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Protein

Protein aurora borealis

Gene

BORA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for the activation of AURKA at the onset of mitosis.1 Publication

GO - Molecular functioni

  • protein kinase binding Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, Mitosis

Enzyme and pathway databases

ReactomeiR-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition
SIGNORiQ6PGQ7

Names & Taxonomyi

Protein namesi
Recommended name:
Protein aurora borealis
Short name:
HsBora
Gene namesi
Name:BORA
Synonyms:C13orf34
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000136122.15
HGNCiHGNC:24724 BORA
MIMi610510 gene
neXtProtiNX_Q6PGQ7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000136122
PharmGKBiPA162378045

Polymorphism and mutation databases

DMDMi74737659

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002732051 – 559Protein aurora borealisAdd BLAST559

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei183PhosphoserineCombined sources1
Modified residuei191PhosphoserineCombined sources1
Modified residuei270PhosphoserineCombined sources1
Modified residuei325PhosphoserineBy similarity1
Modified residuei331PhosphoserineBy similarity1
Modified residuei354PhosphothreonineBy similarity1

Post-translational modificationi

Phosphorylated by AURKA.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6PGQ7
MaxQBiQ6PGQ7
PaxDbiQ6PGQ7
PeptideAtlasiQ6PGQ7
PRIDEiQ6PGQ7
ProteomicsDBi67120

PTM databases

iPTMnetiQ6PGQ7
PhosphoSitePlusiQ6PGQ7

Expressioni

Gene expression databases

BgeeiENSG00000136122 Expressed in 148 organ(s), highest expression level in secondary oocyte
CleanExiHS_C13orf34
ExpressionAtlasiQ6PGQ7 baseline and differential
GenevisibleiQ6PGQ7 HS

Organism-specific databases

HPAiHPA040866

Interactioni

Subunit structurei

Interacts with AURKA.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
PLK1P533503EBI-719836,EBI-476768

GO - Molecular functioni

Protein-protein interaction databases

BioGridi122954, 36 interactors
DIPiDIP-53424N
ELMiQ6PGQ7
IntActiQ6PGQ7, 12 interactors
STRINGi9606.ENSP00000375082

Structurei

3D structure databases

ProteinModelPortaliQ6PGQ7
SMRiQ6PGQ7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi188 – 278Ser-richAdd BLAST91

Sequence similaritiesi

Belongs to the BORA family.Curated

Phylogenomic databases

eggNOGiENOG410IHF2 Eukaryota
ENOG410ZQ9X LUCA
GeneTreeiENSGT00390000013790
HOGENOMiHOG000074046
HOVERGENiHBG080904
InParanoidiQ6PGQ7
KOiK16831
PhylomeDBiQ6PGQ7
TreeFamiTF329674

Family and domain databases

InterProiView protein in InterPro
IPR023252 Aurora_borealis_protein
PANTHERiPTHR14728 PTHR14728, 1 hit
PfamiView protein in Pfam
PF15280 BORA_N, 1 hit
PRINTSiPR02038 AURORABORA

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.iShow all

Isoform 1 (identifier: Q6PGQ7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGDVKESKMQ ITPETPGRIP VLNPFESPSD YSNLHEQTLA SPSVFKSTKL
60 70 80 90 100
PTPGKFRWSI DQLAVINPVE IDPEDIHRQA LYLSHSRIDK DVEDKRQKAI
110 120 130 140 150
EEFFTKDVIV PSPWTDHEGK QLSQCHSSKC TNINSDSPVG KKLTIHSEKS
160 170 180 190 200
DAACQTLLSL PVDFNLENIL GDYFRADEFA DQSPGNLSSS SLRRKLFLDG
210 220 230 240 250
NGSISDSLPS ASPGSPHSGV QTSLEMFYSI DLSPVKCRSP LQTPSSGQFS
260 270 280 290 300
SSPIQASAKK YSLGSITSPS PISSPTFSPI EFQIGETPLS EQRKFTVHSP
310 320 330 340 350
DASSGTNSNG ITNPCIRSPY IDGCSPIKNW SPMRLQMYSG GTQYRTSVIQ
360 370 380 390 400
IPFTLETQGE DEEDKENIPS TDVSSPAMDA AGIHLRQFSN EASTHGTHLV
410 420 430 440 450
VTAMSVTQNQ SSASEKELAL LQDVEREKDN NTVDMVDPIE IADETTWIKE
460 470 480 490 500
PVDNGSLPMT DFVSGIAFSI ENSHMCMSPL AESSVIPCES SNIQMDSGYN
510 520 530 540 550
TQNCGSNIMD TVGAESYCKE SDAQTCEVES KSQAFNMKQD HTTQRCWMKT

ASPFQCSSP
Length:559
Mass (Da):61,203
Last modified:December 21, 2004 - v2
Checksum:iF817E6DC2C7600DB
GO
Isoform 2 (identifier: Q6PGQ7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-87: MGDVKESKMQ...RQALYLSHSR → MNKLSPVLLFLNQQNYQ

Note: No experimental confirmation available.
Show »
Length:489
Mass (Da):53,438
Checksum:iCBD976AE2BA1E52E
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B5LMG6B5LMG6_HUMAN
Aurora borealis
BORA C13orf34, FLJ22624, hCG_1781028
619Annotation score:
A0A087WV86A0A087WV86_HUMAN
Protein aurora borealis
BORA
634Annotation score:
H3BLY2H3BLY2_HUMAN
Protein aurora borealis
BORA
214Annotation score:
A0A087WVC9A0A087WVC9_HUMAN
Protein aurora borealis
BORA
114Annotation score:

Sequence cautioni

The sequence BAB15426 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti545R → K in AAH07119 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_030110210S → L. Corresponds to variant dbSNP:rs9543107Ensembl.1
Natural variantiVAR_030111308S → F. Corresponds to variant dbSNP:rs1146858Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0555431 – 87MGDVK…LSHSR → MNKLSPVLLFLNQQNYQ in isoform 2. 1 PublicationAdd BLAST87

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK026277 mRNA Translation: BAB15426.1 Different initiation.
AK298608 mRNA Translation: BAG60792.1
AL138695 Genomic DNA No translation available.
CH471093 Genomic DNA Translation: EAW80515.1
BC007119 mRNA Translation: AAH07119.1
BC025367 mRNA Translation: AAH25367.2
BC044213 mRNA Translation: AAH44213.1
BC056876 mRNA Translation: AAH56876.2
CCDSiCCDS66560.1 [Q6PGQ7-2]
RefSeqiNP_001273675.1, NM_001286746.1
NP_001273676.1, NM_001286747.1 [Q6PGQ7-2]
NP_079084.3, NM_024808.3
UniGeneiHs.643464

Genome annotation databases

EnsembliENST00000377815; ENSP00000367046; ENSG00000136122 [Q6PGQ7-2]
GeneIDi79866
KEGGihsa:79866
UCSCiuc010thr.3 human [Q6PGQ7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiBORA_HUMAN
AccessioniPrimary (citable) accession number: Q6PGQ7
Secondary accession number(s): B4DQ30
, Q5W0P3, Q5W0P4, Q86YC6, Q96IW9, Q9H640
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: December 21, 2004
Last modified: September 12, 2018
This is version 118 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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