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Entry version 101 (12 Aug 2020)
Sequence version 1 (05 Jul 2004)
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Protein

Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1

Gene

Nyap1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Nyap1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2443880, Nyap1

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Triple knockout mice NYAP1/NYAP2/MYO16 are fertile and appear healthy. However, compared to wild-type mice they show a clear reduction in brain size, exhibiting a reduction in the size of the cortex and striatum, but not the olfactory bulb or corpus callosum. The total neurite length of neurons in these mice is also significantly shorter.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi212Y → F: Abolishes binding to PIK3R2. Slight reduction of phosphorylation in HEK293T cells. Abolishes phosphorylation in HEK293T cells and in neurons; when associated with F-257. 1 Publication1
Mutagenesisi257Y → F: Reduced binding to PIK3R2. Slight reduction of phosphorylation in HEK293T cells. Abolishes phosphorylation in HEK293T cells and neurons; when associated with F-212. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003209301 – 833Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1Add BLAST833

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on tyrosine residues by FYN upon stimulation with CNTN5. Phosphorylation begins at 14 dpc, reaches a peak during perinatal days in brain, then gradually decreases.1 Publication

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6PFX7

PRoteomics IDEntifications database

More...
PRIDEi
Q6PFX7

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6PFX7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6PFX7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed predominantly in brain where it is present in the neurons, but not in astrocytes or oligodendrites.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expression first detected in the cortical plate as early as 14 dpc, peaks in the middle neocortex at postnatal day 1 and then gradually decreases. At postnatal day 1, also expressed in the striatum, but not in the olfactory bulb.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000045348, Expressed in cortical plate and 211 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6PFX7, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ACOT9, ARHGAP26 and PIK3R2.

Interacts with components of the WAVE1 complex, CYFIP1 and NCKAP1; this interaction mediates PI3K-WAVE1 association and actin cytoskeleton remodeling.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
232498, 3 interactors

Protein interaction database and analysis system

More...
IntActi
Q6PFX7, 7 interactors

Molecular INTeraction database

More...
MINTi
Q6PFX7

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000113397

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6PFX7, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6PFX7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni76 – 181Involved in CYFIP1- and NCKAP1-bindingAdd BLAST106

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi276 – 451Pro-richAdd BLAST176
Compositional biasi613 – 617Poly-Glu5

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NYAP family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QRSX, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00890000139453

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_012558_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6PFX7

Identification of Orthologs from Complete Genome Data

More...
OMAi
MICPKAV

Database of Orthologous Groups

More...
OrthoDBi
620667at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6PFX7

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026724, NYAP1
IPR026722, NYAP1/NYAP2
IPR029353, NYAP_C
IPR039482, NYAP_N

The PANTHER Classification System

More...
PANTHERi
PTHR22633, PTHR22633, 1 hit
PTHR22633:SF2, PTHR22633:SF2, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15452, NYAP_C, 1 hit
PF15439, NYAP_N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6PFX7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNLLYRKTKL EWRQHKEEEA KRSSSKEAAP TGPVGPGAVP GPGVRVRDIA
60 70 80 90 100
SLRRSLRMGF MTMPASQEHT PHPCRSTMAP RSLSCHSVGS MDSVGGGPGG
110 120 130 140 150
GLTEDSSTRR PPAKPRRHPS TKLSMAGPGA ETPPSKKAGS QKPAPECRES
160 170 180 190 200
SRKVPPQKPR RSPNTQLSVS FDESCAPAPS PRGANLPLQR LSRASRITGD
210 220 230 240 250
LDAGAQEEEP VYIEMVGDVF RGGGRSGGGL AGPPLGSGGP TPPAAADSDS
260 270 280 290 300
EDSEAIYEEM KYPLPEEAGD GRANGPPPLT APSPPQQTHI LQPHPHPHRR
310 320 330 340 350
PASALPSRRD GTPTKTTPCE IPPPFPNLLQ HRPPLLAFPQ AKSASRAPGD
360 370 380 390 400
GVSRLPVLCH SKEPAGSTPA PQVPARERET PPLPPPPPAA NLLLLGPSGR
410 420 430 440 450
ARSHSTPLPP QGSGQTRGER ELPNSHSMIC PKAAGVPAAH PAPAALLPGP
460 470 480 490 500
PKDKAVSYTM VYSAVKVTTH SVLPAGPPLG VGEPKTEEIS VLHGMLCASS
510 520 530 540 550
RPPVPGKSSP HSGAMGSAAG VLHHRSCLAS PHSLPDPTGG SLTPLWTYPA
560 570 580 590 600
TAAGLKRPPA YDSLKAGGVL NKGCGMGAPS PMVKIQLQEQ GTDGGAFASI
610 620 630 640 650
SCAHVIASAG TPEEEEEMGA AFGAGWALQR KVLYGGRKAK EVDTEEDGAR
660 670 680 690 700
AWNGSTEGPG KVEHEDRGPV PSGIPVRSQG AEGLLARIHH DRGGSRTALP
710 720 730 740 750
VPCQTFPACH RNGDFTGGYR LGRSASTSGV RQAALHTPRP CSQPRDALSQ
760 770 780 790 800
THPVLPLPLP PQPARERDGK LLEVIERKRC VCKEIKARHR PDRGLCKQES
810 820 830
MPILPSWRRV PEPRKSGTPP CRRQHTVLWD TAI
Length:833
Mass (Da):87,668
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3BC67410155550AA
GO
Isoform 2 (identifier: Q6PFX7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     644-645: TE → K

Show »
Length:832
Mass (Da):87,566
Checksum:i1261F818BF47DF0A
GO
Isoform 3 (identifier: Q6PFX7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-259: Missing.
     644-645: TE → K

Show »
Length:573
Mass (Da):60,380
Checksum:iF1357550FC0768B0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PXJ0E9PXJ0_MOUSE
Neuronal tyrosine-phosphorylated ph...
Nyap1 6430598A04Rik
790Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC38036 differs from that shown. Reason: Frameshift.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0317471 – 259Missing in isoform 3. 1 PublicationAdd BLAST259
Alternative sequenceiVSP_031748644 – 645TE → K in isoform 2 and isoform 3. 2 Publications2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB429289 mRNA Translation: BAJ19138.1
AK032567 mRNA Translation: BAC27928.1
AK080821 mRNA Translation: BAC38036.1 Frameshift.
AK148980 mRNA Translation: BAE28710.1
CH466529 Genomic DNA Translation: EDL19242.1
BC057372 mRNA Translation: AAH57372.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS19775.1 [Q6PFX7-1]
CCDS84980.1 [Q6PFX7-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001334434.1, NM_001347505.1 [Q6PFX7-2]
NP_780730.2, NM_175521.3 [Q6PFX7-1]
XP_006504639.1, XM_006504576.3 [Q6PFX7-2]
XP_006504640.1, XM_006504577.3 [Q6PFX7-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000061789; ENSMUSP00000058217; ENSMUSG00000045348 [Q6PFX7-1]
ENSMUST00000118326; ENSMUSP00000113397; ENSMUSG00000045348 [Q6PFX7-1]
ENSMUST00000212152; ENSMUSP00000148318; ENSMUSG00000045348 [Q6PFX7-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
243300

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:243300

UCSC genome browser

More...
UCSCi
uc009adq.1, mouse [Q6PFX7-1]
uc009adr.1, mouse [Q6PFX7-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB429289 mRNA Translation: BAJ19138.1
AK032567 mRNA Translation: BAC27928.1
AK080821 mRNA Translation: BAC38036.1 Frameshift.
AK148980 mRNA Translation: BAE28710.1
CH466529 Genomic DNA Translation: EDL19242.1
BC057372 mRNA Translation: AAH57372.1
CCDSiCCDS19775.1 [Q6PFX7-1]
CCDS84980.1 [Q6PFX7-2]
RefSeqiNP_001334434.1, NM_001347505.1 [Q6PFX7-2]
NP_780730.2, NM_175521.3 [Q6PFX7-1]
XP_006504639.1, XM_006504576.3 [Q6PFX7-2]
XP_006504640.1, XM_006504577.3 [Q6PFX7-2]

3D structure databases

SMRiQ6PFX7
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi232498, 3 interactors
IntActiQ6PFX7, 7 interactors
MINTiQ6PFX7
STRINGi10090.ENSMUSP00000113397

PTM databases

iPTMnetiQ6PFX7
PhosphoSitePlusiQ6PFX7

Proteomic databases

PaxDbiQ6PFX7
PRIDEiQ6PFX7

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
16487, 8 antibodies

Genome annotation databases

EnsembliENSMUST00000061789; ENSMUSP00000058217; ENSMUSG00000045348 [Q6PFX7-1]
ENSMUST00000118326; ENSMUSP00000113397; ENSMUSG00000045348 [Q6PFX7-1]
ENSMUST00000212152; ENSMUSP00000148318; ENSMUSG00000045348 [Q6PFX7-2]
GeneIDi243300
KEGGimmu:243300
UCSCiuc009adq.1, mouse [Q6PFX7-1]
uc009adr.1, mouse [Q6PFX7-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
222950
MGIiMGI:2443880, Nyap1

Phylogenomic databases

eggNOGiENOG502QRSX, Eukaryota
GeneTreeiENSGT00890000139453
HOGENOMiCLU_012558_0_0_1
InParanoidiQ6PFX7
OMAiMICPKAV
OrthoDBi620667at2759
PhylomeDBiQ6PFX7

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
243300, 0 hits in 18 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Nyap1, mouse

Protein Ontology

More...
PROi
PR:Q6PFX7
RNActiQ6PFX7, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000045348, Expressed in cortical plate and 211 other tissues
GenevisibleiQ6PFX7, MM

Family and domain databases

InterProiView protein in InterPro
IPR026724, NYAP1
IPR026722, NYAP1/NYAP2
IPR029353, NYAP_C
IPR039482, NYAP_N
PANTHERiPTHR22633, PTHR22633, 1 hit
PTHR22633:SF2, PTHR22633:SF2, 1 hit
PfamiView protein in Pfam
PF15452, NYAP_C, 1 hit
PF15439, NYAP_N, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNYAP1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6PFX7
Secondary accession number(s): E1CB66
, Q3UF51, Q8BNR4, Q8CCL6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: July 5, 2004
Last modified: August 12, 2020
This is version 101 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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