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Protein

Calmodulin

Gene

calm1a

more
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca2+. Among the enzymes to be stimulated by the calmodulin-Ca2+ complex are a number of protein kinases and phosphatases.

Miscellaneous

This protein has four functional calcium-binding sites.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi21 – 321Add BLAST12
Calcium bindingi57 – 682Add BLAST12
Calcium bindingi94 – 1053Add BLAST12
Calcium bindingi130 – 1414Add BLAST12

GO - Molecular functioni

Keywordsi

LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-DRE-111932 CaMK IV-mediated phosphorylation of CREB
R-DRE-111957 Cam-PDE 1 activation
R-DRE-114608 Platelet degranulation
R-DRE-1474151 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
R-DRE-163615 PKA activation
R-DRE-1855204 Synthesis of IP3 and IP4 in the cytosol
R-DRE-203615 eNOS activation
R-DRE-2514859 Inactivation, recovery and regulation of the phototransduction cascade
R-DRE-2672351 Stimuli-sensing channels
R-DRE-2871809 FCERI mediated Ca+2 mobilization
R-DRE-4086398 Ca2+ pathway
R-DRE-418359 Reduction of cytosolic Ca++ levels
R-DRE-425561 Sodium/Calcium exchangers
R-DRE-442717 CREB phosphorylation through the activation of CaMKK
R-DRE-442729 CREB phosphorylation through the activation of CaMKII
R-DRE-442745 Activation of CaMK IV
R-DRE-442982 Ras activation upon Ca2+ influx through NMDA receptor
R-DRE-445355 Smooth Muscle Contraction
R-DRE-451308 Activation of Ca-permeable Kainate Receptor
R-DRE-5218920 VEGFR2 mediated vascular permeability
R-DRE-5578775 Ion homeostasis
R-DRE-5607763 CLEC7A (Dectin-1) induces NFAT activation
R-DRE-5626467 RHO GTPases activate IQGAPs
R-DRE-5627123 RHO GTPases activate PAKs
R-DRE-5673001 RAF/MAP kinase cascade
R-DRE-70221 Glycogen breakdown (glycogenolysis)
R-DRE-8876725 Protein methylation
R-DRE-936837 Ion transport by P-type ATPases

Names & Taxonomyi

Protein namesi
Recommended name:
Calmodulin
Short name:
CaM
Gene namesi
Name:calm1a
ORF Names:zgc:63926
AND
Name:calm1b
AND
Name:calm2a
Synonyms:calm2d
AND
Name:calm2b
ORF Names:zgc:64036
AND
Name:calm3a
Synonyms:calm2g
ORF Names:zgc:86728
AND
Name:calm3b
ORF Names:zgc:76987
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componentsi: Chromosome 12, Chromosome 13, Chromosome 15, Chromosome 17, Chromosome 20, Chromosome 21

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001982312 – 149CalmodulinAdd BLAST148

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei116N6,N6,N6-trimethyllysineBy similarity1

Keywords - PTMi

Acetylation, Methylation

Proteomic databases

PaxDbiQ6PI52
PRIDEiQ6PI52

Expressioni

Gene expression databases

BgeeiENSDARG00000015050
ExpressionAtlasiQ6PI52 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000092307

Structurei

3D structure databases

ProteinModelPortaliQ6PI52
SMRiQ6PI52
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 43EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini44 – 79EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini81 – 116EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini117 – 149EF-hand 4PROSITE-ProRule annotationAdd BLAST33

Sequence similaritiesi

Belongs to the calmodulin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0027 Eukaryota
COG5126 LUCA
GeneTreeiENSGT00760000118901
HOGENOMiHOG000233018
HOVERGENiHBG012180
InParanoidiQ6PI52
KOiK02183
OMAiESELTDM
OrthoDBiEOG091G0V73
PhylomeDBiQ6PI52
TreeFamiTF300912

Family and domain databases

CDDicd00051 EFh, 2 hits
InterProiView protein in InterPro
IPR039030 Calmodulin
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
PANTHERiPTHR23050:SF311 PTHR23050:SF311, 1 hit
PfamiView protein in Pfam
PF13499 EF-hand_7, 2 hits
SMARTiView protein in SMART
SM00054 EFh, 4 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 4 hits
PS50222 EF_HAND_2, 4 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6PI52-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADQLTEEQI AEFKEAFSLF DKDGDGTITT KELGTVMRSL GQNPTEAELQ
60 70 80 90 100
DMINEVDADG NGTIDFPEFL TMMARKMKDT DSEEEIREAF RVFDKDGNGY
110 120 130 140
ISAAELRHVM TNLGEKLTDE EVDEMIREAD IDGDGQVNYE EFVQMMTAK
Length:149
Mass (Da):16,838
Last modified:January 23, 2007 - v3
Checksum:i6B4BC3FCDE10727B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL935145 Genomic DNA Translation: CAH68889.1
BC044434 mRNA Translation: AAH44434.1
BC045298 mRNA Translation: AAH45298.1
BC053150 mRNA Translation: AAH53150.1
BC054600 mRNA Translation: AAH54600.1
BC059427 mRNA Translation: AAH59427.1
BC059500 mRNA Translation: AAH59500.1
BC065426 mRNA Translation: AAH65426.1
BC066752 mRNA Translation: AAH66752.1
BC068339 mRNA Translation: AAH68339.1
BC071404 mRNA Translation: AAH71404.1
BC097062 mRNA Translation: AAH97062.1
RefSeqiNP_892012.1, NM_182967.1
NP_955864.1, NM_199570.1
NP_956290.1, NM_199996.2
NP_956376.1, NM_200082.1
NP_998516.1, NM_213351.1
NP_999901.1, NM_214736.1
UniGeneiDr.132819
Dr.162036
Dr.6963
Dr.76175
Dr.7638
Dr.76748

Genome annotation databases

EnsembliENSDART00000014868; ENSDARP00000018820; ENSDARG00000015050
ENSDART00000021083; ENSDARP00000010393; ENSDARG00000031427
ENSDART00000034580; ENSDARP00000035027; ENSDARG00000021811
ENSDART00000050308; ENSDARP00000050307; ENSDARG00000034187
ENSDART00000065392; ENSDARP00000065391; ENSDARG00000074057
ENSDART00000172114; ENSDARP00000139118; ENSDARG00000100825
ENSDART00000185357; ENSDARP00000148382; ENSDARG00000034187
ENSDART00000186813; ENSDARP00000156858; ENSDARG00000021811
ENSDART00000187901; ENSDARP00000147971; ENSDARG00000100825
GeneIDi192322
321808
327379
336121
368217
406660
KEGGidre:192322
dre:321808
dre:327379
dre:336121
dre:368217
dre:406660

Similar proteinsi

Entry informationi

Entry nameiCALM_DANRE
AccessioniPrimary (citable) accession number: Q6PI52
Secondary accession number(s): Q4V949
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: January 23, 2007
Last modified: July 18, 2018
This is version 116 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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