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Entry version 126 (26 Feb 2020)
Sequence version 1 (05 Jul 2004)
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Protein

Proline/serine-rich coiled-coil protein 1

Gene

PSRC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate, and for normal rate of chromosomal segregation during anaphase. Plays a role in the regulation of mitotic spindle dynamics. Increases the rate of turnover of microtubules on metaphase spindles, and contributes to the generation of normal tension across sister kinetochores. Recruits KIF2A and ANKRD53 to the mitotic spindle and spindle poles. May participate in p53/TP53-regulated growth suppression.3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • microtubule binding Source: BHF-UCL

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cell division, Mitosis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Proline/serine-rich coiled-coil protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PSRC1
Synonyms:DDA3
ORF Names:FP3214
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:24472 PSRC1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
613126 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6PGN9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
84722

Open Targets

More...
OpenTargetsi
ENSG00000134222

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142671120

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q6PGN9 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PSRC1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74737651

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002737281 – 363Proline/serine-rich coiled-coil protein 1Add BLAST363

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei22PhosphoserineCombined sources1
Modified residuei47PhosphoserineCombined sources1
Modified residuei65PhosphoserineCombined sources1
Modified residuei70PhosphoserineCombined sources1
Modified residuei98PhosphoserineCombined sources1
Modified residuei122PhosphoserineCombined sources1
Modified residuei140PhosphoserineCombined sources1
Modified residuei145PhosphothreonineCombined sources1
Modified residuei186PhosphoserineCombined sources1
Modified residuei190PhosphoserineCombined sources1
Isoform D (identifier: Q6PGN9-4)
Modified residuei42PhosphoserineCombined sources1
Modified residuei45PhosphothreonineCombined sources1
Isoform A (identifier: Q6PGN9-2)
Modified residuei212PhosphoserineCombined sources1
Modified residuei215PhosphothreonineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated during mitosis.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q6PGN9

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q6PGN9

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q6PGN9

MaxQB - The MaxQuant DataBase

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MaxQBi
Q6PGN9

PeptideAtlas

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PeptideAtlasi
Q6PGN9

PRoteomics IDEntifications database

More...
PRIDEi
Q6PGN9

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
67114 [Q6PGN9-1]
67115 [Q6PGN9-2]
67116 [Q6PGN9-3]
67117 [Q6PGN9-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6PGN9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q6PGN9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed in adult and fetal tissues, with highest expression in the adult brain and fetal thymus. Not detected in adult skeletal muscle.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000134222 Expressed in C1 segment of cervical spinal cord and 172 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q6PGN9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q6PGN9 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA049315
HPA056561

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with APC2 (By similarity).

Interacts with KIF2A (PubMed:18411309).

Interacts with ANKRD53; recruits ANKRD53 to the spindle during mitosis (PubMed:26820536).

By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
124224, 22 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

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ELMi
Q6PGN9

Protein interaction database and analysis system

More...
IntActi
Q6PGN9, 15 interactors

Molecular INTeraction database

More...
MINTi
Q6PGN9

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000358925

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6PGN9 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati38 – 4114
Repeati68 – 7124
Repeati238 – 24134
Repeati243 – 24644

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni103 – 2464 X 4 AA repeats of P-X-X-PAdd BLAST144

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili70 – 94Sequence analysisAdd BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi238 – 361Pro/Ser-richAdd BLAST124

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PSRC1 family.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154189

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_067830_0_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q6PGN9

KEGG Orthology (KO)

More...
KOi
K21443

Identification of Orthologs from Complete Genome Data

More...
OMAi
RPSSMKR

Database of Orthologous Groups

More...
OrthoDBi
1567239at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6PGN9

TreeFam database of animal gene trees

More...
TreeFami
TF338374

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026658 DDA3
IPR026657 DDA3/GTSE-1
IPR032768 GTSE1_N

The PANTHER Classification System

More...
PANTHERi
PTHR21584 PTHR21584, 1 hit
PTHR21584:SF1 PTHR21584:SF1, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15259 GTSE1_N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform C (identifier: Q6PGN9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEDLEEDVRF IVDETLDFGG LSPSDSREEE DITVLVTPEK PLRRGLSHRS
60 70 80 90 100
DPNAVAPAPQ GVRLSLGPLS PEKLEEILDE ANRLAAQLEQ CALQDRESAG
110 120 130 140 150
EGLGPRRVKP SPRRETFVLK DSPVRDLLPT VNSLTRSTPS PSSLTPRLRS
160 170 180 190 200
NDRKGSVRAL RATSGKRPSN MKRESPTCNL FPASKSPASS PLTRSTPPVR
210 220 230 240 250
GRAGPSGRAA ASEETRAAKL RVSGSGEFVG LTLKFLHPSP PGPPTPIRSV
260 270 280 290 300
LAPQPSTSNS QRLPRPQGAA AKSSSQLPIP SAIPRPASRM PLTSRSVPPG
310 320 330 340 350
RGALPPDSLS TRKGLPRPST AGHRVRESGH KVPVSQRLNL PVMGATRSNL
360
QPPRKVAVPG PTR
Length:363
Mass (Da):38,796
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4B59C01EB74F3B72
GO
Isoform A (identifier: Q6PGN9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     213-242: Missing.

Show »
Length:333
Mass (Da):35,632
Checksum:i75BC7DB6B0705E2E
GO
Isoform B (identifier: Q6PGN9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     222-310: VSGSGEFVGL...RGALPPDSLS → ACQPNATHQP...KRSGQQARLQ
     311-363: Missing.

Show »
Length:310
Mass (Da):33,638
Checksum:i79C03FBF5111CBBA
GO
Isoform D (identifier: Q6PGN9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-170: Missing.
     213-242: Missing.

Show »
Length:163
Mass (Da):16,981
Checksum:i3B72DF56B3BC730E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5T2Z0Q5T2Z0_HUMAN
Proline/serine-rich coiled-coil pro...
PSRC1
205Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5T2Z1Q5T2Z1_HUMAN
Proline/serine-rich coiled-coil pro...
PSRC1
231Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R3S8S4R3S8_HUMAN
Proline/serine-rich coiled-coil pro...
PSRC1
122Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_051288312R → Q. Corresponds to variant dbSNP:rs34863121Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0226021 – 170Missing in isoform D. 1 PublicationAdd BLAST170
Alternative sequenceiVSP_022591213 – 242Missing in isoform A and isoform D. 2 PublicationsAdd BLAST30
Alternative sequenceiVSP_022592222 – 310VSGSG…PDSLS → ACQPNATHQPECATWQRCPT SGFSVNSKRASKTKHCRTQS AGKWTQGSCFPATKSSCHGC HSQQSAAPQESGSPRTYQVK RSGQQARLQ in isoform B. 1 PublicationAdd BLAST89
Alternative sequenceiVSP_022593311 – 363Missing in isoform B. 1 PublicationAdd BLAST53

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF223000 mRNA Translation: AAN73431.1
AF322891 Genomic DNA Translation: AAN73434.1
AK126567 mRNA Translation: BAC86599.1
AF447874 mRNA Translation: AAQ04649.1
AL390252 Genomic DNA No translation available.
CH471122 Genomic DNA Translation: EAW56373.1
BC056909 mRNA Translation: AAH56909.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS30791.1 [Q6PGN9-3]
CCDS797.1 [Q6PGN9-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001005290.1, NM_001005290.3 [Q6PGN9-3]
NP_001027462.1, NM_001032291.2 [Q6PGN9-2]
NP_116025.1, NM_032636.7 [Q6PGN9-2]
XP_005271340.1, XM_005271283.2 [Q6PGN9-2]
XP_016858049.1, XM_017002560.1 [Q6PGN9-1]
XP_016858050.1, XM_017002561.1 [Q6PGN9-1]
XP_016858051.1, XM_017002562.1 [Q6PGN9-1]
XP_016858052.1, XM_017002563.1 [Q6PGN9-1]
XP_016858053.1, XM_017002564.1 [Q6PGN9-1]
XP_016858054.1, XM_017002565.1
XP_016858055.1, XM_017002566.1 [Q6PGN9-1]
XP_016858056.1, XM_017002567.1 [Q6PGN9-1]
XP_016858057.1, XM_017002568.1
XP_016858058.1, XM_017002569.1 [Q6PGN9-2]
XP_016858059.1, XM_017002570.1 [Q6PGN9-2]
XP_016858065.1, XM_017002576.1 [Q6PGN9-3]
XP_016858066.1, XM_017002577.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000369904; ENSP00000358920; ENSG00000134222 [Q6PGN9-3]
ENST00000369907; ENSP00000358923; ENSG00000134222 [Q6PGN9-2]
ENST00000369909; ENSP00000358925; ENSG00000134222 [Q6PGN9-2]
ENST00000369903; ENSP00000358919; ENSG00000134222 [Q6PGN9-2]
ENST00000409138; ENSP00000474667; ENSG00000134222 [Q6PGN9-1]
ENST00000409267; ENSP00000386323; ENSG00000134222 [Q6PGN9-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
84722

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:84722

UCSC genome browser

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UCSCi
uc001dxc.4 human [Q6PGN9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF223000 mRNA Translation: AAN73431.1
AF322891 Genomic DNA Translation: AAN73434.1
AK126567 mRNA Translation: BAC86599.1
AF447874 mRNA Translation: AAQ04649.1
AL390252 Genomic DNA No translation available.
CH471122 Genomic DNA Translation: EAW56373.1
BC056909 mRNA Translation: AAH56909.1
CCDSiCCDS30791.1 [Q6PGN9-3]
CCDS797.1 [Q6PGN9-2]
RefSeqiNP_001005290.1, NM_001005290.3 [Q6PGN9-3]
NP_001027462.1, NM_001032291.2 [Q6PGN9-2]
NP_116025.1, NM_032636.7 [Q6PGN9-2]
XP_005271340.1, XM_005271283.2 [Q6PGN9-2]
XP_016858049.1, XM_017002560.1 [Q6PGN9-1]
XP_016858050.1, XM_017002561.1 [Q6PGN9-1]
XP_016858051.1, XM_017002562.1 [Q6PGN9-1]
XP_016858052.1, XM_017002563.1 [Q6PGN9-1]
XP_016858053.1, XM_017002564.1 [Q6PGN9-1]
XP_016858054.1, XM_017002565.1
XP_016858055.1, XM_017002566.1 [Q6PGN9-1]
XP_016858056.1, XM_017002567.1 [Q6PGN9-1]
XP_016858057.1, XM_017002568.1
XP_016858058.1, XM_017002569.1 [Q6PGN9-2]
XP_016858059.1, XM_017002570.1 [Q6PGN9-2]
XP_016858065.1, XM_017002576.1 [Q6PGN9-3]
XP_016858066.1, XM_017002577.1

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi124224, 22 interactors
ELMiQ6PGN9
IntActiQ6PGN9, 15 interactors
MINTiQ6PGN9
STRINGi9606.ENSP00000358925

PTM databases

iPTMnetiQ6PGN9
PhosphoSitePlusiQ6PGN9

Polymorphism and mutation databases

BioMutaiPSRC1
DMDMi74737651

Proteomic databases

EPDiQ6PGN9
jPOSTiQ6PGN9
MassIVEiQ6PGN9
MaxQBiQ6PGN9
PeptideAtlasiQ6PGN9
PRIDEiQ6PGN9
ProteomicsDBi67114 [Q6PGN9-1]
67115 [Q6PGN9-2]
67116 [Q6PGN9-3]
67117 [Q6PGN9-4]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
84722

Genome annotation databases

EnsembliENST00000369904; ENSP00000358920; ENSG00000134222 [Q6PGN9-3]
ENST00000369907; ENSP00000358923; ENSG00000134222 [Q6PGN9-2]
ENST00000369909; ENSP00000358925; ENSG00000134222 [Q6PGN9-2]
ENST00000369903; ENSP00000358919; ENSG00000134222 [Q6PGN9-2]
ENST00000409138; ENSP00000474667; ENSG00000134222 [Q6PGN9-1]
ENST00000409267; ENSP00000386323; ENSG00000134222 [Q6PGN9-2]
GeneIDi84722
KEGGihsa:84722
UCSCiuc001dxc.4 human [Q6PGN9-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
84722
DisGeNETi84722

GeneCards: human genes, protein and diseases

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GeneCardsi
PSRC1
HGNCiHGNC:24472 PSRC1
HPAiHPA049315
HPA056561
MIMi613126 gene
neXtProtiNX_Q6PGN9
OpenTargetsiENSG00000134222
PharmGKBiPA142671120

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

GeneTreeiENSGT00940000154189
HOGENOMiCLU_067830_0_0_1
InParanoidiQ6PGN9
KOiK21443
OMAiRPSSMKR
OrthoDBi1567239at2759
PhylomeDBiQ6PGN9
TreeFamiTF338374

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
PSRC1 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
PSRC1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
84722
PharosiQ6PGN9 Tbio

Protein Ontology

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PROi
PR:Q6PGN9
RNActiQ6PGN9 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000134222 Expressed in C1 segment of cervical spinal cord and 172 other tissues
ExpressionAtlasiQ6PGN9 baseline and differential
GenevisibleiQ6PGN9 HS

Family and domain databases

InterProiView protein in InterPro
IPR026658 DDA3
IPR026657 DDA3/GTSE-1
IPR032768 GTSE1_N
PANTHERiPTHR21584 PTHR21584, 1 hit
PTHR21584:SF1 PTHR21584:SF1, 1 hit
PfamiView protein in Pfam
PF15259 GTSE1_N, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPSRC1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6PGN9
Secondary accession number(s): Q5T2Z3
, Q6ZTI8, Q71MG3, Q9BV77
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: July 5, 2004
Last modified: February 26, 2020
This is version 126 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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