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Entry version 144 (17 Jun 2020)
Sequence version 2 (04 Apr 2006)
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Protein

Iodotyrosine deiodinase 1

Gene

IYD

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the oxidative NADPH-dependent deiodination of monoiodotyrosine (L-MIT) or diiodotyrosine (L-DIT) (PubMed:15289438, PubMed:25395621, PubMed:18434651). Acts during the hydrolysis of thyroglobulin to liberate iodide, which can then reenter the hormone-producing pathways (PubMed:18434651). Acts more efficiently on monoiodotyrosine than on diiodotyrosine (PubMed:15289438).3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

FMN1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=2.67 µM for L-DIT1 Publication
  2. KM=1.35 µM for L-MIT1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei128FMN; via amide nitrogenCombined sources1 Publication1
    Binding sitei130Substrate; via amide nitrogenCombined sources1
    Binding sitei157SubstrateCombined sources1 Publication1
    Binding sitei161SubstrateCombined sources1 Publication1
    Binding sitei182SubstrateCombined sources1 Publication1
    Binding sitei279FMNCombined sources1 Publication1

    Regions

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi100 – 104FMNCombined sources1 Publication5
    Nucleotide bindingi128 – 129FMNBy similarity2
    Nucleotide bindingi237 – 239FMNCombined sources1 Publication3

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    • FMN binding Source: UniProtKB
    • iodide peroxidase activity Source: GO_Central
    • oxidoreductase activity Source: UniProtKB

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionOxidoreductase
    LigandFlavoprotein, FMN, NADP

    Enzyme and pathway databases

    BRENDA Comprehensive Enzyme Information System

    More...
    BRENDAi
    1.22.1.1 2681

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-209968 Thyroxine biosynthesis

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Iodotyrosine deiodinase 11 Publication (EC:1.21.1.13 Publications)
    Short name:
    IYD-11 Publication
    Alternative name(s):
    Iodotyrosine dehalogenase 12 Publications
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:IYD1 Publication
    Synonyms:C6orf71, DEHAL11 Publication
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

    Organism-specific databases

    Eukaryotic Pathogen Database Resources

    More...
    EuPathDBi
    HostDB:ENSG00000009765.14

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:21071 IYD

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    612025 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_Q6PHW0

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini24 – 214ExtracellularSequence analysisAdd BLAST191
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei215 – 235HelicalSequence analysisAdd BLAST21
    Topological domaini236 – 289CytoplasmicSequence analysisAdd BLAST54

    Keywords - Cellular componenti

    Cell membrane, Cytoplasmic vesicle, Membrane

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    <p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

    Thyroid dyshormonogenesis 4 (TDH4)1 Publication
    The disease is caused by mutations affecting the gene represented in this entry.
    Disease descriptionA disorder due to thyroid dyshormonogenesis, causing severe hypothyroidism, goiter, excessive levels of iodotyrosine in serum and urine, and variable mental deficits derived from unrecognized and untreated hypothyroidism.
    Related information in OMIM
    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_045963101R → W in TDH4; strongly reduces activity; does not respond to the increase of flavin mononucleotide concentration. 1 PublicationCorresponds to variant dbSNP:rs121918138EnsemblClinVar.1
    Natural variantiVAR_045964105 – 106FI → L in TDH4; strongly reduces activity; does not respond to the increase of flavin mononucleotide concentration. 2
    Natural variantiVAR_045965116I → T in TDH4; strongly reduces activity; marginally respond to the increase of flavin mononucleotide concentration; reduces protein stability. 1 PublicationCorresponds to variant dbSNP:rs121918139EnsemblClinVar.1

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi101R → A: Strongly reduces activity. 1 Publication1
    Mutagenesisi101R → H: Reduces activity. 1 Publication1
    Mutagenesisi105F → A: Activity as the wild type. 1 Publication1
    Mutagenesisi105F → Y: Activity as the wild type. 1 Publication1
    Mutagenesisi116I → V: Activity as the wild type. 1 Publication1

    Keywords - Diseasei

    Congenital hypothyroidism, Disease mutation

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    389434

    MalaCards human disease database

    More...
    MalaCardsi
    IYD
    MIMi274800 phenotype

    Open Targets

    More...
    OpenTargetsi
    ENSG00000009765

    Orphanet; a database dedicated to information on rare diseases and orphan drugs

    More...
    Orphaneti
    95716 Familial thyroid dyshormonogenesis

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA162392352

    Miscellaneous databases

    Pharos NIH Druggable Genome Knowledgebase

    More...
    Pharosi
    Q6PHW0 Tbio

    Chemistry databases

    Drug and drug target database

    More...
    DrugBanki
    DB03374 3,5-Diiodotyrosine

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    IYD

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    91207083

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 23Sequence analysisAdd BLAST23
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000023027824 – 289Iodotyrosine deiodinase 1Add BLAST266

    Proteomic databases

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    Q6PHW0

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...
    MassIVEi
    Q6PHW0

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q6PHW0

    PeptideAtlas

    More...
    PeptideAtlasi
    Q6PHW0

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q6PHW0

    ProteomicsDB: a multi-organism proteome resource

    More...
    ProteomicsDBi
    10043
    67128 [Q6PHW0-1]
    67129 [Q6PHW0-3]
    67130 [Q6PHW0-4]
    67131 [Q6PHW0-5]
    67132 [Q6PHW0-6]
    67133 [Q6PHW0-7]

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q6PHW0

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q6PHW0

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Expressed at a high level in thyroid gland (at protein level). Expressed at a high level in thyroid gland and at lower level in kidney and trachea.1 Publication

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000009765 Expressed in right lobe of thyroid gland and 76 other tissues

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    Q6PHW0 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q6PHW0 HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    ENSG00000009765 Tissue enriched (thyroid)

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Homodimer.

    1 Publication

    <p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

    Hide details

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGRID)

    More...
    BioGRIDi
    133150, 3 interactors

    Protein interaction database and analysis system

    More...
    IntActi
    Q6PHW0, 4 interactors

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000229447

    Miscellaneous databases

    RNAct, Protein-RNA interaction predictions for model organisms.

    More...
    RNActi
    Q6PHW0 protein

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1289
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q6PHW0

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    Protein Data Bank in Europe - Knowledge Base

    More...
    PDBe-KBi
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the nitroreductase family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG3936 Eukaryota
    COG0778 LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00390000004348

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    CLU_070764_1_1_1

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q6PHW0

    KEGG Orthology (KO)

    More...
    KOi
    K17231

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    GANHQPW

    Database of Orthologous Groups

    More...
    OrthoDBi
    1524590at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q6PHW0

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF313415

    Family and domain databases

    Database of protein disorder

    More...
    DisProti
    DP01741

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    3.40.109.10, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR029479 Nitroreductase
    IPR000415 Nitroreductase-like

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF00881 Nitroreductase, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF55469 SSF55469, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 6 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 6 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

    Isoform 1 (identifier: Q6PHW0-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MYFLTPILVA ILCILVVWIF KNADRSMEKK KGEPRTRAEA RPWVDEDLKD
    60 70 80 90 100
    SSDLHQAEED ADEWQESEEN VEHIPFSHNH YPEKEMVKRS QEFYELLNKR
    110 120 130 140 150
    RSVRFISNEQ VPMEVIDNVI RTAGTAPSGA HTEPWTFVVV KDPDVKHKIR
    160 170 180 190 200
    KIIEEEEEIN YMKRMGHRWV TDLKKLRTNW IKEYLDTAPI LILIFKQVHG
    210 220 230 240 250
    FAANGKKKVH YYNEISVSIA CGILLAALQN AGLVTVTTTP LNCGPRLRVL
    260 270 280
    LGRPAHEKLL MLLPVGYPSK EATVPDLKRK PLDQIMVTV
    Length:289
    Mass (Da):33,360
    Last modified:April 4, 2006 - v2
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB73560A682BF6045
    GO
    Isoform 3 (identifier: Q6PHW0-3) [UniParc]FASTAAdd to basket
    Also known as: E

    The sequence of this isoform differs from the canonical sequence as follows:
         230-248: NAGLVTVTTTPLNCGPRLR → VFGKIILKELALISFLNL
         249-289: Missing.

    Show »
    Length:247
    Mass (Da):28,858
    Checksum:i256CCEE175E985A1
    GO
    Isoform 4 (identifier: Q6PHW0-4) [UniParc]FASTAAdd to basket
    Also known as: B

    The sequence of this isoform differs from the canonical sequence as follows:
         230-289: NAGLVTVTTT...KPLDQIMVTV → VNNGITMRHQ...TEGAPGPPRT

    Show »
    Length:293
    Mass (Da):33,781
    Checksum:i2DEF1D502CC9F28E
    GO
    Isoform 5 (identifier: Q6PHW0-5) [UniParc]FASTAAdd to basket
    Also known as: C

    The sequence of this isoform differs from the canonical sequence as follows:
         230-284: NAGLVTVTTT...PDLKRKPLDQ → VNNGITMRHQ...FHFAIEFAAP
         285-289: Missing.

    Show »
    Length:284
    Mass (Da):32,642
    Checksum:i2C8639AEB123CF4F
    GO
    Isoform 6 (identifier: Q6PHW0-6) [UniParc]FASTAAdd to basket
    Also known as: D

    The sequence of this isoform differs from the canonical sequence as follows:
         230-270: NAGLVTVTTT...MLLPVGYPSK → VNNGITMRHQ...SSQGRPGFYC
         271-289: Missing.

    Show »
    Length:270
    Mass (Da):31,367
    Checksum:i501B6AC58642354A
    GO
    Isoform 7 (identifier: Q6PHW0-7) [UniParc]FASTAAdd to basket
    Also known as: F

    The sequence of this isoform differs from the canonical sequence as follows:
         1-55: Missing.
         56-61: QAEEDA → MKEADV
         230-248: NAGLVTVTTTPLNCGPRLR → VFGKIILKELALISFLNL
         249-289: Missing.

    Show »
    Length:192
    Mass (Da):22,460
    Checksum:i5EFAEB7D3AF9FFBC
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    C9JXJ9C9JXJ9_HUMAN
    Iodotyrosine deiodinase 1
    IYD
    270Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    F6VN83F6VN83_HUMAN
    Iodotyrosine deiodinase 1
    IYD
    284Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    F5H543F5H543_HUMAN
    Iodotyrosine deiodinase 1
    IYD
    192Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    H7C0X6H7C0X6_HUMAN
    Iodotyrosine deiodinase 1
    IYD
    89Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    <p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

    The sequence AAY41467 differs from that shown. Reason: Erroneous translation.Curated
    The sequence BAC85255 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Isoform 4 (identifier: Q6PHW0-4)
    <p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti265C → R in AAP22073 (Ref. 1) Curated1

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Natural variantiVAR_045963101R → W in TDH4; strongly reduces activity; does not respond to the increase of flavin mononucleotide concentration. 1 PublicationCorresponds to variant dbSNP:rs121918138EnsemblClinVar.1
    Natural variantiVAR_045964105 – 106FI → L in TDH4; strongly reduces activity; does not respond to the increase of flavin mononucleotide concentration. 2
    Natural variantiVAR_045965116I → T in TDH4; strongly reduces activity; marginally respond to the increase of flavin mononucleotide concentration; reduces protein stability. 1 PublicationCorresponds to variant dbSNP:rs121918139EnsemblClinVar.1
    Natural variantiVAR_025785260L → P1 PublicationCorresponds to variant dbSNP:rs17854906Ensembl.1
    Natural variantiVAR_045966271E → K. Corresponds to variant dbSNP:rs36063028EnsemblClinVar.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0178021 – 55Missing in isoform 7. 1 PublicationAdd BLAST55
    Alternative sequenceiVSP_01780356 – 61QAEEDA → MKEADV in isoform 7. 1 Publication6
    Alternative sequenceiVSP_017805230 – 289NAGLV…IMVTV → VNNGITMRHQTARHRHLIEG PGRSSEACSKLSSQGCPECR SGDCHYHSSQLWPSTEGAPG PPRT in isoform 4. 1 PublicationAdd BLAST60
    Alternative sequenceiVSP_017806230 – 284NAGLV…KPLDQ → VNNGITMRHQTARHRHLIEG PGRSSEACSKLSSQGRPGAS AAGSLFHFAIEFAAP in isoform 5. 1 PublicationAdd BLAST55
    Alternative sequenceiVSP_017807230 – 270NAGLV…GYPSK → VNNGITMRHQTARHRHLIEG PGRSSEACSKLSSQGRPGFY C in isoform 6. 1 PublicationAdd BLAST41
    Alternative sequenceiVSP_017809230 – 248NAGLV…GPRLR → VFGKIILKELALISFLNL in isoform 3 and isoform 7. 1 PublicationAdd BLAST19
    Alternative sequenceiVSP_017810249 – 289Missing in isoform 3 and isoform 7. 1 PublicationAdd BLAST41
    Alternative sequenceiVSP_017812271 – 289Missing in isoform 6. 1 PublicationAdd BLAST19
    Alternative sequenceiVSP_017813285 – 289Missing in isoform 5. 1 Publication5

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AY259176 mRNA Translation: AAP22072.1
    AY259177 mRNA Translation: AAP22073.1
    AY424901 mRNA Translation: AAR84259.1
    AY424902 mRNA Translation: AAR84260.1
    AY957659 mRNA Translation: AAY41465.1
    AY957660 mRNA Translation: AAY41466.1
    AY957661 mRNA Translation: AAY41467.1 Sequence problems.
    AL031010 Genomic DNA No translation available.
    BC056253 mRNA Translation: AAH56253.1
    AK129950 mRNA Translation: BAC85255.1 Different initiation.

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS5227.1 [Q6PHW0-1]
    CCDS55066.1 [Q6PHW0-3]
    CCDS55067.1 [Q6PHW0-4]

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_001158166.1, NM_001164694.1 [Q6PHW0-4]
    NP_001158167.1, NM_001164695.1 [Q6PHW0-3]
    NP_001305424.1, NM_001318495.1
    NP_981932.1, NM_203395.2 [Q6PHW0-1]

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000229447; ENSP00000229447; ENSG00000009765 [Q6PHW0-4]
    ENST00000344419; ENSP00000343763; ENSG00000009765 [Q6PHW0-1]
    ENST00000367335; ENSP00000356304; ENSG00000009765 [Q6PHW0-3]
    ENST00000392256; ENSP00000376085; ENSG00000009765 [Q6PHW0-3]

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    389434

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:389434

    UCSC genome browser

    More...
    UCSCi
    uc003qnu.3 human [Q6PHW0-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AY259176 mRNA Translation: AAP22072.1
    AY259177 mRNA Translation: AAP22073.1
    AY424901 mRNA Translation: AAR84259.1
    AY424902 mRNA Translation: AAR84260.1
    AY957659 mRNA Translation: AAY41465.1
    AY957660 mRNA Translation: AAY41466.1
    AY957661 mRNA Translation: AAY41467.1 Sequence problems.
    AL031010 Genomic DNA No translation available.
    BC056253 mRNA Translation: AAH56253.1
    AK129950 mRNA Translation: BAC85255.1 Different initiation.
    CCDSiCCDS5227.1 [Q6PHW0-1]
    CCDS55066.1 [Q6PHW0-3]
    CCDS55067.1 [Q6PHW0-4]
    RefSeqiNP_001158166.1, NM_001164694.1 [Q6PHW0-4]
    NP_001158167.1, NM_001164695.1 [Q6PHW0-3]
    NP_001305424.1, NM_001318495.1
    NP_981932.1, NM_203395.2 [Q6PHW0-1]

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...
    PDBei

    Protein Data Bank RCSB

    More...
    RCSB PDBi

    Protein Data Bank Japan

    More...
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    4TTBX-ray2.45A/B32-289[»]
    4TTCX-ray2.65A/B/C/D/E/F32-289[»]
    5YAKX-ray2.30A/B/C/D/E/F32-289[»]
    SMRiQ6PHW0
    ModBaseiSearch...
    PDBe-KBiSearch...

    Protein-protein interaction databases

    BioGRIDi133150, 3 interactors
    IntActiQ6PHW0, 4 interactors
    STRINGi9606.ENSP00000229447

    Chemistry databases

    DrugBankiDB03374 3,5-Diiodotyrosine

    PTM databases

    iPTMnetiQ6PHW0
    PhosphoSitePlusiQ6PHW0

    Polymorphism and mutation databases

    BioMutaiIYD
    DMDMi91207083

    Proteomic databases

    jPOSTiQ6PHW0
    MassIVEiQ6PHW0
    PaxDbiQ6PHW0
    PeptideAtlasiQ6PHW0
    PRIDEiQ6PHW0
    ProteomicsDBi10043
    67128 [Q6PHW0-1]
    67129 [Q6PHW0-3]
    67130 [Q6PHW0-4]
    67131 [Q6PHW0-5]
    67132 [Q6PHW0-6]
    67133 [Q6PHW0-7]

    Protocols and materials databases

    Antibodypedia a portal for validated antibodies

    More...
    Antibodypediai
    33325 62 antibodies

    The DNASU plasmid repository

    More...
    DNASUi
    389434

    Genome annotation databases

    EnsembliENST00000229447; ENSP00000229447; ENSG00000009765 [Q6PHW0-4]
    ENST00000344419; ENSP00000343763; ENSG00000009765 [Q6PHW0-1]
    ENST00000367335; ENSP00000356304; ENSG00000009765 [Q6PHW0-3]
    ENST00000392256; ENSP00000376085; ENSG00000009765 [Q6PHW0-3]
    GeneIDi389434
    KEGGihsa:389434
    UCSCiuc003qnu.3 human [Q6PHW0-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    389434
    DisGeNETi389434
    EuPathDBiHostDB:ENSG00000009765.14

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    IYD
    HGNCiHGNC:21071 IYD
    HPAiENSG00000009765 Tissue enriched (thyroid)
    MalaCardsiIYD
    MIMi274800 phenotype
    612025 gene
    neXtProtiNX_Q6PHW0
    OpenTargetsiENSG00000009765
    Orphaneti95716 Familial thyroid dyshormonogenesis
    PharmGKBiPA162392352

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG3936 Eukaryota
    COG0778 LUCA
    GeneTreeiENSGT00390000004348
    HOGENOMiCLU_070764_1_1_1
    InParanoidiQ6PHW0
    KOiK17231
    OMAiGANHQPW
    OrthoDBi1524590at2759
    PhylomeDBiQ6PHW0
    TreeFamiTF313415

    Enzyme and pathway databases

    BRENDAi1.22.1.1 2681
    ReactomeiR-HSA-209968 Thyroxine biosynthesis

    Miscellaneous databases

    BioGRID ORCS database of CRISPR phenotype screens

    More...
    BioGRID-ORCSi
    389434 150 hits in 786 CRISPR screens

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    IYD human

    The Gene Wiki collection of pages on human genes and proteins

    More...
    GeneWikii
    Iodotyrosine_deiodinase

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    389434
    PharosiQ6PHW0 Tbio

    Protein Ontology

    More...
    PROi
    PR:Q6PHW0
    RNActiQ6PHW0 protein

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000009765 Expressed in right lobe of thyroid gland and 76 other tissues
    ExpressionAtlasiQ6PHW0 baseline and differential
    GenevisibleiQ6PHW0 HS

    Family and domain databases

    DisProtiDP01741
    Gene3Di3.40.109.10, 1 hit
    InterProiView protein in InterPro
    IPR029479 Nitroreductase
    IPR000415 Nitroreductase-like
    PfamiView protein in Pfam
    PF00881 Nitroreductase, 1 hit
    SUPFAMiSSF55469 SSF55469, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIYD1_HUMAN
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6PHW0
    Secondary accession number(s): C9JFW2
    , Q2VPW0, Q2VPW1, Q5F1L5, Q5F1L6, Q5THM4, Q6ZP69, Q7Z7D7, Q7Z7D8
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
    Last sequence update: April 4, 2006
    Last modified: June 17, 2020
    This is version 144 of the entry and version 2 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
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