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Protein

All-trans retinoic acid-induced differentiation factor

Gene

Atraid

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Promotes osteoblast cell differentiation and terminal mineralization. Plays a role in inducing the cell cycle arrest via inhibiting CCND1 expression in all-trans-retinoic acid (ATRA) signal pathway (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processDifferentiation

Names & Taxonomyi

Protein namesi
Recommended name:
All-trans retinoic acid-induced differentiation factor
Alternative name(s):
Apoptosis-related protein 3
Short name:
APR-3
Gene namesi
Name:Atraid
Synonyms:Apr3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1918918 Atraid

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 193ExtracellularSequence analysisAdd BLAST168
Transmembranei194 – 214HelicalSequence analysisAdd BLAST21
Topological domaini215 – 223CytoplasmicSequence analysis9

Keywords - Cellular componenti

Cell membrane, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25By similarityAdd BLAST25
ChainiPRO_000002075326 – 223All-trans retinoic acid-induced differentiation factorAdd BLAST198

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi150 ↔ 165PROSITE-ProRule annotation
Disulfide bondi159 ↔ 175PROSITE-ProRule annotation
Disulfide bondi177 ↔ 186PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ6PGD0
PRIDEiQ6PGD0

PTM databases

iPTMnetiQ6PGD0
PhosphoSitePlusiQ6PGD0

Expressioni

Gene expression databases

BgeeiENSMUSG00000013622 Expressed in 286 organ(s), highest expression level in pituitary gland
CleanExiMM_0610007C21RIK
ExpressionAtlasiQ6PGD0 baseline and differential
GenevisibleiQ6PGD0 MM

Interactioni

Subunit structurei

Interacts with NELL1; the interaction promotes osteoblastic differentiation and mineralization.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000013766

Structurei

3D structure databases

ProteinModelPortaliQ6PGD0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini146 – 187EGF-likePROSITE-ProRule annotationAdd BLAST42

Keywords - Domaini

EGF-like domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IYNU Eukaryota
ENOG4111PJW LUCA
GeneTreeiENSGT00390000017252
HOGENOMiHOG000010110
HOVERGENiHBG054041
InParanoidiQ6PGD0
OMAiPGGINAW
OrthoDBiEOG091G0PFL
PhylomeDBiQ6PGD0
TreeFamiTF335766

Family and domain databases

InterProiView protein in InterPro
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
PROSITEiView protein in PROSITE
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6PGD0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASRESGGSR AAALLLVLGV ERALALPEIC TLCPGGMHNL SRVAAYCEDT
60 70 80 90 100
SKLMQARCCL NQKGTILGLD LQNCSLKDPG PNFLQAYTAI IIDLQANPLK
110 120 130 140 150
DDLANTFRGF TQLQTLILPQ DVPCPGGSNA WDNVTSFKDK QICQGQRDLC
160 170 180 190 200
NSTGSPEMCP ENGSCASDGP GLLQCVCADG FHGYKCMRQG SFSLLMFFGI
210 220
LGSTTLAISI LLWGTQRRKA KAS
Length:223
Mass (Da):23,858
Last modified:October 11, 2004 - v2
Checksum:i1CB921F5F6D3E595
GO
Isoform 2 (identifier: Q6PGD0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     37-223: Missing.

Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:36
Mass (Da):3,583
Checksum:i12001B7098C55C61
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z6U7D3Z6U7_MOUSE
All-trans retinoic acid-induced dif...
Atraid
170Annotation score:
F6RYG0F6RYG0_MOUSE
All-trans retinoic acid-induced dif...
Atraid
183Annotation score:
G3UXG8G3UXG8_MOUSE
All-trans retinoic acid-induced dif...
Atraid
143Annotation score:
D3YYN2D3YYN2_MOUSE
All-trans retinoic acid-induced dif...
Atraid
65Annotation score:

Sequence cautioni

The sequence AAH49637 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti23A → S in BAB21981 (PubMed:16141072).Curated1
Sequence conflicti28E → K in BAB21981 (PubMed:16141072).Curated1
Sequence conflicti65T → P in BAB21981 (PubMed:16141072).Curated1
Sequence conflicti70D → N in BAB21981 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03997037 – 223Missing in isoform 2. 1 PublicationAdd BLAST187

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002276 mRNA Translation: BAB21981.1
AK151307 mRNA Translation: BAE30289.1
AK151366 mRNA Translation: BAE30340.1
AK169267 mRNA Translation: BAE41028.1
BC049637 mRNA Translation: AAH49637.1 Sequence problems.
BC057097 mRNA Translation: AAH57097.2
CCDSiCCDS19170.1 [Q6PGD0-1]
RefSeqiNP_082131.2, NM_027855.4 [Q6PGD0-1]
NP_997635.1, NM_212470.3
UniGeneiMm.28144

Genome annotation databases

EnsembliENSMUST00000013766; ENSMUSP00000013766; ENSMUSG00000013622 [Q6PGD0-1]
ENSMUST00000200942; ENSMUSP00000144431; ENSMUSG00000013622 [Q6PGD0-2]
GeneIDi381629
KEGGimmu:381629
UCSCiuc008www.3 mouse [Q6PGD0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002276 mRNA Translation: BAB21981.1
AK151307 mRNA Translation: BAE30289.1
AK151366 mRNA Translation: BAE30340.1
AK169267 mRNA Translation: BAE41028.1
BC049637 mRNA Translation: AAH49637.1 Sequence problems.
BC057097 mRNA Translation: AAH57097.2
CCDSiCCDS19170.1 [Q6PGD0-1]
RefSeqiNP_082131.2, NM_027855.4 [Q6PGD0-1]
NP_997635.1, NM_212470.3
UniGeneiMm.28144

3D structure databases

ProteinModelPortaliQ6PGD0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000013766

PTM databases

iPTMnetiQ6PGD0
PhosphoSitePlusiQ6PGD0

Proteomic databases

PaxDbiQ6PGD0
PRIDEiQ6PGD0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000013766; ENSMUSP00000013766; ENSMUSG00000013622 [Q6PGD0-1]
ENSMUST00000200942; ENSMUSP00000144431; ENSMUSG00000013622 [Q6PGD0-2]
GeneIDi381629
KEGGimmu:381629
UCSCiuc008www.3 mouse [Q6PGD0-1]

Organism-specific databases

CTDi51374
MGIiMGI:1918918 Atraid

Phylogenomic databases

eggNOGiENOG410IYNU Eukaryota
ENOG4111PJW LUCA
GeneTreeiENSGT00390000017252
HOGENOMiHOG000010110
HOVERGENiHBG054041
InParanoidiQ6PGD0
OMAiPGGINAW
OrthoDBiEOG091G0PFL
PhylomeDBiQ6PGD0
TreeFamiTF335766

Miscellaneous databases

PROiPR:Q6PGD0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000013622 Expressed in 286 organ(s), highest expression level in pituitary gland
CleanExiMM_0610007C21RIK
ExpressionAtlasiQ6PGD0 baseline and differential
GenevisibleiQ6PGD0 MM

Family and domain databases

InterProiView protein in InterPro
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
PROSITEiView protein in PROSITE
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiARAID_MOUSE
AccessioniPrimary (citable) accession number: Q6PGD0
Secondary accession number(s): Q3UAH4, Q810Q3, Q9DD14
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: October 11, 2004
Last modified: November 7, 2018
This is version 113 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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