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Entry version 162 (29 Sep 2021)
Sequence version 1 (05 Jul 2004)
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Protein

Probable global transcription activator SNF2L1

Gene

Smarca1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Helicase that possesses intrinsic ATP-dependent chromatin-remodeling activity (By similarity).

ATPase activity is substrate-dependent, and is increased when nucleosomes are the substrate, but is also catalytically active when DNA alone is the substrate (By similarity).

Catalytic subunit of ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (By similarity).

Within the ISWI chromatin-remodeling complexes, slides edge- and center-positioned histone octamers away from their original location on the DNA template (By similarity).

Catalytic activity and histone octamer sliding propensity is regulated and determined by components of the ISWI chromatin-remodeling complexes (By similarity).

The BAZ1A-, BAZ1B-, BAZ2A- and BAZ2B-containing ISWI chromatin-remodeling complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (By similarity).

The CECR2- and RSF1-containing ISWI chromatin-remodeling complexes do not have the ability to slide mononucleosomes to the center of a DNA template (By similarity).

Within the NURF-1 and CERF-1 ISWI chromatin remodeling complexes, nucleosomes are the preferred substrate for its ATPase activity (By similarity).

Within the NURF-1 ISWI chromatin-remodeling complex, binds to the promoters of En1 and En2 to positively regulate their expression and promote brain development (By similarity).

May promote neurite outgrowth (By similarity).

May be involved in the development of luteal cells (By similarity).

By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi212 – 219ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Chromatin regulator, DNA-binding, Helicase, Hydrolase
Biological processTranscription, Transcription regulation
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.7.11.17, 3474

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable global transcription activator SNF2L1 (EC:3.6.4.-By similarity)
Alternative name(s):
ATP-dependent helicase SMARCA1
DNA-dependent ATPase SNF2L
Nucleosome-remodeling factor subunit SNF2L
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Smarca1
Synonyms:Snf2l
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1935127, Smarca1

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSMUSG00000031099

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002492461 – 1046Probable global transcription activator SNF2L1Add BLAST1046

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei120PhosphoserineBy similarity1
Modified residuei123PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki654Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki720Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki742Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei946PhosphotyrosineBy similarity1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q6PGB8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6PGB8

PRoteomics IDEntifications database

More...
PRIDEi
Q6PGB8

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
261430 [Q6PGB8-1]
261431 [Q6PGB8-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6PGB8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6PGB8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Predominantly expressed in cortex, cerebellum, ovaries, testes, uterus and placenta.2 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed throughout the embryo at 9.5 dpc-15.5 dpc. Brain expression increases during the first two weeks of postnatal development.1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By ovulation in ovaries (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000031099, Expressed in adrenal gland and 255 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6PGB8, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6PGB8, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

May form homodimers (By similarity).

Component of the ACF-1 ISWI chromatin remodeling complex at least composed of SMARCA1 and BAZ1A, which regulates the spacing of histone octamers on the DNA template to facilitate access to DNA (By similarity). Within the complex interacts with BAZ1A; the interaction is direct (By similarity).

Component of the WICH-1 ISWI chromatin remodeling complex at least composed of SMARCA1 and BAZ1B/WSTF (By similarity). Within the complex interacts with BAZ1B/WSTF (By similarity).

Component of the NoRC-1 ISWI chromatin remodeling complex at least composed of SMARCA1 and BAZ2A/TIP5 (By similarity). Within the complex interacts with BAZ2A/TIP5 (By similarity).

Component of the BRF-1 ISWI chromatin remodeling complex at least composed of SMARCA1 and BAZ2B (By similarity). Within the complex interacts with BAZ2B (By similarity).

Component of the NURF-1 ISWI chromatin remodeling complex (also called the nucleosome-remodeling factor (NURF) complex) at least composed of SMARCA1, BPTF, RBBP4 and RBBP7 (By similarity). Within the complex interacts with BPTF (By similarity). Within the complex interacts with RBBP4 and RBBP7 (By similarity).

Component of the CERF-1 ISWI chromatin remodeling complex (also called the CECR2-containing-remodeling factor (CERF) complex) at least composed of CECR2 and SMARCA1 (By similarity). Within the complex interacts with CECR2 (By similarity).

Component of the RSF-1 ISWI chromatin remodeling complex at least composed of SMARCA1 and RSF1 (By similarity). Within the complex interacts with RSF1 (By similarity).

Interacts with PRLR (By similarity).

Interacts with ERCC6 (By similarity).

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
220299, 6 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-454, CERF chromatin remodelling complex
CPX-694, NuRF chromatin remodeling complex

Protein interaction database and analysis system

More...
IntActi
Q6PGB8, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000086366

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6PGB8, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6PGB8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini199 – 364Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST166
Domaini494 – 645Helicase C-terminalPROSITE-ProRule annotationAdd BLAST152
Domaini847 – 899SANT 1PROSITE-ProRule annotationAdd BLAST53
Domaini950 – 1014SANT 2PROSITE-ProRule annotationAdd BLAST65

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni27 – 61DisorderedSequence analysisAdd BLAST35
Regioni819 – 840DisorderedSequence analysisAdd BLAST22
Regioni1025 – 1046DisorderedSequence analysisAdd BLAST22

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1003 – 1037Sequence analysisAdd BLAST35

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi315 – 318DEAH box4

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0385, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157297

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6PGB8

Identification of Orthologs from Complete Genome Data

More...
OMAi
IFGKKHD

Database of Orthologous Groups

More...
OrthoDBi
61251at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6PGB8

TreeFam database of animal gene trees

More...
TreeFami
TF300674

Family and domain databases

Conserved Domains Database

More...
CDDi
cd18065, DEXHc_SMARCA1, 1 hit
cd00167, SANT, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1040.30, 1 hit
3.40.50.10810, 1 hit
3.40.50.300, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR020838, DBINO
IPR014001, Helicase_ATP-bd
IPR001650, Helicase_C
IPR009057, Homeobox-like_sf
IPR015194, ISWI_HAND-dom
IPR036306, ISWI_HAND-dom_sf
IPR027417, P-loop_NTPase
IPR001005, SANT/Myb
IPR017884, SANT_dom
IPR015195, SLIDE
IPR044755, SMARCA1_N
IPR038718, SNF2-like_sf
IPR000330, SNF2_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13892, DBINO, 1 hit
PF09110, HAND, 1 hit
PF00271, Helicase_C, 1 hit
PF09111, SLIDE, 1 hit
PF00176, SNF2_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00487, DEXDc, 1 hit
SM00490, HELICc, 1 hit
SM00717, SANT, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF101224, SSF101224, 1 hit
SSF46689, SSF46689, 2 hits
SSF52540, SSF52540, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51192, HELICASE_ATP_BIND_1, 1 hit
PS51194, HELICASE_CTER, 1 hit
PS51293, SANT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6PGB8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEPDTATEAA TVAVSDARAT VVVVEDEQPG PSTFKEEGAA AAATEGTTAT
60 70 80 90 100
EKGEKKEKIT SPFQLKLAAK ASKSEKEMDP EYEEKMVNMP LKADRAKRFE
110 120 130 140 150
FLLKQTELFA HFIQPSAQKS PTSPLNMKLA RPRVKKDDKQ SLISVGDYRH
160 170 180 190 200
RRTEQEEDEE LLSESRKTSN VCVRFEVSPS YVKGGPLRDY QIRGLNWLIS
210 220 230 240 250
LYENGVNGIL ADEMGLGKTL QTIALLGYLK HYRNIPGPHM VLVPKSTLHN
260 270 280 290 300
WMNEFKRWVP SLRVICFVGD KDVRAAFIRD EMMPGEWDVC VTSYEMVIKE
310 320 330 340 350
KSVFKKFHWR YLVIDEAHRI KNEKSKLSEI VREFKSTNRL LLTGTPLQNN
360 370 380 390 400
LHELWALLNF LLPDVFNSAD DFDSWFDTKN CLGDQKLVER LHAVLKPFLL
410 420 430 440 450
RRIKTDVEKS LPPKKEIKIY LGLSKMQREW YTKILMKDID VLNSSGKMDK
460 470 480 490 500
MRLLNILMQL RKCCNHPYLF DGAEPGPPYT TDEHIVGNSG KMVALDKLLA
510 520 530 540 550
RIKEQGSRVL IFSQMTRLLD ILEDYCMWRG YEYSRLDGQT PHEEREEAID
560 570 580 590 600
AFNAPNSSKF IFMLSTRAGG LGINLASADV VILYDSDWNP QVDLQAMDRA
610 620 630 640 650
HRIGQKKPVR VFRLITDNTV EERIVERAEI KLRLDSIVIQ QGRLIDQQSN
660 670 680 690 700
KLAKEEMLQM IRHGATHVFA CKESELTDED IVTILERGEK KTAEMNERMQ
710 720 730 740 750
KMGESSLRNF RMDLEQSLYK FEGEDYREKQ KLGTVEWIEP PKRERKANYA
760 770 780 790 800
VDAYFREALR VSEPKIPKAP RPPKQPNVQD FQFFPPRLFE LLEKEILYYR
810 820 830 840 850
KTIGYKVPRN PEIPNPAIAQ REEQKKIDGA EPLTPQETEE KDKLLTQGFT
860 870 880 890 900
NWTKRDFNQF IKANEKYGRD DIDNIAREVE GKSPEEVMEY SAVFWERCNE
910 920 930 940 950
LQDIEKIMAQ IERGEARIQR RISIKKALDA KIARYKAPFH QLRIQYGTSK
960 970 980 990 1000
GKNYTEEEDR FLICMLHKMG FDRENVYEEL RQCVRNAPQF RFDWFIKSRT
1010 1020 1030 1040
AMEFQRRCNT LISLIEKENM EIEERERAEK KKRATKTPMV KFSAFS
Length:1,046
Mass (Da):121,715
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i11D60F70FE466FC5
GO
Isoform 2 (identifier: Q6PGB8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1040-1046: VKFSAFS → SQKRKAESATESSGRKDVKKVKS

Show »
Length:1,062
Mass (Da):123,465
Checksum:iD8C2D0F878AED9D2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6Z6F4F6Z6F4_MOUSE
Probable global transcription activ...
Smarca1
768Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q8BS67Q8BS67_MOUSE
Probable global transcription activ...
Smarca1
381Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6QS43F6QS43_MOUSE
Probable global transcription activ...
Smarca1
117Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAK52453 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti53G → A in AAK52453 (PubMed:11359880).Curated1
Sequence conflicti53G → A in BAC27109 (PubMed:16141072).Curated1
Sequence conflicti94D → A in AAK52453 (PubMed:11359880).Curated1
Sequence conflicti459Q → H in BAC27109 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0203781040 – 1046VKFSAFS → SQKRKAESATESSGRKDVKK VKS in isoform 2. 1 Publication7

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF325920 mRNA Translation: AAK52453.1 Frameshift.
AK030741 mRNA Translation: BAC27109.1
AL671903 Genomic DNA No translation available.
BC057115 mRNA Translation: AAH57115.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS30104.1 [Q6PGB8-1]
CCDS72374.1 [Q6PGB8-2]

NCBI Reference Sequences

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RefSeqi
NP_001277637.1, NM_001290708.1 [Q6PGB8-2]
NP_444353.3, NM_053123.4 [Q6PGB8-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000077569; ENSMUSP00000076769; ENSMUSG00000031099 [Q6PGB8-1]
ENSMUST00000088973; ENSMUSP00000086366; ENSMUSG00000031099 [Q6PGB8-1]
ENSMUST00000101616; ENSMUSP00000099138; ENSMUSG00000031099 [Q6PGB8-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
93761

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:93761

UCSC genome browser

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UCSCi
uc009tbl.2, mouse [Q6PGB8-1]
uc009tbm.2, mouse [Q6PGB8-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF325920 mRNA Translation: AAK52453.1 Frameshift.
AK030741 mRNA Translation: BAC27109.1
AL671903 Genomic DNA No translation available.
BC057115 mRNA Translation: AAH57115.1
CCDSiCCDS30104.1 [Q6PGB8-1]
CCDS72374.1 [Q6PGB8-2]
RefSeqiNP_001277637.1, NM_001290708.1 [Q6PGB8-2]
NP_444353.3, NM_053123.4 [Q6PGB8-1]

3D structure databases

SMRiQ6PGB8
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi220299, 6 interactors
ComplexPortaliCPX-454, CERF chromatin remodelling complex
CPX-694, NuRF chromatin remodeling complex
IntActiQ6PGB8, 1 interactor
STRINGi10090.ENSMUSP00000086366

PTM databases

iPTMnetiQ6PGB8
PhosphoSitePlusiQ6PGB8

Proteomic databases

EPDiQ6PGB8
PaxDbiQ6PGB8
PRIDEiQ6PGB8
ProteomicsDBi261430 [Q6PGB8-1]
261431 [Q6PGB8-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
518, 195 antibodies

The DNASU plasmid repository

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DNASUi
93761

Genome annotation databases

EnsembliENSMUST00000077569; ENSMUSP00000076769; ENSMUSG00000031099 [Q6PGB8-1]
ENSMUST00000088973; ENSMUSP00000086366; ENSMUSG00000031099 [Q6PGB8-1]
ENSMUST00000101616; ENSMUSP00000099138; ENSMUSG00000031099 [Q6PGB8-2]
GeneIDi93761
KEGGimmu:93761
UCSCiuc009tbl.2, mouse [Q6PGB8-1]
uc009tbm.2, mouse [Q6PGB8-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6594
MGIiMGI:1935127, Smarca1
VEuPathDBiHostDB:ENSMUSG00000031099

Phylogenomic databases

eggNOGiKOG0385, Eukaryota
GeneTreeiENSGT00940000157297
InParanoidiQ6PGB8
OMAiIFGKKHD
OrthoDBi61251at2759
PhylomeDBiQ6PGB8
TreeFamiTF300674

Enzyme and pathway databases

BRENDAi2.7.11.17, 3474

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
93761, 1 hit in 64 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Smarca1, mouse

Protein Ontology

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PROi
PR:Q6PGB8
RNActiQ6PGB8, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000031099, Expressed in adrenal gland and 255 other tissues
ExpressionAtlasiQ6PGB8, baseline and differential
GenevisibleiQ6PGB8, MM

Family and domain databases

CDDicd18065, DEXHc_SMARCA1, 1 hit
cd00167, SANT, 1 hit
Gene3Di1.10.1040.30, 1 hit
3.40.50.10810, 1 hit
3.40.50.300, 1 hit
InterProiView protein in InterPro
IPR020838, DBINO
IPR014001, Helicase_ATP-bd
IPR001650, Helicase_C
IPR009057, Homeobox-like_sf
IPR015194, ISWI_HAND-dom
IPR036306, ISWI_HAND-dom_sf
IPR027417, P-loop_NTPase
IPR001005, SANT/Myb
IPR017884, SANT_dom
IPR015195, SLIDE
IPR044755, SMARCA1_N
IPR038718, SNF2-like_sf
IPR000330, SNF2_N
PfamiView protein in Pfam
PF13892, DBINO, 1 hit
PF09110, HAND, 1 hit
PF00271, Helicase_C, 1 hit
PF09111, SLIDE, 1 hit
PF00176, SNF2_N, 1 hit
SMARTiView protein in SMART
SM00487, DEXDc, 1 hit
SM00490, HELICc, 1 hit
SM00717, SANT, 2 hits
SUPFAMiSSF101224, SSF101224, 1 hit
SSF46689, SSF46689, 2 hits
SSF52540, SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS51192, HELICASE_ATP_BIND_1, 1 hit
PS51194, HELICASE_CTER, 1 hit
PS51293, SANT, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSMCA1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6PGB8
Secondary accession number(s): B1AUP6
, B1AUP7, Q8BSS1, Q91Y58
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: July 5, 2004
Last modified: September 29, 2021
This is version 162 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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