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Entry version 127 (16 Oct 2019)
Sequence version 2 (21 Dec 2004)
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Protein

Protein aurora borealis

Gene

BORA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for the activation of AURKA at the onset of mitosis.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cell division, Mitosis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q6PGQ7

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein aurora borealis
Short name:
HsBora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BORA
Synonyms:C13orf34
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:24724 BORA

Online Mendelian Inheritance in Man (OMIM)

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MIMi
610510 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6PGQ7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000136122

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162378045

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q6PGQ7

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
BORA

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74737659

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002732051 – 559Protein aurora borealisAdd BLAST559

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei183PhosphoserineCombined sources1
Modified residuei191PhosphoserineCombined sources1
Modified residuei270PhosphoserineCombined sources1
Modified residuei325PhosphoserineBy similarity1
Modified residuei331PhosphoserineBy similarity1
Modified residuei354PhosphothreonineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by AURKA.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q6PGQ7

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6PGQ7

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q6PGQ7

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6PGQ7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6PGQ7

PeptideAtlas

More...
PeptideAtlasi
Q6PGQ7

PRoteomics IDEntifications database

More...
PRIDEi
Q6PGQ7

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
67120 [Q6PGQ7-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6PGQ7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6PGQ7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000136122 Expressed in 148 organ(s), highest expression level in secondary oocyte

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6PGQ7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6PGQ7 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA040866

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with AURKA.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
PLK1P533504EBI-719836,EBI-476768

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
122954, 37 interactors

Database of interacting proteins

More...
DIPi
DIP-53424N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
Q6PGQ7

Protein interaction database and analysis system

More...
IntActi
Q6PGQ7, 23 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000479266

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6PGQ7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi188 – 278Ser-richAdd BLAST91

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the BORA family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IHF2 Eukaryota
ENOG410ZQ9X LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000013790

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000074046

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6PGQ7

KEGG Orthology (KO)

More...
KOi
K16831

Database of Orthologous Groups

More...
OrthoDBi
539473at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6PGQ7

TreeFam database of animal gene trees

More...
TreeFami
TF329674

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR023252 Aurora_borealis_protein

The PANTHER Classification System

More...
PANTHERi
PTHR14728 PTHR14728, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15280 BORA_N, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR02038 AURORABORA

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6PGQ7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGDVKESKMQ ITPETPGRIP VLNPFESPSD YSNLHEQTLA SPSVFKSTKL
60 70 80 90 100
PTPGKFRWSI DQLAVINPVE IDPEDIHRQA LYLSHSRIDK DVEDKRQKAI
110 120 130 140 150
EEFFTKDVIV PSPWTDHEGK QLSQCHSSKC TNINSDSPVG KKLTIHSEKS
160 170 180 190 200
DAACQTLLSL PVDFNLENIL GDYFRADEFA DQSPGNLSSS SLRRKLFLDG
210 220 230 240 250
NGSISDSLPS ASPGSPHSGV QTSLEMFYSI DLSPVKCRSP LQTPSSGQFS
260 270 280 290 300
SSPIQASAKK YSLGSITSPS PISSPTFSPI EFQIGETPLS EQRKFTVHSP
310 320 330 340 350
DASSGTNSNG ITNPCIRSPY IDGCSPIKNW SPMRLQMYSG GTQYRTSVIQ
360 370 380 390 400
IPFTLETQGE DEEDKENIPS TDVSSPAMDA AGIHLRQFSN EASTHGTHLV
410 420 430 440 450
VTAMSVTQNQ SSASEKELAL LQDVEREKDN NTVDMVDPIE IADETTWIKE
460 470 480 490 500
PVDNGSLPMT DFVSGIAFSI ENSHMCMSPL AESSVIPCES SNIQMDSGYN
510 520 530 540 550
TQNCGSNIMD TVGAESYCKE SDAQTCEVES KSQAFNMKQD HTTQRCWMKT

ASPFQCSSP
Length:559
Mass (Da):61,203
Last modified:December 21, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF817E6DC2C7600DB
GO
Isoform 2 (identifier: Q6PGQ7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-87: MGDVKESKMQ...RQALYLSHSR → MNKLSPVLLFLNQQNYQ

Note: No experimental confirmation available.
Show »
Length:489
Mass (Da):53,438
Checksum:iCBD976AE2BA1E52E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WV86A0A087WV86_HUMAN
Protein aurora borealis
BORA
634Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WVC9A0A087WVC9_HUMAN
Protein aurora borealis
BORA
54Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B5LMG6B5LMG6_HUMAN
Aurora borealis
BORA C13orf34, FLJ22624, hCG_1781028
619Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494C1R8A0A494C1R8_HUMAN
Protein aurora borealis
BORA
53Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BLY2H3BLY2_HUMAN
Protein aurora borealis
BORA
214Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB15426 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti545R → K in AAH07119 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_030110210S → L. Corresponds to variant dbSNP:rs9543107Ensembl.1
Natural variantiVAR_030111308S → F. Corresponds to variant dbSNP:rs1146858Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0555431 – 87MGDVK…LSHSR → MNKLSPVLLFLNQQNYQ in isoform 2. 1 PublicationAdd BLAST87

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK026277 mRNA Translation: BAB15426.1 Different initiation.
AK298608 mRNA Translation: BAG60792.1
AL138695 Genomic DNA No translation available.
CH471093 Genomic DNA Translation: EAW80515.1
BC007119 mRNA Translation: AAH07119.1
BC025367 mRNA Translation: AAH25367.2
BC044213 mRNA Translation: AAH44213.1
BC056876 mRNA Translation: AAH56876.2

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS66560.1 [Q6PGQ7-2]
CCDS73583.1 [Q6PGQ7-1]
CCDS9446.2 [Q6PGQ7-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001273675.1, NM_001286746.1 [Q6PGQ7-1]
NP_001273676.1, NM_001286747.1 [Q6PGQ7-2]
NP_079084.3, NM_024808.3 [Q6PGQ7-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000390667; ENSP00000375082; ENSG00000136122 [Q6PGQ7-1]
ENST00000651477; ENSP00000498664; ENSG00000136122 [Q6PGQ7-1]
ENST00000652266; ENSP00000498882; ENSG00000136122 [Q6PGQ7-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
79866

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:79866

UCSC genome browser

More...
UCSCi
uc010thr.3 human [Q6PGQ7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK026277 mRNA Translation: BAB15426.1 Different initiation.
AK298608 mRNA Translation: BAG60792.1
AL138695 Genomic DNA No translation available.
CH471093 Genomic DNA Translation: EAW80515.1
BC007119 mRNA Translation: AAH07119.1
BC025367 mRNA Translation: AAH25367.2
BC044213 mRNA Translation: AAH44213.1
BC056876 mRNA Translation: AAH56876.2
CCDSiCCDS66560.1 [Q6PGQ7-2]
CCDS73583.1 [Q6PGQ7-1]
CCDS9446.2 [Q6PGQ7-1]
RefSeqiNP_001273675.1, NM_001286746.1 [Q6PGQ7-1]
NP_001273676.1, NM_001286747.1 [Q6PGQ7-2]
NP_079084.3, NM_024808.3 [Q6PGQ7-1]

3D structure databases

SMRiQ6PGQ7
ModBaseiSearch...

Protein-protein interaction databases

BioGridi122954, 37 interactors
DIPiDIP-53424N
ELMiQ6PGQ7
IntActiQ6PGQ7, 23 interactors
STRINGi9606.ENSP00000479266

PTM databases

iPTMnetiQ6PGQ7
PhosphoSitePlusiQ6PGQ7

Polymorphism and mutation databases

BioMutaiBORA
DMDMi74737659

Proteomic databases

EPDiQ6PGQ7
jPOSTiQ6PGQ7
MassIVEiQ6PGQ7
MaxQBiQ6PGQ7
PaxDbiQ6PGQ7
PeptideAtlasiQ6PGQ7
PRIDEiQ6PGQ7
ProteomicsDBi67120 [Q6PGQ7-1]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
79866

Genome annotation databases

EnsembliENST00000390667; ENSP00000375082; ENSG00000136122 [Q6PGQ7-1]
ENST00000651477; ENSP00000498664; ENSG00000136122 [Q6PGQ7-1]
ENST00000652266; ENSP00000498882; ENSG00000136122 [Q6PGQ7-2]
GeneIDi79866
KEGGihsa:79866
UCSCiuc010thr.3 human [Q6PGQ7-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
79866

GeneCards: human genes, protein and diseases

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GeneCardsi
BORA
HGNCiHGNC:24724 BORA
HPAiHPA040866
MIMi610510 gene
neXtProtiNX_Q6PGQ7
OpenTargetsiENSG00000136122
PharmGKBiPA162378045

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IHF2 Eukaryota
ENOG410ZQ9X LUCA
GeneTreeiENSGT00390000013790
HOGENOMiHOG000074046
InParanoidiQ6PGQ7
KOiK16831
OrthoDBi539473at2759
PhylomeDBiQ6PGQ7
TreeFamiTF329674

Enzyme and pathway databases

ReactomeiR-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition
SIGNORiQ6PGQ7

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
BORA human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
79866
PharosiQ6PGQ7

Protein Ontology

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PROi
PR:Q6PGQ7

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000136122 Expressed in 148 organ(s), highest expression level in secondary oocyte
ExpressionAtlasiQ6PGQ7 baseline and differential
GenevisibleiQ6PGQ7 HS

Family and domain databases

InterProiView protein in InterPro
IPR023252 Aurora_borealis_protein
PANTHERiPTHR14728 PTHR14728, 1 hit
PfamiView protein in Pfam
PF15280 BORA_N, 1 hit
PRINTSiPR02038 AURORABORA

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBORA_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6PGQ7
Secondary accession number(s): B4DQ30
, Q5W0P3, Q5W0P4, Q86YC6, Q96IW9, Q9H640
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: December 21, 2004
Last modified: October 16, 2019
This is version 127 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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