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Protein

Proline/serine-rich coiled-coil protein 1

Gene

PSRC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate, and for normal rate of chromosomal segregation during anaphase. Plays a role in the regulation of mitotic spindle dynamics. Increases the rate of turnover of microtubules on metaphase spindles, and contributes to the generation of normal tension across sister kinetochores. Recruits KIF2A and ANKRD53 to the mitotic spindle and spindle poles. May participate in p53/TP53-regulated growth suppression.3 Publications

GO - Molecular functioni

  • microtubule binding Source: BHF-UCL

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
Proline/serine-rich coiled-coil protein 1
Gene namesi
Name:PSRC1
Synonyms:DDA3
ORF Names:FP3214
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000134222.16
HGNCiHGNC:24472 PSRC1
MIMi613126 gene
neXtProtiNX_Q6PGN9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

DisGeNETi84722
OpenTargetsiENSG00000134222
PharmGKBiPA142671120

Polymorphism and mutation databases

BioMutaiPSRC1
DMDMi74737651

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002737281 – 363Proline/serine-rich coiled-coil protein 1Add BLAST363

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei22PhosphoserineCombined sources1
Modified residuei47PhosphoserineCombined sources1
Modified residuei65PhosphoserineCombined sources1
Modified residuei70PhosphoserineCombined sources1
Modified residuei98PhosphoserineCombined sources1
Modified residuei122PhosphoserineCombined sources1
Modified residuei140PhosphoserineCombined sources1
Modified residuei145PhosphothreonineCombined sources1
Modified residuei186PhosphoserineCombined sources1
Modified residuei190PhosphoserineCombined sources1
Isoform D (identifier: Q6PGN9-4)
Modified residuei42PhosphoserineCombined sources1
Modified residuei45PhosphothreonineCombined sources1
Isoform A (identifier: Q6PGN9-2)
Modified residuei212PhosphoserineCombined sources1
Modified residuei215PhosphothreonineCombined sources1

Post-translational modificationi

Phosphorylated during mitosis.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6PGN9
MaxQBiQ6PGN9
PeptideAtlasiQ6PGN9
PRIDEiQ6PGN9
ProteomicsDBi67114
67115 [Q6PGN9-2]
67116 [Q6PGN9-3]
67117 [Q6PGN9-4]

PTM databases

iPTMnetiQ6PGN9
PhosphoSitePlusiQ6PGN9

Expressioni

Tissue specificityi

Widely expressed in adult and fetal tissues, with highest expression in the adult brain and fetal thymus. Not detected in adult skeletal muscle.1 Publication

Gene expression databases

BgeeiENSG00000134222 Expressed in 173 organ(s), highest expression level in C1 segment of cervical spinal cord
CleanExiHS_PSRC1
ExpressionAtlasiQ6PGN9 baseline and differential
GenevisibleiQ6PGN9 HS

Organism-specific databases

HPAiHPA049315
HPA056561

Interactioni

Subunit structurei

Interacts with APC2 (By similarity). Interacts with KIF2A (PubMed:18411309). Interacts with ANKRD53; recruits ANKRD53 to the spindle during mitosis (PubMed:26820536).By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi124224, 22 interactors
ELMiQ6PGN9
IntActiQ6PGN9, 12 interactors
MINTiQ6PGN9

Structurei

3D structure databases

ProteinModelPortaliQ6PGN9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati38 – 4114
Repeati68 – 7124
Repeati238 – 24134
Repeati243 – 24644

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni103 – 2464 X 4 AA repeats of P-X-X-PAdd BLAST144

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili70 – 94Sequence analysisAdd BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi238 – 361Pro/Ser-richAdd BLAST124

Sequence similaritiesi

Belongs to the PSRC1 family.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

GeneTreeiENSGT00510000048604
HOGENOMiHOG000231348
HOVERGENiHBG080237
InParanoidiQ6PGN9
KOiK21443
OMAiQCALQER
OrthoDBiEOG091G12JI
PhylomeDBiQ6PGN9
TreeFamiTF338374

Family and domain databases

InterProiView protein in InterPro
IPR026658 DDA3
IPR026657 DDA3/GTSE-1
IPR032768 GTSE1_N
PANTHERiPTHR21584 PTHR21584, 1 hit
PTHR21584:SF1 PTHR21584:SF1, 1 hit
PfamiView protein in Pfam
PF15259 GTSE1_N, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform C (identifier: Q6PGN9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEDLEEDVRF IVDETLDFGG LSPSDSREEE DITVLVTPEK PLRRGLSHRS
60 70 80 90 100
DPNAVAPAPQ GVRLSLGPLS PEKLEEILDE ANRLAAQLEQ CALQDRESAG
110 120 130 140 150
EGLGPRRVKP SPRRETFVLK DSPVRDLLPT VNSLTRSTPS PSSLTPRLRS
160 170 180 190 200
NDRKGSVRAL RATSGKRPSN MKRESPTCNL FPASKSPASS PLTRSTPPVR
210 220 230 240 250
GRAGPSGRAA ASEETRAAKL RVSGSGEFVG LTLKFLHPSP PGPPTPIRSV
260 270 280 290 300
LAPQPSTSNS QRLPRPQGAA AKSSSQLPIP SAIPRPASRM PLTSRSVPPG
310 320 330 340 350
RGALPPDSLS TRKGLPRPST AGHRVRESGH KVPVSQRLNL PVMGATRSNL
360
QPPRKVAVPG PTR
Length:363
Mass (Da):38,796
Last modified:July 5, 2004 - v1
Checksum:i4B59C01EB74F3B72
GO
Isoform A (identifier: Q6PGN9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     213-242: Missing.

Show »
Length:333
Mass (Da):35,632
Checksum:i75BC7DB6B0705E2E
GO
Isoform B (identifier: Q6PGN9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     222-310: VSGSGEFVGL...RGALPPDSLS → ACQPNATHQP...KRSGQQARLQ
     311-363: Missing.

Show »
Length:310
Mass (Da):33,638
Checksum:i79C03FBF5111CBBA
GO
Isoform D (identifier: Q6PGN9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-170: Missing.
     213-242: Missing.

Note: No experimental confirmation available.Combined sources
Show »
Length:163
Mass (Da):16,981
Checksum:i3B72DF56B3BC730E
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5T2Z1Q5T2Z1_HUMAN
Proline/serine-rich coiled-coil pro...
PSRC1
231Annotation score:
Q5T2Z0Q5T2Z0_HUMAN
Proline/serine-rich coiled-coil pro...
PSRC1
205Annotation score:
S4R3S8S4R3S8_HUMAN
Proline/serine-rich coiled-coil pro...
PSRC1
122Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_051288312R → Q. Corresponds to variant dbSNP:rs34863121Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0226021 – 170Missing in isoform D. 1 PublicationAdd BLAST170
Alternative sequenceiVSP_022591213 – 242Missing in isoform A and isoform D. 2 PublicationsAdd BLAST30
Alternative sequenceiVSP_022592222 – 310VSGSG…PDSLS → ACQPNATHQPECATWQRCPT SGFSVNSKRASKTKHCRTQS AGKWTQGSCFPATKSSCHGC HSQQSAAPQESGSPRTYQVK RSGQQARLQ in isoform B. 1 PublicationAdd BLAST89
Alternative sequenceiVSP_022593311 – 363Missing in isoform B. 1 PublicationAdd BLAST53

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF223000 mRNA Translation: AAN73431.1
AF322891 Genomic DNA Translation: AAN73434.1
AK126567 mRNA Translation: BAC86599.1
AF447874 mRNA Translation: AAQ04649.1
AL390252 Genomic DNA No translation available.
CH471122 Genomic DNA Translation: EAW56373.1
BC056909 mRNA Translation: AAH56909.1
CCDSiCCDS30791.1 [Q6PGN9-3]
CCDS797.1 [Q6PGN9-2]
RefSeqiNP_001005290.1, NM_001005290.3 [Q6PGN9-3]
NP_001027462.1, NM_001032291.2 [Q6PGN9-2]
NP_116025.1, NM_032636.7 [Q6PGN9-2]
XP_005271340.1, XM_005271283.2 [Q6PGN9-2]
XP_016858049.1, XM_017002560.1 [Q6PGN9-1]
XP_016858050.1, XM_017002561.1 [Q6PGN9-1]
XP_016858051.1, XM_017002562.1 [Q6PGN9-1]
XP_016858052.1, XM_017002563.1 [Q6PGN9-1]
XP_016858053.1, XM_017002564.1 [Q6PGN9-1]
XP_016858054.1, XM_017002565.1
XP_016858055.1, XM_017002566.1 [Q6PGN9-1]
XP_016858056.1, XM_017002567.1 [Q6PGN9-1]
XP_016858057.1, XM_017002568.1
XP_016858058.1, XM_017002569.1 [Q6PGN9-2]
XP_016858059.1, XM_017002570.1 [Q6PGN9-2]
XP_016858065.1, XM_017002576.1 [Q6PGN9-3]
XP_016858066.1, XM_017002577.1
UniGeneiHs.405925

Genome annotation databases

EnsembliENST00000369903; ENSP00000358919; ENSG00000134222 [Q6PGN9-2]
ENST00000369904; ENSP00000358920; ENSG00000134222 [Q6PGN9-3]
ENST00000369907; ENSP00000358923; ENSG00000134222 [Q6PGN9-2]
ENST00000369909; ENSP00000358925; ENSG00000134222 [Q6PGN9-2]
ENST00000409138; ENSP00000474667; ENSG00000134222 [Q6PGN9-1]
ENST00000409267; ENSP00000386323; ENSG00000134222 [Q6PGN9-2]
GeneIDi84722
KEGGihsa:84722
UCSCiuc001dxc.4 human [Q6PGN9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF223000 mRNA Translation: AAN73431.1
AF322891 Genomic DNA Translation: AAN73434.1
AK126567 mRNA Translation: BAC86599.1
AF447874 mRNA Translation: AAQ04649.1
AL390252 Genomic DNA No translation available.
CH471122 Genomic DNA Translation: EAW56373.1
BC056909 mRNA Translation: AAH56909.1
CCDSiCCDS30791.1 [Q6PGN9-3]
CCDS797.1 [Q6PGN9-2]
RefSeqiNP_001005290.1, NM_001005290.3 [Q6PGN9-3]
NP_001027462.1, NM_001032291.2 [Q6PGN9-2]
NP_116025.1, NM_032636.7 [Q6PGN9-2]
XP_005271340.1, XM_005271283.2 [Q6PGN9-2]
XP_016858049.1, XM_017002560.1 [Q6PGN9-1]
XP_016858050.1, XM_017002561.1 [Q6PGN9-1]
XP_016858051.1, XM_017002562.1 [Q6PGN9-1]
XP_016858052.1, XM_017002563.1 [Q6PGN9-1]
XP_016858053.1, XM_017002564.1 [Q6PGN9-1]
XP_016858054.1, XM_017002565.1
XP_016858055.1, XM_017002566.1 [Q6PGN9-1]
XP_016858056.1, XM_017002567.1 [Q6PGN9-1]
XP_016858057.1, XM_017002568.1
XP_016858058.1, XM_017002569.1 [Q6PGN9-2]
XP_016858059.1, XM_017002570.1 [Q6PGN9-2]
XP_016858065.1, XM_017002576.1 [Q6PGN9-3]
XP_016858066.1, XM_017002577.1
UniGeneiHs.405925

3D structure databases

ProteinModelPortaliQ6PGN9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124224, 22 interactors
ELMiQ6PGN9
IntActiQ6PGN9, 12 interactors
MINTiQ6PGN9

PTM databases

iPTMnetiQ6PGN9
PhosphoSitePlusiQ6PGN9

Polymorphism and mutation databases

BioMutaiPSRC1
DMDMi74737651

Proteomic databases

EPDiQ6PGN9
MaxQBiQ6PGN9
PeptideAtlasiQ6PGN9
PRIDEiQ6PGN9
ProteomicsDBi67114
67115 [Q6PGN9-2]
67116 [Q6PGN9-3]
67117 [Q6PGN9-4]

Protocols and materials databases

DNASUi84722
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000369903; ENSP00000358919; ENSG00000134222 [Q6PGN9-2]
ENST00000369904; ENSP00000358920; ENSG00000134222 [Q6PGN9-3]
ENST00000369907; ENSP00000358923; ENSG00000134222 [Q6PGN9-2]
ENST00000369909; ENSP00000358925; ENSG00000134222 [Q6PGN9-2]
ENST00000409138; ENSP00000474667; ENSG00000134222 [Q6PGN9-1]
ENST00000409267; ENSP00000386323; ENSG00000134222 [Q6PGN9-2]
GeneIDi84722
KEGGihsa:84722
UCSCiuc001dxc.4 human [Q6PGN9-1]

Organism-specific databases

CTDi84722
DisGeNETi84722
EuPathDBiHostDB:ENSG00000134222.16
GeneCardsiPSRC1
HGNCiHGNC:24472 PSRC1
HPAiHPA049315
HPA056561
MIMi613126 gene
neXtProtiNX_Q6PGN9
OpenTargetsiENSG00000134222
PharmGKBiPA142671120
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00510000048604
HOGENOMiHOG000231348
HOVERGENiHBG080237
InParanoidiQ6PGN9
KOiK21443
OMAiQCALQER
OrthoDBiEOG091G12JI
PhylomeDBiQ6PGN9
TreeFamiTF338374

Miscellaneous databases

ChiTaRSiPSRC1 human
GeneWikiiPSRC1
GenomeRNAii84722
PROiPR:Q6PGN9
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000134222 Expressed in 173 organ(s), highest expression level in C1 segment of cervical spinal cord
CleanExiHS_PSRC1
ExpressionAtlasiQ6PGN9 baseline and differential
GenevisibleiQ6PGN9 HS

Family and domain databases

InterProiView protein in InterPro
IPR026658 DDA3
IPR026657 DDA3/GTSE-1
IPR032768 GTSE1_N
PANTHERiPTHR21584 PTHR21584, 1 hit
PTHR21584:SF1 PTHR21584:SF1, 1 hit
PfamiView protein in Pfam
PF15259 GTSE1_N, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPSRC1_HUMAN
AccessioniPrimary (citable) accession number: Q6PGN9
Secondary accession number(s): Q5T2Z3
, Q6ZTI8, Q71MG3, Q9BV77
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: July 5, 2004
Last modified: November 7, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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