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Entry version 142 (05 Jun 2019)
Sequence version 1 (05 Jul 2004)
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Protein

Poly [ADP-ribose] polymerase tankyrase-1

Gene

Tnks

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation (PARsylation) of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates PARsylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates PARsylation of TERF1, thereby contributing to the regulation of telomere length. Involved in centrosome maturation during prometaphase by mediating PARsylation of HEPACAM2/MIKI. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. May be involved in spindle pole assembly through PARsylation of NUMA1. Stimulates 26S proteasome activity.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi1227ZincBy similarity1
Metal bindingi1230ZincBy similarity1
Metal bindingi1235ZincBy similarity1
Metal bindingi1238ZincBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processCell cycle, Cell division, Mitosis, mRNA transport, Protein transport, Translocation, Transport, Wnt signaling pathway
LigandMetal-binding, NAD, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-201681 TCF dependent signaling in response to WNT
R-MMU-4641257 Degradation of AXIN
R-MMU-5689880 Ub-specific processing proteases
R-MMU-8948751 Regulation of PTEN stability and activity

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Poly [ADP-ribose] polymerase tankyrase-1Curated (EC:2.4.2.30By similarity)
Alternative name(s):
ADP-ribosyltransferase diphtheria toxin-like 5
Short name:
ARTD5
Protein poly-ADP-ribosyltransferase tankyrase-1Curated (EC:2.4.2.-By similarity)
TRF1-interacting ankyrin-related ADP-ribose polymerase 1
Short name:
Tankyrase I
Tankyrase-1
Short name:
TANK1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Tnks
Synonyms:Tnks1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1341087 Tnks

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Cytoplasm, Cytoskeleton, Golgi apparatus, Membrane, Nuclear pore complex, Nucleus, Telomere

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3232702

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004095111 – 1320Poly [ADP-ribose] polymerase tankyrase-1Add BLAST1320

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on serine residues by MAPK kinases upon insulin stimulation. Phosphorylated during mitosis.By similarity
Ubiquitinated by RNF146 when auto-poly-ADP-ribosylated, leading to its degradation.By similarity
ADP-ribosylated (-auto). Poly-ADP-ribosylated protein is recognized by RNF146, followed by ubiquitination.By similarity

Keywords - PTMi

ADP-ribosylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q6PFX9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6PFX9

PeptideAtlas

More...
PeptideAtlasi
Q6PFX9

PRoteomics IDEntifications database

More...
PRIDEi
Q6PFX9

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6PFX9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6PFX9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000031529 Expressed in 244 organ(s), highest expression level in manus

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6PFX9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6PFX9 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Oligomerizes and associates with TNKS2.

Interacts with the cytoplasmic domain of LNPEP/Otase in SLC2A4/GLUT4-vesicles. Binds to the N-terminus of telomeric TERF1 via the ANK repeats.

Found in a complex with POT1; TERF1 and TINF2.

Interacts with AXIN1.

Interacts with AXIN2.

Interacts with BLZF1 and CASC3.

Interacts with NUMA1.

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
204263, 19 interactors

Database of interacting proteins

More...
DIPi
DIP-61463N

Protein interaction database and analysis system

More...
IntActi
Q6PFX9, 19 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000033929

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q6PFX9

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11320
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6PFX9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati174 – 202ANK 1Add BLAST29
Repeati208 – 237ANK 2Add BLAST30
Repeati241 – 270ANK 3Add BLAST30
Repeati274 – 303ANK 4Add BLAST30
Repeati361 – 390ANK 5Add BLAST30
Repeati394 – 423ANK 6Add BLAST30
Repeati427 – 456ANK 7Add BLAST30
Repeati514 – 546ANK 8Add BLAST33
Repeati550 – 579ANK 9Add BLAST30
Repeati583 – 612ANK 10Add BLAST30
Repeati676 – 705ANK 11Add BLAST30
Repeati709 – 738ANK 12Add BLAST30
Repeati742 – 771ANK 13Add BLAST30
Repeati775 – 803ANK 14Add BLAST29
Repeati829 – 858ANK 15Add BLAST30
Repeati862 – 891ANK 16Add BLAST30
Repeati895 – 924ANK 17Add BLAST30
Repeati928 – 957ANK 18Add BLAST30
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1019 – 1082SAMPROSITE-ProRule annotationAdd BLAST64
Domaini1105 – 1310PARP catalyticPROSITE-ProRule annotationAdd BLAST206

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi9 – 14Poly-His6
Compositional biasi20 – 83Pro-richAdd BLAST64
Compositional biasi112 – 118Poly-Gly7
Compositional biasi121 – 146Ser-richAdd BLAST26

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4177 Eukaryota
COG0666 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156161

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000246964

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6PFX9

KEGG Orthology (KO)

More...
KOi
K10799

Identification of Orthologs from Complete Genome Data

More...
OMAi
FHCVSQG

Database of Orthologous Groups

More...
OrthoDBi
111565at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6PFX9

TreeFam database of animal gene trees

More...
TreeFami
TF326036

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00204 ANK, 5 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.150.50, 1 hit
1.25.40.20, 5 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR012317 Poly(ADP-ribose)pol_cat_dom
IPR001660 SAM
IPR013761 SAM/pointed_sf
IPR028731 TANK1

The PANTHER Classification System

More...
PANTHERi
PTHR24180:SF3 PTHR24180:SF3, 5 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00023 Ank, 2 hits
PF12796 Ank_2, 4 hits
PF13606 Ank_3, 1 hit
PF00644 PARP, 1 hit
PF07647 SAM_2, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01415 ANKYRIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248 ANK, 17 hits
SM00454 SAM, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47769 SSF47769, 1 hit
SSF48403 SSF48403, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 15 hits
PS51059 PARP_CATALYTIC, 1 hit
PS50105 SAM_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6PFX9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAASRRSQHH HHHHQQQLQP APGASAPPPP PPPPLSPGLA PGPTPASPTA
60 70 80 90 100
GGLAPFASPR HGLALPEGDG SRDPPDRPRS PDPVDGAVCT VAAPAAVPAA
110 120 130 140 150
SAAVGVAPTP AGGGGGGGNN SASSASSPTS SSSSSPSSPG SSLAESPEAA
160 170 180 190 200
GVGSTATLGA GAAGLGPGVP AVSGALRELL EACRNGDVSR VKRLVDAANV
210 220 230 240 250
NAKDMAGRKS SPLHFAAGFG RKDVVEHLLQ MGANVHARDD GGLIPLHNAC
260 270 280 290 300
SFGHAEVVSL LLCQGADPNA RDNWNYTPLH EAAIKGKIDV CIVLLQHGAD
310 320 330 340 350
PNIRNTDGKS ALDLADPSAK AVLTGEYKKD ELLEAARSGN EEKLMALLTP
360 370 380 390 400
LNVNCHASDG RKSTPLHLAA GYNRVRIVQL LLQHGADVHA KDKGGLVPLH
410 420 430 440 450
NACSYGHYEV TELLLKHGAC VNAMDLWQFT PLHEAASKNR VEVCSLLLSH
460 470 480 490 500
GADPTLVNCH GKSAVDMAPT PELRERLTYE FKGHSLLQAA READLAKVKK
510 520 530 540 550
TLALEIINFK QPQSHETALH CAVASLHPKR KQVAELLLRK GANVNEKNKD
560 570 580 590 600
FMTPLHVAAE RAHNDVMEVL HKHGAKMNAL DSLGQTALHR AALAGHLQTC
610 620 630 640 650
RLLLSYGSDP SIISLQGFTA AQMGNEAVQQ ILSESTPMRT SDVDYRLLEA
660 670 680 690 700
SKAGDLETVK QLCSPQNVNC RDLEGRHSTP LHFAAGYNRV SVVEYLLHHG
710 720 730 740 750
ADVHAKDKGG LVPLHNACSY GHYEVAELLV RHGASVNVAD LWKFTPLHEA
760 770 780 790 800
AAKGKYEICK LLLKHGADPT KKNRDGNTPL DLVKEGDTDI QDLLRGDAAL
810 820 830 840 850
LDAAKKGCLA RVQKLCTPEN INCRDTQGRN STPLHLAAGY NNLEVAEYLL
860 870 880 890 900
EHGADVNAQD KGGLIPLHNA ASYGHVDIAA LLIKYNTCVN ATDKWAFTPL
910 920 930 940 950
HEAAQKGRTQ LCALLLAHGA DPTMKNQEGQ TPLDLATADD IRALLIDAMP
960 970 980 990 1000
PEALPTCFKP QATVVSASLI SPASTPSCLS AASSIDNLTG PLTDLAVGGA
1010 1020 1030 1040 1050
SNAGDGAAGA ERKEGEVAGL DMNISQFLKS LGLEHLRDIF ETEQITLDVL
1060 1070 1080 1090 1100
ADMGHEELKE IGINAYGHRH KLIKGVERLL GGQQGTNPYL TFHCVNQGTI
1110 1120 1130 1140 1150
LLDLAPEDKE YQSVEEEMQS TIREHRDGGN AGGIFNRYNV IRIQKVVNKK
1160 1170 1180 1190 1200
LRERFCHRQK EVSEENHNHH NERMLFHGSP FINAIIHKGF DERHAYIGGM
1210 1220 1230 1240 1250
FGAGIYFAEN SSKSNQYVYG IGGGTGCPTH KDRSCYICHR QMLFCRVTLG
1260 1270 1280 1290 1300
KSFLQFSTMK MAHAPPGHHS VIGRPSVNGL AYAEYVIYRG EQAYPEYLIT
1310 1320
YQIMKPEAPS QTATAAEQKT
Length:1,320
Mass (Da):140,944
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA90360DC665FFCC0
GO
Isoform 2 (identifier: Q6PFX9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-344: Missing.

Note: No experimental confirmation available.
Show »
Length:976
Mass (Da):106,651
Checksum:i8DE71F21652C3D4A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1B0GRK1A0A1B0GRK1_MOUSE
Poly [ADP-ribose] polymerase
Tnks
151Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GRH5A0A1B0GRH5_MOUSE
Poly [ADP-ribose] polymerase tankyr...
Tnks
48Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti969L → V in BAC33475 (PubMed:16141072).Curated1
Sequence conflicti1025S → I in BAC33475 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0413201 – 344Missing in isoform 2. 1 PublicationAdd BLAST344

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK048860 mRNA Translation: BAC33475.1
AC122458 Genomic DNA No translation available.
BC057370 mRNA Translation: AAH57370.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS22242.1 [Q6PFX9-1]

NCBI Reference Sequences

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RefSeqi
NP_780300.2, NM_175091.3 [Q6PFX9-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000033929; ENSMUSP00000033929; ENSMUSG00000031529 [Q6PFX9-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
21951

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:21951

UCSC genome browser

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UCSCi
uc009lku.1 mouse [Q6PFX9-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK048860 mRNA Translation: BAC33475.1
AC122458 Genomic DNA No translation available.
BC057370 mRNA Translation: AAH57370.1
CCDSiCCDS22242.1 [Q6PFX9-1]
RefSeqiNP_780300.2, NM_175091.3 [Q6PFX9-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3UTMX-ray2.00A/B308-655[»]
4N4TX-ray2.32A/B1097-1307[»]
5HKPX-ray2.20A/B308-655[»]
6CF6X-ray1.93A/B308-655[»]
SMRiQ6PFX9
ModBaseiSearch...

Protein-protein interaction databases

BioGridi204263, 19 interactors
DIPiDIP-61463N
IntActiQ6PFX9, 19 interactors
STRINGi10090.ENSMUSP00000033929

Chemistry databases

BindingDBiQ6PFX9
ChEMBLiCHEMBL3232702

PTM databases

iPTMnetiQ6PFX9
PhosphoSitePlusiQ6PFX9

Proteomic databases

EPDiQ6PFX9
PaxDbiQ6PFX9
PeptideAtlasiQ6PFX9
PRIDEiQ6PFX9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033929; ENSMUSP00000033929; ENSMUSG00000031529 [Q6PFX9-1]
GeneIDi21951
KEGGimmu:21951
UCSCiuc009lku.1 mouse [Q6PFX9-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
8658
MGIiMGI:1341087 Tnks

Phylogenomic databases

eggNOGiKOG4177 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00940000156161
HOGENOMiHOG000246964
InParanoidiQ6PFX9
KOiK10799
OMAiFHCVSQG
OrthoDBi111565at2759
PhylomeDBiQ6PFX9
TreeFamiTF326036

Enzyme and pathway databases

ReactomeiR-MMU-201681 TCF dependent signaling in response to WNT
R-MMU-4641257 Degradation of AXIN
R-MMU-5689880 Ub-specific processing proteases
R-MMU-8948751 Regulation of PTEN stability and activity

Miscellaneous databases

Protein Ontology

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PROi
PR:Q6PFX9

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000031529 Expressed in 244 organ(s), highest expression level in manus
ExpressionAtlasiQ6PFX9 baseline and differential
GenevisibleiQ6PFX9 MM

Family and domain databases

CDDicd00204 ANK, 5 hits
Gene3Di1.10.150.50, 1 hit
1.25.40.20, 5 hits
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR012317 Poly(ADP-ribose)pol_cat_dom
IPR001660 SAM
IPR013761 SAM/pointed_sf
IPR028731 TANK1
PANTHERiPTHR24180:SF3 PTHR24180:SF3, 5 hits
PfamiView protein in Pfam
PF00023 Ank, 2 hits
PF12796 Ank_2, 4 hits
PF13606 Ank_3, 1 hit
PF00644 PARP, 1 hit
PF07647 SAM_2, 1 hit
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 17 hits
SM00454 SAM, 1 hit
SUPFAMiSSF47769 SSF47769, 1 hit
SSF48403 SSF48403, 3 hits
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 15 hits
PS51059 PARP_CATALYTIC, 1 hit
PS50105 SAM_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTNKS1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6PFX9
Secondary accession number(s): Q8BX62
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 31, 2011
Last sequence update: July 5, 2004
Last modified: June 5, 2019
This is version 142 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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