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UniProtKB - Q6PH81 (CP087_HUMAN)

Entry version 121 (11 Dec 2019)
Sequence version 1 (05 Jul 2004)
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Protein

UPF0547 protein C16orf87

Gene

C16orf87

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
UPF0547 protein C16orf87
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:C16orf87
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000155330.9

Human Gene Nomenclature Database

More...HGNCi		HGNC:33754 C16orf87

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q6PH81

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000155330

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA162378458

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q6PH81 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		C16orf87

Domain mapping of disease mutations (DMDM)

More...DMDMi		74737667

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003265211 – 154UPF0547 protein C16orf87Add BLAST154

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei91PhosphoserineCombined sources1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q6PH81

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q6PH81

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q6PH81

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q6PH81

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q6PH81

PeptideAtlas

More...PeptideAtlasi		Q6PH81

PRoteomics IDEntifications database

More...PRIDEi		Q6PH81

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		67121 [Q6PH81-1]
67122 [Q6PH81-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q6PH81

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q6PH81

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000155330 Expressed in 179 organ(s), highest expression level in prostate gland

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q6PH81 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q6PH81 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA041179

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Show more details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		132622, 24 interactors

Protein interaction database and analysis system

More...IntActi		Q6PH81, 22 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000285697

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q6PH81 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q6PH81

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili104 – 132Sequence analysisAdd BLAST29

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the UPF0547 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410IVN4 Eukaryota
ENOG4111SPU LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00390000009505

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000060343

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q6PH81

Identification of Orthologs from Complete Genome Data

More...OMAi		VACKSCT

Database of Orthologous Groups

More...OrthoDBi		1563136at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q6PH81

TreeFam database of animal gene trees

More...TreeFami		TF331719

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR040246 C16orf87-like
IPR018886 UPF0547

The PANTHER Classification System

More...PANTHERi		PTHR31101 PTHR31101, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF10571 UPF0547, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6PH81-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSATRAKKVK MATKSCPECD QQVPVACKSC PCGYIFISRK LLNAKHSEKS 
        60         70         80         90        100
PPSTENKHEA KRRRTERVRR EKINSTVNKD LENRKRSRSN SHSDHIRRGR 
       110        120        130        140        150
GRPKSASAKK HEEEREKQEK EIDIYANLSD EKAFVFSVAL AEINRKIINQ 

RLIL
Length:154
Mass (Da):17,799
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i016A2E075FF60223
GO
Isoform 2 (identifier: Q6PH81-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     55-115: Missing.

Show »
Length:93
Mass (Da):10,431
Checksum:i30DB292DF93014E8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BQL3H3BQL3_HUMAN
UPF0547 protein C16orf87
C16orf87
161Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_03267055 – 115Missing in isoform 2. 1 PublicationAdd BLAST61

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
BX647945 mRNA Translation: CAH56192.1
CH471092 Genomic DNA Translation: EAW82689.1
BC056676 mRNA Translation: AAH56676.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS10724.1 [Q6PH81-1]
CCDS86522.1 [Q6PH81-2]

NCBI Reference Sequences

More...RefSeqi		NP_001001436.1, NM_001001436.3 [Q6PH81-1]
NP_001335589.1, NM_001348660.1 [Q6PH81-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000285697; ENSP00000285697; ENSG00000155330 [Q6PH81-1]
ENST00000394806; ENSP00000378285; ENSG00000155330 [Q6PH81-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		388272

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:388272

UCSC genome browser

More...UCSCi		uc002eek.2 human [Q6PH81-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX647945 mRNA Translation: CAH56192.1
CH471092 Genomic DNA Translation: EAW82689.1
BC056676 mRNA Translation: AAH56676.1
CCDSiCCDS10724.1 [Q6PH81-1]
CCDS86522.1 [Q6PH81-2]
RefSeqiNP_001001436.1, NM_001001436.3 [Q6PH81-1]
NP_001335589.1, NM_001348660.1 [Q6PH81-2]

3D structure databases

SMRiQ6PH81
ModBaseiSearch...

Protein-protein interaction databases

BioGridi132622, 24 interactors
IntActiQ6PH81, 22 interactors
STRINGi9606.ENSP00000285697

PTM databases

iPTMnetiQ6PH81
PhosphoSitePlusiQ6PH81

Polymorphism and mutation databases

BioMutaiC16orf87
DMDMi74737667

Proteomic databases

EPDiQ6PH81
jPOSTiQ6PH81
MassIVEiQ6PH81
MaxQBiQ6PH81
PaxDbiQ6PH81
PeptideAtlasiQ6PH81
PRIDEiQ6PH81
ProteomicsDBi67121 [Q6PH81-1]
67122 [Q6PH81-2]

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		388272

Genome annotation databases

EnsembliENST00000285697; ENSP00000285697; ENSG00000155330 [Q6PH81-1]
ENST00000394806; ENSP00000378285; ENSG00000155330 [Q6PH81-2]
GeneIDi388272
KEGGihsa:388272
UCSCiuc002eek.2 human [Q6PH81-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		388272
EuPathDBiHostDB:ENSG00000155330.9

GeneCards: human genes, protein and diseases

More...GeneCardsi		C16orf87
HGNCiHGNC:33754 C16orf87
HPAiHPA041179
neXtProtiNX_Q6PH81
OpenTargetsiENSG00000155330
PharmGKBiPA162378458

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410IVN4 Eukaryota
ENOG4111SPU LUCA
GeneTreeiENSGT00390000009505
HOGENOMiHOG000060343
InParanoidiQ6PH81
OMAiVACKSCT
OrthoDBi1563136at2759
PhylomeDBiQ6PH81
TreeFamiTF331719

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		C16orf87 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		388272
PharosiQ6PH81 Tdark

Protein Ontology

More...PROi		PR:Q6PH81
RNActiQ6PH81 protein

Gene expression databases

BgeeiENSG00000155330 Expressed in 179 organ(s), highest expression level in prostate gland
ExpressionAtlasiQ6PH81 baseline and differential
GenevisibleiQ6PH81 HS

Family and domain databases

InterProiView protein in InterPro
IPR040246 C16orf87-like
IPR018886 UPF0547
PANTHERiPTHR31101 PTHR31101, 1 hit
PfamiView protein in Pfam
PF10571 UPF0547, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCP087_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6PH81
Secondary accession number(s): Q63HN9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: July 5, 2004
Last modified: December 11, 2019
This is version 121 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries
  3. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
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