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Entry version 123 (11 Dec 2019)
Sequence version 1 (05 Jul 2004)
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Protein

Voltage-dependent calcium channel subunit alpha-2/delta-2

Gene

Cacna2d2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) and possibly T-type (CACNA1G).1 Publication

Miscellaneous

Binds gabapentin, an antiepileptic drug.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi300Divalent metal cationCurated1
Metal bindingi302Divalent metal cationCurated1
Metal bindingi304Divalent metal cationCurated1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalcium channel, Ion channel, Voltage-gated channel
Biological processCalcium transport, Ion transport, Transport
LigandCalcium, Metal-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-112308 Presynaptic depolarization and calcium channel opening
R-MMU-422356 Regulation of insulin secretion
R-MMU-5576892 Phase 0 - rapid depolarisation
R-MMU-5576893 Phase 2 - plateau phase

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Voltage-dependent calcium channel subunit alpha-2/delta-2
Alternative name(s):
Protein ducky
Voltage-gated calcium channel subunit alpha-2/delta-2
Cleaved into the following 2 chains:
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Cacna2d2
Synonyms:Kiaa0558
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1929813 Cacna2d2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini19 – 1116ExtracellularSequence analysisAdd BLAST1098
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1117 – 1137HelicalSequence analysisAdd BLAST21
Topological domaini1138 – 1154CytoplasmicSequence analysisAdd BLAST17

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Defects in Cacna2d2 are the cause of ducky phenotype (du). Du mice have spike-wave seizures characteristic of absence epilepsy and ataxia, with accompanying decreased calcium channel current in cerebellar Purkinje cells.4 Publications

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mice exhibit growth retardation, reduced life span, ataxic gait with apoptosis of cerebellar granule cells followed by Purkinje cell depletion, enhanced susceptibility to seizures, and cardiac abnormalities.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi282R → A: Induces a strong decrease in gabapentin-binding. 1 Publication1
Mutagenesisi300D → A: Abolishes metal-binding and ability to regulate calcium current. 1 Publication1
Mutagenesisi302S → A: Abolishes metal-binding and ability to regulate calcium current. 1 Publication1
Mutagenesisi304S → A: Abolishes metal-binding and ability to regulate calcium current. 1 Publication1

Keywords - Diseasei

Disease mutation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 18Sequence analysisAdd BLAST18
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000030464019 – 1154Voltage-dependent calcium channel subunit alpha-2/delta-2Add BLAST1136
ChainiPRO_000030464119 – 1004Voltage-dependent calcium channel subunit alpha-2-2Sequence analysisAdd BLAST986
ChainiPRO_00003046421005 – 1154Voltage-dependent calcium channel subunit delta-2Sequence analysisAdd BLAST150

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi205N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi389N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi421N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi446 ↔ 1101Interchain (between alpha-2-2 and delta-2 chains)By similarity
Glycosylationi510N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi543N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi627N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi864N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated.2 Publications
May be proteolytically processed into subunits alpha-2-2 and delta-2 that are disulfide-linked. It is however unclear whether such cleavage really takes place in vivo and has a functional role. According to PubMed:11306709, it is processed, at least in vitro, while according to PubMed:17052222, it is only poorly processed in vivo.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6PHS9

PRoteomics IDEntifications database

More...
PRIDEi
Q6PHS9

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
2436 [Q6PHS9-2]
2821

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6PHS9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Predominantly expressed in brain in a restricted pattern. Also expressed at lower level in kidney and testis Not expressed in lung at any moment of development. In brain, it localizes to sections of P21 brain. Expressed at high level in the cerebellum, with moderate levels in medulla, pons, and striatum. Also expressed in cortex, hippocampus, habenula and nucleus reticularis thalami (nRT). Strongly expressed in cerebellar Purkinje cells.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000010066 Expressed in 260 organ(s), highest expression level in heart

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6PHS9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6PHS9 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Dimer formed of alpha-2-2 and delta-2 chains; disulfide-linked. Voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1 (CACNA1), alpha-2 (CACNA2D), beta (CACNB) and delta (CACNA2D) subunits in a 1:1:1:1 ratio (Probable).

1 Publication

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q6PHS9, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000132512

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6PHS9 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6PHS9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini294 – 472VWFAPROSITE-ProRule annotationAdd BLAST179
Domaini488 – 577CacheAdd BLAST90

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi300 – 304MIDAS-like motif5

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The MIDAS-like motif in the VWFA domain binds divalent metal cations and is required to promote trafficking of the alpha-1 (CACNA1) subunit to the plasma membrane by an integrin-like switch.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2353 Eukaryota
ENOG410XPDX LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156238

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6PHS9

KEGG Orthology (KO)

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KOi
K04859

Identification of Orthologs from Complete Genome Data

More...
OMAi
CEMDCDV

Database of Orthologous Groups

More...
OrthoDBi
510149at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6PHS9

TreeFam database of animal gene trees

More...
TreeFami
TF315824

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.410, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013680 VDCC_a2/dsu
IPR013608 VWA_N
IPR002035 VWF_A
IPR036465 vWFA_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08473 VGCC_alpha2, 1 hit
PF00092 VWA, 1 hit
PF08399 VWA_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00327 VWA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53300 SSF53300, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50234 VWFA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6PHS9-1) [UniParc]FASTAAdd to basket
Also known as: Alpha2delta-2a

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAVPARTCGA SWPGPVRTAR PWPGRGPRPC PDPRGPASGP ARPLLLLLPP
60 70 80 90 100
LLLLPLLTAP GASAYSFPQQ HTMQHWARRL EQEIDGVMRI FGGVQQLREI
110 120 130 140 150
YKDNRNLFEV QENEPQKLVE KVAGDIESLL DRKVQALKRL ADAAENFQKA
160 170 180 190 200
HRWQDNIKEE DIMYYDAKAD AELDDPESED MERGSKTSAL RLDFIEDPNF
210 220 230 240 250
KNKVNYSYTA VQIPTDIYKG STVILNELNW TEALENVFIE NRRQDPTLLW
260 270 280 290 300
QVFGSATGVT RYYPATPWRA PKKIDLYDVR RRPWYIQGAS SPKDMVIIVD
310 320 330 340 350
VSGSVSGLTL KLMKTSVCEM LDTLSDDDYV NVASFNEKAQ PVSCFTHLVQ
360 370 380 390 400
ANVRNKKVFK EAVQGMVAKG TTGYKAGFEY AFDQLQNSNI TRANCNKMIM
410 420 430 440 450
MFTDGGEDRV QDVFEKYNWP NRTVRVFTFS VGQHNYDVTP LQWMACTNKG
460 470 480 490 500
YYFEIPSIGA IRINTQEYLD VLGRPMVLAG KDAKQVQWTN VYEDALGLGL
510 520 530 540 550
VVTGTLPVFN LTQDGPGEKK NQLILGVMGI DVALNDIKRL TPNYTLGANG
560 570 580 590 600
YVFAIDLNGY VLLHPNLKPQ TTNFREPVTL DFLDAELEDE NKEEIRRSMI
610 620 630 640 650
DGDKGHKQIR TLVKSLDERY IDEVIRNYTW VPIRSTNYSL GLVLPPYSTY
660 670 680 690 700
YLQANLSDQI LQVKLPISKL KDFEFLLPSS FESEGHVFIA PREYCKDLNA
710 720 730 740 750
SDNNTEFLKN FIELMEKVTP DSKQCNNFLL HNLILDTGIT QQLVERVWRD
760 770 780 790 800
QDLNTYSLLA VFAATDGGIT RVFPNKAAED WTENPEPFNA SFYRRSLDNH
810 820 830 840 850
GYIFKPPHQD SLLRPLELEN DTVGVLVSTA VELSLGRRTL RPAVVGVKLD
860 870 880 890 900
LEAWAEKFKV LASNRTHQDQ PQKCGPSSHC EMDCEVNNED LLCVLIDDGG
910 920 930 940 950
FLVLSNQNHQ WDQVGRFFSE VDANLMLALY NNSFYTRKES YDYQAACAPQ
960 970 980 990 1000
PPGNLGAAPR GVFVPTIADF LNLAWWTSAA AWSLFQQLLY GLIYHSWFQA
1010 1020 1030 1040 1050
DPAEAEGSPE TRESSCVMKQ TQYYFGSVNA SYNAIIDCGN CSRLFHAQRL
1060 1070 1080 1090 1100
TNTNLLFVVA EKPLCSQCEA GRLLQKETHS DGPEQCELVQ RPRYRRGPHI
1110 1120 1130 1140 1150
CFDYNATEDT SDCGRGASFP PSLGVLVSLQ LLLLLGLPPR PQPQVHSFAA

SRHL
Length:1,154
Mass (Da):130,385
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAE4F646D89A96053
GO
Isoform 2 (identifier: Q6PHS9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     665-672: LPISKLKD → Y
     873-873: K → KQ

Show »
Length:1,148
Mass (Da):129,781
Checksum:i9B49FF0547F82851
GO
Isoform 3 (identifier: Q6PHS9-3) [UniParc]FASTAAdd to basket
Also known as: Alpha2delta-2c

The sequence of this isoform differs from the canonical sequence as follows:
     1079-1080: HS → HCPA

Show »
Length:1,156
Mass (Da):130,569
Checksum:iADB4926D2EA690E8
GO
Isoform 4 (identifier: Q6PHS9-4) [UniParc]FASTAAdd to basket
Also known as: Alpha2delta-2b

The sequence of this isoform differs from the canonical sequence as follows:
     665-672: LPISKLKD → Y

Show »
Length:1,147
Mass (Da):129,653
Checksum:i9DEBB0CE22DCD170
GO
Isoform 5 (identifier: Q6PHS9-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     665-672: LPISKLKD → Y
     873-873: K → KQ
     1079-1080: HS → HCPA

Show »
Length:1,150
Mass (Da):129,965
Checksum:iCC37C76BB5CE5EB9
GO
Isoform 6 (identifier: Q6PHS9-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     873-873: K → KQ
     1079-1080: HS → HCPA

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Length:1,157
Mass (Da):130,697
Checksum:i8AB34388111AFD12
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q683E9Q683_MOUSE
Voltage-dependent calcium channel s...
Cacna2d2
1,157Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAL01651 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti657S → R in AAG47846 (PubMed:11130987).Curated1
Sequence conflicti657S → R in AAL01650 (PubMed:11487633).Curated1
Sequence conflicti657S → R in AAR89454 (PubMed:14660671).Curated1
Sequence conflicti704N → S in AAG47846 (PubMed:11130987).Curated1
Sequence conflicti704N → S in AAL01650 (PubMed:11487633).Curated1
Sequence conflicti704N → S in AAR89454 (PubMed:14660671).Curated1
Sequence conflicti710N → D in AAG47846 (PubMed:11130987).Curated1
Sequence conflicti710N → D in AAL01650 (PubMed:11487633).Curated1
Sequence conflicti710N → D in AAR89454 (PubMed:14660671).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti99E → EIYKDNRNLFEVQENEPQKL VEKVAGDIESLLDRKVQALK in du; variant allele entla. 1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_028061665 – 672LPISKLKD → Y in isoform 2, isoform 4 and isoform 5. 4 Publications8
Alternative sequenceiVSP_028062873K → KQ in isoform 2, isoform 5 and isoform 6. 2 Publications1
Alternative sequenceiVSP_0280631079 – 1080HS → HCPA in isoform 3, isoform 5 and isoform 6. 4 Publications2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF247139 mRNA Translation: AAG47846.1
AF247141 mRNA Translation: AAL01650.1
AF247142 mRNA Translation: AAL01651.1 Frameshift.
AY502107 mRNA Translation: AAR89454.1
AK044603 mRNA Translation: BAC31998.1
AK164143 mRNA Translation: BAE37646.1
AK161839 mRNA Translation: BAE36599.1
BC056389 mRNA Translation: AAH56389.1
BC158058 mRNA Translation: AAI58059.1
AB093246 mRNA Translation: BAC41430.1
AF169633 mRNA Translation: AAD48037.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS52916.1 [Q6PHS9-1]
CCDS52917.1 [Q6PHS9-2]
CCDS72304.1 [Q6PHS9-3]
CCDS72305.1 [Q6PHS9-5]

NCBI Reference Sequences

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RefSeqi
NP_001167518.1, NM_001174047.1 [Q6PHS9-3]
NP_001167520.1, NM_001174049.1 [Q6PHS9-4]
NP_001167521.1, NM_001174050.1 [Q6PHS9-2]
NP_064659.2, NM_020263.3 [Q6PHS9-1]
XP_011241201.1, XM_011242899.2 [Q6PHS9-6]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000010210; ENSMUSP00000010210; ENSMUSG00000010066 [Q6PHS9-2]
ENSMUST00000085092; ENSMUSP00000082173; ENSMUSG00000010066 [Q6PHS9-1]
ENSMUST00000166799; ENSMUSP00000126029; ENSMUSG00000010066 [Q6PHS9-6]
ENSMUST00000168532; ENSMUSP00000132512; ENSMUSG00000010066 [Q6PHS9-3]
ENSMUST00000170737; ENSMUSP00000125943; ENSMUSG00000010066 [Q6PHS9-5]

Database of genes from NCBI RefSeq genomes

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GeneIDi
56808

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:56808

UCSC genome browser

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UCSCi
uc009rli.2 mouse [Q6PHS9-2]
uc009rlj.2 mouse [Q6PHS9-4]
uc012haf.1 mouse [Q6PHS9-1]
uc057apw.1 mouse [Q6PHS9-3]
uc057apx.1 mouse [Q6PHS9-5]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF247139 mRNA Translation: AAG47846.1
AF247141 mRNA Translation: AAL01650.1
AF247142 mRNA Translation: AAL01651.1 Frameshift.
AY502107 mRNA Translation: AAR89454.1
AK044603 mRNA Translation: BAC31998.1
AK164143 mRNA Translation: BAE37646.1
AK161839 mRNA Translation: BAE36599.1
BC056389 mRNA Translation: AAH56389.1
BC158058 mRNA Translation: AAI58059.1
AB093246 mRNA Translation: BAC41430.1
AF169633 mRNA Translation: AAD48037.1
CCDSiCCDS52916.1 [Q6PHS9-1]
CCDS52917.1 [Q6PHS9-2]
CCDS72304.1 [Q6PHS9-3]
CCDS72305.1 [Q6PHS9-5]
RefSeqiNP_001167518.1, NM_001174047.1 [Q6PHS9-3]
NP_001167520.1, NM_001174049.1 [Q6PHS9-4]
NP_001167521.1, NM_001174050.1 [Q6PHS9-2]
NP_064659.2, NM_020263.3 [Q6PHS9-1]
XP_011241201.1, XM_011242899.2 [Q6PHS9-6]

3D structure databases

SMRiQ6PHS9
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ6PHS9, 1 interactor
STRINGi10090.ENSMUSP00000132512

PTM databases

GlyConnecti2436 [Q6PHS9-2]
2821
PhosphoSitePlusiQ6PHS9

Proteomic databases

PaxDbiQ6PHS9
PRIDEiQ6PHS9

Genome annotation databases

EnsembliENSMUST00000010210; ENSMUSP00000010210; ENSMUSG00000010066 [Q6PHS9-2]
ENSMUST00000085092; ENSMUSP00000082173; ENSMUSG00000010066 [Q6PHS9-1]
ENSMUST00000166799; ENSMUSP00000126029; ENSMUSG00000010066 [Q6PHS9-6]
ENSMUST00000168532; ENSMUSP00000132512; ENSMUSG00000010066 [Q6PHS9-3]
ENSMUST00000170737; ENSMUSP00000125943; ENSMUSG00000010066 [Q6PHS9-5]
GeneIDi56808
KEGGimmu:56808
UCSCiuc009rli.2 mouse [Q6PHS9-2]
uc009rlj.2 mouse [Q6PHS9-4]
uc012haf.1 mouse [Q6PHS9-1]
uc057apw.1 mouse [Q6PHS9-3]
uc057apx.1 mouse [Q6PHS9-5]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
9254
MGIiMGI:1929813 Cacna2d2

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
Search...

Phylogenomic databases

eggNOGiKOG2353 Eukaryota
ENOG410XPDX LUCA
GeneTreeiENSGT00940000156238
InParanoidiQ6PHS9
KOiK04859
OMAiCEMDCDV
OrthoDBi510149at2759
PhylomeDBiQ6PHS9
TreeFamiTF315824

Enzyme and pathway databases

ReactomeiR-MMU-112308 Presynaptic depolarization and calcium channel opening
R-MMU-422356 Regulation of insulin secretion
R-MMU-5576892 Phase 0 - rapid depolarisation
R-MMU-5576893 Phase 2 - plateau phase

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Cacna2d2 mouse

Protein Ontology

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PROi
PR:Q6PHS9
RNActiQ6PHS9 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000010066 Expressed in 260 organ(s), highest expression level in heart
ExpressionAtlasiQ6PHS9 baseline and differential
GenevisibleiQ6PHS9 MM

Family and domain databases

Gene3Di3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR013680 VDCC_a2/dsu
IPR013608 VWA_N
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PfamiView protein in Pfam
PF08473 VGCC_alpha2, 1 hit
PF00092 VWA, 1 hit
PF08399 VWA_N, 1 hit
SMARTiView protein in SMART
SM00327 VWA, 1 hit
SUPFAMiSSF53300 SSF53300, 1 hit
PROSITEiView protein in PROSITE
PS50234 VWFA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCA2D2_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6PHS9
Secondary accession number(s): B2RY16
, Q3TPT9, Q3TSS6, Q6REE3, Q8C8R8, Q8CHE9, Q920H5, Q920H6, Q9EQG2, Q9R142
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: July 5, 2004
Last modified: December 11, 2019
This is version 123 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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