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Protein

Protein BUD31 homolog

Gene

Bud31

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the pre-mRNA splicing process. May play a role as regulator of AR transcriptional activity; may increase AR transcriptional activity.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

ReactomeiR-MMU-72163 mRNA Splicing - Major Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Protein BUD31 homolog
Alternative name(s):
Protein G10 homolog
Gene namesi
Name:Bud31
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:2141291 Bud31

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002236271 – 144Protein BUD31 homologAdd BLAST144

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei125N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ6PGH1
MaxQBiQ6PGH1
PaxDbiQ6PGH1
PeptideAtlasiQ6PGH1
PRIDEiQ6PGH1

PTM databases

iPTMnetiQ6PGH1
PhosphoSitePlusiQ6PGH1

Expressioni

Gene expression databases

BgeeiENSMUSG00000038722
CleanExiMM_BUD31
ExpressionAtlasiQ6PGH1 baseline and differential
GenevisibleiQ6PGH1 MM

Interactioni

Subunit structurei

Identified in the spliceosome C complex. May interact with AR.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ6PGH1, 1 interactor
MINTiQ6PGH1
STRINGi10090.ENSMUSP00000125590

Structurei

3D structure databases

ProteinModelPortaliQ6PGH1
SMRiQ6PGH1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni59 – 67Interaction with ARBy similarity9

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi2 – 10Nuclear localization signalSequence analysis9

Domaini

Contains a short sequence motif (Phe-Xaa-Xaa-Phe-Tyr) that can bind to AR and may modulate AR activity.By similarity

Sequence similaritiesi

Belongs to the BUD31 (G10) family.Curated

Phylogenomic databases

eggNOGiKOG3404 Eukaryota
COG5132 LUCA
GeneTreeiENSGT00390000014300
HOGENOMiHOG000235066
HOVERGENiHBG080938
InParanoidiQ6PGH1
KOiK12873
OMAiCRGCSSD
OrthoDBiEOG091G0PEI
PhylomeDBiQ6PGH1
TreeFamiTF105609

Family and domain databases

InterProiView protein in InterPro
IPR018230 BUD31/G10-rel_CS
IPR001748 G10
PANTHERiPTHR19411 PTHR19411, 1 hit
PfamiView protein in Pfam
PF01125 G10, 1 hit
PRINTSiPR00322 G10
PROSITEiView protein in PROSITE
PS00997 G10_1, 1 hit
PS00998 G10_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6PGH1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPKVKRSRKA PPDGWELIEP TLDELDQKMR EAETEPHEGK RKVESLWPIF
60 70 80 90 100
RIHHQKTRYI FDLFYKRKAI SRELYEYCIK EGYADKNLIA KWKKQGYENL
110 120 130 140
CCLRCIQTRD TNFGTNCICR VPKSKLEVGR IIECTHCGCR GCSG
Length:144
Mass (Da):17,000
Last modified:March 28, 2018 - v2
Checksum:i520B8E74C97D0926
GO
Isoform 2 (identifier: Q6PGH1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     32-72: Missing.

Show »
Length:103
Mass (Da):11,905
Checksum:i4A18F875B134EB03
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05935132 – 72Missing in isoform 2. Add BLAST41

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC127411 Genomic DNA No translation available.
BC057025 mRNA Translation: AAH57025.1
CCDSiCCDS19857.1 [Q6PGH1-2]
CCDS80463.1 [Q6PGH1-1]
RefSeqiNP_001008705.1, NM_001008705.2 [Q6PGH1-2]
NP_001297699.1, NM_001310770.1 [Q6PGH1-1]
NP_001297700.1, NM_001310771.1 [Q6PGH1-1]
UniGeneiMm.277413
Mm.474456

Genome annotation databases

EnsembliENSMUST00000159018; ENSMUSP00000124999; ENSMUSG00000038722 [Q6PGH1-1]
ENSMUST00000160075; ENSMUSP00000125564; ENSMUSG00000038722 [Q6PGH1-1]
ENSMUST00000162308; ENSMUSP00000125590; ENSMUSG00000038722 [Q6PGH1-2]
ENSMUST00000162594; ENSMUSP00000125738; ENSMUSG00000038722 [Q6PGH1-1]
GeneIDi231889
KEGGimmu:231889
UCSCiuc009amg.1 mouse [Q6PGH1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiBUD31_MOUSE
AccessioniPrimary (citable) accession number: Q6PGH1
Secondary accession number(s): E0CX20
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: March 28, 2018
Last modified: May 23, 2018
This is version 95 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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