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Protein

N-alpha-acetyltransferase 35, NatC auxiliary subunit

Gene

Naa35

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues. Involved in regulation of apoptosis and proliferation of smooth muscle cells.1 Publication

Caution

PubMed:16484612 decribes a Naa35/Egap-containing complex as evolutionary conserved NatC complex; however, the mMak3 protein investigated in this context corresponds to mammalian NAA50 and not NAA30 and its interaction with NAA35 is ambiguous.Curated

GO - Molecular functioni

  • peptide alpha-N-acetyltransferase activity Source: GO_Central

GO - Biological processi

  • negative regulation of apoptotic process Source: UniProtKB
  • N-terminal protein amino acid acetylation Source: GO_Central
  • smooth muscle cell proliferation Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
N-alpha-acetyltransferase 35, NatC auxiliary subunit
Alternative name(s):
Embryonic growth-associated protein
Protein MAK10 homolog
Gene namesi
Name:Naa35
Synonyms:Egap, Mak10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1925939 Naa35

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003086161 – 725N-alpha-acetyltransferase 35, NatC auxiliary subunitAdd BLAST725

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei187PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6PHQ8
MaxQBiQ6PHQ8
PaxDbiQ6PHQ8
PeptideAtlasiQ6PHQ8
PRIDEiQ6PHQ8

PTM databases

iPTMnetiQ6PHQ8
PhosphoSitePlusiQ6PHQ8

Expressioni

Gene expression databases

BgeeiENSMUSG00000021555 Expressed in 290 organ(s), highest expression level in secondary oocyte
ExpressionAtlasiQ6PHQ8 baseline and differential
GenevisibleiQ6PHQ8 MM

Interactioni

Subunit structurei

Component of the N-terminal acetyltransferase C (NatC) complex, which is composed of NAA35, NAA38 and NAA30.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022038

Structurei

3D structure databases

ProteinModelPortaliQ6PHQ8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MAK10 family.Curated

Phylogenomic databases

eggNOGiKOG2343 Eukaryota
ENOG410XS3T LUCA
GeneTreeiENSGT00390000002445
HOGENOMiHOG000068098
HOVERGENiHBG099871
InParanoidiQ6PHQ8
KOiK20823
OMAiASYQFLE
OrthoDBiEOG091G06Y3
PhylomeDBiQ6PHQ8
TreeFamiTF320627

Family and domain databases

InterProiView protein in InterPro
IPR007244 NatC_AcTrfase_Mak10
PANTHERiPTHR21373 PTHR21373, 1 hit
PfamiView protein in Pfam
PF04112 Mak10, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

Q6PHQ8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVMKATVDDD ASGWELGVPE KMEKSSTSWV DITQDFEDAC RELKLGELLH
60 70 80 90 100
DKLFGLFEAM SAIEMMDPKM DAGMIGNQVN RKVLNFEQAI KDGTIKIKDL
110 120 130 140 150
SLPELIGIMD TCFCCLITWL EGHSLAQTVF TCLYIHNPDF IEDPAMKAFA
160 170 180 190 200
LGILKICDIA REKVNKAAVF EEEDFQSMTY GFKMANSVTD LRVTGMLKDV
210 220 230 240 250
EDDLQRRVKS TRSRQGEERD PEVELEHQQC LAAFSRVKFT RVLLTVLIAF
260 270 280 290 300
TKKETSAVAE AQKLMVQAAD LLSAIHTSLH HGIQAQNGTT KGDHPIMMGF
310 320 330 340 350
EPLVNQRLLP PTFPRYAKII KREEMVNYFS RLIDRIKTVC EVVNLPNLHC
360 370 380 390 400
ILDFFCEFSE QSPCVLSRSL LQTTFLVDNK KVFGTHLMQD MVKDALRSFV
410 420 430 440 450
SPPVLSPKCC LYNNHQAKDC IDSFVTHCVR PFCSLVQIHG HNRARQRDKL
460 470 480 490 500
GHILEEFATL QDEAEKVDAA LHTMLLKQEP QRQHLACLGT WVLYHNLRIM
510 520 530 540 550
IQYLLSGFEL ELYSMHEYYY IYWYLSEFLY AWLMSTLSRA DGSQMAEERI
560 570 580 590 600
MEEQQKGRSS KKTKKKKKVR PLSREITMSQ AYQNMCAGMF KTMVAFDMDG
610 620 630 640 650
KVRKPKFELD SEQVRYEHRF APFNSVMTPP PVHYLQFKEM SDLNKYSPPP
660 670 680 690 700
QSPELYVAAS KHFQQAKMIL ENIPNPDREV SRILKVAKPN FVVMKLLAGG
710 720
HKKESKVPPE FDFSVHKYFP VVKLV
Length:725
Mass (Da):83,306
Last modified:July 5, 2004 - v1
Checksum:i5362E77747B5F248
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6UFC8F6UFC8_MOUSE
N-alpha-acetyltransferase 35, NatC ...
Naa35
152Annotation score:
E9Q2U4E9Q2U4_MOUSE
N-alpha-acetyltransferase 35, NatC ...
Naa35
111Annotation score:
E9Q6K7E9Q6K7_MOUSE
N-alpha-acetyltransferase 35, NatC ...
Naa35
236Annotation score:
F6WYJ5F6WYJ5_MOUSE
N-alpha-acetyltransferase 35, NatC ...
Naa35
213Annotation score:
F7A8R0F7A8R0_MOUSE
N-alpha-acetyltransferase 35, NatC ...
Naa35
402Annotation score:
F6ZAJ8F6ZAJ8_MOUSE
N-alpha-acetyltransferase 35, NatC ...
Naa35
147Annotation score:

Sequence cautioni

The sequence AAH27201 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti246V → L in AAM52342 (PubMed:16484612).Curated1
Sequence conflicti608E → G in BAC30316 (PubMed:16141072).Curated1
Sequence conflicti666A → T in AAM52342 (PubMed:16484612).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY102701 mRNA Translation: AAM52342.1
AK039316 mRNA Translation: BAC30316.1
BC027201 mRNA Translation: AAH27201.1 Sequence problems.
BC056435 mRNA Translation: AAH56435.1
CCDSiCCDS26575.1
RefSeqiNP_084429.2, NM_030153.2
XP_006517522.1, XM_006517459.3
UniGeneiMm.253902

Genome annotation databases

EnsembliENSMUST00000022038; ENSMUSP00000022038; ENSMUSG00000021555
GeneIDi78689
KEGGimmu:78689
UCSCiuc007quu.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY102701 mRNA Translation: AAM52342.1
AK039316 mRNA Translation: BAC30316.1
BC027201 mRNA Translation: AAH27201.1 Sequence problems.
BC056435 mRNA Translation: AAH56435.1
CCDSiCCDS26575.1
RefSeqiNP_084429.2, NM_030153.2
XP_006517522.1, XM_006517459.3
UniGeneiMm.253902

3D structure databases

ProteinModelPortaliQ6PHQ8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022038

PTM databases

iPTMnetiQ6PHQ8
PhosphoSitePlusiQ6PHQ8

Proteomic databases

EPDiQ6PHQ8
MaxQBiQ6PHQ8
PaxDbiQ6PHQ8
PeptideAtlasiQ6PHQ8
PRIDEiQ6PHQ8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022038; ENSMUSP00000022038; ENSMUSG00000021555
GeneIDi78689
KEGGimmu:78689
UCSCiuc007quu.2 mouse

Organism-specific databases

CTDi60560
MGIiMGI:1925939 Naa35

Phylogenomic databases

eggNOGiKOG2343 Eukaryota
ENOG410XS3T LUCA
GeneTreeiENSGT00390000002445
HOGENOMiHOG000068098
HOVERGENiHBG099871
InParanoidiQ6PHQ8
KOiK20823
OMAiASYQFLE
OrthoDBiEOG091G06Y3
PhylomeDBiQ6PHQ8
TreeFamiTF320627

Miscellaneous databases

ChiTaRSiNaa35 mouse
PROiPR:Q6PHQ8
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021555 Expressed in 290 organ(s), highest expression level in secondary oocyte
ExpressionAtlasiQ6PHQ8 baseline and differential
GenevisibleiQ6PHQ8 MM

Family and domain databases

InterProiView protein in InterPro
IPR007244 NatC_AcTrfase_Mak10
PANTHERiPTHR21373 PTHR21373, 1 hit
PfamiView protein in Pfam
PF04112 Mak10, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiNAA35_MOUSE
AccessioniPrimary (citable) accession number: Q6PHQ8
Secondary accession number(s): Q05CD3, Q8BYJ9, Q8K3H2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: July 5, 2004
Last modified: November 7, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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