
Highly expressed in brain. Not expressed in lung or liver. Down-regulated in brain from patients suffering from Alzheimer disease.1 Publication
Inductioni
Down-regulated in colon cancer cells, due to CpG hypermethylation of its promoter.1 Publication
Gene expression databases
Bgeei | ENSG00000198908, Expressed in female gonad and 194 other tissues |
Genevisiblei | Q6PI77, HS |
Organism-specific databases
HPAi | ENSG00000198908, Tissue enhanced (brain) |
Interactioni
Binary interactionsi
Q6PI77
GO - Molecular functioni
- protein homodimerization activity Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 123320, 59 interactors |
IntActi | Q6PI77, 65 interactors |
MINTi | Q6PI77 |
STRINGi | 9606.ENSP00000361820 |
Miscellaneous databases
RNActi | Q6PI77, protein |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 166 – 171 | Poly-Glu | 6 |
Sequence similaritiesi
Belongs to the GPRASP family.Curated
Phylogenomic databases
eggNOGi | ENOG502RU0K, Eukaryota |
GeneTreei | ENSGT00940000161990 |
HOGENOMi | CLU_036908_0_0_1 |
InParanoidi | Q6PI77 |
OMAi | TIWPKAP |
OrthoDBi | 860703at2759 |
PhylomeDBi | Q6PI77 |
TreeFami | TF335652 |
Family and domain databases
Gene3Di | 1.25.10.10, 1 hit |
InterProi | View protein in InterPro IPR011989, ARM-like IPR006911, ARM-rpt_dom IPR016024, ARM-type_fold IPR043374, BHLHb9/GASP-1/GASP-2 |
PANTHERi | PTHR46414, PTHR46414, 1 hit |
Pfami | View protein in Pfam PF04826, Arm_2, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
i Sequence
Sequence statusi: Complete.
Q6PI77-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAGTKNKTRA QAKTEKKAAI QAKAGAEREA TGVVRPVAKT RAKAKAKTGS
60 70 80 90 100
KTDAVAEMKA VSKNKVVAET KEGALSEPKT LGKAMGDFTP KAGNESTSST
110 120 130 140 150
CKNEAGTDAW FWAGEEATIN SWFWNGEEAG NSFSTKNDKP EIGAQVCAEE
160 170 180 190 200
LEPAAGADCK PRSGAEEEEE ENVIGNWFWE GDDTSFDPNP KPVSRIVKPQ
210 220 230 240 250
PVYEINEKNR PKDWSEVTIW PNAPAVTPAV LGFRSQAPSE ASPPSYIVLA
260 270 280 290 300
SAEENACSLP VATACRPSRN TRSCSQPIPE CRFDSDPCIQ TIDEIRRQIR
310 320 330 340 350
IREVNGIKPF ACPCKMECYM DSEEFEKLVS LLKSTTDPLI HKIARIAMGV
360 370 380 390 400
HNVHPFAQEF INEVGVVTLI ESLLSFPSPE MRKKTVITLN PPSGDERQRK
410 420 430 440 450
IELHVKHMCK ETMSFPLNSP GQQSGLKILG QLTTDFVHHY IVANYFSELF
460 470 480 490 500
HLLSSGNCKT RNLVLKLLLN MSENPTAARD MINMKALAAL KLIFNQKEAK
510 520 530 540
ANLVSGVAIF INIKEHIRKG SIVVVDHLSY NTLMAIFREV KEIIETM
Sequence cautioni
The sequence BAB21792 differs from that shown. Reason: Erroneous initiation.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_049266 | 132 | S → G. Corresponds to variant dbSNP:rs2179675Ensembl. | 1 | |
Natural variantiVAR_049267 | 318 | C → R. Corresponds to variant dbSNP:rs4514179EnsemblClinVar. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF547055 mRNA Translation: AAQ12077.1 AB051488 mRNA Translation: BAB21792.1 Different initiation. AL035427 Genomic DNA No translation available. CH471190 Genomic DNA Translation: EAW54726.1 BC041409 mRNA Translation: AAH41409.1 |
CCDSi | CCDS14502.1 |
RefSeqi | NP_001135996.1, NM_001142524.1 NP_001135997.1, NM_001142525.1 NP_001135998.1, NM_001142526.1 NP_001135999.1, NM_001142527.1 NP_001136000.1, NM_001142528.1 NP_001136001.1, NM_001142529.1 NP_001136002.1, NM_001142530.1 NP_085142.1, NM_030639.2 |
Genome annotation databases
Ensembli | ENST00000361229; ENSP00000354675; ENSG00000198908 ENST00000372735; ENSP00000361820; ENSG00000198908 ENST00000447531; ENSP00000405893; ENSG00000198908 ENST00000448867; ENSP00000391722; ENSG00000198908 ENST00000457056; ENSP00000403226; ENSG00000198908 |
GeneIDi | 80823 |
KEGGi | hsa:80823 |
UCSCi | uc004ejo.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF547055 mRNA Translation: AAQ12077.1 AB051488 mRNA Translation: BAB21792.1 Different initiation. AL035427 Genomic DNA No translation available. CH471190 Genomic DNA Translation: EAW54726.1 BC041409 mRNA Translation: AAH41409.1 |
CCDSi | CCDS14502.1 |
RefSeqi | NP_001135996.1, NM_001142524.1 NP_001135997.1, NM_001142525.1 NP_001135998.1, NM_001142526.1 NP_001135999.1, NM_001142527.1 NP_001136000.1, NM_001142528.1 NP_001136001.1, NM_001142529.1 NP_001136002.1, NM_001142530.1 NP_085142.1, NM_030639.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 123320, 59 interactors |
IntActi | Q6PI77, 65 interactors |
MINTi | Q6PI77 |
STRINGi | 9606.ENSP00000361820 |
PTM databases
iPTMneti | Q6PI77 |
PhosphoSitePlusi | Q6PI77 |
Genetic variation databases
BioMutai | BHLHB9 |
DMDMi | 74749201 |
Proteomic databases
EPDi | Q6PI77 |
MassIVEi | Q6PI77 |
PaxDbi | Q6PI77 |
PeptideAtlasi | Q6PI77 |
PRIDEi | Q6PI77 |
ProteomicsDBi | 67143 |
Protocols and materials databases
Antibodypediai | 28945, 45 antibodies |
Genome annotation databases
Ensembli | ENST00000361229; ENSP00000354675; ENSG00000198908 ENST00000372735; ENSP00000361820; ENSG00000198908 ENST00000447531; ENSP00000405893; ENSG00000198908 ENST00000448867; ENSP00000391722; ENSG00000198908 ENST00000457056; ENSP00000403226; ENSG00000198908 |
GeneIDi | 80823 |
KEGGi | hsa:80823 |
UCSCi | uc004ejo.4, human |
Organism-specific databases
CTDi | 80823 |
DisGeNETi | 80823 |
GeneCardsi | BHLHB9 |
HGNCi | HGNC:29353, BHLHB9 |
HPAi | ENSG00000198908, Tissue enhanced (brain) |
MIMi | 300921, gene |
neXtProti | NX_Q6PI77 |
OpenTargetsi | ENSG00000198908 |
PharmGKBi | PA134895992 |
VEuPathDBi | HostDB:ENSG00000198908.11 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502RU0K, Eukaryota |
GeneTreei | ENSGT00940000161990 |
HOGENOMi | CLU_036908_0_0_1 |
InParanoidi | Q6PI77 |
OMAi | TIWPKAP |
OrthoDBi | 860703at2759 |
PhylomeDBi | Q6PI77 |
TreeFami | TF335652 |
Enzyme and pathway databases
PathwayCommonsi | Q6PI77 |
Miscellaneous databases
BioGRID-ORCSi | 80823, 14 hits in 625 CRISPR screens |
GenomeRNAii | 80823 |
Pharosi | Q6PI77, Tdark |
PROi | PR:Q6PI77 |
RNActi | Q6PI77, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000198908, Expressed in female gonad and 194 other tissues |
Genevisiblei | Q6PI77, HS |
Family and domain databases
Gene3Di | 1.25.10.10, 1 hit |
InterProi | View protein in InterPro IPR011989, ARM-like IPR006911, ARM-rpt_dom IPR016024, ARM-type_fold IPR043374, BHLHb9/GASP-1/GASP-2 |
PANTHERi | PTHR46414, PTHR46414, 1 hit |
Pfami | View protein in Pfam PF04826, Arm_2, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | BHLH9_HUMAN | |
Accessioni | Q6PI77Primary (citable) accession number: Q6PI77 Secondary accession number(s): Q9C0G2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 20, 2008 |
Last sequence update: | July 5, 2004 | |
Last modified: | April 7, 2021 | |
This is version 135 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families