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Protein

F-BAR and double SH3 domains protein 1

Gene

Fchsd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
F-BAR and double SH3 domains protein 1
Gene namesi
Name:Fchsd1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:2441771 Fchsd1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002782131 – 688F-BAR and double SH3 domains protein 1Add BLAST688

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei442PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6PFY1
PRIDEiQ6PFY1

PTM databases

iPTMnetiQ6PFY1
PhosphoSitePlusiQ6PFY1

Expressioni

Gene expression databases

BgeeiENSMUSG00000038524 Expressed in 69 organ(s), highest expression level in bone marrow macrophage
CleanExiMM_FCHSD1
ExpressionAtlasiQ6PFY1 baseline and differential
GenevisibleiQ6PFY1 MM

Interactioni

Protein-protein interaction databases

IntActiQ6PFY1, 1 interactor
STRINGi10090.ENSMUSP00000047878

Structurei

3D structure databases

ProteinModelPortaliQ6PFY1
SMRiQ6PFY1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 280F-BARPROSITE-ProRule annotationAdd BLAST269
Domaini466 – 527SH3 1PROSITE-ProRule annotationAdd BLAST62
Domaini544 – 607SH3 2PROSITE-ProRule annotationAdd BLAST64

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili360 – 386Sequence analysisAdd BLAST27

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi608 – 686Pro-richAdd BLAST79

Keywords - Domaini

Coiled coil, Repeat, SH3 domain

Phylogenomic databases

eggNOGiENOG410INNZ Eukaryota
ENOG410XSX6 LUCA
GeneTreeiENSGT00510000046732
HOGENOMiHOG000046016
HOVERGENiHBG063540
InParanoidiQ6PFY1
KOiK20125
OMAiYKIQNHG
OrthoDBiEOG091G02AL
PhylomeDBiQ6PFY1
TreeFamiTF324557

Family and domain databases

CDDicd11761 SH3_FCHSD_1, 1 hit
Gene3Di1.20.1270.60, 1 hit
InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR031160 F_BAR
IPR001060 FCH_dom
IPR034936 FCHSD
IPR034935 FCHSD1
IPR035460 FCHSD_SH3_1
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PANTHERiPTHR15735 PTHR15735, 1 hit
PTHR15735:SF4 PTHR15735:SF4, 1 hit
PfamiView protein in Pfam
PF00611 FCH, 1 hit
PF00018 SH3_1, 1 hit
PF14604 SH3_9, 1 hit
SMARTiView protein in SMART
SM00055 FCH, 1 hit
SM00326 SH3, 2 hits
SUPFAMiSSF103657 SSF103657, 1 hit
SSF50044 SSF50044, 2 hits
PROSITEiView protein in PROSITE
PS51741 F_BAR, 1 hit
PS50002 SH3, 2 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6PFY1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQPPPRKVKP AQEVKLRFLE QLSILQTRQQ READLLEDIR SYSKQRAAIE
60 70 80 90 100
REYGQALQKL AGPFLKREGQ RSGEADSRTV FGAWRCLLDA TVAGGQTRLQ
110 120 130 140 150
ASDRYRDLAG GTGRSAKEQV LRKGTESLQQ AQAEVLQSVR ELSRSRKLYG
160 170 180 190 200
QRQRVWALAQ EKAADVQARL NRSDHGIFHS RTSLQKLSTK LSAQSAQYSQ
210 220 230 240 250
QLRAARNEYL LNLVATNAHL AHYYQEELPA LLKVLVSELS EYLRDPLTLL
260 270 280 290 300
GHTELEAAEM ILEHARHGGK ATSQVNWEQD VKLFLQGPGV FSPTPPQQFQ
310 320 330 340 350
PAGADQVCGL EWGAGGMAGE SGLEKEVQRW TSRAARDYKI QHHGHRVLQR
360 370 380 390 400
LEQRRQQAPG REAPGVEQRL QEVRENIRRA QVSQVKGAAR LALLQEAGLD
410 420 430 440 450
VQRWLKPAMT QAQDEVEQER RLSEARLSQR DLSPTAEDAE LSDFDECEEA
460 470 480 490 500
GELFEEPAPP ALATRPLPCP AHVVFGYQAG REDELTITEG EWLEVIEEGD
510 520 530 540 550
ADEWVKARNQ HGEAGFVPER YLNFPDLSLP ESCHGIDNPS GGEPTAFLAR
560 570 580 590 600
ALYSYTGQSE EELSFPEGAL IRLLPRAQDG VDDGFWRGEF GGHVGVFPSL
610 620 630 640 650
LVEELLGPPG PPELSDPEQM LPSPSPPSFS PPAPTCALDG STAPALPSDK
660 670 680
VLDCPGPLDM MVPRLRPMRP PPPPPAKAPD PGHPDPLT
Length:688
Mass (Da):76,256
Last modified:July 5, 2004 - v1
Checksum:i98A9293622D063F2
GO
Isoform 2 (identifier: Q6PFY1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-259: Missing.

Show »
Length:429
Mass (Da):46,952
Checksum:i68AF287DDEA83245
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PVQ1E9PVQ1_MOUSE
F-BAR and double SH3 domains protei...
Fchsd1
137Annotation score:
E9Q363E9Q363_MOUSE
F-BAR and double SH3 domains protei...
Fchsd1
108Annotation score:
E9QA76E9QA76_MOUSE
F-BAR and double SH3 domains protei...
Fchsd1
57Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0231661 – 259Missing in isoform 2. 1 PublicationAdd BLAST259

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK079461 mRNA Translation: BAC37653.1
BC057367 mRNA Translation: AAH57367.1
CCDSiCCDS37786.1 [Q6PFY1-1]
RefSeqiNP_783615.2, NM_175684.4 [Q6PFY1-1]
UniGeneiMm.285060

Genome annotation databases

EnsembliENSMUST00000043437; ENSMUSP00000047878; ENSMUSG00000038524 [Q6PFY1-1]
GeneIDi319262
KEGGimmu:319262
UCSCiuc008ero.1 mouse [Q6PFY1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK079461 mRNA Translation: BAC37653.1
BC057367 mRNA Translation: AAH57367.1
CCDSiCCDS37786.1 [Q6PFY1-1]
RefSeqiNP_783615.2, NM_175684.4 [Q6PFY1-1]
UniGeneiMm.285060

3D structure databases

ProteinModelPortaliQ6PFY1
SMRiQ6PFY1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ6PFY1, 1 interactor
STRINGi10090.ENSMUSP00000047878

PTM databases

iPTMnetiQ6PFY1
PhosphoSitePlusiQ6PFY1

Proteomic databases

PaxDbiQ6PFY1
PRIDEiQ6PFY1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000043437; ENSMUSP00000047878; ENSMUSG00000038524 [Q6PFY1-1]
GeneIDi319262
KEGGimmu:319262
UCSCiuc008ero.1 mouse [Q6PFY1-1]

Organism-specific databases

CTDi89848
MGIiMGI:2441771 Fchsd1

Phylogenomic databases

eggNOGiENOG410INNZ Eukaryota
ENOG410XSX6 LUCA
GeneTreeiENSGT00510000046732
HOGENOMiHOG000046016
HOVERGENiHBG063540
InParanoidiQ6PFY1
KOiK20125
OMAiYKIQNHG
OrthoDBiEOG091G02AL
PhylomeDBiQ6PFY1
TreeFamiTF324557

Miscellaneous databases

PROiPR:Q6PFY1
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000038524 Expressed in 69 organ(s), highest expression level in bone marrow macrophage
CleanExiMM_FCHSD1
ExpressionAtlasiQ6PFY1 baseline and differential
GenevisibleiQ6PFY1 MM

Family and domain databases

CDDicd11761 SH3_FCHSD_1, 1 hit
Gene3Di1.20.1270.60, 1 hit
InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR031160 F_BAR
IPR001060 FCH_dom
IPR034936 FCHSD
IPR034935 FCHSD1
IPR035460 FCHSD_SH3_1
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PANTHERiPTHR15735 PTHR15735, 1 hit
PTHR15735:SF4 PTHR15735:SF4, 1 hit
PfamiView protein in Pfam
PF00611 FCH, 1 hit
PF00018 SH3_1, 1 hit
PF14604 SH3_9, 1 hit
SMARTiView protein in SMART
SM00055 FCH, 1 hit
SM00326 SH3, 2 hits
SUPFAMiSSF103657 SSF103657, 1 hit
SSF50044 SSF50044, 2 hits
PROSITEiView protein in PROSITE
PS51741 F_BAR, 1 hit
PS50002 SH3, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiFCSD1_MOUSE
AccessioniPrimary (citable) accession number: Q6PFY1
Secondary accession number(s): Q8BV86
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: July 5, 2004
Last modified: September 12, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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