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Entry version 100 (13 Nov 2019)
Sequence version 1 (05 Jul 2004)
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Protein

Aspartate-rich protein 1

Gene

DRICH1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Aspartate-rich protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DRICH1
Synonyms:C22orf43
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:28031 DRICH1

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6PGQ1

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

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OpenTargetsi
ENSG00000189269

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA164717092

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q6PGQ1

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
DRICH1

Domain mapping of disease mutations (DMDM)

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DMDMi
74737656

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003195921 – 229Aspartate-rich protein 1Add BLAST229

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q6PGQ1

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q6PGQ1

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q6PGQ1

PeptideAtlas

More...
PeptideAtlasi
Q6PGQ1

PRoteomics IDEntifications database

More...
PRIDEi
Q6PGQ1

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
67119

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6PGQ1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6PGQ1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000189269 Expressed in 92 organ(s), highest expression level in right testis

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6PGQ1 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA020446

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
119396, 8 interactors

Protein interaction database and analysis system

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IntActi
Q6PGQ1, 8 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000316137

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi116 – 205Asp-richAdd BLAST90

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IUXS Eukaryota
ENOG4110PSK LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00520000056310

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000112089

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6PGQ1

Identification of Orthologs from Complete Genome Data

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OMAi
CGWPRGK

Database of Orthologous Groups

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OrthoDBi
990299at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6PGQ1

TreeFam database of animal gene trees

More...
TreeFami
TF340710

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR042865 DRICH1-like

The PANTHER Classification System

More...
PANTHERi
PTHR15880 PTHR15880, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6PGQ1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGNILTCCIN SHCGWPRGKD APCYESDTDI YETVAAATSE STTVEPGKLD
60 70 80 90 100
VGATEGQDLQ HISNQKMPTG PPEDRLSLKF LPSSEEDNDD AKILPSPVQG
110 120 130 140 150
SSEDNLSLVC LPRSEDDDCD DDDDDDAQIL PSRVQGGCYR FDSSSCSSED
160 170 180 190 200
NLSLVCLPRS EDDDCDDDDD DAQILPSPVQ ACSEDSLFLR CSLRHKDEEE
210 220
EDDDDIHITA RIESDLTLES LSDEEIHPG
Length:229
Mass (Da):25,064
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBB7B6F201690A1F2
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAB75693 differs from that shown. Intron retention.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti120Missing in CAG30256 (PubMed:15461802).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0390144I → T. Corresponds to variant dbSNP:rs3827318Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
CR456370 mRNA Translation: CAG30256.1
AL080197 mRNA Translation: CAB75693.1 Sequence problems.
AP000346 Genomic DNA No translation available.
BC056888 mRNA Translation: AAH56888.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS42985.1

NCBI Reference Sequences

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RefSeqi
NP_057533.2, NM_016449.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000317749; ENSP00000316137; ENSG00000189269
ENST00000614553; ENSP00000483208; ENSG00000189269

Database of genes from NCBI RefSeq genomes

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GeneIDi
51233

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:51233

UCSC genome browser

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UCSCi
uc002zxf.3 human

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR456370 mRNA Translation: CAG30256.1
AL080197 mRNA Translation: CAB75693.1 Sequence problems.
AP000346 Genomic DNA No translation available.
BC056888 mRNA Translation: AAH56888.1
CCDSiCCDS42985.1
RefSeqiNP_057533.2, NM_016449.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi119396, 8 interactors
IntActiQ6PGQ1, 8 interactors
STRINGi9606.ENSP00000316137

PTM databases

iPTMnetiQ6PGQ1
PhosphoSitePlusiQ6PGQ1

Polymorphism and mutation databases

BioMutaiDRICH1
DMDMi74737656

Proteomic databases

jPOSTiQ6PGQ1
MassIVEiQ6PGQ1
PaxDbiQ6PGQ1
PeptideAtlasiQ6PGQ1
PRIDEiQ6PGQ1
ProteomicsDBi67119

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
51233

Genome annotation databases

EnsembliENST00000317749; ENSP00000316137; ENSG00000189269
ENST00000614553; ENSP00000483208; ENSG00000189269
GeneIDi51233
KEGGihsa:51233
UCSCiuc002zxf.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
51233

GeneCards: human genes, protein and diseases

More...
GeneCardsi
DRICH1
HGNCiHGNC:28031 DRICH1
HPAiHPA020446
neXtProtiNX_Q6PGQ1
OpenTargetsiENSG00000189269
PharmGKBiPA164717092

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IUXS Eukaryota
ENOG4110PSK LUCA
GeneTreeiENSGT00520000056310
HOGENOMiHOG000112089
InParanoidiQ6PGQ1
OMAiCGWPRGK
OrthoDBi990299at2759
PhylomeDBiQ6PGQ1
TreeFamiTF340710

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
DRICH1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
51233
PharosiQ6PGQ1

Protein Ontology

More...
PROi
PR:Q6PGQ1

Gene expression databases

BgeeiENSG00000189269 Expressed in 92 organ(s), highest expression level in right testis
GenevisibleiQ6PGQ1 HS

Family and domain databases

InterProiView protein in InterPro
IPR042865 DRICH1-like
PANTHERiPTHR15880 PTHR15880, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDRIC1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6PGQ1
Secondary accession number(s): Q6ICJ8, Q6P4I3, Q9NU31
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: July 5, 2004
Last modified: November 13, 2019
This is version 100 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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