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Protein

DNA-directed RNA polymerase I subunit RPA43

Gene

twistnb

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. May be involved in recruitment of Pol I to rDNA promoters (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTranscription

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerase I subunit RPA43
Alternative name(s):
Twist neighbor protein
Gene namesi
Name:twistnb
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Unplaced

Organism-specific databases

ZFINiZDB-GENE-041007-3 twistnb

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

DNA-directed RNA polymerase, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002886341 – 391DNA-directed RNA polymerase I subunit RPA43Add BLAST391

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6PHG8

Interactioni

Subunit structurei

Component of the RNA polymerase I (Pol I) complex consisting of at least 13 subunits.By similarity

Protein-protein interaction databases

STRINGi7955.ENSDARP00000104602

Structurei

3D structure databases

ProteinModelPortaliQ6PHG8
SMRiQ6PHG8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili289 – 353Sequence analysisAdd BLAST65

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi73 – 76Poly-Lys4
Compositional biasi242 – 253Poly-LysAdd BLAST12
Compositional biasi385 – 391Poly-Lys7

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4134 Eukaryota
ENOG4111JD4 LUCA
HOGENOMiHOG000060204
HOVERGENiHBG108416
InParanoidiQ6PHG8
KOiK03004

Family and domain databases

Gene3Di3.30.1490.120, 1 hit
InterProiView protein in InterPro
IPR036898 RNA_pol_Rpb7-like_N_sf
IPR005576 RNA_pol_Rpb7_N
PfamiView protein in Pfam
PF03876 SHS2_Rpb7-N, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q6PHG8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MANWTQEDGA PTPVTNPSEV SQVSGGSVTG GPAVTSCLIP SFAEAVKLLK
60 70 80 90 100
ARYSCLVLDT HRRHISLPPV HLKKKKTGIQ EQLNAELLKY SNSLDGVPVA
110 120 130 140 150
YDNIKVVGQH GNIYDDQGFI HFNIEASFVI FRPKNGSRLM GVINKMGASH
160 170 180 190 200
VGCLVHGCFN ASVMKPNALT SDQWRDSGLC VGQSLEFEVF QLDADAAGVL
210 220 230 240 250
LIRGRLDRSR VQELVAQFEQ KQVTAESSTE ADATEDTTDS PKPKKKKKRK
260 270 280 290 300
KDKNDTESSM EECVNNSSLQ ETSEHHQTTT EEDCSANGRH KEKKKKKKRD
310 320 330 340 350
KNDTESSMDE CMNNNSLQET ALDTTEEDCN ANERHKEKKK KKKRDKQQDS
360 370 380 390
AEIVPTSDSS GYISDKTSRK RALEAGDDTE TPAAKKKKKS K
Length:391
Mass (Da):43,286
Last modified:May 29, 2007 - v2
Checksum:i8DB4E9FA05C7B893
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1R1A1F1R1A1_DANRE
DNA-directed RNA polymerase I subun...
twistnb
390Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti239D → G in AAT68101 (PubMed:15256591).Curated1
Sequence conflicti292E → EK in AAT68101 (PubMed:15256591).Curated1
Sequence conflicti338 – 339Missing in AAT68101 (PubMed:15256591).Curated2
Sequence conflicti379T → I in AAT68101 (PubMed:15256591).Curated1
Sequence conflicti382P → L in AAT68101 (PubMed:15256591).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY648783 mRNA Translation: AAT68101.1
BC056557 mRNA Translation: AAH56557.1
RefSeqiNP_001007154.1, NM_001007153.1
UniGeneiDr.18556

Genome annotation databases

GeneIDi402856
KEGGidre:402856

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY648783 mRNA Translation: AAT68101.1
BC056557 mRNA Translation: AAH56557.1
RefSeqiNP_001007154.1, NM_001007153.1
UniGeneiDr.18556

3D structure databases

ProteinModelPortaliQ6PHG8
SMRiQ6PHG8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000104602

Proteomic databases

PaxDbiQ6PHG8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi402856
KEGGidre:402856

Organism-specific databases

CTDi221830
ZFINiZDB-GENE-041007-3 twistnb

Phylogenomic databases

eggNOGiKOG4134 Eukaryota
ENOG4111JD4 LUCA
HOGENOMiHOG000060204
HOVERGENiHBG108416
InParanoidiQ6PHG8
KOiK03004

Miscellaneous databases

PROiPR:Q6PHG8

Family and domain databases

Gene3Di3.30.1490.120, 1 hit
InterProiView protein in InterPro
IPR036898 RNA_pol_Rpb7-like_N_sf
IPR005576 RNA_pol_Rpb7_N
PfamiView protein in Pfam
PF03876 SHS2_Rpb7-N, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRPA43_DANRE
AccessioniPrimary (citable) accession number: Q6PHG8
Secondary accession number(s): Q6DRH6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 29, 2007
Last modified: October 10, 2018
This is version 72 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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