UniProtKB - Q6PG37 (ZN790_HUMAN)
Protein
Zinc finger protein 790
Gene
ZNF790
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in transcriptional regulation.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 196 – 220 | C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 226 – 248 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 254 – 276 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 282 – 304 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 310 – 332 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 338 – 360 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 366 – 388 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 394 – 416 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 422 – 444 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 450 – 472 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 478 – 500 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 506 – 528 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 534 – 556 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q6PG37 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 790 |
Gene namesi | Name:ZNF790 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:33114, ZNF790 |
neXtProti | NX_Q6PG37 |
VEuPathDBi | HostDB:ENSG00000197863.8 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000197863 |
PharmGKBi | PA162410507 |
Miscellaneous databases
Pharosi | Q6PG37, Tdark |
Genetic variation databases
BioMutai | ZNF790 |
DMDMi | 296453059 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000261336 | 1 – 636 | Zinc finger protein 790Add BLAST | 636 |
Proteomic databases
jPOSTi | Q6PG37 |
MassIVEi | Q6PG37 |
MaxQBi | Q6PG37 |
PaxDbi | Q6PG37 |
PeptideAtlasi | Q6PG37 |
PRIDEi | Q6PG37 |
ProteomicsDBi | 67112 |
PTM databases
iPTMneti | Q6PG37 |
PhosphoSitePlusi | Q6PG37 |
Expressioni
Gene expression databases
Bgeei | ENSG00000197863, Expressed in quadriceps femoris and 120 other tissues |
ExpressionAtlasi | Q6PG37, baseline and differential |
Organism-specific databases
HPAi | ENSG00000197863, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 132730, 4 interactors |
IntActi | Q6PG37, 4 interactors |
STRINGi | 9606.ENSP00000349161 |
Miscellaneous databases
RNActi | Q6PG37, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 5 – 76 | KRABPROSITE-ProRule annotationAdd BLAST | 72 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 196 – 220 | C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 226 – 248 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 254 – 276 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 282 – 304 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 310 – 332 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 338 – 360 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 366 – 388 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 394 – 416 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 422 – 444 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 450 – 472 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 478 – 500 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 506 – 528 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 534 – 556 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000163643 |
HOGENOMi | CLU_002678_0_9_1 |
InParanoidi | Q6PG37 |
OMAi | TFIWASY |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q6PG37 |
TreeFami | TF341817 |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 9 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 12 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 9 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 12 hits PS50157, ZINC_FINGER_C2H2_2, 13 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
Q6PG37-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAHLMMFRDV AVDFSQEEWE CLDLEQRDLY RDVMLENYSN MVSLGFCIYQ
60 70 80 90 100
PEAFSLLEKG KEPWKILRDE TRGPCPDMQS RCQTKKLLPK NGIFEREIAQ
110 120 130 140 150
LEIMRICKNH SLDCLCFRGD WEGNTQFQTL QDNQEECFKQ VIRTCEKRPT
160 170 180 190 200
FNQHTVFNLH QRLNTGDKLN EFKELGKAFI SGSDHTQHQL IHTSEKFCGD
210 220 230 240 250
KECGNTFLPD SEVIQYQTVH TVKKTYECKE CGKSFSLRSS LTGHKRIHTG
260 270 280 290 300
EKPFKCKDCG KAFRFHSQLS VHKRIHTGEK SYECKECGKA FSCGSDLTRH
310 320 330 340 350
QRIHTGEKPY ECNECRKAFS QRSHLIKHQR IHTGEKPYEC KECGKAFTRG
360 370 380 390 400
SHLTQHQRIH TGEKSHECKE CGKAFIRGSN LAQHQNVHVG RKPYKCEKCG
410 420 430 440 450
KAYIWSSHLA RHQRIHTGRK PYECKQCGKT FTWASYLAQH EKIHNERKSY
460 470 480 490 500
ECKECGKTFL HGSEFNRHQK IHTGERNYEC KECGKTFFRG SELNRHQKIH
510 520 530 540 550
TGKRPYECEE CGKAFLWGSQ LTRHQRMHTG EEPYVCKECG KSFIWGSQLT
560 570 580 590 600
RHKKIHTDAE PYGCKKSSHI FSHHSYFTEQ KIHNSANLCE WTDYGNTFSH
610 620 630
ESNFAQHQNI YTFEKSYEFK DFEKAFSSSS HFISLL
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9PL27 | E9PL27_HUMAN | Zinc finger protein 790 | ZNF790 | 135 | Annotation score: | ||
E9PQ03 | E9PQ03_HUMAN | Zinc finger protein 790 | ZNF790 | 49 | Annotation score: | ||
E9PRR6 | E9PRR6_HUMAN | Zinc finger protein 790 | ZNF790 | 179 | Annotation score: | ||
K7EQ58 | K7EQ58_HUMAN | Zinc finger protein 790 | ZNF790 | 140 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_060434 | 301 | Q → R1 PublicationCorresponds to variant dbSNP:rs3745775Ensembl. | 1 | |
Natural variantiVAR_057453 | 486 | T → S. Corresponds to variant dbSNP:rs4369791Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC020928 Genomic DNA No translation available. BC057245 mRNA Translation: AAH57245.1 |
CCDSi | CCDS12496.1 |
RefSeqi | NP_001229729.1, NM_001242800.1 NP_001229730.1, NM_001242801.1 NP_001229731.1, NM_001242802.1 NP_996777.2, NM_206894.3 XP_005258960.1, XM_005258903.4 XP_011525252.1, XM_011526950.2 |
Genome annotation databases
Ensembli | ENST00000356725; ENSP00000349161; ENSG00000197863 ENST00000613249; ENSP00000480764; ENSG00000197863 ENST00000614179; ENSP00000480834; ENSG00000197863 ENST00000615484; ENSP00000478852; ENSG00000197863 |
GeneIDi | 388536 |
KEGGi | hsa:388536 |
UCSCi | uc002oew.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC020928 Genomic DNA No translation available. BC057245 mRNA Translation: AAH57245.1 |
CCDSi | CCDS12496.1 |
RefSeqi | NP_001229729.1, NM_001242800.1 NP_001229730.1, NM_001242801.1 NP_001229731.1, NM_001242802.1 NP_996777.2, NM_206894.3 XP_005258960.1, XM_005258903.4 XP_011525252.1, XM_011526950.2 |
3D structure databases
SMRi | Q6PG37 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 132730, 4 interactors |
IntActi | Q6PG37, 4 interactors |
STRINGi | 9606.ENSP00000349161 |
PTM databases
iPTMneti | Q6PG37 |
PhosphoSitePlusi | Q6PG37 |
Genetic variation databases
BioMutai | ZNF790 |
DMDMi | 296453059 |
Proteomic databases
jPOSTi | Q6PG37 |
MassIVEi | Q6PG37 |
MaxQBi | Q6PG37 |
PaxDbi | Q6PG37 |
PeptideAtlasi | Q6PG37 |
PRIDEi | Q6PG37 |
ProteomicsDBi | 67112 |
Protocols and materials databases
Antibodypediai | 44747, 29 antibodies |
Genome annotation databases
Ensembli | ENST00000356725; ENSP00000349161; ENSG00000197863 ENST00000613249; ENSP00000480764; ENSG00000197863 ENST00000614179; ENSP00000480834; ENSG00000197863 ENST00000615484; ENSP00000478852; ENSG00000197863 |
GeneIDi | 388536 |
KEGGi | hsa:388536 |
UCSCi | uc002oew.4, human |
Organism-specific databases
CTDi | 388536 |
GeneCardsi | ZNF790 |
HGNCi | HGNC:33114, ZNF790 |
HPAi | ENSG00000197863, Low tissue specificity |
neXtProti | NX_Q6PG37 |
OpenTargetsi | ENSG00000197863 |
PharmGKBi | PA162410507 |
VEuPathDBi | HostDB:ENSG00000197863.8 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000163643 |
HOGENOMi | CLU_002678_0_9_1 |
InParanoidi | Q6PG37 |
OMAi | TFIWASY |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q6PG37 |
TreeFami | TF341817 |
Enzyme and pathway databases
PathwayCommonsi | Q6PG37 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
Miscellaneous databases
BioGRID-ORCSi | 388536, 12 hits in 1007 CRISPR screens |
ChiTaRSi | ZNF790, human |
GenomeRNAii | 388536 |
Pharosi | Q6PG37, Tdark |
PROi | PR:Q6PG37 |
RNActi | Q6PG37, protein |
Gene expression databases
Bgeei | ENSG00000197863, Expressed in quadriceps femoris and 120 other tissues |
ExpressionAtlasi | Q6PG37, baseline and differential |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 9 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 12 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 9 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 12 hits PS50157, ZINC_FINGER_C2H2_2, 13 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZN790_HUMAN | |
Accessioni | Q6PG37Primary (citable) accession number: Q6PG37 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 28, 2006 |
Last sequence update: | May 18, 2010 | |
Last modified: | April 7, 2021 | |
This is version 146 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - SIMILARITY comments
Index of protein domains and families