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Entry version 135 (02 Jun 2021)
Sequence version 1 (05 Jul 2004)
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Protein

Exocyst complex component 8

Gene

Exoc8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processExocytosis, Protein transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-264876, Insulin processing
R-MMU-5620916, VxPx cargo-targeting to cilium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Exocyst complex component 8
Alternative name(s):
Exocyst complex 84 kDa subunit
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Exoc8
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2142527, Exoc8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell projection, Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002275511 – 716Exocyst complex component 8Add BLAST716

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei15PhosphoserineBy similarity1
Modified residuei313PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q6PGF7

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6PGF7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6PGF7

PeptideAtlas

More...
PeptideAtlasi
Q6PGF7

PRoteomics IDEntifications database

More...
PRIDEi
Q6PGF7

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
275557

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6PGF7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6PGF7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000074030, Expressed in pineal body and 285 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6PGF7, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8 (By similarity).

Interacts (via PH domain) with GTP-bound RALA and RALB (By similarity).

Interacts with SH3BP1; required for the localization of both SH3BP1 and the exocyst to the leading edge of migrating cells (By similarity).

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
221786, 11 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-4982, Exocyst, Exoc6 variant
CPX-4983, Exocyst, Exoc6b variant

Protein interaction database and analysis system

More...
IntActi
Q6PGF7, 3 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000095915

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6PGF7, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6PGF7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini173 – 273PHPROSITE-ProRule annotationAdd BLAST101

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni129 – 150DisorderedSequence analysisAdd BLAST22
Regioni275 – 319DisorderedSequence analysisAdd BLAST45

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the EXO84 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2215, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000015936

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_025760_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6PGF7

Identification of Orthologs from Complete Genome Data

More...
OMAi
FKILMFP

Database of Orthologous Groups

More...
OrthoDBi
1357584at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6PGF7

TreeFam database of animal gene trees

More...
TreeFami
TF105819

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.58.1210, 1 hit
1.20.58.1220, 1 hit
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016159, Cullin_repeat-like_dom_sf
IPR033961, Exo84
IPR032403, Exo84_C
IPR042561, Exo84_C_1
IPR042560, Exo84_C_2
IPR011993, PH-like_dom_sf
IPR001849, PH_domain

The PANTHER Classification System

More...
PANTHERi
PTHR21426, PTHR21426, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16528, Exo84_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00233, PH, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF74788, SSF74788, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50003, PH_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6PGF7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSDSGASRLR RQLESGGFEA RLYVKQLSQQ SDGDRDLQEH RQRVQALAEE
60 70 80 90 100
TAQNLKRNVY QNYRQFIETA REISYLESEM YQLSHLLTEQ KSSLESIPLA
110 120 130 140 150
LLPAAAAGAS AGEDTAGAGP RERGAVQAGF LPGPAGVPRE GSGTGEEGKQ
160 170 180 190 200
RTLTTLLEKV EGCRDLLETP GQYLVYNGDL VEYDADHMAQ LQRVHGFLMN
210 220 230 240 250
DCLLVATWLP QRRGMYRYNA LYPLDRLAVV NVKDNPPMKD MFKLLMFPES
260 270 280 290 300
RIFQAENAKI KREWLEVLEE TKRALSDKRR REQEEAAAPR APPPVTSKGS
310 320 330 340 350
NPFEDEDDEE LATPEAEEEK VDLSMEWIQE LPEDLDVCIA QRDFEGAVDL
360 370 380 390 400
LDKLNHYLED KPSPPPVKEL RAKVDERVRQ LTEVLVFELS PDRSLRGGPK
410 420 430 440 450
ATRRAVSQLI RLGQCTKACE LFLRNRAAAV HTAIRQLRIE GATLLYIHKL
460 470 480 490 500
CHVFFTSLLE TAREFETDFA GTDSGCYSAF VVWARSAMGM FVDAFSKQVF
510 520 530 540 550
DSKESLSTAA ECVKVAKEHC QQLGEIGLDL TFIIHALLVK DIQGALHSYK
560 570 580 590 600
EIIIEATKHR NSEEMWRRMN LMTPEALGKL KEEMKSCGVS NFEQYTGDDC
610 620 630 640 650
WVNLSYTVVA FTKQTMGFLE EALKLYFPEL HMVLLESLVE IILVAVQHVD
660 670 680 690 700
YSLRCEQDPE KKAFIRQNAS FLYETVLPVV ERRFEEGVGK PAKQLQDLRN
710
ASRLLRVNPE STTSVV
Length:716
Mass (Da):81,035
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE512707F1DEF36E1
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC057052 mRNA Translation: AAH57052.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS22777.1

NCBI Reference Sequences

More...
RefSeqi
NP_932771.1, NM_198103.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000098312; ENSMUSP00000095915; ENSMUSG00000074030

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
102058

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:102058

UCSC genome browser

More...
UCSCi
uc009nxw.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC057052 mRNA Translation: AAH57052.1
CCDSiCCDS22777.1
RefSeqiNP_932771.1, NM_198103.2

3D structure databases

SMRiQ6PGF7
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi221786, 11 interactors
ComplexPortaliCPX-4982, Exocyst, Exoc6 variant
CPX-4983, Exocyst, Exoc6b variant
IntActiQ6PGF7, 3 interactors
STRINGi10090.ENSMUSP00000095915

PTM databases

iPTMnetiQ6PGF7
PhosphoSitePlusiQ6PGF7

Proteomic databases

EPDiQ6PGF7
MaxQBiQ6PGF7
PaxDbiQ6PGF7
PeptideAtlasiQ6PGF7
PRIDEiQ6PGF7
ProteomicsDBi275557

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
20797, 89 antibodies

The DNASU plasmid repository

More...
DNASUi
102058

Genome annotation databases

EnsembliENSMUST00000098312; ENSMUSP00000095915; ENSMUSG00000074030
GeneIDi102058
KEGGimmu:102058
UCSCiuc009nxw.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
149371
MGIiMGI:2142527, Exoc8

Phylogenomic databases

eggNOGiKOG2215, Eukaryota
GeneTreeiENSGT00390000015936
HOGENOMiCLU_025760_0_0_1
InParanoidiQ6PGF7
OMAiFKILMFP
OrthoDBi1357584at2759
PhylomeDBiQ6PGF7
TreeFamiTF105819

Enzyme and pathway databases

ReactomeiR-MMU-264876, Insulin processing
R-MMU-5620916, VxPx cargo-targeting to cilium

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
102058, 11 hits in 53 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Exoc8, mouse

Protein Ontology

More...
PROi
PR:Q6PGF7
RNActiQ6PGF7, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000074030, Expressed in pineal body and 285 other tissues
GenevisibleiQ6PGF7, MM

Family and domain databases

Gene3Di1.20.58.1210, 1 hit
1.20.58.1220, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR016159, Cullin_repeat-like_dom_sf
IPR033961, Exo84
IPR032403, Exo84_C
IPR042561, Exo84_C_1
IPR042560, Exo84_C_2
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
PANTHERiPTHR21426, PTHR21426, 1 hit
PfamiView protein in Pfam
PF16528, Exo84_C, 1 hit
SMARTiView protein in SMART
SM00233, PH, 1 hit
SUPFAMiSSF74788, SSF74788, 1 hit
PROSITEiView protein in PROSITE
PS50003, PH_DOMAIN, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiEXOC8_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6PGF7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: July 5, 2004
Last modified: June 2, 2021
This is version 135 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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