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UniProtKB - Q6PG46 (Q6PG46_HUMAN)
Protein
Submitted name:
AKAP5 protein
Gene
AKAP5
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- adenylate cyclase binding Source: InterPro
- calmodulin binding Source: UniProtKB-UniRule
GO - Biological processi
- positive regulation of adenylate cyclase activity Source: InterPro
Keywordsi
Molecular function | Calmodulin-bindingPROSITE-ProRule annotation |
Names & Taxonomyi
Protein namesi | Submitted name: AKAP5 proteinImported |
Gene namesi | Name:AKAP5Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Subcellular locationi
Other locations
- Membrane ARBA annotation; Lipid-anchor ARBA annotation
Plasma Membrane
- plasma membrane Source: InterPro
Keywords - Cellular componenti
MembraneARBA annotationPTM / Processingi
Keywords - PTMi
PhosphoproteinARBA annotationProteomic databases
PeptideAtlasi | Q6PG46 |
Interactioni
GO - Molecular functioni
- adenylate cyclase binding Source: InterPro
- calmodulin binding Source: UniProtKB-UniRule
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 76 – 96 | AKAP_CAM_BDInterPro annotationAdd BLAST | 21 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 122 | DisorderedSequence analysisAdd BLAST | 122 | |
Regioni | 171 – 198 | DisorderedSequence analysisAdd BLAST | 28 | |
Regioni | 239 – 298 | DisorderedSequence analysisAdd BLAST | 60 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 76 – 96 | AKAP CaM-bindingPROSITE-ProRule annotationAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 33 | Basic and acidic residuesSequence analysisAdd BLAST | 33 | |
Compositional biasi | 240 – 260 | Polar residuesSequence analysisAdd BLAST | 21 |
Phylogenomic databases
OrthoDBi | 567120at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR042375, AKAP5 IPR001573, AKAP_WSK |
PANTHERi | PTHR15182, PTHR15182, 1 hit |
Pfami | View protein in Pfam PF03832, WSK, 1 hit |
PROSITEi | View protein in PROSITE PS51893, AKAP_CAM_BD, 1 hit |
i Sequence
Sequence statusi: Fragment.
Q6PG46-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
METTISEIHV ENKDEKRSAE GSPGAERQKE KASMLCFKRR KKAAKALKPK
60 70 80 90 100
AGSEAADVAR KCPQEAGASD QPEPTRGAWA SLKRLVTRRK RSESSKQQKP
110 120 130 140 150
LEGEMQPAIN AEDADLSKKK AKSRLKIPCI KFPRGPKRSN HSKIIEDSDC
160 170 180 190 200
SIKVQEEAEI LDIQTQTPLN DQATKAKSTQ DLSEGISRKD GDEVCESNVS
210 220 230 240 250
NSITSGEKVI SVELGLDNGH SAIQTGTLIL EEIETIKEKQ DVQPQQASPL
260 270 280 290
ETSETDHQQP VLSDVPPLPA IPDQQIVEEA SNSTLESAPK KKKKKKKK
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 298 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC057229 mRNA Translation: AAH57229.1 |
RefSeqi | NP_004848.3, NM_004857.3 |
Genome annotation databases
GeneIDi | 9495 |
KEGGi | hsa:9495 |
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC057229 mRNA Translation: AAH57229.1 |
RefSeqi | NP_004848.3, NM_004857.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | Q6PG46 |
Protocols and materials databases
DNASUi | 9495 |
Genome annotation databases
GeneIDi | 9495 |
KEGGi | hsa:9495 |
Organism-specific databases
CTDi | 9495 |
PharmGKBi | PA24669 |
Phylogenomic databases
OrthoDBi | 567120at2759 |
Miscellaneous databases
BioGRID-ORCSi | 9495, 11 hits in 1073 CRISPR screens |
GenomeRNAii | 9495 |
Gene expression databases
Genevisiblei | Q6PG46, HS |
Family and domain databases
InterProi | View protein in InterPro IPR042375, AKAP5 IPR001573, AKAP_WSK |
PANTHERi | PTHR15182, PTHR15182, 1 hit |
Pfami | View protein in Pfam PF03832, WSK, 1 hit |
PROSITEi | View protein in PROSITE PS51893, AKAP_CAM_BD, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | Q6PG46_HUMAN | |
Accessioni | Q6PG46Primary (citable) accession number: Q6PG46 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 5, 2004 |
Last sequence update: | July 5, 2004 | |
Last modified: | May 25, 2022 | |
This is version 84 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |