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Protein
Submitted name:

Leucine rich repeat protein 2, neuronal, isoform CRA_b

Gene

Lrrn2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Submitted name:
Leucine rich repeat protein 2, neuronal, isoform CRA_bImported
Submitted name:
Leucine-rich repeat protein 2, neuronalImported
Gene namesi
Name:Lrrn2Imported
ORF Names:mCG_52291Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:106037 Lrrn2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei630 – 648HelicalSequence analysisAdd BLAST19

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_501509844220 – 730Sequence analysisAdd BLAST711

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiENSMUSG00000026443 Expressed in 138 organ(s), highest expression level in hippocampal field

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027706

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini422 – 511Ig-likeInterPro annotationAdd BLAST90

Keywords - Domaini

Immunoglobulin domainSAAS annotation, Leucine-rich repeatSAAS annotation, RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00760000118831
HOGENOMiHOG000252914
HOVERGENiHBG052361
OMAiTEYWACL
OrthoDBiEOG091G066E
TreeFamiTF334360

Family and domain databases

CDDicd00063 FN3, 1 hit
Gene3Di2.60.40.10, 1 hit
3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR003961 FN3_dom
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF07679 I-set, 1 hit
PF13855 LRR_8, 3 hits
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00408 IGc2, 1 hit
SM00369 LRR_TYP, 10 hits
SM00082 LRRCT, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS51450 LRR, 10 hits

Sequencei

Sequence statusi: Complete.

Q6PHP6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRLLVAALLL SWVAGTTAAA PVVPWRVPCP PQCACQIRPW YTPRSSYREA
60 70 80 90 100
TTVDCNDLFL TAVPPRLPAG TQTLLLQSNS ISRIDQTELA YLANLTELDL
110 120 130 140 150
SQNSFSDARD CDFQALPQLL SLHLEENRLN RLEDHSFAGL TSLQELYLNH
160 170 180 190 200
NQLCRISPRA FAGLGNLLRL HLNSNLLRTI DSRWFEMLPN LEILMIGGNK
210 220 230 240 250
VDAILDMNFR PLANLRSLVL AGMSLREISD YALEGLQSLE SLSFYDNQLA
260 270 280 290 300
QVPKRALEQV PGLKFLDLNK NPLQRVGPGD FANMLHLKEL GLNNMEELVS
310 320 330 340 350
IDKFALVNLP ELTKLDITNN PRLSFIHPRA FHHLPQMETL MLNNNALSAL
360 370 380 390 400
HQQTVESLPN LQEVGLHGNP IRCDCVIRWA NATGTHVRFI EPQSTLCAEP
410 420 430 440 450
PDLQRRPVRE VPFREMTDHC LPLISPRSFP SSLQIASGES TVLHCRALAE
460 470 480 490 500
PEPEIYWVTP AGVRLTPARS GRRYRVFPEG TLELRRVTAE EAGLYTCVAQ
510 520 530 540 550
NLVGADTKTV SVVVGHAPFQ PGRDKGPGLK LHVQETHPYH ILLFWAPPPN
560 570 580 590 600
IVSTNLTWSS ASSLRDHEAP ALARLPRGTH RYNITRLLPA TEYWACLQVA
610 620 630 640 650
FADAHTQLAC VWARTKEASP CHRALGDRPG LIAILALAVL LLAAGLAAHL
660 670 680 690 700
GRGQSKQGVV GEKPLLPVWA FWGWSAPSVR VVSAPLVLPW NPGRKQPRCQ
710 720 730
MGRGCHHHCL NIAEVPPGLS SREITRTTLH
Length:730
Mass (Da):81,123
Last modified:July 5, 2004 - v1
Checksum:iEF0B0FC966AC46F7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC124095 Genomic DNA No translation available.
AC137948 Genomic DNA No translation available.
BC056458 mRNA Translation: AAH56458.1
CH466520 Genomic DNA Translation: EDL39668.1
RefSeqiNP_034862.1, NM_010732.4
UniGeneiMm.39640

Genome annotation databases

EnsembliENSMUST00000027706; ENSMUSP00000027706; ENSMUSG00000026443
GeneIDi16980
KEGGimmu:16980
UCSCiuc007cpi.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC124095 Genomic DNA No translation available.
AC137948 Genomic DNA No translation available.
BC056458 mRNA Translation: AAH56458.1
CH466520 Genomic DNA Translation: EDL39668.1
RefSeqiNP_034862.1, NM_010732.4
UniGeneiMm.39640

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027706

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027706; ENSMUSP00000027706; ENSMUSG00000026443
GeneIDi16980
KEGGimmu:16980
UCSCiuc007cpi.2 mouse

Organism-specific databases

CTDi10446
MGIiMGI:106037 Lrrn2

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00760000118831
HOGENOMiHOG000252914
HOVERGENiHBG052361
OMAiTEYWACL
OrthoDBiEOG091G066E
TreeFamiTF334360

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026443 Expressed in 138 organ(s), highest expression level in hippocampal field

Family and domain databases

CDDicd00063 FN3, 1 hit
Gene3Di2.60.40.10, 1 hit
3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR003961 FN3_dom
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF07679 I-set, 1 hit
PF13855 LRR_8, 3 hits
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00408 IGc2, 1 hit
SM00369 LRR_TYP, 10 hits
SM00082 LRRCT, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS51450 LRR, 10 hits
ProtoNetiSearch...

Entry informationi

Entry nameiQ6PHP6_MOUSE
AccessioniPrimary (citable) accession number: Q6PHP6
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: November 7, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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